Can a puff of cannabis stop a migraine? small study investigates
NCT ID NCT05427630
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested three different strengths of inhaled cannabis (2.5%, 5%, and 10% THC) against a placebo to see if they could quickly relieve migraine headaches. Twenty adults with migraine took part in a crossover design, meaning each person tried all options. The main goal was pain freedom two hours after treatment, along with relief from the most bothersome symptom like nausea or light sensitivity. The study was suspended, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Inhaled cannabis flower (THC 2.5%, 5%, 10%)
- What this could lead to
- If it works, this could point toward a fast-acting, plant-based option for easing migraine pain and related symptoms like nausea or light sensitivity.
- What could go wrong
- This is a very small pilot study (20 people) that was suspended, so results may not be reliable or generalizable. Cannabis can cause side effects like dizziness or anxiety, and its long-term effects on migraine are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Center for Pain Medicine, UC San Diego
La Jolla, California, 92037, United States
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