MIGRAINE

This study tests whether the drug ubrogepant can prevent menstrual migraines when taken daily for a week around each period. About 496 women with regular cycles and a history of menstrual migraines will receive either ubrogepant or a placebo for three cycles, then all may receive…

This study tests whether rimegepant, a dissolving tablet, can prevent migraines in children and adolescents ages 6 to under 18. About 640 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces the number of migraine days p…

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency a…

This pilot study explores whether taking high-dose cocoa extract supplements is feasible and acceptable for people with episodic migraine. Researchers will compare two doses of cocoa extract to a placebo, tracking how many participants stick with the daily pills for 12 weeks. The…

This study tests the long-term safety of eptinezumab (Vyepti) in 600 children and teens aged 6 to 17 with chronic or episodic migraine. Participants must have completed a prior study. The main goal is to track side effects over time, with additional measures of drug levels and im…

This study is testing whether the drug rimegepant, taken as a tablet every other day, can help prevent migraines in adults who have at least four migraine days per month. Researchers will track changes in migraine frequency over three to twelve months. The goal is to see if rimeg…

This study tests whether blocking a small artery in the brain (the middle meningeal artery) with a special glue can prevent chronic migraines. About 70 adults with hard-to-treat chronic migraine will receive the procedure. The main goal is to see if it safely reduces the number o…

This Phase 2 trial tests whether a new drug called MEDI0618 can safely reduce the number of migraine headache days in adults with episodic migraine. About 488 participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug lowe…

This phase 2 trial tests whether a weekly dose of cabergoline, a drug that affects dopamine, can reduce the number of migraine days in adults with episodic migraine (4-14 migraine days per month). 150 participants will be randomly assigned to receive cabergoline (0.5 mg or 1.0 mg…

This observational study will follow 700 people with migraine who are prescribed anti-CGRP drugs (monoclonal antibodies or gepants) for prevention. Over two years, researchers will track changes in monthly headache days, migraine impact, and disability. The goal is to see how the…

This study tests a simple 10-question scale designed to help neurologists quickly identify migraine patients who could benefit from physiotherapy. Many migraine patients have neck problems that make their headaches worse, but neurologists often lack time or training to assess thi…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial features, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) to …

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This study looks at the safety and effectiveness of atogepant, a drug already approved for migraine prevention, in Korean adults. About 3000 people with chronic or episodic migraines will take the drug as prescribed by their doctor and be followed for up to 12 weeks. The goal is …

This study tests whether the medicine rimegepant can prevent migraines in teenagers aged 12 to 17 who have frequent, long-lasting headaches. About 200 teens will take either rimegepant or a placebo every other day for 3 months, then all will receive rimegepant for a year. The goa…

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study tests a small device placed inside the nose that delivers gentle stimulation to prevent migraines. 110 adults with migraines will use the device at home every other day for six weeks. Researchers will track how many migraine days they have compared to a group that star…

This pilot study tests whether a structured, evidence-based physical therapy program (including education, aerobic exercise, and relaxation) works better than standard physiotherapy for adults with migraine. About 195 participants aged 18-70 with a confirmed migraine diagnosis wi…

This study is testing a nurse-led mind-body program to help children and teens with migraine have fewer headache days. The program combines different treatment parts, like relaxation and coping skills, to find the best mix. The study will include 260 participants aged 10-17 who h…

This study is testing a digital care program for adults with migraine. The program includes a wearable device that uses nerve stimulation, personalized exercises, and support from a care team. The goal is to see if it can reduce the number of migraine days per month. About 140 pe…

This study tests an investigational inhaled medication called ASY202 (dihydroergotamine dry powder) for treating migraine attacks in adults. Participants use a handheld inhaler to take the drug or a placebo during separate migraine episodes, and neither they nor the study team kn…

This study compares two non-drug, virtual programs for adults with migraine. Both involve 8 weekly group sessions and online learning. Researchers want to see if these programs can reduce migraine-related disability and improve mood. Participants can continue their usual medicati…

This pilot study from Mayo Clinic tests whether a virtual lifestyle behavior training program can help people with chronic migraine have fewer attacks. Sixty adults with chronic migraine for at least one year will be randomly assigned to either the lifestyle program or a sham edu…

This study tests an oral medication called ubrogepant, already approved for adults, to see if it safely and effectively treats migraine attacks in children and adolescents aged 6 to 17. About 1,059 participants with a history of migraine will receive either a low or high dose of …

This study tests whether a home-based virtual reality (VR) neurofeedback program is practical and helpful for adolescents aged 10-16 with migraine. Participants use a wearable EEG headband that reads brain activity and guides the VR experience during short sessions three times a …

This study tests if a lidocaine infusion into blood vessels in the skull can reduce chronic migraine pain, frequency, and duration. It involves 40 adults aged 18-75 with severe, hard-to-treat migraines. The treatment numbs pain receptors to provide relief.

