Fondazione Policlinico Universitario Agostino Gemelli Irccs

This study aims to evaluate how well custom 3D-printed and modular prosthetic implants work for rebuilding bone after surgery to remove bone tumors. It will follow 100 adults who have had these implants to see how well they function, improve quality of life, and what complication…

This study aims to see how well dental implants work for patients who get them in a hospital setting, often while managing other health conditions. Researchers will follow 20 patients to check if the implants stay in place, if the bone around them is healthy, and how satisfied pa…

This study is testing whether a daily dietary supplement can help support the natural health and defenses of the male reproductive system in men who have an HPV infection and are experiencing infertility. It will involve 48 couples where the man has HPV. Half the couples will tak…

This study aims to find out if using a robot to assist in gastric bypass surgery is as safe and effective as the standard laparoscopic method for people with severe obesity. Researchers will compare the two approaches in 512 patients, looking at complications, recovery time, and …

This study is testing whether a new type of oral iron supplement (Sucrosomial iron) can treat iron-deficiency anemia in pregnant women as effectively as the standard intravenous (IV) iron treatment. It will involve 82 women in their second or third trimester. The main goal is to …

This study aims to measure how successful root canal treatments and retreatments are when performed in a hospital dental clinic. Researchers will follow 75 adult patients for up to 5 years, checking for pain, healing on X-rays, and whether the treated tooth survives. The goal is …

This study is testing whether a daily dietary supplement can help men clear an active HPV infection and support their sperm health. It involves couples where the man has HPV and the woman does not, and they are trying to get pregnant. The goal is to see if the supplement helps cl…

This study is testing a new personalized treatment for bile leaks that don't heal with standard procedures after liver surgery or transplant. Doctors will grow a patient's own bile duct cells in the lab into tiny 3D structures called organoids, then deliver them back to the leak …

This study aims to find the best fertility-sparing surgery for young women with cervical adenocarcinoma. Researchers will compare three different surgical techniques to see which one best controls the cancer while allowing for successful future pregnancies. They will analyze exis…

This study aims to see how well a specific oral hormone therapy (relugolix combination therapy) works for reducing pelvic pain in women with endometriosis during routine medical care. It will follow about 33 women for 24 weeks to measure changes in their pain levels and other sym…

This study will compare two surgical approaches for removing the uterus for benign (non-cancerous) conditions like fibroids or heavy bleeding. Researchers will follow 500 patients for three years to see which method—total removal or partial removal—leads to better long-term quali…

This study aims to find the best place to inject a common blood thinner (enoxaparin) in people with severe obesity. Researchers will compare injections in the arm versus the abdomen to see which location provides more consistent drug levels in the blood. The goal is to better pre…

This study is testing a questionnaire designed to help breast cancer patients on specific medications decide when they truly need to visit the hospital for a check-up. It aims to improve patients' quality of life by reducing unnecessary hospital trips while ensuring they get care…

This study compares two surgical tools for treating a serious jaw bone condition caused by certain medications. It will enroll 34 patients to see if a newer, ultrasonic 'piezoelectric' tool causes less pain and discomfort after surgery than the traditional rotating drill. The mai…

This study is testing a procedure to help preserve jawbone after a tooth is pulled, making it easier to place a dental implant later. Researchers will follow 50 patients at a hospital in Italy to see how well the bone graft works and how successful the implants are. They will use…

This early study is testing whether injecting a patient's own stem cells into the small intestine can help control type 2 diabetes. Researchers will deliver the cells through a standard endoscopy procedure to target the area near the pancreas. The main goal is to check if this ap…

This study aims to see if a special type of ultrasound can be used to diagnose a rare liver condition called porto-sinusoidal vascular disorder (PSVD) without needing a surgical biopsy. Researchers will compare the ultrasound results from 100 people who have PSVD to those who hav…

This study aims to find better ways to spot the earliest signs of glaucoma, a disease that can silently damage vision. Researchers will use advanced eye scans and vision tests on 60 people with high eye pressure or early glaucoma. The goal is to improve early detection so treatme…

This study aims to see if a non-invasive ultrasound test can accurately identify problems with the tiny blood vessels in the heart. It will involve 35 people who have chest pain despite having clear main heart arteries, along with some healthy volunteers for comparison. Researche…

This study aims to see if special ultrasound scans can accurately measure pressure in the liver's blood vessels without using invasive needle procedures. Researchers will test 107 adults with liver cirrhosis who have already had or need the standard invasive pressure test. They'l…

This study aims to see if a standard, non-invasive heart scan (TTE) is accurate enough to rule out a serious heart infection called infective endocarditis. If it is, many patients could avoid needing a more invasive and uncomfortable test (TOE). The researchers will enroll 350 pa…

This study is testing a new type of ultrasound scan to see if it can accurately tell whether a liver cancer treatment has worked. It will involve 200 adults who have had a heat-based treatment to destroy small liver tumors. The goal is to see if this safer, radiation-free scan ca…

