MIGRAINE

This study is testing if a quarterly injection called fremanezumab can help prevent migraines that occur around a woman's menstrual period. It involves 72 women aged 18-45 who experience these menstrual migraines. Participants will receive either the real medicine or a placebo in…

This study is testing how well a prescription wearable device works to prevent migraines in real-world use. It involves 150 people with chronic migraines who will use the device every other day for three months. The main goal is to see if using the device reduces the average numb…

This study is observing how well a daily medication called atogepant works to prevent migraine attacks in real-world settings. It will follow 500 people in Italy with episodic or chronic migraines for up to two years, tracking how many headache days they have and how the treatmen…

This study is checking the safety of a wearable armband device for migraine when people use it more often than the official instructions recommend. It involves 2,000 people who already use the device in their daily lives. Researchers are looking for any side effects from using th…

This study is testing whether a monthly injection called erenumab can safely reduce the number of migraine days for children and teenagers. It involves about 457 participants, aged 6 to 17, who have episodic migraines. The main goal is to see if the treatment leads to fewer migra…

This study is testing whether the medication desvenlafaxine can help prevent frequent migraine attacks. It involves 440 adults who get migraines several times a month. Researchers will measure if taking the drug for 12 weeks reduces how often people get migraines and how bad they…

This study is testing whether a migraine prevention drug called eptinezumab can help people who still have frequent migraines despite trying other similar preventive medications. It will involve about 150 adults who have at least 8 migraine days per month. The main goal is to see…

This study is testing a new investigational drug called Lu AG09222 to see if it can help prevent migraines. It is for people who have tried 1 to 4 other migraine prevention medications without success. Researchers will compare different doses of the drug against a placebo to find…

This study aimed to use advanced brain scanning to find the exact spots in the brain that cause seizures in people with hard-to-treat epilepsy. The goal was to create a better, non-invasive map to guide surgeons, potentially helping more people become seizure-free after surgery. …

This study aims to see how satisfied patients are with two already-approved migraine medications, ubrogepant and atogepant, when used in everyday life. It will follow about 200 adults in Israel who are prescribed one of these drugs by their doctor for 90 days. The main goal is to…

This study aims to understand how consistently a migraine medication called rimegepant works for people in real life. It will follow 250 adults in the UK who already have a prescription for this drug to treat their migraine attacks. Participants will report their symptoms and med…

This study is testing whether a personalized training program that teaches coping skills can help people with migraines. Researchers are enrolling 60 adults with migraine to see if this non-drug approach reduces pain, improves daily life, and lowers disability over six months. Th…

This study aimed to test the safety and effectiveness of a new pill combining naltrexone and acetaminophen for treating migraine attacks as they happen. It was designed for adults with a history of migraines to see if the combination could stop headache pain and other bothersome …

This study is testing whether a small electrical stimulation device placed on the skin can help treat migraine attacks. Researchers are comparing the device to a placebo in 206 adults with migraines to see if it reduces headache pain and symptoms like nausea and light sensitivity…

This study is looking at how well a prescribed, wearable device works for treating migraine attacks in US veterans. The device uses gentle electrical pulses to target pain. Researchers want to see if using the device helps reduce pain and the need for extra rescue medications.

This study aimed to test if a procedure called middle meningeal artery embolization could help people with chronic migraines that don't get better with medication. The procedure, which blocks a specific artery in the head, would be tested in patients who had tried and failed at l…

This study is observing how well the medication rimegepant works for treating migraine attacks in everyday life. It will follow 3000 adults in China for up to a year to see how quickly it relieves pain, how satisfied people are with the relief, and if it helps them return to norm…

This small pilot study is testing whether inhaling cannabis can quickly stop migraine pain and other symptoms like light sensitivity. Twenty adults with migraines will try three different strengths of cannabis and a placebo during separate attacks to see which works best. The goa…

This study tests whether inhaling isopropyl alcohol vapors (like rubbing alcohol scent) works better than a eucalyptus scent at reducing nausea during migraine attacks. Researchers are comparing the two approaches in 50 adults who regularly experience migraines with nausea. The g…

This study is testing whether taking omega-3 fish oil supplements for 12 weeks can help reduce migraine pain and improve quality of life for children and teenagers aged 10-17. Researchers are comparing the supplement to a placebo (a dummy pill) in 58 participants to see if it low…

This study is testing whether a smartphone app that guides daily breathing exercises can help reduce migraine frequency and severity. Researchers will enroll 30 adults with chronic migraines to try the 8-week app program or a sham control. The main goal is to see if the app is pr…

This study is observing whether certain powerful migraine medications might also help relieve common bladder symptoms like urgency, frequency, and pain. Researchers will follow 200 women with both hard-to-treat migraines and bladder issues. They will compare symptom changes in wo…

This study is testing whether mindfulness training delivered by phone or video can help adults with frequent migraines and mild-to-moderate depressive symptoms. Researchers are comparing these approaches to usual care to see if they're practical and acceptable. The main goal is t…

This study compares three gentle stimulation techniques to see which works best for reducing migraine symptoms. Researchers are testing traditional acupuncture, electroacupuncture (with gentle electrical stimulation), and laser acupuncture (using low-level lasers instead of needl…

This study is exploring whether learning and practicing Transcendental Meditation can help reduce how often people get migraines and improve their daily life. It involves 30 adults in the US who experience migraines 6 to 14 days per month. Participants will learn the meditation t…

This remote study aimed to provide holistic education and pastoral counseling to help people manage stress and improve wellness in daily life. It was designed for specific unmarried Alaska Medicaid recipients who met religious and lifestyle criteria. The study was withdrawn befor…

This study aimed to test if a nasal spray called zavegepant could quickly relieve migraine pain. Adults with a history of migraines would have used the spray at home during up to four attacks to see if it made the pain go away within two hours. The trial was withdrawn by the spon…

This study aims to understand how puberty and changes in sex hormones, like testosterone, influence pain sensitivity and migraine symptoms in adolescents. Researchers are comparing 100 teens aged 11-15, some with migraines and some without, to see how their hormone levels relate …

This study aims to better understand the biology of different headache disorders, including migraines and cluster headaches. Researchers will use capsaicin (from chili peppers) and ice water to trigger mild, temporary pain responses in participants with headaches and healthy volu…

This study aims to understand how headaches, especially migraines, impact employees' work and quality of life. Researchers will analyze existing survey data from over 1,300 employees at Libbs Pharmaceutical. The goal is to learn about headache types, their effects on job performa…

This study aims to understand why young women with migraines might have a higher risk of heart disease. Researchers are comparing how the bodies of women with and without migraines react to a high-fat meal, looking at inflammation, blood vessel function, and stress responses. The…

This study looks back at medical records to see if taking the migraine medication rimegepant during pregnancy is linked to any risks for the mother or baby. It compares pregnancy outcomes in three groups: women with migraines who took rimegepant, women with migraines who took oth…

This study aims to understand if having difficulty identifying and describing emotions (called alexithymia) is linked to how often people get migraines. Researchers will observe 350 female participants, aged 12 to 65, who have migraines. They will measure emotional awareness and …

This study aims to better understand specific brain changes, called white matter hyperintensities, seen on MRI scans. Researchers will compare brain images from 50 women with migraines, small vessel ischemic disease, or multiple sclerosis. The goal is to learn more about these co…