MIGRAINE

This study aims to see if closing a small, common heart hole called a patent foramen ovale (PFO) can improve brain function and reduce severe migraines in adults. Researchers will follow 45 adults with frequent migraines and a PFO who are already scheduled for the closure procedu…

This small, early-stage study is testing the safety of a procedure that blocks arteries in the head to see if it can help people with severe, untreatable chronic migraines. Researchers will perform the procedure on 13 adults whose migraines have not improved with standard medicat…

This study is observing if a treatment called pulsed radiofrequency, applied to a nerve at the back of the head, can help people with migraines. It will follow 100 adults with migraines to see if the treatment reduces their overall pain sensitivity, skin tenderness during attacks…

This study is testing whether a home-based virtual reality (VR) program is a practical and acceptable way to help teens manage migraines. Researchers will have 38 teens with migraines try one of two different VR programs at home for four weeks. The main goal is to see if teens ca…

This study is testing whether a gentle, non-invasive electrical stimulation applied to the outer ear can help people with frequent migraines. Researchers will compare the real stimulation to a fake 'sham' treatment in 102 adults to see if it reduces headache pain, lessens disabil…

This study is testing whether a mind-body therapy called Basic Body Awareness Therapy, combined with lifestyle recommendations, can help people with migraines. Researchers will work with 40 adults who have frequent migraines to see if the therapy reduces headache pain and improve…

This study aims to identify which migraine patients are most likely to benefit from a specific nerve-blocking injection. Researchers will follow 460 adults with hard-to-treat migraines to see how their headaches change after the treatment. The goal is to help doctors better selec…

This study is testing if a personalized 8-week physical therapy program can help people with migraine. The program includes specific neck exercises, balance training, and pain education. Researchers will compare it to standard care to see if it better reduces pain and fatigue and…

This study is testing a smartphone app designed to help adults with migraines. The app teaches skills like stress management and identifying triggers to reduce how often and how severe migraines are. Researchers will enroll 415 people in Canada to see if using the app leads to fe…

This study is testing whether a 6-week program using a free mind-body mobile app along with gentle, guided movement exercises can help people manage chronic pain. Researchers will enroll 100 adults who have experienced pain for at least six months. The main goal is to see if this…

This study is testing whether following a low-glutamate diet can reduce migraine frequency, severity, and duration. Researchers will enroll 40 adults with migraines and compare those on the special diet to a wait-list control group continuing their usual diet. The goal is to see …

This small pilot study is testing whether a gentle massage technique called manual lymphatic drainage can help people with frequent migraines. Twenty participants will either receive the massage therapy or be in a control group. Researchers will measure changes in pain, migraine …

This study aims to understand how common and what types of headaches occur in adults with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), a rare inflammatory condition of the brain and spinal cord. Researchers will observe about 25 patients to describe th…

This study aims to understand if a natural brain chemical called adrenomedullin can trigger migraine attacks. Researchers will give participants a migraine prevention drug (erenumab) first to block one pathway, then give adrenomedullin to see if it still causes a migraine. The go…

This study aims to understand how migraine affects the brain's ability to calm itself down. Researchers will use a safe, non-invasive magnet to measure brain signals in 20 people with migraine and compare them to healthy volunteers. The goal is to gather knowledge about migraine'…