Fondazione Policlinico Universitario Agostino Gemelli Irccs

This pilot study tests whether injecting a patient's own fat-derived cells into the lower esophagus is safe and feasible for treating GERD that doesn't respond well to medication. Fifteen adults with chronic acid reflux will undergo a minimally invasive endoscopic procedure. The …

This study looks at whether a higher dose of the blood thinner clopidogrel works better for people with essential thrombocythemia (ET), a rare blood disorder that raises the risk of dangerous blood clots. The standard dose may not work well for many ET patients, so researchers wi…

This study tests a precise radiation therapy guided by MRI for people with up to 5 spots of cancer spread in the abdomen from stomach, bowel, or ovarian cancers. About 34 adults will receive this non-invasive treatment to shrink tumors and delay the need for chemotherapy. The goa…

This study looks at whether people with HIV who are already well-controlled on daily pills can switch to a long-acting injection given every two months. The goal is to see how many stay on the injection without stopping or needing to change treatment over 48 weeks. The study will…

This early-stage study aims to develop a personalized treatment for children with syndromic craniosynostosis, a group of rare genetic disorders where skull bones fuse too early. The approach uses a nano-engineered gel to deliver custom genetic medicine directly to the affected ar…

This study looks at whether placing a bone graft in the tooth socket right after extraction helps preserve the jawbone for future dental implants. Fifty adults who need implants will receive the graft and be followed with scans and checkups. The goal is to see if this approach al…

This study tests whether a daily dietary supplement containing EGCG (from green tea), vitamin B12, hyaluronic acid, and folic acid can help men with HPV maintain genital health and possibly clear the virus. The trial will include 96 participants (48 couples) and compare those tak…

This early study tests if injecting a person's own stem cells into the upper gut is safe and feasible for treating type 2 diabetes. The stem cells are taken from belly fat and processed before being injected during a scope procedure. Only 15 people will take part, and the main go…

This pilot study tests whether a daily dietary supplement containing EGCG, folic acid, vitamin B12, and hyaluronic acid can help men clear an active HPV infection and improve sperm health. The study involves 34 couples trying to conceive, where the male partner has HPV and the fe…

This phase 2 trial tests whether a patient's own bile duct cells, grown into tiny organoids in a lab, can be used to patch persistent bile leaks after liver surgery. Researchers will take a small bile duct sample during surgery, store it, and if a leak doesn't heal with standard …

This study tests whether a new oral iron supplement called Sucrosomial iron (Sideral Folico) can effectively treat iron deficiency anemia in pregnant women. Researchers will enroll 82 pregnant women between 24 and 32 weeks of pregnancy with mild to moderate anemia. The goal is to…

This study will compare two types of minimally invasive gastric bypass surgery for people with severe obesity: one done with a robot (DaVinci) and the other done by hand (laparoscopy). Researchers want to see which approach leads to fewer complications and is more cost-effective.…

This study explores whether a special ultrasound technique, called dynamic contrast-enhanced ultrasound (DCE-US), can diagnose porto-sinusoidal vascular disorder (PSVD) without needing a liver biopsy. Researchers will compare ultrasound images from 100 people with PSVD or cirrhos…

This study looks at whether a non-invasive ultrasound of the heart can diagnose blood vessel problems in people with chest pain but no blocked arteries. About 35 patients who previously had an invasive heart test will get an ultrasound instead. The goal is to see if the ultrasoun…

This study checks if a simple chest ultrasound (TTE) can accurately rule out infective endocarditis, a serious heart infection. If TTE is reliable, many patients can avoid a more invasive throat probe (TOE). Researchers will study 350 adults with suspected infection to compare th…

This study tests whether a combination of contrast-enhanced ultrasound and spleen stiffness measurement can accurately detect high blood pressure in the liver (portal hypertension) in people with cirrhosis. Currently, doctors must insert a catheter into a neck vein to measure thi…

This study tests a new way to use contrast-enhanced ultrasound (CEUS) to see if liver cancer treatment (ablation) worked. Researchers will compare the new CEUS criteria with standard CT or MRI scans in 200 adults. If accurate, this could make follow-up safer and easier by avoidin…

