MIGRAINE

This study compares three oral medications—atogepant (newer), topiramate, and propranolol (older)—to see which prevents migraines better and is easier to tolerate. About 1,335 adults with migraine will be randomly assigned to one of the drugs and track their headaches for 12 week…

This study looks at the long-term safety of eptinezumab in 600 children and teens aged 6 to 17 who have chronic or episodic migraine. Participants must have completed a previous study of the same drug. The main goal is to track side effects over time, with additional measures of …

This study tests an investigational drug called MEDI0618 to see if it can safely reduce the number of migraine headache days in adults with episodic migraine. About 488 participants will receive either the drug or a placebo as a shot under the skin. The goal is to find out if the…

This study tests if a daily pill called ubrogepant can prevent migraines that happen around a woman's period. About 496 women with menstrual migraines will take the pill or a placebo for 7 days each cycle. The goal is to see if it reduces the number of migraine days and is safe t…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial expressions, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) …

This study tests whether adding a daily pill (amitriptyline) to cognitive behavioral therapy (CBT) delivered via video is better than CBT alone for preventing migraines in children aged 7-17. Researchers will track headache days and disability over time. The goal is to find the m…

This study tests whether the drug rimegepant can prevent migraines in children and adolescents aged 6 to 17 who have frequent migraines. Participants will receive either the drug or a placebo for 12 weeks to see if it reduces the number of migraine days per month. The goal is to …

This study tests a small device you put in your nose to prevent migraines. 110 adults with migraines will use it at home every other day for six weeks. The goal is to see if it safely reduces the number of migraine days each month.

This study is checking the safety and effectiveness of atogepant, a drug already approved for migraine prevention, in Korean adults. About 3000 people with chronic or episodic migraines will take the drug as prescribed by their doctor and be followed for up to 12 weeks. The goal …

This study tests a dissolving tablet called rimegepant to prevent migraines in adolescents aged 12 to 17 who have chronic migraine (15+ headache days per month). About 200 teens will take either rimegepant or a placebo every other day for 3 months, then all will receive rimegepan…

This study tests a program called RELAXaHEAD, a behavioral approach delivered through an app to help people with migraines manage their condition remotely. About 356 participants will use the app and report how it affects their daily disability and quality of life over several we…

This study tests if a new biodegradable heart implant can reduce migraine days better than a standard metal implant in people with a common heart hole called PFO. About 400 adults aged 18-65 with frequent migraines and PFO will receive one of the two implants. The goal is to see …

This study looks at how well the migraine prevention drug atogepant works for adults in real-world settings. About 1000 people who are already prescribed atogepant by their doctor will be followed for 2 years. The goal is to see how many feel much better or very much better since…

This study tests whether injecting a steroid into muscle trigger points (knots) works as well as injecting it directly into the knee joint for people with chronic knee osteoarthritis pain. About 1,000 adults aged 45 and older with knee pain will receive one of the two injections …

This study tests a new group therapy program for teens aged 13-17 with migraine. The program combines high-intensity interval training, muscle relaxation, and education over 18 weeks. Researchers want to see if it reduces headache frequency, pain, and medication use compared to n…

This study compares two medicines, flunarizine and propranolol, to see which works better at reducing migraine attacks in children aged 8 to 15. The goal is to lower the number of migraines and improve daily life. About 44 children with frequent migraines will take one of the two…

This study tests whether a home-based virtual reality (VR) program that uses brain activity to guide relaxation is feasible and acceptable for teens aged 10–16 with migraines. Participants will use a wearable EEG headband during VR sessions three times a week for four weeks. The …

This study follows 700 people with migraine who are taking newer preventive drugs (anti-CGRP medications) to see how well they work in everyday life. Researchers will track changes in monthly headache days and migraine impact over two years. The goal is to understand real-world b…

This study looks at whether a 16-week supervised aerobic exercise program, combined with a single session of pain education, can help women aged 18 to 48 who have migraines. Participants will be randomly assigned to either the exercise group or a control group that gets advice on…

This study looks at whether taking the migraine drug ubrogepant during the earliest signs of a migraine (called the prodrome phase) can prevent moderate to severe headache pain. About 189 adults who already use ubrogepant will take it as prescribed and report their symptoms over …

This study tests whether the drug eptinezumab can quickly stop a migraine attack when given as an IV infusion. Researchers will measure how fast headache pain and other bothersome symptoms go away. The study involves 50 adults with migraine who are already receiving the drug as p…

This study looks at whether adding a steroid pill (dexamethasone) to a standard nerve block can stop migraines from returning within 72 hours. About 84 adults with migraines who get relief from a nerve block in the emergency room will be randomly assigned to also receive either t…

This study tests whether ubrogepant, a drug already approved for adults, can safely and effectively treat migraine attacks in children and adolescents aged 6 to 17. About 1,059 participants with a history of migraine will receive either a low or high dose of ubrogepant or a place…

This study tests whether a lifestyle behavior program can help people with chronic migraine have fewer and less severe headaches. Researchers will also look for biological markers linked to improvement. The goal is to see if this approach is practical and liked by participants, w…

This study is testing whether a gentle electrical zap to an artery in the head can safely ease migraine pain. Researchers will try the procedure on 12 adults with chronic migraines that haven't improved with standard treatments. The main goal is to see if the approach is safe and…

This study tests if cabergoline, a drug used for other conditions, can prevent episodic migraines in adults who have 4 to 14 migraine days per month. Participants will take a weekly pill (either 0.5 mg, 1.0 mg, or a placebo) for 12 weeks, then all will receive cabergoline for ano…

This study tests whether combining green light therapy with a mild electrical brain stimulation (tDCS) can lower how often migraines happen and how bad they hurt. Researchers will enroll 40 adults who get migraines with moderate to severe pain. The goal is to find a safe, non-dru…

