Fondazione Policlinico Universitario Agostino Gemelli Irccs

This study tests whether injecting a special solution made from umbilical cord blood into the eye can slow or stop the worsening of dry age-related macular degeneration (AMD), a leading cause of vision loss. About 36 people aged 65 and older with dry AMD in both eyes will receive…

This study tests a new way to manage blood pressure and fluids during complex ovarian cancer surgery. The approach uses artificial intelligence to help doctors keep blood pressure stable and avoid giving too much fluid. The goal is to reduce serious complications like kidney inju…

This study is testing whether injections of a substance made from umbilical cord blood (called platelet-rich plasma) can slow down vision loss in people with dry age-related macular degeneration (AMD), a common cause of blindness in older adults. The treatment aims to stop or red…

This study tests whether an automated fluid management system can help maintain stable blood pressure during colorectal surgery in high-risk patients. Researchers will compare the amount of fluids given and how often blood pressure drops occur. The goal is to improve safety and o…

This study looks at whether a special laser (micropulse laser) can help people with central serous chorioretinopathy (CSC) whose condition did not improve with medication. About 36 adults with fluid buildup in the eye for at least 6 months will receive the laser treatment. Resear…

This study compares three ways to help people with severe low oxygen levels breathe better without needing a breathing tube: a helmet that pushes air in, a helmet that keeps airways open (CPAP), and high-flow oxygen through the nose. About 1,200 adults with acute respiratory fail…

This study looks at two medications for acromegaly, a condition causing too much growth hormone. The goal is to see which drug better prevents spine fractures over one year. About 120 adults whose acromegaly is not controlled by first-line treatments will take either Pasireotide …

This study tests whether transplanting healthy donor stool into the gut can eliminate dangerous, antibiotic-resistant bacteria (CRE) in 52 adult carriers. Participants receive either a real fecal transplant or a placebo via colonoscopy, then are monitored for up to 3 months. The …

This study tests whether giving several fecal microbiota transplants (FMT) works better than a single one to clear recurrent C. difficile infection in people with ulcerative colitis. About 64 adults with active colitis and repeat C. diff will receive either one or multiple infusi…

This study tests whether fecal transplants from specially selected 'superdonors' can help people with mild-to-moderate ulcerative colitis achieve remission. 42 adults with a recent diagnosis will receive either the superdonor transplant or a placebo, first by colonoscopy and then…

This study aims to see if ultrasound images of healthy ovaries can predict whether a woman carries a harmful BRCA gene mutation, which raises the risk of breast and ovarian cancer. Researchers will develop a computer model using thousands of images from over 6,400 women. If succe…

This study looks at whether DNA from a routine Pap test can find early signs of ovarian cancer in women with a high genetic risk. Researchers will compare DNA from Pap smears with tissue samples taken during preventive surgery. If successful, this could lead to a simple screening…

This study looks at whether a non-invasive ultrasound technique that measures spleen stiffness can accurately identify high blood pressure in the liver and risky enlarged veins (varices) in people with advanced chronic liver disease. Researchers will enroll 450 adults and compare…

This study compares two methods to find cancer cells in lymph nodes removed during surgery for endometrial cancer. About 1,922 women with early-stage cancer will be randomly assigned to have their lymph nodes checked either by the standard ultrastaging method or by a newer techni…

This study aims to create a new, non-invasive screening tool for colorectal cancer by analyzing gut bacteria in stool samples. Researchers will collect samples from 1,006 people aged 50-74 who are part of a national screening program and have had a positive fecal test. The goal i…

This study is testing a new, non-invasive scanning method that measures spleen stiffness to better detect and monitor advanced liver scarring in people with fatty liver disease (MASLD). Researchers will follow 500 adult patients with confirmed or suspected advanced liver disease …

This study tests a remote rehabilitation program for frail older adults (ages 65-90) with movement or thinking problems. The program combines physical and mental exercises done at home using technology. The goal is to see if this approach improves balance, thinking, and daily fun…

