Could a dissolving tablet stop migraines in kids?

NCT ID NCT05156398

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 6 times

Summary

This study tests whether rimegepant, a dissolving tablet, can prevent migraines in children and adolescents ages 6 to under 18. About 640 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces the number of migraine days per month compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rimegepant (a drug taken as a dissolving tablet)
What this could lead to: If it works, this could give children and teens a new option to prevent migraines and reduce the number of headache days each month.
What could go wrong: This is a phase 3 trial, but results may not apply to all children. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hyperacusis migraine disorder Nausea Photophobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

Locations

ASST Spedali Civili di Brescia
RECRUITING

Brescia, 25069, Italy
Accel Research Sites Network - Edgewater Clinical Research Unit
ACTIVE_NOT_RECRUITING

Edgewater, Florida, 32132, United States
Advanced Investigative Medicine, Inc.
RECRUITING

Hawthorne, California, 90250, United States
Advanced Neurosciences Research, LLC
TERMINATED

Fort Collins, Colorado, 80528, United States
Alina Clinical Trials, LLC.
RECRUITING

Dallas, Texas, 75209, United States
Atago Hospital
RECRUITING

Kochi, Kochi, 780-0051, Japan
Augusta University
RECRUITING

Augusta, Georgia, 30912, United States
Avera McKennan Hospital & University Health Center
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Avera Medical Group Pediatrics - Dawley Farm
RECRUITING

Sioux Falls, South Dakota, 57110, United States
Avera Research Institute
RECRUITING

Sioux Falls, South Dakota, 57108, United States
Carolina Institute for Clinical Research, LLC
ACTIVE_NOT_RECRUITING

Fayetteville, North Carolina, 28303, United States
Centre Hospitalier Intercommunal de Creteil
RECRUITING

Créteil, 94000, France
Centre Hospitalier Universitaire de Montpellier
ACTIVE_NOT_RECRUITING

Montpellier, 34295, France
Children's and Women's Health Centre of British Columbia
TERMINATED

Vancouver, British Columbia, V6H 3V4, Canada
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Clinical Research Center Sp. z o.o. MEDIC-R Sp. k.
RECRUITING

Poznan, Greater Poland Voivodeship, 61-731, Poland
Coastal Pediatric Research
ACTIVE_NOT_RECRUITING

Charleston, South Carolina, 29414, United States
Colorado Springs Neurological Associates
ACTIVE_NOT_RECRUITING

Colorado Springs, Colorado, 80907, United States
Complete Health Research
ACTIVE_NOT_RECRUITING

Ormond Beach, Florida, 32174, United States
D&H Tamarac Research Center LLC
RECRUITING

Tamarac, Florida, 33321, United States
DCT-McAllen Primary Care Research, LLC dba Discovery Clinical Trials
RECRUITING

McAllen, Texas, 78503, United States
DCT-Stone Oak, LLC dba Discovery Clinical Trials
RECRUITING

San Antonio, Texas, 78258, United States
DM Clinical Research (Administrative Office Only)
RECRUITING

Tomball, Texas, 77375, United States
DM Clinical Research - Cy Fair
RECRUITING

Houston, Texas, 77065, United States
Dent Neurosciences Research Center, Inc.
ACTIVE_NOT_RECRUITING

Amherst, New York, 14226, United States
Diamond Headache Clinic
TERMINATED

Chicago, Illinois, 60642, United States
Direct Helpers Research Center
RECRUITING

Hialeah, Florida, 33012, United States
Divisione di Neurologia, Ospedale Pediatrico Bambino Gesu
RECRUITING

Rome, Rome/lazio, 00165, Italy
Extraordinary Family Healthcare
ACTIVE_NOT_RECRUITING

Snellville, Georgia, 30078, United States
Hikita Pediatric Clinic
RECRUITING

Kiryu-shi, Gunma, 376-0035, Japan
Hopital des Enfants
RECRUITING

Toulouse, 31059, France
Hospital Alvaro Cunqueiro
RECRUITING

Vigo, Galicia, 36312, Spain
Hospital Clinico Universitario de Valladolid (HCUV)
RECRUITING

Valladolid, Castille and León, 47003, Spain
Hospital Universitari Parc Tauli
RECRUITING

Sabadell, Barcelona, 08208, Spain
Hospital Universitario y Politecnico La Fe
RECRUITING

Valencia, 46026, Spain
IRCCS San Raffaele
RECRUITING

Rome, Lazio, 00166, Italy
Instituto de Investigaciones del Sueno
RECRUITING

Madrid, 28036, Spain
Istituto Neurologico "Carlo Besta" Fondazione IRCCS
RECRUITING

Milan, Lombardy, 20133, Italy
Jinnouchi Neurosurgical Clinic
RECRUITING

Kasuga-shi, Fukuoka, 816-0802, Japan
Konan Medical Center
RECRUITING

Higashinada-ku Kobe-shi, Hyōgo, 658-0064, Japan
Lynn Health Science Institute
ACTIVE_NOT_RECRUITING

Oklahoma City, Oklahoma, 73112, United States
MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
MTZ Clinical Research Powered by Pratia
TERMINATED

Warsaw, Masovian Voivodeship, 02-172, Poland
Meridian Clinical Research, LLC
ACTIVE_NOT_RECRUITING

