Migraine drug vyepti tested in kids for long-term safety

NCT ID NCT05164172

Recruiting now Disease control Sponsor: H. Lundbeck A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests the long-term safety of eptinezumab (Vyepti) in 600 children and teens aged 6 to 17 with chronic or episodic migraine. Participants must have completed a prior study. The main goal is to track side effects over time, with additional measures of drug levels and immune response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

eptinezumab (Vyepti)

What this could lead to

If successful, this could confirm that eptinezumab is a safe long-term option to reduce migraine frequency in children and teens.

What could go wrong

This is an extension study focused on safety, not effectiveness. It may not show strong benefits, and side effects or lack of response could limit its use.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AGA Clinical Trials - Hialeah - 4980 W 10th Ave
RECRUITING

Hialeah, Florida, 33012, United States
AO Brotzu - Clinica di Neuropsichiatria dell'Infanzia e dell'Adolescenza
RECRUITING

Cagliari, Sardinia, 09121, Italy
AthleticoMed
RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-752, Poland
Axcess Medical Research
COMPLETED

Loxahatchee Groves, Florida, 33470-9272, United States
Azienda Ospedaliero Universitaria A Meyer (Duplicate)
RECRUITING

Florence, Tuscany, 50139, Italy
Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara
RECRUITING

Pisa, Tuscany, 56126, Italy
CHUVI - H.U. Alvaro Cunqueiro
RECRUITING

Vigo, Pontevedra, 36312, Spain
Centro Clínico Académico, Braga - Hospital de Braga
RECRUITING

Braga, 4710-243, Portugal
Centro de Investigacion Medico Biologica y de Terapia Avanzada S.C.
RECRUITING

Guadalajara, Jalisco, 44700, Mexico
Centro de Investigaciones Médicas Tucumán - PPDS
RECRUITING

San Miguel de Tucumán, Tucumán Province, T4000AXL, Argentina
Centrum Medyczne Plejady Magdalena Celinska - Lowenhoff, Michal Zolnowski Spolka komandytowa
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-363, Poland
Children and Youth Health Care Institute of Vojvodina
RECRUITING

Novi Sad, 21 000, Serbia
Children's Specialty Group - 3 Commercial Place
RECRUITING

Norfolk, Virginia, 23510, United States
Children's Wisconsin - Milwaukee Campus - PIN
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Childrens Hospital Medical Center of Akron
RECRUITING

Akron, Ohio, 44308-1063, United States
Childrens University Hospital
RECRUITING

Belgrade, 11000, Serbia
Cincinnati Children's Hospital Medical Center - PIN
RECRUITING

Cincinnati, Ohio, 45229-3026, United States
Clinical Centre of Vojvodina
RECRUITING

Novi Sad, 21 000, Serbia
Clinical Research Institute SC-Mexico
RECRUITING

Ampl San Lucas Tepetlacalco, State of Mexico, 54055, Mexico
Dent Neurosciences Research Center Incorporated
COMPLETED

Amherst, New York, 14226-1727, United States
ETG Lublin - PPDS
RECRUITING

Lublin, Lublin Voivodeship, 20-412, Poland
ETG Neuroscience - PPDS
RECRUITING

Warsaw, Masovian Voivodeship, 02-677, Poland
Eskisehir Osmangazi Universitesi Tip Fakultesi Hastanesi
RECRUITING

Eskişehir, 26480, Turkey (Türkiye)
Expertia S.A- Mautalén Salud e Investigación
COMPLETED

Buenos Aires, C1128AAF, Argentina
Fondazione IRCCS Istituto Neurologico Carlo Besta
COMPLETED

Milan, Lombardy, 20133, Italy
Fondazione Istituto Neurologico Nazionale Casimiro Mondino IRCCS
RECRUITING

Pavia, 27100, Italy
Great Ormond Street Hospital - PPDS
RECRUITING

London, Greater London, WC1N 3JH, United Kingdom
Helen Devos Childrens' Hospital - PIN
COMPLETED

Grand Rapids, Michigan, 49503-2528, United States
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Privado de La Comunidad
COMPLETED

Mar del Plata, Buenos Aires, 7603, Argentina
Hospital Universitari i Politecnic La Fe de Valencia
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Vall d'Hebron - PPDS
RECRUITING

