MIGRAINE

This study aims to find the most effective way to prevent migraines in children and teens using telehealth. Researchers will compare cognitive behavioral therapy (CBT) delivered via video calls alone versus CBT combined with the medication amitriptyline. The trial involves 400 yo…

This study aims to see if a medicine called rimegepant can help prevent migraines in teenagers aged 12-17 who have chronic migraines (15 or more headache days a month). For the first 3 months, half the participants will take rimegepant every other day and half will take a placebo…

This study is testing whether a daily pill called ubrogepant can prevent migraines that occur around a woman's menstrual period. About 500 adult women with a history of menstrual migraines will take either the study pill or a placebo for 7 days each month. Researchers will track …

This study is monitoring the safety and real-world effectiveness of atogepant, an already-approved oral medication for preventing migraines. It will follow 3,000 Korean adults with chronic or episodic migraines who are prescribed the drug by their doctors as part of their normal …

This study is testing the safety and initial effectiveness of a minimally invasive procedure for adults with severe, treatment-resistant chronic migraines. The procedure involves injecting a medical glue-like substance into a specific artery in the head to block its blood flow. R…

This study is testing if a medication called cabergoline, taken just once a week, can help prevent migraine attacks in adults. Researchers will compare two different doses against a placebo (inactive pill) in 150 people who get 4 to 14 migraine days per month. The main goal is to…

This study aims to check the long-term safety of eptinezumab, a medication given by infusion, in children and teens aged 6 to 17 who have chronic or episodic migraine. It is an extension for participants who completed a previous 12-week study. The main goal is to monitor for any …

This study aims to find out which of two existing drugs, flunarizine or propranolol, works better to prevent migraines in children. It will involve 44 kids aged 8 to 15 who have frequent migraines. Researchers will measure how much each drug reduces the children's headache-relate…

This study aims to see how well and how safely the medication rimegepant works to prevent migraines in everyday life. It will follow 100 people with frequent migraines for two years as they take the medication every other day. Researchers will track how many migraine days they ha…

This study is testing whether a medication called rimegepant can safely prevent migraines in children and adolescents aged 6 to 18. Researchers will compare the drug to a placebo (a pill with no medicine) to see if it reduces the number of migraine days each month over 12 weeks. …

This study compares a new biodegradable heart implant to a traditional metal one for treating migraines in people with a small heart hole called PFO. Researchers want to see if the dissolving implant reduces migraine days per month better than the permanent metal version, with fe…

This study aims to find out which of three oral medications works best to prevent migraine attacks in adults. Researchers will compare a newer drug, atogepant, against two older, commonly used drugs, topiramate and propranolol. About 1,335 participants will be randomly assigned t…

This study aims to see how well newer migraine prevention drugs work for people in everyday life over two years. It will follow 700 patients who are already prescribed these specific medications by their doctors. Researchers will check in every six months to track headache freque…

This study aims to see how well the approved migraine prevention drug atogepant works for adults in real-world settings, outside of controlled clinical trials. It will follow about 1000 people who have been prescribed the drug by their doctors for two years. The main goal is to m…

This study is testing an experimental injection called MEDI0618 to see if it safely reduces how often people get migraines. It will compare the drug against a placebo (a shot with no medicine) in about 488 adults who get episodic migraines. The main goal is to see if the treatmen…

This study is testing a new method to objectively diagnose and monitor light sensitivity. Researchers will measure participants' facial muscle reactions, pupil responses, and other physical signals when exposed to light. The goal is to create a more reliable test for light sensit…

This study is testing whether a nasal stimulation device can help prevent migraine headaches. 110 adults with frequent migraines will use the device at home every other day for six weeks. Researchers will compare whether using the device reduces the number of migraine days people…

This study is testing whether a new nasal spray called PRT-064040 can relieve migraine pain and symptoms. Researchers will compare the spray to a placebo in 456 adults who experience moderate to severe migraines. The main goal is to see how many people become pain-free within 2 h…

This study compares two fast-acting migraine medications, Nurtec ODT and Maxalt MLT-ODT, to see which one works better for adults who come to the emergency department with a severe migraine attack. Researchers will measure how much pain relief each pill provides at 60 minutes and…

This study is testing how well and how safely a medication called rimegepant works to treat migraine attacks as they happen. It will enroll 100 people with migraines to take a dissolving tablet when a migraine starts and track their pain and symptoms over several hours. The main …

This study is observing how well the migraine medication ubrogepant helps patients return to normal daily activities and how satisfied they are with the treatment. About 167 adults in Canada who experience at least 3 moderate-to-severe migraine attacks per month will participate.…

This study is testing how well and how safe a nasal spray called zavegepant works for quickly treating migraine attacks. It is for people who are already taking certain daily or monthly medications to prevent migraines. Researchers want to see if the spray relieves headache pain …

This study is testing a new lifestyle and behavior program to help manage chronic migraine. Researchers will enroll 60 adults who have had chronic migraine for at least a year to see if the program is practical and acceptable. The main goals are to check if people can stick with …

This study is testing whether an intravenous medication called eptinezumab can stop a migraine attack while it is actively happening. It will involve 50 people who experience migraines and are already scheduled to start this treatment. Researchers will measure how quickly the mig…

