New hope for teens with chronic migraines: rimegepant trial begins
NCT ID NCT06616194
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 4 times
Summary
This study tests whether the medicine rimegepant can prevent migraines in teenagers aged 12 to 17 who have frequent, long-lasting headaches. About 200 teens will take either rimegepant or a placebo every other day for 3 months, then all will receive rimegepant for a year. The goal is to see if the medicine reduces the number of migraine days per month and is safe for long-term use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ASL1 Avezzano-Sulmona-L'Aquila
L’Aquila, Abruzzo, 67100, Italy
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Adult & Child Neurology Medical Associates
Long Beach, California, 90806, United States
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Affiliated Hospital of Jiangsu University
Zhenjiang, Jiangsu, 212001, China
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All India Institute of Medical Sciences
New Delhi, National Capital Territory of Delhi, 110029, India
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Anhui Provincial Hospital
Hefei, 230001, China
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Artemis hospital
Gurugram, Haryana, 122001, India
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Asst Spedali Civili Di Brescia
Brescia, 25123, Italy
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AthleticoMed
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-752, Poland
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Avera Medical Group Pediatric Specialists
Sioux Falls, South Dakota, 57105, United States
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Avera Medical Group Pediatrics - Dawley Farm
Sioux Falls, South Dakota, 57110, United States
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Avera Research Institute - Sioux Falls
Sioux Falls, South Dakota, 57108, United States
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CHUVI- Hospital Alvaro Cunqueiro
Vigo, Pontevedra, 36213, Spain
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CaRe Clinic
Red Deer, Alberta, T4P 1K4, Canada
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Centrum Medyczne Hope Clinic Sebastian Szklener
Lublin, Lublin Voivodeship, 20-701, Poland
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Chicago Headache Center and Research Institute
Chicago, Illinois, 60657, United States
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Chicago Headache Center and Research Institute
Naperville, Illinois, 60563, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Chopda Medicare & Research Centre Pvt. Ltd; Magnum Heart Institute
Nashik, Maharashtra, 422005, India
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Clinical Research Institute Helsinki University Central Hospital Ltd
Helsinki, 00280, Finland
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Clinvest Headlands Llc
Springfield, Missouri, 65807, United States
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Dell Children's Medical Center
Austin, Texas, 78723, United States
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Detska fakultna nemocnica s poliklinikou Banska Bystrica
Banská Bystrica, 97409, Slovakia
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Detska nemocnice FN Brno
Brno, Brno-město, 613 00, Czechia
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Dr Sękowska Leczenie Bólu
Warsaw, Masovian Voivodeship, 01-018, Poland
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Dr. Kenessey Albert Kórház
Balassagyarmat, Nógrád megye, 2660, Hungary
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Duke Children's Health Center
Durham, North Carolina, 27710, United States
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Duke Health Center Creekstone
Durham, North Carolina, 27703, United States
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Duke Lenox Baker Children's
Durham, North Carolina, 27705, United States
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Fakultni Nemocnice Motol a Homolka
Prague, 150 06, Czechia
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Fakultni Thomayerova nemocnice
Prague, Praha 4, 14059, Czechia
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Fakultni nemocnice Hradec Kralove
Hradec Králové, Hradec Králové, 500 05, Czechia
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Fakultni nemocnice Ostrava
Ostrava, Moravian-Silesian Region, 708 52, Czechia
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Fondazione Istituto Neurologico C. Mondino
Pavia, 27100, Italy
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General Hospital of Ningxia Medical University
Yinchuan, Ningxia, 750004, China
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Granger Medical Holladay - Holladay Clinic
Salt Lake City, Utah, 84117, United States
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Guangzhou First People's Hospital
Guangzhou, Guangdong, 510180, China
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Headlands Research-El Paso
El Paso, Texas, 79902, United States
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Hospital Clínico Universitario de Valladolid
Valladolid, 47005, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [barcelona], 08035, Spain
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Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
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Hospital Universitario HM Puerta del Sur
Madrid, Madrid, Comunidad de, 28938, Spain
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Hospital Universitario HM Sanchinarro
Madrid, 28050, Spain
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Hospital Universitario Virgen Del Rocio
Seville, 41013, Spain
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I.C.O.T. Università La Sapienza
Latina, 04100, Italy
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IN MEDIC s.r.o.
Bardejov, Slovakia
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IRCCS Istituto Neurologico Carlo Besta
Milan, Lombardy, 20133, Italy
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IRCCS San Raffaele Roma
Rome, ROMA, 00163, Italy
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IRCCS San Raffaele Roma
Roma, 00166, Italy
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Jingzhou First People's Hospital
Jingzhou, Hubei, 434000, China
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KONZILIUM s.r.o.
