New nasal spray could offer quick migraine relief for those on preventives
NCT ID NCT06401642
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests zavegepant (Zavzpret), a nasal spray already approved for migraines, in 200 adults who also take CGRP-targeting preventive medications. Researchers want to see if it provides headache relief within 2 to 4 hours and improves daily function. The goal is to find a safe, effective rescue treatment for people already managing migraines with preventives.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
zavegepant (Zavzpret) nasal spray
What this could lead to
If it works, this could give people on migraine preventives a fast-acting option to stop migraine attacks when they occur.
What could go wrong
This is a small, early-phase study (200 people) and results may not apply to everyone. Side effects are possible, and the drug may not work better than existing options.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Arizona
RECRUITINGPhoenix, Arizona, 85254, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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