Could cocoa extract help tame migraines? scientists launch pilot study

NCT ID NCT06808230

Recruiting now Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This pilot study explores whether taking high-dose cocoa extract supplements is feasible and acceptable for people with episodic migraine. Researchers will compare two doses of cocoa extract to a placebo, tracking how many participants stick with the daily pills for 12 weeks. The study also collects data on migraine days and severity, but its main goal is to see if a larger trial is possible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cocoa extract (dietary supplement)
What this could lead to: If successful, this could pave the way for larger trials testing cocoa flavanols as a potential dietary approach to reduce migraine frequency.
What could go wrong: This is a small pilot study focused on feasibility, not on proving effectiveness. It may not show any benefit for migraines, and high doses could cause side effects.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.