This study looks at whether a ketogenic (low-carb, high-fat) diet helps rectal cancer patients follow their diet plan during chemoradiation. About 194 people will be split into two groups: one gets a personalized keto diet, the other gets standard nutrition advice. The main goal …

This study looks at whether a 12-month home exercise program can help thinking skills in people with Parkinson's disease who also have mild memory or attention problems. About 150 adults aged 30–80 will either do moderate-to-vigorous aerobic exercise at home or continue their usu…

This study is for people with colorectal cancer that has spread only to the liver. Researchers want to see if MRI scans can help doctors decide who should have surgery to remove liver tumors. About 100 adults will take part, and the study will track how often surgery plans change…

This study looks for biological markers in people with pancreatic cysts (IPMN) to better predict which ones are likely to become cancer. By analyzing tissue and blood samples from 3,600 participants, researchers hope to improve risk assessment and guide personalized treatment. Th…

This study looks at the gut bacteria of 315 people to understand why some develop long-term stomach issues after an infection. Researchers will compare those with post-infection IBS to healthy people and those who recovered without IBS. The goal is to find specific bacteria patte…

This study looks at how the shape of the roof of the mouth changes in 36 children with a cross-bite (where upper teeth sit inside lower teeth) after using a rapid palatal expander. The children have different face growth patterns (high, normal, or low angle). Researchers will tak…

This study aims to gather and analyze medical information from 10,000 people diagnosed with endometrial cancer in Italy. Researchers will look at how the cancer's molecular and immune features affect how long patients live without the disease coming back. The goal is to build a d…

This study looks at autoimmune encephalitis, a condition where the immune system attacks the brain, causing rapid confusion and dysfunction. Researchers want to understand why some patients have known antibodies while others test negative, and they aim to discover new antibodies …

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is linked to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat in 100 adults aged 18–80. Participants will have one visit for blood tests…

This study follows 34 adults with FSHD, a muscle disease that can weaken breathing, for one year. Researchers will use ultrasound to measure diaphragm movement and thickness, comparing it to standard breathing tests. The goal is to see if ultrasound can detect changes in respirat…

This study looks at whether a short teaching session can help people without a spleen understand their higher risk of serious infections and the importance of vaccines. About 100 adults who had their spleen removed at one hospital will take a quiz before and after the lesson. The…

This study aims to collect information from 10,000 women in Italy who carry BRCA1 or BRCA2 gene mutations, which increase the risk of certain cancers. By gathering data on where these mutations are found and how they affect health, researchers hope to improve prevention and care …

This study compares three different facemasks used with a breathing machine in 20 people whose lungs are not removing carbon dioxide well. The goal is to see which mask helps the diaphragm work less hard and clears carbon dioxide more effectively. Participants will try each mask …

This study looks at whether it is safe to avoid creating a stoma (a surgical opening in the belly) after removing part of the bowel during ovarian cancer surgery. About 395 women with advanced ovarian cancer who are at low risk for complications will be followed. The goal is to s…

This study tracks 20 adults with chronic hepatitis delta (a serious liver infection) who are starting a new drug called bulevirtide. Researchers want to see how the drug changes the gut's bacteria and bile acids over 48 weeks, and how those changes relate to inflammation and live…

This study looks at whether a blood or stool test that detects tumor DNA (called ctDNA) can help doctors better manage gastrointestinal cancers like pancreas, colon, and bile duct cancer. About 100 adults with these cancers will provide samples, and researchers will track surviva…

This study tracks how fecal microbiota transplantation (FMT) changes the gut bacteria of 20 people with repeat C. difficile infections. Researchers will analyze stool samples before and up to 90 days after the procedure to understand why FMT works so well. The goal is to learn mo…

This study aims to collect ultrasound images of the female reproductive system from 25,000 patients during routine care. The images will be stored in a digital library along with follow-up information to help train doctors and develop artificial intelligence tools. The goal is to…

This study creates tiny, lab-grown copies of liver tumors from 150 patients to better understand liver cancer and test how well different treatments might work. Participants will have their tumor samples collected during surgery, but no new treatment is given. The goal is to lear…