Dubnica nad Váhom, Slovakia
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Konan Medical Center
Kobe, Hyōgo, 658-0064, Japan
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Kuopion Yliopistollinen Sairaala
Kuopio, Northern Savonia, 70210, Finland
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London Health Sciences Centre - Verspeeten Family Cancer Centre
London, Ontario, N6A 5W9, Canada
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MIGRE Polskie Centrum Leczenia Migreny
Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
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Mallikatta Neuro Centre
Mangalore, Karnataka, 575002, India
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MedicArt Sp. z o. o.
Wroclaw, Lower Silesian Voivodeship, 53-025, Poland
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Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
Warsaw, Masovian Voivodeship, 04-501, Poland
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Michigan Headache & Neurological Institute
Ann Arbor, Michigan, 48104, United States
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NZOZ Neuromed M. i M. Nastaj Sp. P.
Lublin, 20-064, Poland
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Nagaseki Headache Clinic
Kai, Yamanashi, 400-0124, Japan
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Nagykanizsai Kanizsai Dorottya Korhaz
Nagykanizsa, Zala County, 8800, Hungary
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Neurosphera
Warsaw, Masovian Voivodeship, 02-829, Poland
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New Children's Hospital
Helsinki, 00290, Finland
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New England Regional Headache Center
Worcester, Massachusetts, 01609, United States
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OnSite Clinical Solutions
Charlotte, North Carolina, 28211, United States
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Ospedale San Paolo Bari
Bari, Apulia, 70132, Italy
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Peking University People's Hospital
Beijing, Beijing Municipality, 100044, China
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Rutgers University
New Brunswick, New Jersey, 08901, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Semmelweis Egyetem
Budapest, 1083, Hungary
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Semmelweis Egyetem
Budapest, 1094, Hungary
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Shanghai Children's Hospital
Shanghai, 200062, China
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Sir Ganga Ram Hospital
New Delhi, National Capital Territory of Delhi, 110060, India
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Specjalistyczne Gabinety Sp. z o.o.
Krakow, Lesser Poland Voivodeship, 30-539, Poland
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Stollery Children's Hospital
Edmonton, Alberta, T6G 2B7, Canada
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Tampereen yliopistollinen sairaala
Tampere, Pirkanmaa, 33520, Finland
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Tanaka Neurosurgery&Headache Clinic
Kagoshima, 890-0052, Japan
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Tennoji Department of Neurosurgery
Osaka, 545-0053, Japan
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Terveystalo Oulu
Oulu, North Ostrobothnia, 90100, Finland
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Terveystalo Pulssi
Turku, 20100, Finland
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Terveystalo Tampere
Tampere, 33100, Finland
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The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400016, China
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The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215006, China
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The Second Affiliated Hospital of Hebei Medical University
Shijiazhuang, China
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The Second Xiangya Hospital of Central South University
Changsha, Hunan, 410011, China
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The Third Xiangya Hospital of Central South University
Changsha, Hunan, 410013, China
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The University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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Tokyo Headache Clinic
Shibuya-ku, Tokyo, 151-0051, Japan
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Tominaga Clinic
Osaka, Osaka, 556-0015, Japan
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Turku University Hospital
Turku, Southwest Finland, 20520, Finland
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UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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University Of Alberta Hospital
Edmonton, Alberta, T6G 1W9, Canada
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Univerzitna nemocnica Martin
Martin, 036 59, Slovakia
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Wake Forest University Baptist Medical Center ( WFUBMC )
Winston-Salem, North Carolina, 27157, United States
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Wasatch Clinical Research, LLC
Salt Lake City, Utah, 84107, United States
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Wuhan Children's Hospital
Wuhan, Hubei, 430010, China
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Wuxi Children's Hospital
Wuxi, Jiangsu, 214023, China
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Xenoscience Inc
Phoenix, Arizona, 85004, United States
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Yamaguchi Clinic
Nishinomiya, Hyōgo, 663-8204, Japan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a numbing nose treatment stop migraine pain in its tracks?
- Can migraine meds be safe while breastfeeding? a new study investigates
- Could a symptom registry unmask hidden migraine variants?
- A migraine-blocking antibody tested in children as young as 6
- Mind over migraine: brain network may explain why some expect side effects
- The eyes as a window to the brain: can a simple scan monitor MS, Alzheimer's, and Parkinson's?