This study is testing whether adding magnesium to the standard migraine medication prochlorperazine helps reduce pain faster for people visiting the emergency room. Researchers will enroll 100 adults with migraines to compare pain relief at 30, 45, and 60 minutes after treatment.…

This early study is testing whether a new procedure that uses gentle electrical stimulation on a specific artery in the head is safe and practical for people with severe, hard-to-treat migraines. Researchers will perform the procedure on 12 adults to see if it can be done without…

This study is testing a new non-drug approach to help people with migraines. Researchers want to see if combining exposure to green light with a gentle electrical brain stimulation technique can reduce how often migraines occur and how painful they are. The study will involve 40 …

This study is testing a weekly group program designed to help teens with migraines. The program combines exercise, muscle relaxation techniques, and education about migraines. Researchers want to see if this non-drug approach can reduce how often teens get migraines and how bad t…

This study aims to see if Xeomin injections work differently for preventing migraines in two groups of patients: those with a history of traumatic brain injury (TBI) and those with a history of anomalous health incidents (AHIs, sometimes called 'Havana Syndrome'). Researchers wil…

This study is testing a smartphone app called RELAXaHEAD to see if it can help people with migraines. Researchers will enroll 356 participants from primary care clinics to try the app's behavioral techniques for 6 weeks. The main goal is to see if the app reduces how much migrain…

This study is testing whether injecting a steroid medication into tight muscle knots (trigger points) around the knee works as well as injecting it directly into the knee joint for relieving osteoarthritis pain. Researchers will enroll over 1,000 adults with chronic knee pain and…

This study is testing if taking the migraine medication ubrogepant during the early 'prodrome' phase—when people first notice warning signs like fatigue or light sensitivity—can prevent moderate or severe headaches from developing over the next 24 hours. It involves about 189 adu…

This study is testing whether a supervised aerobic exercise program, combined with education about pain, can help women with migraines. It will compare this approach to general recommendations for home-based physical activity. The goal is to see if exercise can reduce migraine-re…

This study is testing if a pill called ubrogepant is safe and effective at quickly stopping migraine attacks in children and teenagers aged 6 to 17. Ubrogepant is already approved for adults. About 1,059 young people with a history of migraines will take either the study drug or …

This study is testing if a pill called atogepant can quickly stop migraine attacks when taken at the start of symptoms. It will involve about 1300 adults with a history of migraines. Participants will try the pill or a placebo for four migraines, then all receive the active pill,…

This study is testing if taking the medication rimegepant *before* exposure to a known personal migraine trigger can prevent the headache from happening. It involves 60 adults in the US who reliably get migraines after specific triggers like exercise, stress, or air travel. Resea…

This study is testing a mind-body skills program delivered by nurses to help children and teens (ages 10-17) with migraines reduce their headache days. Researchers are comparing different versions of the program to find the most effective combination of coaching sessions, home pr…

This study aims to understand what happens in the brain of people with Visual Snow Syndrome (VSS), a condition where people constantly see tiny flickering dots. Researchers will compare brain scans and vision tests from 100 people, including those with VSS, those with migraines, …

This study aims to understand why some migraine patients do not get relief from common triptan medications. Researchers will compare blood levels of tryptophan, a dietary nutrient, and related substances in patients who respond well to triptans versus those who do not. The goal i…

This study aims to understand the safety of the migraine medication Aimovig (erenumab) during pregnancy. It will follow pregnant women with migraines who are either taking Aimovig or not, to compare rates of major birth defects and other pregnancy outcomes in their babies. The go…

This study aims to understand the connection between physical activity, sleep, and mental health in people with and without mood disorders like bipolar disorder and depression. Over 1,200 participants, including patients and their healthy family members, will wear activity monito…

This study aims to build a large registry to better understand different types of headaches, including migraines and tension headaches. It will follow 10,000 participants aged 12 and over for a long time, collecting information on their symptoms, treatments, brain scans, genetics…

This study aims to understand the safety of two migraine medicines, Ubrelvy and Qulipta, when taken during pregnancy. It will follow about 1,884 pregnant women with migraines in the US and Canada to track health outcomes for both mothers and their babies up to one year after birt…

This study uses a powerful 7 Tesla MRI scanner to take detailed pictures of the brain in people with migraine, drug-resistant epilepsy, or visual snow syndrome. Researchers want to see how the brain's structure and activity differ in these conditions compared to healthy volunteer…

This study aims to understand if the migraine medication rimegepant is safe during pregnancy. It will follow pregnant women with migraines, some who take the drug and some who do not, to track the health of both mother and baby for up to a year after birth. The goal is to collect…

This study aims to understand how migraine headaches affect thinking, memory, and mood. Researchers will examine 150 migraine patients to see how cognitive function changes during different headache phases and with different treatments. The goal is to create a clearer picture of …

This study aims to find markers that can predict which patients with frequent migraines will respond well to a specific class of antibody drugs. Researchers will follow 350 patients for a year, collecting blood samples and brain scans to look for patterns linked to treatment succ…

This study is testing whether adding an AI-powered educational tool to standard migraine education helps patients understand their condition better. It will enroll 140 adults newly diagnosed with migraine. Researchers will compare how much patients learn from standard education a…