This study tests whether artificial intelligence (AI) can predict the type of ovarian cancer and how well surgery might work by analyzing videos from a diagnostic laparoscopy. Researchers will collect videos from 100 women with advanced ovarian cancer and train an AI to recognize…

This study looks at 60 adults with high eye pressure or early open-angle glaucoma to see if combining advanced eye scans and vision tests can detect damage sooner. Participants will have standard eye exams plus special imaging of the optic nerve. The goal is to improve how doctor…

This study compares a new DNA sequencing platform (MGI) against the current standard (Illumina) for diagnosing hereditary cancers like breast and ovarian cancer, Lynch syndrome, and intestinal polyposis. Researchers will analyze 248 patient samples using both platforms to see if …

This study tests whether neurofeedback — a type of brain training using real-time brainwave feedback — can reduce musculoskeletal pain in people with chronic inflammatory bowel disease (IBD). Eighty adults with IBD and persistent pain will be randomly assigned to either 8 session…

This study tests a dietary supplement called GenesiDol for managing muscle and joint pain in people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. About 40 adults with persistent pain will take the supplement for 8 weeks to see if it reduces pa…

This observational study will follow 33 women with endometriosis who are taking relugolix combination therapy for pelvic pain. Researchers will track pain changes over 24 weeks using a standard pain scale, along with other symptoms and safety. The goal is to see how well this tre…

This study tests whether a short, intensive psychological program before lung cancer surgery can lower anxiety and depression. About 138 adults scheduled for lung cancer surgery will be split into three groups: one receiving four weekly therapy sessions, one refusing support, and…

This study tests a simple home questionnaire for women with HR+HER2- advanced breast cancer who are taking CDK4/6 inhibitors and hormone therapy. The goal is to see if the questionnaire can accurately identify which patients truly need to come to the hospital for a check-up, pote…

This study compares two surgical techniques for treating medication-related osteonecrosis of the jaw (MRONJ), a condition where jawbone dies due to certain drugs. Thirty-four adults with stage 1 or 2 MRONJ will be randomly assigned to receive either traditional rotary instrument …

This study compares total laparoscopic hysterectomy (removing the whole uterus including the cervix) with subtotal laparoscopic hysterectomy (keeping the cervix) in 500 women with benign conditions like fibroids or endometriosis. The main goal is to see which surgery leads to bet…

This study tests whether a daily oral supplement containing bioactive collagen peptides can improve quality of life for menopausal women with vaginal dryness, pain, and mild urinary incontinence. 43 women will take the supplement for 16 weeks and report changes in symptoms and se…

This study looks at how two sedative drugs, dexmedetomidine and remifentanil, affect breathing effort in patients with acute hypoxemic respiratory failure who are receiving high-flow nasal oxygen. Researchers will measure changes in inspiratory effort and symptoms like shortness …

This study investigates the role of the Sonic Hedgehog signaling pathway in brain arteriovenous malformations (AVMs), abnormal tangles of blood vessels that can cause bleeding or stroke. Researchers will analyze leftover brain tissue from 20–30 adults undergoing AVM surgery and c…

This observational study looks at how being overweight or obese, and changes in lifestyle, impact work performance, quality of life, and well-being in medical residents. Researchers will track 600 participants for 12 months, measuring body weight, lifestyle habits, and using ques…

This study investigates whether deep brain stimulation (DBS) of the subthalamic nucleus alters inflammation in people with Parkinson's disease. Researchers will measure inflammatory and neurodegenerative markers in the blood of 90 participants before and after DBS surgery, compar…

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This study will survey 370 adult cancer patients about their knowledge, attitudes, and practices regarding physical exercise. The goal is to understand why many patients don't exercise enough and what barriers they face. Results will help create better exercise programs and possi…

This study looks at how doctors in tumor board meetings work together when discussing ovarian and uterine cancer cases. About 400 physicians will fill out surveys after each meeting to measure things like communication, teamwork, and decision-making. The goal is to understand wha…

