Promising new treatment for rare liver disease shows potential in Late-Stage trial
NCT ID NCT06060665
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a drug called seladelpar in 96 adults with primary biliary cholangitis (PBC), a rare liver disease. Participants had not responded well or could not tolerate the standard treatment. The goal was to see if seladelpar could lower a key liver enzyme (alkaline phosphatase) to normal levels over 52 weeks. This is a disease-control study, as PBC typically requires ongoing management.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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(G.I.R.I.) GI Research Institute Foundation
Vancouver, V6Z 2K5, Canada
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American Research Corporation - San Antonio, TX
Austin, Texas, 78757, United States
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Baylor College of Medicine - Baylor Clinic
Houston, Texas, 77030, United States
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Bon Secours Liver Institute of Hampton Roads
Richmond, Virginia, 23226, United States
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California Liver Research Institute
Pasadena, California, 91105, United States
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California Pacific Medical Center
San Francisco, California, 94115, United States
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Centre de Recherche du Centre Hospitallier de I'Universite de Montreal (CRCHUM)
Montreal, H2X3J4, Canada
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Covenant Metabolic Specialists, LLC
Sarasota, Florida, 33912, United States
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Covenant Metabolic Specialists, LLC
Tampa, Florida, 33606, United States
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Digestive Healthcare of Georgia
Atlanta, Georgia, 30309, United States
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Florida Research Institute
Lakewood Rch, Florida, 34211, United States
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Galen Hepatology
Hixson, Tennessee, 37343, United States
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Gastro Health Research
Miami, Florida, 33176, United States
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Gastro Health Research
Liberty Township, Ohio, 45044, United States
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Gastrointestinal Associates of Northeast Tennessee, P.C.
Johnson City, Tennessee, 37604, United States
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Henry Ford Health System
Novi, Michigan, 48377, United States
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Kansas City Research Institute
Kansas City, Missouri, 64131, United States
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Liver Associates of Texas, P.A.
Houston, Texas, 77030, United States
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Liver Center of Texas
Dallas, Texas, 75234, United States
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Louisiana Research Center, LLC
Shreveport, Louisiana, 71105, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mercy Medical Center - Baltimore, Maryland
Baltimore, Maryland, 21202, United States
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New York University (NYU) Langone Medical Center
New York, New York, 10016, United States
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New-York-Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, 11215, United States
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Northwell Health Center for Liver Disease and Transplantation
Manhasset, New York, 11030, United States
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Northwestern Medicine Clinical Research Unit (CRU)
Chicago, Illinois, 60611, United States
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OGI - Gastro One
Cordova, Tennessee, 38018, United States
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Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104, United States
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Soma Clinical Trials, LLC
Denison, Texas, 75020, United States
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South Denver Gastroenterology
Englewood, Colorado, 80113, United States
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Stanford University
Seattle, Washington, 98195, United States
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The Institute for Liver Health II LLC dba Arizona Clinical Trials; Arizona Liver Health
Chandler, Arizona, 85224, United States
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The Liver Institute at Methodist Dallas Medical Center
Dallas, Texas, 75203, United States
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
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Tulane University Medical Center
New Orleans, Louisiana, 70112, United States
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UPMC Center for Liver Health
Pittsburgh, Pennsylvania, 15213, United States
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University of California (UC) Davis Medical Center
Sacramento, California, 95817, United States
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University of Colorado Denver - School of Medicine - Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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University of Miami - Schiff Center for Liver Diseases
Miami, Florida, 33136, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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University of Rochester Medical Center - Strong Memorial Hospital
Rochester, New York, 14642, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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Velocity Clinical Research - Seattle
Seattle, Washington, 98105, United States
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Weill Cornell Medicine
New York, New York, 10065, United States