Fondazione Policlinico Universitario Agostino Gemelli Irccs

This pilot study tests whether a daily supplement containing EGCG, folic acid, vitamin B12, and hyaluronic acid can help men with active HPV infection clear the virus and support genital health. About 34 couples trying to conceive will take part, with the male partner receiving e…

This study tests a new, non-invasive treatment for rare genetic conditions that cause the skull bones to fuse too early. The approach uses custom-designed genetic medicines delivered via a special nano-ink gel applied directly to the skull. The goal is to slow or stop abnormal bo…

This study looks at whether people with HIV who are already well-controlled on daily pills can switch to a long-acting injection given every 2 months. The goal is to see how many stay on the shots without stopping or needing to change treatment over 48 weeks. About 200 adults wit…

This study tests whether a daily dietary supplement containing EGCG, vitamin B12, hyaluronic acid, and folic acid can help men with HPV maintain natural defenses in the genital tract and reduce the risk of passing the virus to their female partner. The study involves 96 participa…

This study tests whether a new type of oral iron supplement (Sucrosomial iron) can treat iron deficiency anemia in pregnant women as effectively as intravenous (IV) iron, but with fewer side effects and lower cost. The trial will include 82 pregnant women between 24 and 32 weeks …

This study tests a new treatment for people with bile leaks that won't heal after standard procedures. Doctors will take a small sample of bile duct tissue during surgery, grow it into mini-organs in the lab, and then inject them into the leak site. The goal is to see if these la…

This early study tests if injecting a person's own fat stem cells into the upper gut can safely improve blood sugar control in type 2 diabetes. About 15 adults with poorly controlled diabetes will receive the treatment through an endoscope. The main goal is to check safety, but r…

This study aims to see if a non-invasive ultrasound test can accurately diagnose coronary artery issues in 35 patients with stable chest pain but no major blockages. Participants will undergo the ultrasound and results will be compared to previous invasive tests. A small group of…

This study tests a new way to use contrast-enhanced ultrasound (CEUS) to see if liver cancer treatment (ablation) worked completely. Researchers will compare CEUS results with standard CT or MRI scans in 200 adults. If accurate, this method could reduce the need for radiation or …

This study explores whether a special ultrasound technique (dynamic contrast-enhanced ultrasound) can accurately diagnose a rare liver condition called porto-sinusoidal vascular disorder (PSVD) without needing an invasive liver biopsy. Researchers will compare ultrasound results …

This study looks at new methods to find early signs of glaucoma, a leading cause of blindness. About 60 adults with glaucoma or high eye pressure will get advanced eye scans and vision tests. The goal is to catch damage sooner and improve current diagnosis.

This study looks at whether a combination of ultrasound and spleen stiffness measurements can accurately detect dangerous high blood pressure in the liver (portal hypertension) without using an invasive needle test. Researchers will enroll 107 adults with liver cirrhosis and comp…

This study looks at whether a non-invasive heart ultrasound (TTE) can accurately rule out infective endocarditis, a serious heart infection. Researchers will compare TTE results to the standard, more invasive test (TOE) in 350 adults. If TTE proves reliable, many patients could a…

This study compares a newer, gentler surgical tool (piezoelectric) with standard tools for treating a jaw bone condition caused by certain medications. About 34 adults with stage 1 or 2 medication-related jaw osteonecrosis will be randomly assigned to one of the two surgical meth…

This study looks at how well a daily pill called relugolix combination therapy works for easing endometriosis pain over 24 weeks in everyday medical practice. About 33 women aged 18 to 50 with confirmed endometriosis and moderate to severe pain will take part. The goal is to see …

This study looks at whether a short program of four weekly counseling sessions before lung cancer surgery can lower anxiety and depression in patients. About 138 adults scheduled for lung cancer surgery will be split into three groups: one getting the counseling, one that refuses…

This study tests whether a daily oral supplement containing collagen peptides and other ingredients can improve quality of life for menopausal women with vaginal dryness, pain, and mild urinary incontinence. Over 16 weeks, 43 women will report changes in symptoms and sexual funct…

This study tests whether a dietary supplement called GenesiDol can reduce joint and muscle pain in people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. About 40 adults with persistent pain will take the supplement for 8 weeks. The goal is to s…

This study tests whether a brain-training technique called neurofeedback can reduce muscle and joint pain in people with inflammatory bowel disease (IBD). Eighty adults with IBD and persistent pain will use a special device to learn how to control their brain activity. The goal i…