This pilot study investigates how well a dual-wavelength diode laser can destroy endometriotic tissue inside ovarian cysts (endometriomas). Researchers will apply the laser to cyst walls removed during surgery and examine the tissue under a microscope to see if all abnormal cells…

This study looks at whether a new method of interpreting fetal heart rate recordings (cardiotocography) can better identify when a baby is not getting enough oxygen during labor. Researchers will review data from 1,000 full-term pregnancies, combining past records and new enrollm…

This study aims to create a computer program that can predict how much pain medicine each woman will need during labour. Researchers will collect data from 12,500 women receiving epidurals and use machine learning to identify who needs higher or lower doses. The goal is to tailor…

This study looks at how removing part or all of the pancreas changes blood sugar control in adults who already have diabetes and need pancreatic surgery. Researchers will track 408 patients over time to see if diabetes gets worse depending on how much pancreas is removed. The goa…

This study will follow about 579 adults who need surgery to remove part or all of their pancreas but do not have diabetes before the operation. Researchers want to see how often new diabetes develops after surgery and whether the amount of pancreas removed changes that risk. The …

This study will test a new tool called the Stroke Mimics Score (SMS) in 1000 adults who come to the emergency room with stroke-like symptoms. The goal is to see if the SMS can accurately tell the difference between a real stroke and a condition that looks like a stroke but isn't …

This study looks at how people with severe obesity perceive internal body signals (like hunger and fullness) before and after bariatric surgery. Researchers will follow 300 adults for two years to see if changes in body awareness and views on illness affect eating behaviors after…

This study aims to understand why some teeth fail to erupt (come in) properly. Researchers will look at dental records and test for changes in the PTH1R gene in 50 patients with eruption problems. The goal is to improve diagnosis and distinguish between different causes, such as …

This study looks at a new way to classify ovarian cysts found in unborn babies using detailed ultrasound features. Researchers will follow 100 pregnant women whose fetuses have an ovarian cyst, tracking the cyst's size and appearance over time. The goal is to see if this classifi…

This study will show 20 cases of basal cell carcinoma (the most common skin cancer) to doctors from different specialties—dermatologists, oncologists, surgeons, and radiation therapists—to see how they classify and treat the same cases. The goal is to understand why there is so m…

This study looks at whether a thorough health assessment before liver surgery can help older patients (70+) have fewer serious complications and recover better. Researchers will give 242 participants a special geriatric evaluation that checks frailty, memory, nutrition, and daily…

This study will check 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have stomach pain, bloating, or diarrhea. Researchers will use breath tests to see if a condition called SIBO (too much bacteria in…

This study looks at two ways to measure endometriosis growths in the bowel before and during surgery. About 98 women will get both a standard vaginal ultrasound before surgery and a special ultrasound during their operation. The goal is to see if the during-surgery ultrasound giv…

This study looks at whether using ultrasound during surgery helps doctors better remove deep endometriosis from the bowel while keeping the bowel wall safe. About 57 women with bowel endometriosis will have their surgery guided by ultrasound. The goal is to see if this approach r…

The MISTIC study will examine 1000 adults to see if early, symptom-free artery disease is linked to thinking and memory problems. Participants will get non-invasive imaging of their arteries and cognitive tests. This is an observational study, not a treatment trial, aiming to imp…

This study will enroll 400 older hospital patients (age 65+) to see if using estimated or self-reported weight and height instead of exact measurements leads to incorrect nutrition assessments. Researchers will compare the different measurement methods and check how they affect s…

This study aims to understand how fat around the belly and heart relates to inflammation and early signs of heart disease, diabetes, and fatty liver. Researchers will enroll 400 adults without known heart or liver disease. Participants will undergo non-invasive tests like ultraso…

This study aims to detect and measure microplastics in pancreas tissue from 10 patients having pancreatic surgery. Researchers will also check fat tissue and blood samples. The goal is to see if microplastics are present and whether they might be linked to metabolic problems or c…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This study surveys 480 Italian dental students to understand their attitudes, knowledge, and any discriminatory behavior toward HIV-positive patients. Participants answer anonymous questions about their comfort, knowledge of HIV, and use of safety protocols. The goal is to identi…

