MIGRAINE

This study tested a wearable device that uses gentle electrical pulses to help prevent migraines. 150 people with chronic migraine used the device regularly for 3 months. Researchers measured changes in monthly migraine days and overall improvement to see if the device works in r…

This study tests a new drug called Lu AG09222 to see if it can prevent migraines in people who have already tried 1 to 4 other preventive medications without success. About 874 adults with frequent migraines (at least 4 per month) will receive either the drug or a placebo to find…

This study follows 250 UK adults with migraine who already use rimegepant for acute attacks. Over 12 weeks, participants complete daily surveys to report how quickly the drug provides meaningful pain relief and eases other symptoms. The goal is to understand consistency of respon…

This study followed 100 adults with migraine who received a treatment called pulsed radiofrequency to a nerve at the back of the head. Researchers measured changes in pain sensitivity, skin tenderness, and migraine-related disability over 3 months. The goal was to see if this tre…

This study aimed to see if a procedure called middle meningeal artery embolization could help people with chronic migraines that don't get better with medication. The plan was to block a small artery in the brain to reduce pain and disability. However, the study was withdrawn bef…

This study tests a client-centered coping skills training program for people with migraine. Over 6 months, researchers will measure pain, quality of life, and disability in 60 adults aged 18-65. The goal is to see if learning coping strategies can reduce migraine burden.

This study looks at whether omega-3 supplements (like fish oil) can help reduce migraine pain and improve daily life in children and teens aged 10 to 17. Over 12 weeks, researchers will measure changes in blood omega-3 levels and track pain intensity. The goal is to find a simple…

This study looks at how well the migraine medication ubrogepant helps adults in Canada return to normal activities after a migraine attack. About 167 participants will take the drug as prescribed by their doctor and be followed for up to 12 weeks. The main goal is to see how many…

This study tests if a medicine called fremanezumab can reduce migraines that happen around a woman's period. Women aged 18 to 45 with menstrual migraines will get either the medicine or a placebo injection every three months for six months. They will track their migraines in a di…

This study tests whether the drug erenumab can prevent migraines in children (ages 6 to under 12) and adolescents (12 to under 18) who have episodic migraines. About 457 participants will receive either erenumab or a placebo. The main goal is to see if the drug reduces the number…

This study is testing a new, non-invasive device that delivers gentle vibrations to the belly, back, or head to help people with chronic pain conditions like pelvic pain, abdominal pain, low back pain, and migraine. About 50 adults will try the device or a placebo to see if it sa…

This study tested whether inhaling cannabis can quickly relieve migraine pain. Twenty adults with migraines tried three different strengths of cannabis and a placebo (fake cannabis) to see which worked best. The goal was to find a fast-acting treatment for migraine attacks.

This study aimed to test a new combination of naltrexone and acetaminophen for treating migraine attacks. It was designed for adults with migraine who would treat one attack per stage. The trial was withdrawn before enrolling any participants, so no results are available.

This study looks at whether using the Nerivio wearable device more often than the label says is safe for people with migraine. Researchers are checking for side effects in 2000 participants who used the device at high frequency. The goal is to understand the safety of extra use, …

This study tests whether mindfulness-based cognitive therapy delivered by phone or video can help people with both migraine and depressive symptoms. 145 adults with 4-20 headache days per month and mild to moderate depression are taking part. The goal is to see if the program is …

This study looks at whether inhaling essential oils like lavender and peppermint can change how sensitive people with migraine are to pressure pain. Two hundred adults with migraine will inhale one of four scents (lavender, peppermint, both, or a plain control) for 15 minutes. Re…

This study tests whether acupuncture can reduce migraine pain and lower signs of brain stress and inflammation in the blood. Researchers will compare three types of gentle stimulation—laser, electro, and traditional acupuncture—in 75 adults with migraines. The goal is to find a s…

This study tests an online program called Migraine Manager that helps teens ages 11-17 with migraines build healthy habits like drinking water, eating regular meals, exercising, and sleeping well. About 160 teens will be split into two groups: one using the tool and one receiving…

This study looks at whether practicing Transcendental Meditation (TM) can lower how often migraines happen and how much they affect daily life. Thirty adults with migraines will learn TM and practice it twice a day for 20 minutes. Researchers will track migraine days and quality …