This study compares two laparoscopic hysterectomy methods (total vs supracervical) for benign conditions like fibroids and endometriosis. About 500 women will be followed for 3 years to see which surgery leads to better quality of life and fewer complications. The goal is to help…

This study compares two types of weight-loss surgery for people with severe obesity: robot-assisted and traditional laparoscopic gastric bypass. Researchers will track complications, recovery time, and costs in 512 adults to see which approach is better. The goal is to find the s…

This study looks at 400 adults without known heart or liver disease to understand how fat around the heart and belly is linked to early signs of heart disease, diabetes, and fatty liver. Participants will have non-invasive tests like ultrasound and blood work. The goal is to find…

This study tests a new questionnaire called PET that measures how patients feel about their telemedicine visits. Researchers will ask 200 adults who had a video or phone appointment to fill out the survey. The goal is to make sure the questionnaire is reliable and captures what m…

This study looks at different surgical methods to treat a rare type of cervical cancer while preserving the ability to have children. Researchers will review past data and their own records to compare how well each surgery controls the cancer and allows for successful pregnancies…

This study aims to find early warning signs in the blood that could predict heart damage in children and teens who have been treated with a type of chemotherapy called anthracyclines. Researchers will measure specific proteins and other substances in the blood of 40 childhood can…

This study looks at why some baby or adult teeth fail to come in properly. Researchers will study 50 people with this rare condition to find better ways to tell apart the different causes, including a genetic form. The goal is to help doctors make more accurate diagnoses and impr…

This study looks at 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have belly pain, bloating, or diarrhea. Researchers will use simple breath tests to check if a gut bacteria overgrowth (SIBO) is the …

This study involves 50 adults with a certain type of advanced breast cancer (HR+HER2-) who are taking hormone therapy and CDK4/6 inhibitors. Researchers want to see if a simple questionnaire can accurately tell which patients truly need to come to the hospital for a check-up. If …

This study will monitor 150 adults with type 2 diabetes, some with heart failure or kidney disease, to see how a class of drugs called SGLT2 inhibitors affects the balance between the 'fight or flight' and 'rest and digest' nervous systems. Participants will wear a heart monitor …

This study looks at how aortic disease affects patients' quality of life, fatigue, mental health, and ability to work. Researchers will follow 300 adults aged 18 to 70 for one year. The goal is to better understand these challenges and help create care that supports both health a…

This study looks at whether having nurses switch departments every two months helps them gain new skills, feel less burned out, and improve the workplace. About 86 nurses from a heart hospital will take part, with some rotating and others staying put. Researchers will measure cha…

This study is developing a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will interview patients and test the questionnaire with 275 adults to make sure it is accurate and reliable. The goal is to give doct…

This study looks at whether a special ultrasound technique (speckle tracking) can better predict survival and heart problems after mitral valve surgery compared to the current standard method. Researchers will follow 300 adults with severe mitral regurgitation who are having surg…

This study measures levels of two proteins, SCUBE-1 and SCUBE-3, in the blood of women with polycystic ovary syndrome (PCOS) and compares them to healthy women. Researchers want to see if these proteins can act as markers of inflammation and help explain the higher risk of heart …

This study will follow 2,000 people with cancer and their family members to better understand the link between cancer and mental health issues like depression and memory problems. Researchers will compare those with and without psychiatric disorders to see how these conditions ch…

This study looks at two ways of using a breathing machine in patients with severe lung injury (ARDS). It compares a method that lets patients breathe on their own with a method that fully controls their breathing, sometimes with muscle relaxants. The goal is to see which approach…

This study aims to find and measure microplastics in the pancreas of 10 people having pancreatic surgery. Researchers will also check fat tissue and blood. The goal is to see if microplastics are linked to metabolic problems or cancer. This is an early, observational study, not a…

This study tests whether artificial intelligence (AI) can accurately predict the type of ovarian cancer and how well surgery will work by analyzing videos from a routine diagnostic procedure (laparoscopy). Researchers will enroll 100 adults with advanced ovarian cancer. The goal …

This study looks at how often adults in palliative care (end-of-life support) are given blood-thinning medications. Researchers will review the records of 410 hospitalized patients to see current prescribing patterns. The goal is to gather information that could help create bette…