This study is observing how well a non-surgical procedure using a scope (endoscopy) works to treat narrowed bile ducts that can happen after a liver transplant. About 40 adults who have this condition will be followed to see if the treatment clears the blockage. The goal is to ga…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with connective tissue diseases like scleroderma or rheumatoid arthritis. Researchers will analyze tiny particles in the blood and use AI to examine lung scans from 200 partici…

This study will collect information from 1000 adults in Italy who have advanced (stage IV) lung cancer. Researchers want to understand the different types of lung cancer and their features when first found. No new treatments are tested; the goal is simply to learn more about the …

This study looks at 50 women with ovarian cancer that came back quickly after treatment. The goal is to collect information about their health and tumors to help doctors better predict outcomes and plan care. No new treatment is being tested; instead, researchers are observing an…

This study aims to better understand cervical mucus and find biological markers that could help diagnose or predict reproductive problems. Researchers will compare healthy women with those who have unexplained infertility by taking mucus samples and tracking their menstrual cycle…

This study looks at how common mild depression is in people who have had their first heart attack. Researchers will follow 100 patients for 12 months to see if these mild symptoms affect recovery, heart health, and quality of life. The goal is to gather information that could lea…

This study looks at how drugs that interact with the body's natural cannabis-like system affect bladder muscle contractions. Researchers will collect a small piece of healthy-looking bladder tissue from 65 adults having bladder cancer surgery. In the lab, they will test whether t…

This study is creating a questionnaire in Italian to find out how much people who have had their spleen removed know about preventing infections. A team of 20 healthcare experts will use a structured method called Delphi to decide which questions to include. The goal is to better…

This study looks at a specific genetic change called hMLH1 hypermethylation in stomach cancer. Researchers want to understand how this change relates to patient traits and lifestyle, and whether it affects how tumors respond to chemotherapy. By studying 245 patients who had stoma…

This study tests whether artificial intelligence (AI) can analyze images from a camera during a keyhole surgery (laparoscopy) to predict how much of the cancer can be removed in advanced ovarian cancer. About 151 participants with stage III or IV ovarian cancer will take part. Th…

This study looks at how blood flow changes in the kidney and gut arteries during heart surgery when a heart-lung machine is used. The goal is to understand why some patients develop kidney injury after surgery. Researchers will use an ultrasound probe placed in the esophagus to m…

This study looks at how people with obesity feel about their quality of life after a less invasive stomach procedure called endoscopic vertical gastroplasty (GVE). Researchers will interview 20 Italian adults who had the procedure at least six months ago. The goal is to understan…

This study surveys about 264 Italian hospitals that treat endometrial cancer to find out how often they use a test called POLE testing. POLE testing helps doctors know which patients have a very low risk of cancer coming back, so they can safely skip extra treatments like radiati…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find ovarian cancer recurrence earlier than current methods like CT scans or CA-125 blood tests. About 30 women with advanced ovarian cancer will give blood samples over time during their follow-up. I…

This study aims to better predict which kidney transplant patients who develop diabetes will face serious complications like heart disease or kidney failure. Researchers will use advanced testing and artificial intelligence to find new markers in blood, urine, and kidney tissue. …

This study aims to understand how exposure to heavy metals, nanoparticles, and other pollutants might lead to allergies and other health problems. Researchers will compare blood, urine, and skin test results from 280 adults—some with metal allergies, some with related health issu…

This study tests whether a special ultrasound (D-CEUS) can help doctors see if a type of radiation therapy (PRRT) is working in people with advanced neuroendocrine tumors of the pancreas or gut. About 30 adults will get the ultrasound before and after treatment. The goal is to fi…

This study looks at bone density in 100 pregnant women (ages 30-45) between weeks 35 and 41 of pregnancy. Half are carrying one baby, half are carrying twins. Researchers use a special ultrasound-like scan (REMS) and questionnaires to see if twin pregnancies cause greater bone lo…

This study aims to better understand the patterns seen on lung ultrasound scans in people with chronic lung diseases. Researchers will enroll 25 adult patients with conditions like COPD or interstitial lung disease. They will compare ultrasound images with other breathing measure…