This study tests whether basic body awareness therapy (gentle movement and mindfulness exercises) combined with lifestyle advice can reduce migraine attacks and improve daily life. Researchers will track pain, sleep, and quality of life in 40 adults who have at least 3 migraines …

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This study tests if blocking the middle meningeal arteries in the brain is safe and feasible for people with hard-to-treat chronic migraines. About 13 participants will undergo the procedure and be followed for 6 months. The goal is to reduce migraine-causing substances in the br…

This study looks at whether taking a steroid pill (dexamethasone) after a nerve block in the emergency room can prevent migraines from returning within 72 hours. About 84 adults with migraines will be followed by phone or text to see if their headache comes back. The goal is to f…

This study looks at whether a supervised aerobic exercise program, combined with a single session of pain education, can reduce migraine-related disability and improve sensory and muscle function. One hundred women with migraine will either exercise on a treadmill three times a w…

This study tests whether injecting a long-lasting numbing medication (Exparel) into the side of the nose can reduce severe face and headache pain. About 15 adults with conditions like migraine or cluster headache will receive either the drug or a placebo, then switch groups. The …

This study tests a new way to treat severe migraines by using a mild electrical current on an artery in the head. Researchers want to see if the procedure is safe and practical for people whose headaches don't get better with standard treatments. About 12 adults with chronic migr…

This study tests a group therapy program for teens aged 13-17 with migraine. The program combines high-intensity interval training, progressive muscle relaxation, and education over 18 weeks. Researchers want to see if it reduces headache frequency, pain, and the need for medicat…

This study looks at whether taking ubrogepant (a migraine medication) during the earliest phase of a migraine—called the prodrome—can prevent moderate to severe headache pain. About 189 adults who already use ubrogepant will take it as usual and report their symptoms over 13 week…

This Phase 2 trial tests whether a single dose of PRT-064040 nasal spray can quickly relieve moderate to severe migraine pain and the most bothersome symptoms. About 456 adults with a history of migraines will receive either the spray or a placebo. The main goal is to see if more…

This study tests whether giving magnesium along with the standard migraine drug prochlorperazine reduces pain more than the drug alone. About 100 adults with migraines in the emergency department will receive either the combination or a placebo. Researchers will measure pain chan…

This study is testing how well and how safely the drug rimegepant works for treating migraine attacks as they happen. Researchers will follow 100 people with migraine (with or without aura, or chronic migraine) who take a 75 mg rimegepant tablet when they have an attack. The main…

This study looks at whether the migraine drug eptinezumab can stop a migraine attack while it is being given through an IV. Researchers want to know how fast the headache goes away and if other bothersome symptoms also disappear. The study will include 50 adults who have migraine…

This study compares two medicines, flunarizine and propranolol, to see which works better at reducing migraine attacks in children aged 8 to 15. The trial will enroll 44 kids who have frequent migraines and measure improvement using a special disability score. The goal is to find…

This study tests whether injecting a steroid and numbing medicine into muscle trigger points can relieve knee osteoarthritis pain as well as injecting into the knee joint itself. About 1,000 adults with knee arthritis and at least one tender muscle spot will receive either a trig…

This study tests whether combining green light therapy with a gentle, non-invasive brain stimulation technique (tDCS) can reduce how often migraines happen and how bad they hurt. Researchers will enroll 40 adults with frequent, painful migraines. Participants will track their hea…

This study tests whether taking rimegepant before a known trigger (like exercise, alcohol, or stress) can prevent a migraine from developing. It involves 60 adults with migraine who have reliable triggers. Participants take the medication ahead of the trigger and report if a head…

This study looks at whether Xeomin injections can reduce migraine pain and frequency in people who have had a traumatic brain injury or an unexplained health incident. About 60 adults will receive the injections and report their headache changes over 12 weeks. The goal is to see …