This study aims to create a database of 686 adults with suspected or confirmed tuberculosis at an Italian hospital. Researchers will analyze patient data to build a risk score that helps doctors quickly decide who needs isolation and who can be ruled out. The goal is to improve d…

This study surveys 300 doctors to understand how they decide whether to continue or stop blood thinners in patients receiving palliative care. Using hypothetical cases, researchers aim to uncover patterns in these complex decisions. The study is observational and does not involve…

This study aims to find out how often headaches happen in people with MOGAD, a rare disease that affects the brain and nerves. Researchers will look at the medical records of 25 adults and also follow them forward in time to describe headache patterns. The goal is to better under…

This study uses an anonymous online survey to ask 200 women with gynecologic cancers whether they would be interested in receiving long chemotherapy infusions at night instead of during the day. The goal is to understand patient preferences and potential barriers. No treatment is…

This study looks at how different levels of ventilator pressure affect the heart and lungs in 20 patients with moderate-to-severe ARDS. Researchers will test three pressure settings to see which one best balances lung collapse and overstretching while keeping the heart pumping we…

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic in Rome. Researchers will check how well the teeth heal using X-rays and symptom reports over up to 5 years. The goal is to understand success rates and how factors like over…

This study will follow 2,500 patients with liver cirrhosis or portal hypertension who are scheduled for elective medical procedures. Researchers want to find out how often bleeding happens and what factors predict it, beyond standard blood tests. The goal is to improve safety by …

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study tests whether a structured training program helps radiologic technologists safely place IV lines for contrast-enhanced CT or MRI scans. Nine technologists will be trained, and researchers will measure their skills, complication rates, and patient satisfaction. The goal…

This study will test 20 adults with moderate-to-severe ARDS to see whether a controlled breathing machine (with or without muscle paralysis) or a machine that lets them breathe on their own is better at preventing lung injury. Each patient will try four different ventilation sett…

This study will measure levels of two proteins, SCUBE-1 and SCUBE-3, in the blood of women with polycystic ovary syndrome (PCOS) and compare them to healthy women. Researchers want to see if these proteins are linked to inflammation and a higher risk of heart problems. About 56 w…

This study reviews past research and hospital data to compare three types of fertility-sparing surgeries for cervical adenocarcinoma: conization, simple trachelectomy, and radical trachelectomy. The goal is to see which offers the best balance between controlling cancer and allow…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study will follow 20 patients who need dental implants in a hospital setting, many of whom have other health conditions or take medications. Researchers will track bone loss around the implants, how long they last, and patient satisfaction. The goal is to learn more about im…

This study tests a new questionnaire called PET (Patient Experience in Telehealth) to see if it accurately measures how patients feel about telemedicine visits. Researchers will ask 200 adults who had a telemedicine appointment at an Italian hospital to fill out the survey. The g…

This study brings together 10 experts in cardiology, personalized medicine, and digital health to create recommendations for using wearable devices and polygenic risk scores in heart disease prevention. Through online surveys, they will identify which genomic, digital, and clinic…

This study will check if certain blood markers (like NLR and PLR) can predict how well people recover after surgery for a joint infection. Researchers will follow 200 adults who need a two-stage joint replacement revision. The goal is to find cheap, easy tests that help doctors p…

This study looks at how well people do after surgery to remove bone tumors and rebuild the bone with special implants. It includes 100 adults aged 30 to 70 with certain bone cancers or tumors that have spread to bone. The goal is to learn more about how these custom or 3D-printed…

This study will analyze blood samples from 24 adults with generalized myasthenia gravis who are being treated with ravulizumab. Researchers will look for changes in thousands of proteins over 26 weeks to find markers that show how well the treatment is working and whether the ner…

This study looks at whether people with oral lichen planus, a chronic mouth condition, have higher risks for heart problems or blood clots. Researchers will check blood samples from 55 adults for natural anticoagulant deficiencies and antiphospholipid antibodies. The goal is to b…