This study checks if surgeons can tell key details about ovarian cancer by looking at images from a camera inside the belly. About 70-80 surgeons will review pictures from 50 patients and guess the cancer type and growth pattern. The goal is to see if visual clues can help choose…

This study brings together 10 experts in cardiology, personalized medicine, and digital health to develop practical recommendations for using wearable devices and polygenic risk scores to prevent heart disease. Through online surveys, the experts will identify key requirements fo…

This study looks at 300 children (ages 0-20) with respiratory infections to see if chest ultrasound can predict how sick they will get. Researchers will check ultrasound patterns and combine them with oxygen levels to forecast hospitalization and ICU needs. The goal is to improve…

This study looks at 1,000 adults to see if early signs of artery hardening are linked to memory and thinking problems. Participants get non-invasive scans and cognitive tests at one visit. No treatment is given—the goal is to better understand how blood vessel health affects brai…

This study aims to understand how doctors make tough choices about blood-thinning medications for patients receiving palliative care. Researchers will survey 300 physicians using hypothetical cases to see whether they would continue or stop these drugs. No treatments are given; t…

This study aims to create a risk score that helps doctors quickly tell which patients with suspected tuberculosis actually need isolation. Researchers will collect data from 686 hospitalized adults to build a model based on symptoms, history, and test results. The goal is to impr…

This study looks at how mothers and fathers feel about the father being present or absent during a planned cesarean section. Researchers will interview 30 couples in Rome to understand their emotions and expectations. The goal is to learn how to better support families and improv…

This study will measure two substances (IL-6 and lactate) in the blood of mothers and their newborns to see if they can signal infection or inflammation in the baby before birth. Researchers will compare 160 full-term pregnant women whose fetal heart rate patterns suggest possibl…

This study will look at 120 pregnant women with high blood pressure or preeclampsia to see if special ultrasound scans and blood tests can predict who will develop severe problems. The goal is to find better ways to identify women at highest risk, so doctors can monitor them more…

This study checks if a newer, cheaper DNA sequencing machine (MGI) works as well as the current standard (Illumina) for finding gene changes linked to hereditary cancers like breast, ovarian, and Lynch syndrome. Researchers will compare results from 248 stored DNA samples using b…

This study tests whether motivational interviewing—a type of counseling—delivered through video calls can help people with idiopathic pulmonary fibrosis (IPF) improve their self-care. About 124 adults with IPF will take part. The goal is to see if this approach helps them better …

This study uses donated human bodies (cadavers) to test new, less invasive ways to perform brain and spine surgery. Researchers will measure how much space and visibility each method gives surgeons. The goal is to improve surgical training and find better techniques, without usin…

This study looks at whether a thorough geriatric assessment before liver surgery (hepatectomy) can reduce major complications in patients aged 70 and older. Researchers will follow 242 participants to see if this approach improves safety and recovery. The goal is to tailor care f…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and remote monitoring to understand why some patients respond well to treatment while others do not. The goal is to id…

This study looks at how different skin doctors (dermatologists, surgeons, oncologists) classify and treat a common skin cancer called basal cell carcinoma. Researchers will show 20 patient cases to specialists and see if they agree on the stage and best treatment. The goal is to …

This study looks at whether a detailed ultrasound system (IOTA) can better predict which ovarian cysts in unborn babies will cause problems. About 100 pregnant women will join, and their babies' cysts will be tracked with multiple scans before and after birth. The goal is to safe…

This study looks at a new way to offer vaccines to adults with chronic illnesses or weakened immune systems while they are in the hospital. The goal is to see if offering vaccines during hospital visits helps more people get vaccinated. Researchers will track how many patients ar…

This study surveys 480 Italian dental students to understand their attitudes, knowledge, and any discriminatory behavior toward HIV-positive patients. Researchers want to see if students feel uncomfortable treating these patients and if they follow proper sterilization protocols.…

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic. Researchers will check healing using X-rays and symptom reports for up to 5 years. The goal is to see how often these treatments succeed in a hospital setting and how factor…

This study compares two types of ultrasound to see which better measures severe bowel endometriosis before surgery. About 98 women will get both a standard vaginal ultrasound and a special ultrasound during their operation. The goal is to help surgeons plan more precisely and pos…

This study tests whether using ultrasound during surgery helps doctors better remove deep endometriosis from the bowel while keeping the bowel wall safe. About 57 women aged 20-60 with bowel endometriosis will take part. The goal is to see if ultrasound measurements during surger…