This study tests a nasal spray device called MIG-SPRAY in 45 adults with migraine to see how well it is tolerated. Participants are randomly assigned to use the device or not, and they report any side effects and migraine episodes daily. The goal is to compare side effects, migra…

This study looks at how well Rimegepant works for treating migraine attacks in everyday life. About 3,000 adults with migraine will take the drug as needed and report their pain levels, relief timing, and satisfaction. Researchers will also track long-term effects on migraine fre…

This study tests whether a smartphone app that guides slow, paced breathing can help reduce migraine attacks. Thirty adults with chronic migraine will use the app for 10 minutes daily over 8 weeks. The goal is to see if the app is easy to use and if it lowers headache frequency a…

This study looks at how well the drug atogepant works to prevent migraines in everyday life. About 500 adults with migraine (with or without aura) will take atogepant and report their migraine days over a year. The goal is to see if it reduces migraine frequency and is safe and t…

This study tested a small electrical nerve stimulation device (TENS) to see if it can reduce migraine pain and related symptoms like nausea and light sensitivity. About 200 adults with migraines took part in a double-blind trial where some used the real device and others a fake o…

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 150 adults who have migraines at least 8 days per month and did not get enough relief from previous CGRP-targeting therapies. Participants receive the drug and report changes in symptoms …

This study tested whether a nasal spray called zavegepant can quickly stop migraine pain. Adults with migraines would have used the spray at home when pain hit moderate or severe. The goal was pain freedom within 2 hours, compared to a placebo. The study was withdrawn before enro…

This study tests whether desvenlafaxine, a medication, can reduce how often and how severe migraines are in people who get them frequently. About 440 adults with episodic migraines will take the drug and report their migraine days over 12 weeks. The goal is to see if this drug ca…

This study aimed to see if holistic pastoral counseling could help people manage stress at work and in daily life. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who had internet access and a Bible. However, the study was withdrawn before any participa…

This study looks at how headaches, especially migraines, impact the work and daily life of Libbs employees. Researchers will analyze data from over 1,300 workers who previously filled out questionnaires through a health app. The goal is to understand headache patterns, their effe…

This study looks at how headache disorders like migraine and cluster headaches affect pain signals in the body. Researchers will use capsaicin (from chili peppers) and ice water to trigger mild pain or tearing, then measure changes in molecules and tear production. The goal is to…

This study uses advanced MRI scans to better understand white matter hyperintensities (bright spots on brain images) found in women with migraines. Researchers will compare these spots to those seen in other conditions like small vessel disease and multiple sclerosis. The goal is…

This study looks at how a high-fat, high-carb meal affects inflammation, blood vessel function, and stress responses in young women with migraine compared to healthy women. Thirty women aged 18-35, including both normal-weight and obese participants, will have a single in-person …

This study looks at whether alexithymia—trouble recognizing or describing emotions—is linked to how often women get migraines. Researchers will survey 350 women aged 12-65 with migraine to see if emotional awareness affects headache patterns. No treatment is given; the goal is si…

This study aims to understand if taking rimegepant during pregnancy affects the health of the baby or the pregnancy. Researchers will compare pregnancy outcomes in women with migraine who took rimegepant to those who did not. The study includes pregnant women aged 16 to 49 and tr…

This study aimed to create a database of high-frequency brain signals to better understand epilepsy, migraines, and other brain conditions. It planned to use advanced software to map brain functions in healthy volunteers. However, the study was withdrawn before enrolling anyone, …

This study looks at how two migraine treatments (CGRP inhibitors and Botox injections) change bladder symptoms like urgency, frequency, and pain in women. Researchers will compare symptoms before and after 3 months of treatment using questionnaires. The goal is to understand if t…

This study explores how changing sex hormone levels during puberty relate to migraine pain in adolescents aged 11 to 15. Researchers will measure pain sensitivity and hormone levels in 100 teens with and without migraines. The goal is to better understand the link between hormone…

This study looks at how people with primary headaches (like migraines or tension headaches) feel pain compared to healthy individuals. Researchers will check tenderness in head and neck muscles and measure pain sensitivity in other body areas. The goal is to better understand wha…