Simple blood test could spot hidden liver disease in women
NCT ID NCT07573514
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a reflex blood test to find primary biliary cholangitis (PBC) earlier in women aged 40 and older. When routine blood work shows certain liver enzyme elevations, the lab automatically checks for antibodies linked to PBC. The goal is to see if this automatic follow-up catches more cases of this often-silent disease, which can lead to cirrhosis if untreated.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Reflex blood testing (ALP/GGT followed by AMA/ANA)
- What this could lead to
- If successful, this reflex testing approach could become a standard screening tool to diagnose primary biliary cholangitis earlier, potentially preventing liver damage and improving long-term health.
- What could go wrong
- This is an observational study, not a treatment trial. It may not prove that earlier diagnosis improves outcomes, and the reflex test could miss some cases or lead to false positives.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fondazione Policlinico Universitaro A. Gemelli IRCSS,UOC Medicina Interna e Gastroenterologia,Largo A. Gemelli,
Roma, 00168, Italy
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