This study will follow 100 adults in southern Italy who have severe infections caused by carbapenem-resistant Enterobacterales (CRE), a type of bacteria that is hard to treat. Researchers want to learn more about the bacteria's resistance patterns and genetic traits to help docto…

This study aims to see how well preserving the jawbone right after a tooth extraction helps with placing dental implants later. Researchers will follow 50 adults who need this bone-saving procedure before getting implants. The goal is to measure bone changes and implant success i…

This study looks at whether estimated or self-reported weight and height in older hospital patients (age 65+) lead to incorrect nutrition assessments. Researchers will compare these estimates with exact measurements and see how they affect nutrition scores. The goal is to improve…

This study looks at whether a structured training program helps radiologic technologists (the staff who run imaging machines) safely place IVs for contrast dye in CT or MRI scans. Researchers will train 9 technologists and then check how well they perform, how often complications…

This study aims to better understand why some young people (ages 18-25) with mood disorders are at risk for suicide. Researchers will combine brain imaging, genetic tests, and microbiome analysis to identify risk factors. They will also test whether a non-invasive brain stimulati…

This study will look at 25 adults with MOGAD, a rare disease that affects the brain and nerves, to find out how often they get headaches and what those headaches are like. Researchers will collect information from medical records and interviews to see if headaches are linked to o…

This study looks at whether injecting a blood thinner (enoxaparin) into the arm or the belly works better for people with severe obesity (BMI over 40). The goal is to find the best spot to prevent dangerous blood clots. About 80 adults will take part, and researchers will measure…

This study looks at whether children with thin gums are more likely to have severely crowded teeth. Researchers will examine 180 kids aged 5-16 at different stages of tooth development. The goal is to help dentists plan better treatments and prevent gum problems later in life.

This study aims to uncover new reasons why blood clots form in people with heart disease, diabetes, and other illnesses. Researchers will analyze blood samples from 200 patients with carotid artery stenosis to measure markers of oxidative stress and clotting factors. The goal is …

This study aims to find out if simple, inexpensive blood tests can predict how well patients recover after surgery for an infected joint replacement. Researchers will follow 200 adults with infected hip or knee replacements who need a two-stage revision surgery. The goal is to id…

This study looks at whether people with oral lichen planus, a chronic inflammatory mouth condition, have a higher risk of heart problems or blood clots. Researchers will measure natural anticoagulant levels and antiphospholipid antibodies in 55 adults with the condition. The goal…

This study looks at how well special prosthetic implants work for people who need bone removed due to tumors. Researchers will track 100 patients aged 30 to 70 who receive modular or 3D-printed implants. The goal is to learn more about recovery, function, and complications after …

This study uses an anonymous online survey to ask 200 women with gynecologic cancers if they would be interested in receiving long chemotherapy infusions at night. The goal is to understand patient preferences and barriers, helping hospitals decide if a nighttime day hospital ser…

This study looks at how different levels of pressure from a breathing machine affect the heart in people with moderate-to-severe acute respiratory distress syndrome (ARDS). Researchers will test three pressure settings in 20 patients to see how lung collapse and overstretching im…

This study will follow 500 people who recently had a stroke or mini-stroke to see how well they take their prescribed cholesterol-lowering medications. Researchers want to know if patients reach their LDL cholesterol goals and if better adherence can prevent another stroke. The g…

This study looks at 2500 adults with liver scarring (cirrhosis) or high blood pressure in the liver (portal hypertension) to find out how often bleeding happens during planned medical procedures. Standard blood tests often fail to predict bleeding, so researchers will track real-…

This study looks at a rare condition called MRKH syndrome, where women are born without a fully formed uterus and vagina. Researchers will use ultrasound and genetic tests to better describe the different ways this condition can appear. The goal is to create a new, more detailed …

This study looks at bacteria living inside breast tumors and nearby healthy tissue, as well as in the gut and urine, of 240 women with breast cancer. Researchers want to see if these bacteria differ by cancer subtype and if they relate to how the tumor behaves. The goal is to gat…

This study will follow 20 patients who need dental implants after tooth loss, all treated in a hospital setting. Researchers want to see how well the implants work over time, especially in people who also have other health conditions or take other medications. The goal is to lear…

This study aims to understand how the drug ravulizumab affects people with generalized myasthenia gravis, a condition that causes muscle weakness. Researchers will analyze blood samples from 24 adult patients before and during treatment to look for changes in proteins that might …