This study tests if a new biodegradable heart implant can reduce migraine days better than a standard metal implant in people with a small hole in the heart (PFO). The new implant is designed to dissolve over time, potentially avoiding long-term complications like metal allergies…

This study tests a remote behavioral program called RELAXaHEAD for people with migraines. About 356 adults will use the app to learn skills that may reduce migraine-related disability and improve quality of life. The goal is to see if this approach works better than usual care, a…

This study compares two fast-dissolving migraine tablets, rimegepant (Nurtec ODT) and rizatriptan (Maxalt MLT-ODT), in adults coming to the emergency room with a migraine. The goal is to see which drug provides better pain relief within 60 and 120 minutes. 80 participants will re…

This study tests zavegepant (Zavzpret), a nasal spray already approved for migraines, in 200 adults who also take CGRP-targeting preventive medications. Researchers want to see if it provides headache relief within 2 to 4 hours and improves daily function. The goal is to find a s…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study looks at whether people with migraine have different shoulder muscle activity and arm performance compared to those without migraine. Researchers will measure muscle signals and shoulder movement in 50 adults aged 18-55. The goal is to understand how migraine might aff…

This study checks if a new melt-in-the-mouth version of a migraine drug works the same as the approved tablet. It involves 36 healthy adults who will take both forms at different times. The goal is to see if the body absorbs the drug similarly, not to treat migraines.

This study looks at 179 adults with migraine who also have neck or lower back pain. Researchers want to understand if these pains share common causes, like changes in how the brain processes pain. Participants will answer questionnaires and undergo pain assessments. The goal is t…

This study looks at how migraine headaches relate to pain sensitivity, work stress, and muscle pain in people who work at desks. Researchers will compare 159 office workers with and without migraine to find connections that could lead to better workplace health. The goal is to un…

This study aims to understand how the information given to patients about their treatment affects their response to migraine medication. Researchers will give 60 adults with chronic migraine four different treatment conditions in a random order and measure changes in headache int…

This study looks at how sleep problems and stress can trigger migraines in adults. Participants wear a WHOOP band to track sleep and body signals, and answer daily questions via a smartphone app. The goal is to find personal patterns and give tailored advice to reduce migraine at…

This study follows pregnant women with migraine who took rimegepant (Nurtec) and those who did not, to compare rates of birth defects and other pregnancy complications. About 780 participants will be tracked through 12 months after birth. The goal is to gather safety data, not to…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This online registry is studying the safety and effectiveness of the CEFALY device, a non-invasive nerve stimulator worn on the forehead, for treating migraines during and after pregnancy. Pregnant women aged 18-44 with migraines can join, regardless of whether they use the devic…

This study tests whether adding AI-powered education to standard migraine education helps people newly diagnosed with migraine understand their condition better. 140 adults aged 18-65 will be split into two groups: one gets standard education alone, the other gets standard educat…

This study looks at why over 20% of migraine patients don't respond well to triptans, a common migraine medication. Researchers will compare tryptophan and related substances in the blood of 144 people who either respond or don't respond to triptans. The goal is to understand the…

This study looks at how migraine affects thinking, memory, and emotions in 150 adults. Researchers will test cognitive skills and link them to mood, anxiety, and headache patterns. The goal is to better understand the full impact of migraine on daily life.

This study is collecting information from 10,000 people aged 12 and older with common headache disorders like migraine and tension-type headaches. Researchers will track their symptoms, brain scans, genetics, and thinking abilities over time. The goal is to better understand thes…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots across their vision. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or he…

This observational study tracks the safety of Ubrelvy and Qulipta, two migraine drugs, when used during pregnancy. Researchers will follow about 1,884 pregnant women with migraine in the US and Canada, comparing those who take either drug to a group who does not. The goal is to s…

This study follows pregnant women with migraine who take Aimovig (erenumab-aooe) to see if the drug increases the risk of major birth defects. Researchers will compare their babies to those of women with migraine who did not take Aimovig. The goal is to gather real-world safety d…

This study uses a powerful 7T MRI scanner to look at brain structure and activity in people with migraine, visual snow, or epilepsy, as well as healthy volunteers. The goal is to better understand how these conditions affect the brain. No treatment or medication is tested—only ob…

This study is looking for ways to predict which migraine patients will respond well to a class of drugs called anti-CGRP monoclonal antibodies. Researchers will analyze clinical, biological, and brain imaging data from 350 adults with frequent migraines. The goal is to find bioma…