Fondazione Policlinico Universitario Agostino Gemelli Irccs

This study tests whether a fecal transplant from a healthy donor can clear carbapenem-resistant Enterobacteriaceae (CRE) from the gut of carriers. Fifty-two adults with CRE in their gut will be randomly assigned to receive either a real fecal transplant or a placebo via colonosco…

This study tests whether giving several fecal transplants (instead of just one) works better to clear repeat C. diff infections in people with ulcerative colitis. About 64 adults with active colitis and repeat C. diff will receive either one or multiple infusions of healthy donor…

This study tests whether fecal transplants from carefully selected 'superdonors' can help people with mild-to-moderate ulcerative colitis achieve remission. 42 adults with a recent diagnosis will receive either superdonor FMT or a placebo via colonoscopy and capsules. The main go…

This study tests whether an automated fluid management system can improve blood pressure stability during colorectal surgery. It involves 80 high-risk adults (age 18+, ASA 3) scheduled for laparoscopic colorectal surgery. The goal is to see if the system helps doctors give the ri…

This study looks at whether a 12-month home exercise program can improve thinking skills in people with Parkinson's disease who also have mild memory or attention problems. Researchers will compare exercisers to a sedentary group and measure changes in movement, mood, and blood m…

This study tests three ways to help patients with severe low oxygen levels breathe better without needing a breathing tube. About 1,200 adults will be randomly assigned to receive either a helmet mask that pushes air, a helmet mask that keeps airways open, or high-flow oxygen thr…

This study tests whether injecting a special blood product from umbilical cords into the eye can slow vision loss in people with dry age-related macular degeneration (AMD). The trial will involve 36 participants aged 65 and older with bilateral dry AMD. One eye will receive the i…

This pilot study is testing whether injections of a substance made from umbilical cord blood (called CB-PRP) can slow the progression of dry age-related macular degeneration (AMD), a common cause of vision loss in older adults. The study will enroll 36 people aged 65 and older wi…

This study tests a low-energy laser treatment for central serous chorioretinopathy, an eye condition where fluid builds up under the retina. The 36 participants have not improved with standard medications. The laser aims to reduce fluid and improve vision by targeting the back of…

This study looks at whether the drug Pasireotide LAR can reduce the risk of spine fractures in people with acromegaly better than another drug, Pegvisomant. Acromegaly is a condition where too much growth hormone weakens bones, leading to painful fractures. Researchers will follo…

This study explores whether DNA from routine Pap smears can detect early signs of ovarian cancer in women with high-risk gene mutations. Researchers will compare genetic changes in Pap test samples with tissue removed during preventive surgery. If the method works, it could becom…

This study tests whether ultrasound images of healthy ovaries can predict if a woman carries a harmful BRCA gene mutation, which raises the risk of breast and ovarian cancers. Researchers will develop a computer model using thousands of images from women with known BRCA status. I…

This study aims to develop a new, non-invasive diagnostic tool for colorectal cancer by analyzing gut microbiome signatures in stool samples. Researchers will enroll 1006 participants aged 50-74 who have tested positive on the standard fecal immunochemical test (FIT). By combinin…

This study is testing whether measuring spleen stiffness with a special ultrasound probe can detect advanced liver scarring in people with metabolic fatty liver disease (MASLD). Researchers will follow 500 adults for up to several years to see if the test predicts serious liver p…

This study tests whether artificial intelligence (AI) can analyze videos from a keyhole surgery (laparoscopy) to predict if ovarian cancer tumors can be completely removed. The goal is to help doctors choose the best treatment plan—surgery first or chemotherapy first—for each pat…

This study is testing whether a non-invasive ultrasound of the spleen can accurately detect dangerous vein swelling and high blood pressure in the liver. Researchers will enroll 450 adults with advanced chronic liver disease. If successful, this simple scan could replace the curr…

This study compares two methods—OSNA and ultrastaging—for finding cancer in lymph nodes removed during surgery for early-stage endometrial cancer. About 1,900 women will be randomly assigned to one of the two detection techniques. The goal is to see which method finds more cancer…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This study tests whether remote rehabilitation can help frail older adults improve their ability to walk and think at the same time. Researchers will enroll 80 people aged 65 to 90 who have chronic movement or thinking problems. Participants will receive dual-task training via te…

This study looks at whether people with rectal cancer can stick to a ketogenic diet (very low carbs, high fat) during chemoradiation. About 194 participants will be randomly assigned to either the ketogenic diet or a standard Mediterranean diet for 5 weeks. The main goal is to se…

This study will track jaw muscle activity in 42 adults with chronic jaw pain and teeth grinding (bruxism) who use a custom mouth splint at night. Participants will wear a portable device for 24 hours to measure muscle activity before starting the splint, two weeks later, and afte…