This study tests whether adding magnesium to the usual migraine drug prochlorperazine provides faster pain relief for adults visiting the emergency department with a migraine. About 100 participants will receive either the combination or the drug alone, and their pain levels will…

This study tests if blocking a small artery in the head (the middle meningeal artery) with a special glue can prevent chronic migraines in people who haven't responded to other treatments. About 70 adults aged 18-65 with refractory chronic migraine will be enrolled. The goal is t…

This study looks at whether Xeomin injections can reduce migraine pain and frequency in people who have had a traumatic brain injury or an unexplained health incident. Researchers will compare how well the treatment works for each group. The goal is to find better ways to manage …

This study tests whether taking rimegepant before a known trigger—like exercise, alcohol, or stress—can prevent a migraine from starting. About 60 adults with predictable triggers will take the drug ahead of planned activities and report if a headache occurs within 24 hours. The …

This study is testing how well the drug rimegepant works for treating migraine attacks in 100 adults with episodic or chronic migraine. Researchers will measure pain relief two hours after taking the drug and track any side effects. The goal is to see if rimegepant is effective a…

This study looks at whether zavegepant (Zavzpret), a nasal spray already approved for migraines, works well and is safe for people who are already taking a CGRP-targeting preventive medication. About 200 adults with 2 to 8 migraines per month will use the spray at the start of an…

This study compares two different virtual, non-drug programs for adults with migraines. Both involve 8 weekly online sessions and extra learning materials. The goal is to see which program better reduces migraine-related disability and improves daily life. Participants can contin…

This study tests whether a single injection of a long-lasting numbing medicine (Exparel) into the side of the nose can reduce craniofacial pain, including migraine and cluster headaches. About 15 adults who get temporary relief from a standard numbing spray will receive either th…

This study tests a nurse-led mind-body program to help children with migraines have fewer headache days. It will enroll 260 kids aged 10-17 who have migraines with or without aura. The program combines different amounts of three treatment parts to find the best approach for reduc…

This study looks at how well and how safely the drug rimegepant works to prevent migraines. About 100 adults with episodic or chronic migraines will take rimegepant for up to 12 months. Researchers will track changes in the number of migraine days per month to see if the drug red…

This study tests a new nasal spray called PRT-064040 for treating moderate to severe migraines quickly. About 456 people aged 18-75 with a history of migraines will receive either the spray or a placebo. The main goal is to see if the spray can stop pain and the most bothersome s…

This study tests whether atogepant, a drug already approved to prevent migraines, can also stop a migraine attack quickly once it starts. About 1,300 adults with a history of migraines will take either atogepant or a placebo at the start of a migraine and report if their pain goe…

This study compares two fast-dissolving migraine pills, rimegepant (Nurtec ODT) and rizatriptan (Maxalt MLT-ODT), in adults coming to the emergency department with a migraine. About 80 participants will receive one of the two drugs, and researchers will measure pain relief at 60 …

This study looks at how migraine impacts thinking skills like memory and attention, as well as emotions like anxiety and depression. Researchers will test 150 adults with migraine to understand these connections. The goal is to better define the cognitive and psychological profil…

This study watches pregnant women with migraines who take Ubrelvy or Qulipta, and compares them to pregnant women with migraines who don't take these drugs. Researchers will track the health of mothers and babies up to 12 months after birth. No new treatment is given—participants…

This online registry tracks pregnant women with migraines to see if a device that stimulates a nerve in the head is safe and helpful during and after pregnancy. About 550 women will fill out short surveys over 12 months, with no required changes to their current migraine treatmen…

This study follows 780 pregnant women with migraine to see if taking the drug rimegepant affects pregnancy or baby health. Some women take the drug, others do not. Researchers track birth defects, pregnancy complications, and infant health up to 12 months after birth.

This study uses a powerful 7T MRI scanner to look at brain structure and function in people with migraine, visual snow, or epilepsy, and compares them to healthy volunteers. The goal is to better understand how these conditions affect the brain and why they often occur together. …

This study is for pregnant women with migraine who have taken the drug AIMOVIG (erenumab-aooe) during pregnancy. Researchers will compare their babies' health, especially birth defects, to babies born to women with migraine who did not take the drug. The goal is to better underst…

This study aims to find ways to predict how well a person with migraine will respond to a class of drugs called anti-CGRP monoclonal antibodies. Researchers will analyze clinical, biological, and brain imaging data from 350 participants aged 18 to 65 with high-frequency or chroni…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or healthy vision will pa…

This study will follow 10,000 people aged 12 and older who have primary headache disorders like migraine or tension-type headache, or medication-overuse headache. Researchers will collect data on genetics, brain scans, thinking skills, and daily life to better understand these co…

This study watches how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or migraines, as well as healthy volunteers. Over two years, participants wear activity trackers and light sensors, answer daily mood questions on…

This study looks at how sleep problems and stress can trigger migraine attacks. Adults with episodic migraine wear a WHOOP band to track sleep and body signals, and answer daily questions on a smartphone app. The goal is to find personal patterns and give tailored advice to impro…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…

This study involves 60 adults with chronic migraine to understand how drug and placebo responses interact during treatment. Participants will receive four different treatment conditions in a random order, and researchers will measure headache intensity, migraine days, and side ef…

This study aims to understand why over 20% of people with migraine don't get relief from triptan medications. Researchers will compare levels of tryptophan and related substances in the blood of people who respond well to triptans versus those who don't. The study involves 144 ad…

This study looks at whether adding AI-assisted education to standard migraine education helps people understand their condition better. About 140 adults newly diagnosed with migraine will take part. They will answer questions about migraine before and after education to see if th…