This study is testing a new artificial intelligence (AI) tool designed to help doctors make better decisions for ovarian cancer patients. The AI will analyze videos taken during a diagnostic procedure to try to predict the specific type of cancer and whether surgeons will likely …

This study aims to create and test a practical system for hospitals to offer and give recommended vaccines to adults with chronic diseases or weakened immune systems. It will involve 1,500 patients, offering vaccines during their hospital visits or stays. The goal is to see if th…

This research aims to understand and prevent suicide in young adults (18-25) with mood disorders. It will test whether a non-invasive brain stimulation technique (dTMS) reduces suicidal thoughts and risk. The study also collects extensive health data—including brain scans, geneti…

This study is testing whether a daily oral supplement containing collagen peptides can improve quality of life and ease symptoms like vaginal dryness, pain, and urinary incontinence in menopausal women. It will involve 43 participants who will take the supplement for 16 weeks. Th…

This study is testing whether a special dietary supplement called GenesiDol can help reduce joint and muscle pain in people with inflammatory bowel disease (IBD). It will involve 40 adults with IBD who experience persistent musculoskeletal pain. Researchers will measure changes i…

This study is testing whether a brief psychological support program before lung cancer surgery can help reduce patients' anxiety and depression. It will involve 138 adults scheduled for surgery, comparing those who receive four weekly therapy sessions to those who do not. The mai…

This study is testing whether a remote coaching program using video calls can help people with idiopathic pulmonary fibrosis (IPF) better manage their own care. It aims to see if this approach improves how patients monitor their symptoms, follow their treatment, and handle flare-…

This study is testing whether a brain training technique called neurofeedback can help manage chronic pain in people with inflammatory bowel disease (IBD). Researchers will enroll 80 adults with IBD and persistent musculoskeletal pain. Half will receive eight sessions of neurofee…

This study aims to understand how common and what types of headaches occur in adults with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), a rare inflammatory condition of the brain and spinal cord. Researchers will observe about 25 patients to describe th…

This study aims to better understand the connection between cancer and mental health conditions like depression and anxiety. It will observe 2,000 participants, including cancer patients with psychiatric symptoms, their family members, and several comparison groups. Researchers w…

This study aims to better understand MRKH syndrome, a rare condition where a woman is born without a uterus or with an underdeveloped one. Researchers will collect detailed ultrasound scans and other medical information from 25 patients to create a new system for classifying the …

This study compares two different DNA sequencing machines to see if they give similar results for genetic testing in cancer patients. Researchers will test the same patient samples on both the new MGI machine and the established Illumina machines. The goal is to determine if the …

This study aims to understand how fat around the heart and belly is linked to body-wide inflammation and early signs of future health problems like diabetes, fatty liver disease, and heart disease. Researchers will enroll 400 adults without known heart or liver disease. Participa…

This study aims to discover new ways that dangerous blood clots form in people with heart and blood vessel diseases. Researchers will analyze blood samples from 200 patients who have narrowing of the carotid artery in their neck, with or without symptoms. The goal is to identify …

This study aims to test a new questionnaire designed to measure patients' experiences with telemedicine (virtual doctor visits). Researchers will ask at least 200 adults who recently used telemedicine services to complete the survey. The goal is to create a reliable tool that cap…

This study aims to identify simple blood markers that can predict whether surgery to treat infected joint replacements will be successful. Researchers will follow 200 patients who have surgery for infected artificial joints, tracking their recovery over at least 12 months. The go…

This study aims to understand what types of bacteria live inside breast cancer tumors and how they differ across various breast cancer subtypes. Researchers will collect tumor tissue, normal tissue, urine, and stool samples from 240 women undergoing breast cancer surgery. The goa…

This study aims to understand how the drug ravulizumab affects people with generalized myasthenia gravis by tracking changes in their blood proteins over time. Researchers will follow 24 adult patients for 26 weeks, collecting blood samples to identify proteins linked to treatmen…

This study aims to understand why some patients with pancreatic problems continue to have digestive symptoms and weight loss even while taking standard enzyme replacement pills. Researchers will use simple breath tests to check for a condition called SIBO (small intestinal bacter…

This study aims to understand whether surgeons can accurately identify specific features of advanced ovarian cancer just by looking at it during surgery. Researchers will ask 70-80 experienced ovarian cancer surgeons to review laparoscopic images from 19 patients and describe wha…

This study is asking patients with gynecologic cancers if they would be interested in receiving their long chemotherapy treatments at night. Researchers want to know if a nighttime clinic would be more convenient for patients' daily lives. They will survey 200 patients to gather …

This study aims to understand if there is a link between a child's gum type and how crowded their teeth are. Researchers will observe 180 children, aged 5 to 16, measuring their gum thickness and the amount of crowding in their teeth. The goal is to gather information that could …

This study aims to understand if two specific proteins (SCUBE-1 and SCUBE-3) in the blood could serve as markers for inflammation and heart disease risk in women with polycystic ovary syndrome (PCOS). Researchers will compare protein levels in 56 women with PCOS—some with normal …