This study tracks 300 adults with aortic disease to measure how their condition impacts quality of life, fatigue, mental health, and ability to work. Researchers will use questionnaires over 12 months to gather data. The goal is to better understand these challenges and help desi…

This study observes 1000 people with severe aortic stenosis and kidney disease who are getting a TAVI procedure. Researchers want to see how removing the blocked valve affects the kidneys' response to contrast dye used during the procedure. The goal is to understand if TAVI lower…

This study looks at whether children with thin gums are more likely to have severely crowded teeth. Researchers will examine 180 kids aged 5 to 16 at different stages of tooth development. The goal is to find early warning signs so dentists can prevent future gum problems.

This study looks at whether lung ultrasound can detect emphysema (a type of lung damage) as well as CT scans do. About 1,600 people with or without emphysema will get both an ultrasound and a CT scan. The goal is to find patterns on ultrasound that match the damage seen on CT, wh…

This study creates miniature, lab-grown versions of liver cancer tumors from patient biopsies. Researchers will test how well different treatments work on these models and look at how gut health and the tumor's environment affect the disease. The goal is to better understand live…

This study will enroll 25 adults with interstitial lung disease or COPD to investigate the physical origins of ultrasound artifacts seen in lung scans. Researchers will compare ultrasound findings with CT scans and wearable sensor data to understand what these artifacts really me…

This study tests a structured program to help adolescents with epilepsy transition from pediatric to adult healthcare. Researchers will compare how many patients attend their first adult clinic appointment and whether they return to pediatric care. The goal is to improve self-man…

This study looks at the immune cells inside pituitary tumors to better understand how they behave. Researchers will analyze tumor samples from 60 adults who are having surgery to remove their pituitary tumor. The goal is to find clues that could lead to new immune-based treatment…

This study follows 2,300 children with epilepsy to see how their thinking and learning abilities change over many years. Researchers will track brain development, seizure control, and quality of life. The goal is to find early signs that predict how a child's cognitive skills wil…

This pilot study tests whether an AI-based system can help doctors better manage fluids and blood pressure during complex ovarian cancer surgery. The system uses special software to guide fluid infusions and predict drops in blood pressure. The goal is to reduce complications lik…

This study aims to gather and analyze detailed medical information from 10,000 people diagnosed with endometrial cancer in Italy. Researchers will look at how the cancer's molecular and immune features affect how long patients stay free of the disease and how long they live overa…

This study surveys about 264 Italian hospitals that treat endometrial cancer to find out how often they use POLE testing. POLE testing helps doctors know which patients have a very low risk of cancer returning and may not need extra treatment. The goal is to understand current pr…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with connective tissue diseases like scleroderma or rheumatoid arthritis. Researchers will analyze tiny particles in the blood called extracellular vesicles and use AI to exami…

This study looks at how certain drugs that affect the body's endocannabinoid system (similar to cannabis) change the way bladder muscle contracts. Researchers will take a small piece of healthy-looking bladder tissue from 65 adults having bladder cancer surgery. They will test th…

This study looks at 50 patients with ovarian cancer that has come back quickly (within 6 months). Researchers will track their health and survival to learn more about who responds best to treatment. The goal is to improve how doctors classify and care for these patients.

This observational study is looking at the gut microbiome of 315 people, including those with irritable bowel syndrome that started after an infection. Researchers will compare their gut bacteria to people who had an infection but no IBS, and to healthy controls. The goal is to f…

This study is developing a questionnaire in Italian to find out how much people who have had their spleen removed know about preventing infections. A team of 20 healthcare experts will use a structured method to agree on the best questions. The final tool will help researchers an…

This study aims to better predict which kidney transplant patients who develop diabetes will later suffer serious complications like heart disease or kidney failure. Researchers will use machine learning and genetic analysis to find new markers in blood, urine, and kidney tissue.…

This study looks at bone density in 100 pregnant women (ages 30-45) with either one baby or twins during the third trimester. Researchers use a special ultrasound-like scan and questionnaires to check bone health and fracture risk. The goal is to see if carrying twins leads to gr…

This study aims to understand how people with obesity feel about their quality of life after undergoing endoscopic vertical gastroplasty (GVE), a less invasive alternative to traditional weight-loss surgery. Researchers will interview 20 Italian adults who had the procedure at le…

This study looks at how common mild depression is in people who have had their first heart attack. Researchers will follow 100 patients for 12 months to see if these mild symptoms affect recovery, heart health, and quality of life. The goal is to better understand the link betwee…

