Brigham And Women's Hospital

This pilot study explores whether taking high-dose cocoa extract supplements is feasible and acceptable for people with episodic migraine. Researchers will compare two doses of cocoa extract to a placebo, tracking how many participants stick with the daily pills for 12 weeks. The…

This phase 2 trial is testing whether a supplement called nicotinamide mononucleotide (NMN) can protect the heart and kidneys of people undergoing coronary artery bypass surgery. Researchers will give NMN or a placebo to 90 adults at higher risk of complications. The main goal is…

This study tests whether a long-acting buprenorphine injection can be used to start treatment for opioid use disorder without causing severe withdrawal. Thirty adults with opioid use disorder will stay in a hospital for three days, receive fentanyl to prevent withdrawal, and then…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This study tests whether computer alerts can help doctors prescribe cholesterol-lowering drugs to people with peripheral artery disease (PAD) who aren't taking them. About 400 adults with PAD will be randomly assigned to have their doctors receive an alert or not. The goal is to …

This study tests whether dapagliflozin, a drug already used for diabetes and other kidney diseases, can help people with lupus nephritis. About 33 adults with active lupus kidney inflammation will receive either dapagliflozin or a placebo alongside their usual treatment. The main…

This study tests whether a drug called defibrotide is safe and feasible for people with severe COVID-19 pneumonia. About 42 adults with confirmed COVID-19 and lung infiltrates will receive the drug intravenously. Researchers will monitor for bleeding and low blood pressure as key…

This study tests a program that gives food supplements to pregnant women, new mothers, and their babies, along with advice on healthy eating, exercise, and infant feeding. The goal is to reduce both maternal obesity and child stunting in rural Indigenous communities in Guatemala.…

This study aims to help 10 women with absolute uterine infertility (no uterus or one that doesn't work) have a baby through a uterus transplant from a donor. Participants will first undergo IVF to create embryos, then receive the transplant, followed by embryo transfer and pregna…

This study tests whether a uterus from a deceased donor can be transplanted into women who cannot get pregnant due to a missing or non-working uterus. Participants must first create and freeze at least six embryos through IVF. After transplant and recovery, embryos are implanted.…

This study tests whether a supplement called NMN can improve kidney health in people with type 2 diabetes and diabetic kidney disease. About 156 adults will take either NMN or a placebo twice daily for 6 months. The main goal is to see if NMN reduces protein in the urine, a key s…

This study compares two common diabetes drug classes—SGLT2 inhibitors and GLP-1 receptor agonists—to see which better prevents heart attacks, strokes, kidney failure, and death in 6,000 people with type 2 diabetes and heart disease or high risk. Participants are randomly assigned…

This study compares two blood pressure medications, eplerenone and chlorthalidone, in 75 adults with high blood pressure and thickened heart muscle. Researchers want to see if eplerenone improves blood flow to the heart and how efficiently the heart uses oxygen. Participants will…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests a drug called elranatamab in people with AL amyloidosis that has come back or not responded to prior treatment. The goal is to find a safe dose and see if the drug can reduce abnormal protein levels. About 49 adults will take part in this early-phase trial.

This study tests a nasal spray called foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The spray aims to reduce brain inflammation by calming overactive immune cells. Participants will use the spray three times a week for eight weeks and have brain scan…

This study tests whether a new type of radiation machine that uses MRI to guide treatment is safe and practical for people with gastric, breast, or other cancers. About 70 adults will receive radiation guided by real-time MRI, sometimes with chemotherapy. The goal is to see if th…

This study tests a program called OPTIONS that helps older adults recover after breaking a hip or leg. The program provides information on exercise, healthy eating, and bone-strengthening medications to patients in nursing homes and after they go home. Researchers will include ab…

This study looks at whether a higher dose of the TB medicine rifampicin is safe and works well in children with both HIV and TB. Twenty children will take their usual HIV and TB drugs, but for two weeks the rifampicin dose will be increased. Researchers will measure drug levels i…

This study tests a new way to help people with HIV stick to their medication. Participants join an adherence club where they pick up 6 months of medicine at once and can get peer support. The goal is to see if this approach improves viral suppression and keeps people in care comp…

This study looks at two treatments—plasma exchange (a blood-filtering procedure) and the drug daratumumab—to see if they help patients with multiple myeloma recover from acute kidney injury caused by light chain cast nephropathy. Researchers will track 450 adults to see who survi…

This Phase 2 trial tests whether the drug BRS201 (a form of vitamin B12) can improve liver health in people with primary sclerosing cholangitis (PSC), a rare liver disease. Over 8 weeks, 28 participants will take either the drug or a placebo for 4 weeks each, in random order. The…

This study tests two drugs—pyridostigmine (Mestinon) and low-dose naltrexone (LDN)—alone or together in 160 adults with ME/CFS or Long COVID who also have orthostatic intolerance (difficulty standing). Over 3 months, participants take gradually increasing doses and complete exerc…

