Fondazione Policlinico Universitario Agostino Gemelli Irccs

This study looks at how well a combination of two drugs (trifluridine/tipiracil and bevacizumab) works for people with metastatic colorectal cancer. About 300 patients across 15 Italian hospitals are being observed to see how long they live and how long the cancer stays under con…

This study looks at whether a two-step blood test can help doctors find primary biliary cholangitis (PBC) earlier in women over 40 who are at risk. PBC is a chronic liver disease that often has no early symptoms, leading to delayed diagnosis. The test automatically checks for spe…

This study is testing whether two markers in the blood, PLIN2 and RAB14, can accurately diagnose non-alcoholic steatohepatitis (NASH) and advanced liver scarring. Researchers will analyze blood samples from 828 people with NASH, type 2 diabetes, or obesity. If successful, this ap…

This study compares two types of nerve blocks (SPSIP block vs. ICN block) to control pain after lung surgery using a small incision. About 28 adults with lung tumors will be randomly assigned to one block. The goal is to see which block reduces pain, lowers the need for opioids, …

This study is testing a drug called cenobamate in 30 adults with autoimmune epilepsy, a condition where the immune system attacks the brain and causes seizures that often don't respond to standard treatments. The goal is to see if cenobamate can reduce seizure frequency by at lea…

This study tests a surgical technique that creates a pouch from the small intestine to replace the removed stomach. The goal is to reduce dumping syndrome—a common, unpleasant side effect—and improve nutrition and quality of life. About 26 adults with stomach cancer or a high-ris…

This study is testing a new camera-based system called HERO that uses artificial intelligence to measure heart rate, breathing, oxygen levels, blood pressure, body position, and even pain or emotions in heart patients. The goal is to see if the system's readings match standard mo…

This study is testing a questionnaire to see how well it measures self-care in people with idiopathic pulmonary fibrosis (IPF). The tool was originally designed for COPD patients and is being adapted for IPF. 156 adults with IPF who can read and write in Italian are taking part. …

This study looks at how many adults in hospital wards and long-term care homes need extra support for serious illness on a single day (November 11). Researchers will collect information from about 3,000 people using a simple questionnaire. The goal is to find gaps in care and hel…

This study explores a new way to predict how ovarian cancer will respond to chemotherapy. Researchers take thin slices of a patient's tumor and test different drugs on them in the lab. The goal is to see if this method can accurately forecast which treatment will work best for ea…

This study is testing a new way to care for people with rare diseases. It brings together specialists, new technologies like genetic testing, and better coordination between hospitals and local services. The goal is to help 136 patients get a faster diagnosis and reduce unnecessa…

This study looks at whether a blood test that finds tiny bits of tumor DNA (called ctDNA) can help doctors decide who needs extra treatment after surgery for early ovarian cancer. Researchers will test stored blood samples from 50 patients taken before and after surgery. The goal…

This study looks at how a special camera called optical coherence tomography (OCT) helps doctors decide whether and how to open blocked heart arteries during a procedure. About 3,200 adults with various heart conditions will be followed to see if using OCT leads to better short- …

This study looks at how common Charles Bonnet Syndrome (CBS) is in people with vision loss from conditions like macular degeneration or glaucoma. CBS causes complex visual hallucinations in people who are otherwise mentally healthy. Researchers will survey 640 participants to bet…

This study looks at whether a short, 15-minute neurological exam can help doctors find infants at risk for brain development problems. Researchers will test 300 babies up to 24 months old using a standard checklist. The goal is to improve early detection so children can get help …

This study checks if a set of thinking and memory tests usually done in person can be given remotely with the help of an examiner. Researchers will compare results from in-person and computer-based versions in 14 adults aged 50-90 with mild dementia. The goal is to make these ass…

This study aims to understand how T-cells (a type of immune cell) respond to the Takeda dengue vaccine. Researchers will analyze blood samples from 30 healthy adults before and after vaccination to identify markers that may predict protection. The goal is to learn more about the …

This study is testing a new genetic test (called Gersom panel) in 4,000 people with breast, ovarian, or colorectal cancer. The goal is to see if the test can accurately find inherited genetic risks and tumor mutations that might guide treatment choices. Participants provide blood…

This study looks at 40 adults with FSHD, a genetic muscle disease that causes progressive weakness. Researchers will use MRI scans and 3D motion capture to see how muscle damage relates to walking and posture problems. The goal is to find better ways to design orthopedic devices …