Savannah, Georgia, 31406, United States
Meridian Clinical Research, LLC
ACTIVE_NOT_RECRUITING

Portsmouth, Virginia, 23703, United States
Mito Kyodo General Hospital
NOT_YET_RECRUITING

Mito, Ibaraki, 310-0015, Japan
Monroe Carell Jr Children's Hospital at Vanderbilt
TERMINATED

Nashville, Tennessee, 37232, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
NZOZ Neuromed M. i M. Nastaj Sp. P.
RECRUITING

Lublin, Lublin Voivodeship, 20-064, Poland
NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS
ACTIVE_NOT_RECRUITING

Katowice, Silesian Voivodeship, 40-123, Poland
NeuroCare Plus
RECRUITING

Houston, Texas, 77094, United States
Neurologia Slaska Centrum Medyczne
RECRUITING

Katowice, Silesian Voivodeship, 40-689, Poland
New Med Research, Inc
TERMINATED

Hollywood, Florida, 33020, United States
Next Stage Sp. Z o.o.
RECRUITING

Warsaw, WOJ. Mazowieckie, 02-121, Poland
Nola Research Works, LLC
RECRUITING

New Orleans, Louisiana, 70125, United States
North Texas Center for Clinical Research
RECRUITING

Frisco, Texas, 75034, United States
Northwest Clinical Trials, Inc.
RECRUITING

Boise, Idaho, 83704, United States
Papillion Research Center/CCT Research
RECRUITING

Papillion, Nebraska, 68046, United States
Red Star Research, LLC
ACTIVE_NOT_RECRUITING

Lake Jackson, Texas, 77566, United States
Renew Health Clinical Research LLC
ACTIVE_NOT_RECRUITING

Snellville, Georgia, 30078, United States
Renown Regional Medical Center
ACTIVE_NOT_RECRUITING

Reno, Nevada, 89502, United States
Roy Blunt NextGen Precision Health Building
RECRUITING

Columbia, Missouri, 65211, United States
SCLA Management - Drop Box
RECRUITING

Houston, Texas, 77077, United States
SCLA Management Office
RECRUITING

Houston, Texas, 77077, United States
Safe Haven Clinical Research
TERMINATED

Clinton, Mississippi, 39056, United States
Saitama Neuropsychiatric Institute
RECRUITING

Chuo-ku Saitama-shi, Saitama, 338-8577, Japan
Santos Research Center, CORP
RECRUITING

Tampa, Florida, 33615, United States
Sapienza Universita di Roma Polo Pontino - ICOT, Headache clinic
RECRUITING

Latina, Latina/lazio, 04100, Italy
Sendai Headache and Neurology Clinic
RECRUITING

Taihaku-ku Sendai-shi, Miyagi, 982-0014, Japan
Tanaka Neurosurgery & Headache Clinic
RECRUITING

Kagoshima, Kagoshima-ken, 890-0052, Japan
Tennouji Dai Brain Clinic
RECRUITING

Abeno-ku Osaka-shi, Osaka, 545-0053, Japan
Texas Institute for Neurological Disorders
ACTIVE_NOT_RECRUITING

Sherman, Texas, 75092, United States
The Belinga Clinic
ACTIVE_NOT_RECRUITING

Fort Smith, Arkansas, 72901, United States
Tokyo Headache Clinic
RECRUITING

Shibuya-ku, Tokyo, 151-0051, Japan
Tokyo Medical University Hospital
RECRUITING

Shinjuku-ku, Tokyo, 160-0023, Japan
Tominaga Clinic
RECRUITING

Naniwa-ku, Osaka, 556-0015, Japan
Tribe Clinical Research LLC
TERMINATED

Greenville, South Carolina, 29607, United States
UOSVD Centro Epilessia ed EEG dellEta Evolutiva
RECRUITING

Bari, BARI / Puglia, 70132, Italy
University of Missouri
RECRUITING

Columbia, Missouri, 65212, United States
University of Missouri Health Care - Investigation Pharmacy
RECRUITING

Columbia, Missouri, 65212, United States
University of Missouri-Clinical and Translational Sciences Unit
RECRUITING

Columbia, Missouri, 65212, United States
Velocity Clinical Research
ACTIVE_NOT_RECRUITING

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research San Diego
ACTIVE_NOT_RECRUITING

La Mesa, California, 91942, United States
Velocity Clinical Research, Grand Island
RECRUITING

Grand Island, Nebraska, 68803, United States
Velocity Clinical Research, Washington DC
RECRUITING

Washington D.C., District of Columbia, 20016, United States
Victoria Clinical Research Group
TERMINATED

Victoria, Texas, 77901, United States
Virgen del Rocio Hospital
RECRUITING

Seville, 41013, Spain
WR-Mount Vernon Clinical Research, LLC
ACTIVE_NOT_RECRUITING

Sandy Springs, Georgia, 30328, United States
Wojewodzki Specjalistyczny Szpital Dzieciecy
RECRUITING

Krakow, Lesser Poland Voivodeship, 31-503, Poland
Yamaguchi Clinic
RECRUITING

Nishinomiya-shi, Hyōgo, 663-8204, Japan

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