This study observes how often blood-thinning drugs are prescribed to patients receiving palliative care. Researchers will track 410 adults to understand current practices, since there are no clear guidelines. The goal is to gather information that could lead to better, more consi…

This study checks if surgeons can tell key details about ovarian cancer by looking at images from a camera inside the belly. About 70-80 surgeons will review pictures from 19 patients and guess the cancer type and growth pattern. The goal is to see if visual clues can help plan t…

This observational study looks at women with MRKH syndrome, a rare condition where the uterus and vagina are underdeveloped. Researchers will use ultrasound and other imaging to describe the anatomy and create a new classification system. The goal is to improve diagnosis and unde…

This study will follow 120 pregnant women with high blood pressure or preeclampsia to see if certain ultrasound scans and blood tests can predict who will develop severe disease. Researchers will measure blood flow in the mother's heart, eyes, and womb, along with lung ultrasound…

This study uses 35 donated human bodies to test and compare different brain and spine surgery techniques. Surgeons will measure how much space and visibility each method provides, and test new tools. The goal is to improve surgical training and make future operations safer and le…

This study will follow 500 people who recently had a stroke or mini-stroke to see how well they stick with cholesterol-lowering treatments like statins and diet changes. Researchers want to learn how many patients reach their LDL cholesterol goals and whether better control reduc…

This study will check if certain blood markers can predict heart damage in children and teens who had anthracycline chemotherapy for cancer. Researchers will compare blood tests and heart imaging results from 40 survivors and healthy volunteers. The goal is to find early warning …

This study looks at bacteria living inside breast tumors and compares them to bacteria in the gut and urine of 240 women undergoing breast cancer surgery. Researchers want to see if these microbes differ across cancer subtypes and if they relate to tumor features. The goal is to …

This study aims to discover new reasons why blood clots form in people with heart disease, diabetes, and other illnesses. Researchers will analyze blood samples from 200 patients with narrowed neck arteries to look for markers of cell damage and clotting factors. The goal is to f…

This study looks at whether injecting the blood thinner enoxaparin into the arm or the abdomen works better for preventing blood clots in people with severe obesity (BMI over 40). Researchers will measure drug levels in the blood to see which injection site gives the right amount…

This study looks at whether measuring IL-6 and lactate in cord blood can detect early signs of infection or inflammation in full-term newborns. Researchers will compare 160 women whose fetal heart rate patterns suggest possible inflammation with those whose patterns are normal. I…

This study aims to better understand why young people (ages 18-25) with mood disorders may be at risk for suicide. Researchers will collect clinical, brain imaging, genetic, and microbiome data from 180 participants to identify risk factors. They will also test whether a non-inva…

This study tests whether motivational interviewing, delivered through video calls and online platforms, can improve self-care in 124 adults with idiopathic pulmonary fibrosis (IPF). Participants will be randomly assigned to receive the counseling or usual care. Researchers will m…

This study interviews 30 couples (60 parents) after a planned cesarean section to understand how the father's presence or absence in the operating room affects both parents' emotional experience. Researchers will talk to parents 48-72 hours after birth, asking about their expecta…

This study looks at whether having nurses rotate through different heart care units every two months helps them learn more and feel less burned out. About 86 nurses will take part, with some rotating and others staying in their usual unit. Researchers will measure skills, job sat…

This study will follow 100 adults in southern Italy who have severe infections caused by carbapenem-resistant Enterobacterales (CRE), a type of superbug. Researchers will analyze the bacteria's genes and resistance patterns, and track how patients respond to three specific antibi…

This study will observe 300 children and young adults (ages 0-20) with respiratory tract infections to see if chest ultrasound can predict their outcomes, such as need for hospitalization or ICU care. Researchers will use an ultrasound score and combine it with clinical data to s…

This study looks at 300 people with severe mitral regurgitation who need heart surgery. Researchers want to see if a special ultrasound technique called speckle tracking can better predict who will do well after surgery, compared to the current standard method. The study only use…