MIGRAINE

This pilot study tests whether manual lymphatic drainage (MLD), a gentle massage technique, can reduce migraine pain and improve quality of life. Twenty adults with frequent migraines will receive either MLD or standard care. Researchers will measure pain, disability, and sleep c…

This study tests whether a mind-body mobile app combined with a guided gentle movement program can help people with chronic pain feel better. About 100 adults aged 19 to 75 with pain lasting at least 6 months will use the app and do weekly movement sessions for 6 weeks. Researche…

This study tests whether osteopathic manual therapy—gentle techniques on the neck and head—can reduce how often migraines happen and how much they interfere with daily life. Researchers will compare the therapy to usual care in 45 adults aged 18 to 50 who have frequent migraines.…

This study tests whether a personalized physiotherapy program—including exercises and education—can reduce pain, fatigue, and improve physical function in people with migraine. About 50 adults with migraine will be randomly assigned to either the personalized program or standard …

This study tests an experimental drug called NB001 for quickly stopping migraine pain and bothersome symptoms in adults. About 120 people with migraines will receive either NB001 or a placebo pill. The main goal is to see if more people are pain-free and symptom-free two hours af…

This study tests whether a low-glutamate diet can reduce the number and severity of migraine attacks in adults. Participants either follow the special diet or continue their usual eating habits while tracking symptoms. Researchers will also look at blood markers to understand how…

This study tests a smartphone app called Health enSuite Migraine to help adults aged 18-50 manage their migraine headaches. The app teaches techniques like stress management, relaxation, and trigger tracking. Researchers will see if using the app reduces the number of migraine da…

This study tests whether basic body awareness therapy (gentle movement and mindfulness exercises) combined with lifestyle advice can reduce migraine attacks and improve daily life. Forty adults aged 18–55 who have at least three migraines per month will take part. Researchers wil…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce migraine headache intensity, disability, and sleep problems. About 102 adults with episodic migraine will receive either real or sham stimulation three times a week for 12 wee…

This study tests whether blocking two arteries in the brain (middle meningeal arteries) with a special plug called Onyx can safely reduce chronic migraine pain. About 13 adults with hard-to-treat migraines will get the procedure and be followed for 6 months. The goal is to see if…

This study aims to see if a fully online mindfulness program is a practical and acceptable option for teens aged 12-17 who have migraines. Researchers will compare a group mindfulness program to a group headache education program, both delivered via telehealth. The main goal is t…

This study looks at 45 adults with migraine with aura and a small hole in the heart called PFO. It aims to see if closing that hole can improve brain activity, thinking, and mood over 12 months. Participants will have brain scans, memory tests, and fill out questionnaires before …

This study looks at how migraine headaches relate to pain sensitivity, work stress, and muscle pain in people who work at desks. Researchers will compare 159 office workers with and without migraine to find patterns. The goal is to better understand these connections and help imp…

This study will track 25 adults with MOGAD, a rare disease that attacks the brain and spinal cord, to see how often they get headaches and what those headaches are like. Researchers will review past medical records and follow patients over time. The goal is to better understand h…

This study looks at whether a natural brain chemical called adrenomedullin can cause migraine attacks in people who already get migraines. Researchers will give the chemical to 26 adults with migraine without aura, after they have taken a preventive migraine drug (erenumab). The …

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples to measure a molecule called CGRP and hormone levels. The goal is to better understand th…

This study compares how well people with migraine can imagine movements (motor imagery) compared to healthy individuals. Researchers will also look at how these mental abilities relate to body awareness, balance, anxiety, and depression. About 136 adults aged 18-65 will participa…

This study looks at how people with episodic and chronic migraine experience pain differently. Researchers will measure pain sensitivity using a special tool called Algopeg and compare it to standard methods. The goal is to better understand migraine-related pain and its impact o…

This study aims to understand how migraine affects the brain's ability to control itself. Researchers will use a safe, non-invasive technique called transcranial magnetic stimulation (TMS) to measure brain activity in 20 migraine patients and 20 healthy people. The goal is to see…

This study aims to uncover why people with migraine often also have neck and lower back pain. Researchers will measure pain sensitivity, psychological factors, and disability in 179 adults with migraine and accompanying spinal pain. The goal is to better understand shared pain me…

This study will follow 460 people with migraine who are getting a nerve block for the first time. Researchers will track their headaches, daily function, and other health details for three months. The goal is to figure out which patients are most likely to benefit, so doctors can…