Barcelona, 8025, Spain
Hospital Universitario Virgen del Rocio - PPDS
RECRUITING

Seville, 41013, Spain
Hospital de Niños de La Santisima Trinidad
RECRUITING

Córdoba-Barrio Crisol, Córdoba Province, X5014AKM, Argentina
ICARO Investigaciones en Medicina, S.A de C.V
RECRUITING

Chihuahua City, 31000, Mexico
INECO Neurociencias Oroño
RECRUITING

Rosario, Santa Fe Province, S2000DTP, Argentina
IRCCS Istituto Giannina Gaslini
RECRUITING

Genoa, Liguria, 16147, Italy
IRCCS Ospedale Pediatrico Bambino Gesu
RECRUITING

Rome, Lazio, 00165, Italy
Instituto Médico Río Cuarto
RECRUITING

Río Cuarto, Córdoba Province, 5800, Argentina
Instituto de Investigationes Clinicas para la Salud A.C.
RECRUITING

Durango, 34000, Mexico
Instytut Zdrowia Dr Boczarska-Jedynak Sp. z o.o. Sp. k.
RECRUITING

Oświęcim, Lesser Poland Voivodeship, 32-600, Poland
Izmir City Hospital
RECRUITING

Bayraklı, İzmir, 35540, Turkey (Türkiye)
James Paget University Hospitals NHS Foundation Trust
RECRUITING

Great Yarmouth, Norfolk, NR31 6LA, United Kingdom
Ki Health Partners LLC DBA New England Institute for Clinical Research
RECRUITING

Stamford, Connecticut, 06905-1206, United States
London Health Sciences Centre -800 Commissioners Rd E
RECRUITING

London, Ontario, N6A 5W9, Canada
MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
MTZ Clinical Research Powered by PRATIA - PPDS
RECRUITING

Warsaw, Masovian Voivodeship, 02-172, Poland
Marshall University Medical Center
RECRUITING

Huntington, West Virginia, 25701-3656, United States
Mersin University Medical Faculty
RECRUITING

Mersin, 33169, Turkey (Türkiye)
Michigan Head Pain and Neurological Institute
COMPLETED

Ann Arbor, Michigan, 48104-5131, United States
Michigan State University - Department of Neurology
COMPLETED

East Lansing, Michigan, 48824-7015, United States
NW FL Clinical Research Group, LLC
RECRUITING

Gulf Breeze, Florida, 32561-4458, United States
OnSite Clinical Solutions, LLC - Randolph Rd - Charlotte
COMPLETED

Charlotte, North Carolina, 28211-5027, United States
Ospedale San Raffaele S.r.l.
RECRUITING

Milan, Lombardy, 20132, Italy
Queen Elizabeth University Hospital - PPDS
RECRUITING

Glasgow, G514TF, United Kingdom
Road Runner Research Ltd
RECRUITING

San Antonio, Texas, 78249-3539, United States
Royal Hospital for Children and Young People - PIN
RECRUITING

Edinburgh, Midlothian, EH16 4TJ, United Kingdom
The Kids Clinic
RECRUITING

Ajax, Ontario, L1Z 0M1, Canada
True North Neurology
RECRUITING

Commack, New York, 11725-2808, United States
ULS de Almada-Seixal, EPE - Hospital Garcia de Orta
RECRUITING

Almada, Setúbal District, 2805-267, Portugal
ULS de Coimbra, EPE - Hospital Pediátrico de Coimbra
RECRUITING

Coimbra, 3000-602, Portugal
ULS de Santo António, EPE - Centro Materno Infantil Norte
RECRUITING

Porto Covo, Setúbal District, 4050-651, Portugal
ULS de São João, EPE - Hospital de São João
RECRUITING

Porto, 4200-319, Portugal
University Clinical Center Kragujevac
RECRUITING

Kragujevac, 34000, Serbia
University Clinical Center Nis
RECRUITING

Niš, 18 000, Serbia
University of Kentucky
RECRUITING

Lexington, Kentucky, 40536-7001, United States
University of Maryland School of Medicine
RECRUITING

Baltimore, Maryland, 21201-1544, United States
University of South Florida
RECRUITING

Tampa, Florida, 33612-6601, United States
Vancouver Island Health Authority
RECRUITING

Victoria, British Columbia, V8R 1J8, Canada
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06511, United States