MIGRAINE

This study tests whether a set of dietary supplements taken at different phases of a migraine cycle can improve quality of life and reduce headache days in adults with migraine. Participants take a daily foundational supplement, with additional supplements during the luteal phase…

This study will test two FDA-approved migraine drugs, rimegepant (a tablet that dissolves on the tongue) and zavegepant (a nasal spray), in 100 adults visiting the emergency department for a migraine. The goal is to see if these drugs provide pain relief within 2 hours without ne…

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study tests a physiotherapy program that combines neck muscle exercises with a gentle nerve stimulation technique (transcutaneous vagus nerve stimulation) in 50 adults with migraine. The goal is to see if this approach can reduce pain, improve daily function, and boost quali…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tests a virtual behavioral program for people with chronic migraine. Researchers want to find the best combination of techniques and see if letting patients choose their treatment helps. The goal is to reduce migraine frequency and intensity.

This study tests a new drug, elismetrep, to see if it can quickly stop migraine pain and bothersome symptoms like nausea or light sensitivity. About 1800 adults with frequent migraines will receive either the drug or a placebo. The main goal is to measure how many people are pain…

This study tests if a procedure called middle meningeal artery embolization can help people with frequent migraines. The procedure uses tiny coils to block a blood vessel in the head. Researchers want to see if it reduces migraine days and the need for migraine medications. The s…

This study looks at whether anti-IL-6 drugs, used for inflammatory conditions like rheumatoid arthritis, can also reduce migraine frequency and intensity. Researchers will compare 320 people taking anti-IL-6 drugs to those on anti-TNF drugs. Participants will report how their mig…

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

This study tests whether a new drug called NB001 can quickly stop migraine pain and other bothersome symptoms. About 120 adults with migraines will take different doses of NB001 or a placebo at the start of an attack. Researchers will check if pain and symptoms go away within 2 h…

This study tests whether osteopathic manipulation—gentle manual techniques on the neck and head—can reduce migraine pain and its impact on daily life. 45 adults with frequent migraines will receive the therapy. The goal is to see if this drug-free approach offers real relief.

This study tests three different types of tinted lenses—FL41 glasses, Biomedics55 contacts, and Altius grey-green contacts—to see which works best for reducing light sensitivity (photophobia) in people who get migraines or have other eye conditions. About 200 volunteers who have …

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This pilot study tests whether manual lymphatic drainage, a gentle massage technique, can help people with migraine. Twenty adults aged 20-55 who have at least 4 migraines per month will receive either the massage or standard care. Researchers will measure pain, disability, and q…

This study will test whether a smartphone app called Health enSuite Migraine can help people aged 18 to 50 reduce how often they get migraine headaches. The app teaches simple techniques like managing triggers, relaxing, and changing negative thoughts. About 415 Canadian adults w…

This study looks at whether eating less glutamate—a natural compound found in many foods—can reduce the number and severity of migraine attacks in adults. Forty participants will either follow a low-glutamate diet or continue their usual eating habits while tracking their headach…

This study tests whether a personalized physiotherapy program—including manual therapy, neck exercises, balance training, and pain education—can reduce pain, fatigue, and improve physical function in people with migraine. Fifty adults aged 18-55 with 2-8 migraine attacks per mont…

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This study will follow 460 migraine patients who receive a nerve block injection in the back of the head. Researchers want to find out which patient traits—like migraine type or headache patterns—predict a good response. The goal is to help doctors choose the right treatment for …

This study will test whether using a mind-body mobile app combined with a guided, gentle movement program can help people with chronic pain. One hundred adults aged 19 to 75 with persistent pain for at least 6 months will use the app daily and follow audio-guided movement session…

This study follows 50 adults with migraines who have had or plan to have a procedure called middle meningeal artery embolization as part of their regular care. Researchers will look at how headache frequency, severity, medication use, and quality of life change over 12 months. Th…

This study will measure how sensitive people with episodic and chronic migraine are to pressure pain, and how that relates to their headache burden and quality of life. Researchers will compare a standard pressure pain device with a new tool called Algopeg, which is like a calibr…

This study looks at whether people with migraine have different motor imagery abilities—like mentally picturing movements—compared to healthy people. Researchers will use questionnaires, mental timing tests, and brain scans to measure these abilities. They also want to see if the…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples. The goal is to find differences in a molecule called CGRP and hormone patterns that may …

This study aims to find out how often headaches happen in people with MOGAD, a rare disease that affects the brain and nerves. Researchers will look at the medical records of 25 adults and also follow them forward in time to describe headache patterns. The goal is to better under…

This study gives a natural brain chemical called adrenomedullin to 26 people with migraines to see if it triggers an attack. Participants first receive a migraine-preventing drug (erenumab) to block related receptors. The goal is to understand how migraines start, not to test a n…

This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…

This study will use a non-invasive technique called transcranial magnetic stimulation (TMS) to measure brain activity in 20 people—10 with migraine and 10 healthy controls. By comparing how the brain's motor cortex responds, researchers hope to learn more about how migraine affec…

This study looks at 70 children aged 1 month to 18 years who have neurological disorders like epilepsy, migraine, or stroke. Researchers will use echocardiograms and ECGs to check for hidden heart problems. The goal is to understand if heart issues are common in these children an…