Fondazione Policlinico Universitario Agostino Gemelli Irccs

This study is collecting data on how well endoscopic procedures work to treat bile duct narrowing that occurs after liver transplantation. Researchers will follow 40 adult patients who develop this complication to see if the endoscopic treatment successfully opens the narrowed du…

This study is testing whether a special high-fat, low-carbohydrate diet (ketogenic diet) helps rectal cancer patients better tolerate their radiation and chemotherapy treatment. Researchers will compare patients on this special diet to patients following standard nutrition guidel…

This study is testing a new rehabilitation program that uses technology—like clinic robots and home tablet games—to help frail older adults improve their ability to walk and think at the same time, which is crucial for preventing falls. Researchers will compare this tech-based pr…

This study is testing whether injections of a substance made from umbilical cord blood and platelets can slow or stop the progression of dry age-related macular degeneration (AMD), a common cause of vision loss in older adults. Researchers will give the injections to 36 participa…

This study is testing a gentle laser treatment for people with a chronic eye condition called central serous chorioretinopathy (CSC), where fluid builds up under the retina and blurs vision. It is for patients whose condition has not improved after six months of standard medicati…

This study aims to see if a drug called Pasireotide LAR is better than another drug, Pegvisomant, at preventing spine fractures in adults with acromegaly whose disease is not well-controlled. Acromegaly often weakens bones, making fractures common. Researchers will compare the ra…

This study is testing whether using an automated computer system to guide fluid delivery during colorectal surgery helps keep patients' blood pressure stable. It will compare the automated system to standard care in 80 high-risk patients. The goal is to see if this approach reduc…

This study is testing whether a fecal microbiota transplant (FMT) can clear dangerous, drug-resistant bacteria from a person's gut. Researchers will compare the transplant to a placebo in 52 adults who carry these bacteria. The goal is to see if restoring healthy gut bacteria can…

This pilot study is testing whether injections of umbilical cord blood platelet-rich plasma into the eye can slow or stop the progression of dry age-related macular degeneration (AMD). Researchers will enroll 36 participants aged 65+ with bilateral dry AMD to compare the injectio…

This study is testing whether a 12-month, home-based aerobic exercise program can improve thinking skills and slow cognitive decline in people with Parkinson's disease who have mild memory problems. Researchers will enroll 150 participants to compare those who follow the exercise…

This study is testing whether some ovarian cancer patients can safely skip getting a temporary stoma bag (an opening in the abdomen for waste) after major bowel surgery. Researchers want to see if carefully selected 'low-risk' patients heal just as well without this common proced…

This study tests which breathing support method works best to avoid putting patients on mechanical ventilators. It compares two types of helmet-based breathing support against high-flow nasal oxygen in 1,200 ICU patients with severe breathing failure. The main goal is to see whic…

This study is testing a special type of ultrasound scan to see if it can accurately detect dangerous high blood pressure in the liver and identify risky swollen veins in the food pipe (esophagus). It involves 450 adults with advanced liver disease. The goal is to gather informati…

This study is testing a new blood test that looks for tiny pieces of cancer DNA to see if it can detect the return of ovarian cancer earlier than current methods like scans and other blood markers. It will involve 30 women with advanced ovarian cancer who have just been diagnosed…

This study aims to improve treatment planning for advanced ovarian cancer by using artificial intelligence (AI) to analyze videos taken during a diagnostic camera procedure (laparoscopy). The AI will try to predict whether a patient's tumors can be successfully removed with immed…

This study aims to see if a newer, faster molecular test (OSNA) works as well as the current standard method (ultrastaging) for detecting whether endometrial cancer has spread to nearby lymph nodes during surgery. Researchers will randomly assign nearly 2,000 patients to have the…

This study is testing three different breathing masks to see which one helps patients with high carbon dioxide levels breathe more easily. Researchers will measure how much effort patients need to breathe, their comfort levels, and how well the masks remove carbon dioxide. The tr…

This study aims to understand how fat buildup in the pancreas relates to the risk of developing type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat in 100 participants and see how it connects to their metabolic hea…