This study aims to see if a job rotation program helps heart care nurses. It will compare nurses who switch between different units every two months with those who stay in their usual roles. Researchers want to know if rotating improves nurses' skills, reduces burnout, and create…

This study aims to understand how often blood-thinning medications are prescribed to patients receiving end-of-life (palliative) care. It will observe 410 hospitalized adults who have been referred for this type of care. The goal is to describe current medical practices, as there…

This study aims to understand how well patients follow their prescribed cholesterol-lowering treatments after a stroke or mini-stroke (TIA). Researchers will observe 500 patients for 90 days to see how many stick to their treatment plan, reach healthy cholesterol goals, and avoid…

This study aims to find better ways to predict which pregnant women with high blood pressure will develop severe, dangerous forms of preeclampsia. Researchers will observe 120 women, using ultrasound scans and blood tests to look for early warning signs. The goal is to help docto…

This study aims to see if a newer, more detailed type of heart ultrasound (called speckle tracking) can better predict survival and other health outcomes for patients having surgery for a leaky mitral valve. It will compare this new scan's predictions against the current standard…

This study aims to understand why some patients with heart rhythm problems respond well to treatments like pacemakers or ablation, while others do not. Researchers will observe 253 adults with various heart conditions who are scheduled for these procedures. By using advanced hear…

This study aims to find out if tiny plastic particles, called microplastics, are present in the human pancreas for the first time. Researchers will analyze tissue from 10 people having pancreas surgery to look for these plastics. They also want to see if the amount of plastic fou…

This study aims to create a tool to help doctors better predict which hospitalized patients have tuberculosis. Researchers will collect information from about 686 adult patients who are suspected of having TB. The goal is to develop a score that helps decide who needs isolation f…

This study aims to better understand when and why patients with severe liver pressure (portal hypertension) bleed during planned medical procedures. It will follow 2500 patients to track bleeding events and identify which patient and procedure factors are most predictive of risk.…

This study aims to gather detailed information about severe infections caused by bacteria that are resistant to many antibiotics. Researchers in southern Italy will collect data from 100 adult patients to understand how common these infections are, which specific bacteria are inv…

This study aims to understand if people with oral lichen planus (a chronic inflammatory mouth condition) have a higher risk of developing blood clots or heart problems. Researchers will follow 55 adults with this condition for one year, measuring specific blood factors related to…

This study aims to see if measuring certain substances (IL-6 and lactate) in the mother's and baby's blood at birth can help identify early signs of infection or inflammation in the baby. Researchers will compare two groups of full-term pregnant women: those with a concerning fet…

This study aims to improve how surgeons are trained for delicate brain and spine operations. Researchers will carefully test and measure different surgical techniques on 35 donated human bodies to see which methods give surgeons the best view and working space. The goal is to fin…

This study aims to understand how diseases of the body's main artery (aorta) affect people's quality of life, energy levels, and ability to work. Researchers will follow 300 patients for one year to measure changes in their work capacity and well-being. The goal is to gather info…

This study aims to understand how doctors make decisions about continuing or stopping blood-thinning medications for patients in palliative (comfort) care. Researchers will survey 300 Italian physicians using hypothetical patient scenarios. The goal is to learn about current medi…

This study aims to understand how different pressure settings on a breathing machine affect heart function in patients with severe acute respiratory distress syndrome (ARDS). Researchers will test three pressure levels in 20 patients to see how lung collapse and overstretching im…

This study aims to understand the experiences of mothers and fathers when the father is either present or absent during a planned cesarean birth. Researchers will interview about 30 couples in Italy after their baby is born to learn about their feelings, expectations, and the sup…

This study aims to see if a simple chest ultrasound scan can help doctors predict how serious a child's respiratory infection will be and how long they might need to stay in the hospital. Researchers will observe 300 children and young adults (ages 0-20) who come to the emergency…

This study aims to understand which of two common breathing machine strategies better protects the lungs of patients with severe breathing failure (ARDS). Researchers will compare a method that lets patients breathe on their own a bit with one where the machine does all the work.…

This study aims to understand how a common diabetes medication (SGLT2 inhibitors) affects the body's automatic nervous system, which controls the heart. Researchers will monitor the heart rate patterns of 150 adults with type 2 diabetes, some of whom also have heart failure or ch…

This study aims to create practical guidelines for doctors and healthcare systems on how to best use two modern tools for preventing heart disease: wearable fitness trackers and genetic risk scores. A small panel of experts in cardiology, personalized medicine, and digital health…

This study is testing a new training program for imaging technologists (the staff who operate CT and MRI machines) to learn how to safely place the small IV needed for contrast dye injections. Researchers want to see if the training improves the technologists' skills, reduces com…

This study aims to find early warning signs in the blood that could predict future heart damage in children and teens who were successfully treated for cancer with a type of drug called anthracyclines. Researchers will compare blood tests and heart scans from 40 young cancer surv…