Tears may hold key to migraine diagnosis and treatment tracking

NCT ID NCT07690696

Not yet recruiting Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study investigates whether biomarkers in tear fluid can help diagnose migraine and monitor response to anti-CGRP therapies. Researchers will compare tear and blood samples from 400 people with migraine and healthy controls. A subgroup will be followed over time to see how biomarkers change during treatment. The goal is to develop a simple, non-invasive tool for migraine management.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple tear test to diagnose migraine and track how well treatments work.
What could go wrong: This is an observational study, not a treatment trial. The findings may not translate into a practical diagnostic tool or change clinical practice.

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Conditions

The condition(s) this trial relates to.

Headache Lacerations migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

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