This study aims to gather detailed health information from 10,000 Italian women who carry BRCA1 or BRCA2 gene mutations, which increase cancer risk. Researchers will track participants over time to better understand how these mutations lead to cancer and to improve prevention and…

This study is testing whether a special type of ultrasound scan can better track how well a targeted radiation therapy works for advanced neuroendocrine tumors. Researchers will scan 30 patients before, during, and after their radiation treatment to see if changes in blood flow t…

This study tests whether a hospital-based education program helps patients who have had their spleen removed understand their infection risks and vaccination needs. Researchers will provide structured education sessions and informational materials to 100 adult patients, then meas…

This study aims to see if analyzing tiny bits of tumor DNA found in blood and stool (called ctDNA) can help doctors better manage treatment for people with cancers of the digestive system, like pancreatic, colon, and bile duct cancer. It will observe 100 patients to see if these …

This study aims to grow miniature versions of liver tumors in the lab using patient tissue samples. Researchers will test how these mini-tumors respond to different cancer drugs and study how gut bacteria might affect treatment success. The goal is to better understand what makes…

This study aims to create a large database of gynecological ultrasound images to help train doctors and develop artificial intelligence (AI) tools for better diagnosis. It will collect images from up to 25,000 women during their routine care, along with their health outcomes. The…

This study aims to find biological markers that can better predict which pancreatic cysts (called IPMNs) are likely to turn into cancer. Researchers will analyze tissue and blood samples from 3,600 patients to understand the differences between low-risk and high-risk cysts. The g…

This study aims to understand how blood flow to the kidneys and intestines changes during heart-lung bypass surgery. Researchers will use a special ultrasound probe to measure blood speed in these organs in 92 patients undergoing planned heart surgery. The goal is to see if chang…

This study aims to understand why some stomach cancers develop specific DNA changes and how these changes affect the disease. Researchers will analyze tissue samples from 245 people who had stomach cancer surgery to look for patterns between these DNA changes, patient characteris…

This study aims to understand how exposure to heavy metals and tiny particles (nanoparticles) in the environment contributes to skin and body-wide allergic reactions. Researchers will compare 280 adults, including people with metal allergies and healthy volunteers, by measuring m…

This study aims to better understand the signals seen on lung ultrasound scans in people with chronic lung diseases like COPD and interstitial lung disease. Researchers will collect ultrasound images and breathing data from 25 hospitalized and outpatient participants to learn how…

This study aims to understand how fecal microbiota transplantation (FMT) works for patients with recurrent C. difficile infections. Researchers will analyze stool samples from 20 patients before and after they receive an FMT procedure to see how the community of gut bacteria chan…

This study aims to collect detailed information about 1000 Italian patients newly diagnosed with advanced lung cancer. Researchers will look at patient backgrounds, symptoms, scan results, and the specific biology of their tumors. The goal is to create a clearer picture of how th…

This study aims to understand how a hepatitis D treatment called bulevirtide affects gut bacteria and bile acids in patients. Researchers will follow 20 patients with hepatitis D and liver damage, collecting samples over 48 weeks to see how these gut factors change during treatme…

This study aims to see if using MRI scans helps doctors better decide which colorectal cancer patients with cancer spread only to the liver can safely have surgery. It will observe 100 patients to see if the MRI changes the surgical plan, either ruling patients in or out for the …

This study aims to better understand how autoimmune encephalitis develops and to search for new disease-causing antibodies that current tests might miss. Researchers will analyze blood samples from about 20 adult patients diagnosed with specific types of this brain inflammation d…

This study is creating a questionnaire to measure how much people who have had their spleen removed know about preventing serious infections. Experts in infection prevention will help design the survey questions through an online voting process. The goal is to build a tool for fu…

This study aims to understand how the shape of the roof of the mouth (palate) changes in children with a specific bite problem (posterior cross-bite) after they are treated with a rapid palatal expander. It will observe 36 children with different facial growth patterns. The main …

This study aims to see if a simple ultrasound scan can be a better tool for tracking breathing problems in adults with Facioscapulohumeral Muscular Dystrophy (FSHD). Researchers will follow 34 patients for one year, comparing ultrasound images of the main breathing muscle (the di…