This study aims to better understand cervical mucus and find biological markers that could help diagnose or predict reproductive problems like infertility. Researchers will use infrared spectroscopy to analyze mucus samples from 24 women—some healthy and some with unexplained inf…

This study tracks how fecal microbiota transplantation (FMT) alters the gut microbiome in 20 adults with recurrent Clostridioides difficile infection. Researchers will analyze stool samples before and up to 90 days after FMT to see which bacteria take hold. The goal is to underst…

This study aims to better understand autoimmune encephalitis, a condition where the immune system attacks the brain. Researchers will analyze blood and spinal fluid from 20 patients to find new antibodies that may explain the disease in people who currently test negative. The goa…

This study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…

This study is collecting blood, urine, and breath samples from 280 adults—including those with metal allergies and healthy volunteers—to see if exposure to heavy metals and pollutants leaves distinct biological markers. Researchers will compare levels of metals, lung function, an…

This study looks at how the drug bulevirtide changes gut bacteria and bile acids in people with hepatitis delta (a serious liver infection). Researchers will follow 20 patients for 48 weeks, collecting stool and blood samples to see how these changes relate to liver health. The g…

This study is testing a new blood test that looks for tumor DNA (ctDNA) to see if it can find ovarian cancer coming back earlier than current methods like CT scans or CA-125 blood tests. About 30 women with advanced ovarian cancer will give blood samples over time during their fo…

This study looks at whether giving splenectomy patients a structured lesson about infection risks and recommended vaccines helps them understand and remember better. About 100 adults who had their spleen removed at one hospital will take a quiz before and after the lesson. The go…

This study follows 40 liver transplant patients who develop non-anastomotic biliary strictures—narrowing of the bile ducts not at the connection point. Doctors use an endoscope to place plastic stents and then track how well the strictures resolve. The goal is to gather real-worl…

This study is testing whether a special type of ultrasound (called D-CEUS) can predict if a targeted radiation therapy (PRRT) is working in people with advanced neuroendocrine tumors of the pancreas or gut. About 30 adults with these tumors will get D-CEUS scans before, during, a…

This study looks at how a specific gene change (called hMLH1 hypermethylation) affects stomach cancer. Researchers will study 245 patients who had stomach cancer surgery to find links between lifestyle, genetics, and how the cancer behaves. The goal is to better understand why so…

This study looks at how blood flow in the kidney and gut arteries changes during heart surgery when a heart-lung machine is used. The goal is to learn if these changes are linked to kidney injury after surgery. About 92 adults having heart surgery will take part, and blood flow w…

This study is collecting health information from 10,000 women in Italy who carry BRCA1 or BRCA2 gene mutations, which raise the risk of certain cancers. Researchers aim to better understand where these mutations are most common and how to improve care. Participants simply provide…

This study looks at whether it is safe to avoid creating a temporary stoma (a bag on the belly to collect stool) after removing part of the bowel during surgery for advanced ovarian cancer. About 395 women at low risk for bowel leaks will be followed to see how often leaks happen…

This study compares three different facemasks used with a breathing machine (noninvasive ventilation) in 20 people whose lungs are not removing carbon dioxide well. The goal is to see which mask reduces the work of breathing and helps clear CO2 more effectively. Participants will…

This study follows 34 adults with FSHD over one year to see how their breathing muscles change. Researchers will use ultrasound to measure diaphragm thickness and movement, along with standard breathing tests. The goal is to find out if ultrasound can detect respiratory problems …

This study aims to understand how fat buildup in the pancreas (pancreatic steatosis) is linked to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat and compare it with blood sugar and other metabolic tests. 100 a…

This study looks at how MRI scans can help manage colorectal cancer that has spread only to the liver. Researchers will track 100 patients to see if MRI results change whether doctors consider surgery possible. The goal is to better understand how MRI can guide treatment decision…

This study is looking for biological markers in the blood and tissue that can tell apart harmless pancreatic cysts (IPMN) from those that are likely to turn into pancreatic cancer. Researchers will follow 3,600 patients with IPMN across four Italian hospitals, collecting blood sa…

This observational study is gathering information from 1,000 people with advanced (stage IV) lung cancer in Italy. Researchers will look at patients' demographics, symptoms, imaging, and tumor samples to better understand the disease at the time of diagnosis. No new treatments or…

This pilot study looks at how the roof of the mouth changes shape in 36 growing children with posterior cross-bite after using a rapid palatal expander for about six months. Researchers will use 3D scans to compare before and after treatment in children with different facial grow…

This study is testing whether measuring ctDNA (bits of tumor DNA) in blood or stool can help doctors manage patients with cancers of the digestive tract, including pancreas, colon, and bile duct cancers. Researchers will track survival and see how these markers relate to outcomes…