This study tests a new surgical procedure for people who have had a leg amputated. The surgery builds special connections between muscles to help the brain better control the remaining limb and restore a sense of position and movement. Researchers will enroll 26 adults who alread…

This study tests a new oral drug called BRS201 in 20 adults with severe ulcerative colitis who have not improved with standard treatments. Participants take the drug twice daily for 4 weeks and attend 8 clinic visits for blood, stool, and urine tests. The goal is to see if BRS201…

This study tests a new way to perform arm amputations that may allow people to better control advanced prosthetic arms and even feel where their limb is in space. Twenty participants will be split into two groups: ten will get the new surgery, and ten will have a standard amputat…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with opioid use disorder reduce cravings and avoid relapse. About 46 adults who are already taking buprenorphine will receive either semaglutide or a placebo for 12 weeks. The goal is …

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. Researchers will measure changes in heart strain using ultrasound. The trial aims to enroll 20 adults aged 21-80 with moderate to severe kidney diseas…

This phase 2 trial tests whether a higher daily dose of radiation over three weeks is better than the standard dose for people aged 65 and older with newly diagnosed glioblastoma, an aggressive brain cancer. About 56 participants will be randomly assigned to one of two radiation …

This study will enroll 1,000 adults aged 35-85 with chest pain or shortness of breath to see if a new, detailed MRI blood flow measurement can more accurately diagnose heart disease than standard MRI. Participants will receive a contrast agent called Gadavist during stress and re…

This study tests a new PET scan that uses a special tracer to find blood clots inside the heart. It involves 20 people with cardiac amyloidosis and atrial fibrillation. The goal is to see if this scan can spot clots better than current methods, which could help prevent strokes.

This study is testing whether regular MRI scans of the brain can find cancer that has spread from the breast to the brain, even before symptoms appear. It involves 214 people with metastatic or inflammatory breast cancer. The goal is to see if early detection through screening im…

This study tests a special MRI technique to help doctors tell whether an enlarged spot in the brain after radiation is the tumor growing back or harmless scar tissue from the radiation. About 100 adults with brain metastases who had radiation will get this MRI before any surgery.…

This study tests whether a special ultrasound done during an endoscopy can accurately detect liver scarring in people with obesity and suspected non-alcoholic fatty liver disease. Researchers will compare this new method to standard tests and liver biopsy in 150 adults. The proce…

This study tests whether a new type of PET scan (18F-DCFPyL PSMA-PET) can show prostate cancer lesions as well as the standard scan (68Ga-PSMA-11 PET/CT) in 30 men with advanced prostate cancer who are receiving a targeted radiation therapy (177Lu-vipivotide tetraxetan). The goal…

This study tests a new needle holder frame for MRI-guided prostate biopsy in 15 people with suspected prostate cancer. The goal is to see if the frame helps doctors take tissue samples more accurately from suspicious areas seen on MRI. If successful, this could make the procedure…

This early study tests whether a special PET scan using 18F-fluciclovine can find prostate cancer that doesn't show up well on standard PSMA scans. The study will include 30 men with advanced prostate cancer that either has low PSMA levels or has changed into a more aggressive ne…

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study tests whether taking a daily statin (rosuvastatin) for one year can safely prevent life-threatening blood clots in people with cancer. Current clot-preventing drugs raise bleeding risks, so a safer option is needed. The trial will enroll 4,000 adults with newly diagnos…

This trial tests a prevention bundle for hospital patients who carry C. difficile bacteria but have no symptoms. The bundle includes enhanced room cleaning and special precautions. Researchers hope to prevent these carriers from developing active infections and spreading the bact…

This study tests whether a computer alert can help doctors remember to prescribe blood-thinning medicine for high-risk patients after they leave the hospital. Blood clots are a serious risk for some hospitalized patients, even after discharge. The trial will include 400 adults ag…

This pilot study tests whether flushing a nephrostomy tube (a tube that drains urine from the kidney) with salt water every day actually prevents blockages. Twenty adults who have or will get a nephrostomy tube will be randomly assigned to flush daily or not flush at all. Researc…

This study tests whether an artificial intelligence program can analyze chest CT scans to find calcium buildup in heart arteries—a sign of hidden heart disease. Doctors will receive this information and may start or increase cholesterol-lowering medications to prevent future hear…

This study tests whether giving high doses of magnesium before and during surgery can prevent kidney damage caused by the chemotherapy drug cisplatin. About 130 adults with mesothelioma will receive either magnesium or a placebo. The goal is to see if magnesium helps keep kidneys…

This pilot study will test whether chiropractic care can help people with episodic migraine (4-13 migraine days per month). Sixty adults aged 18-65 will receive either personalized chiropractic care or headache health education. The main goal is to see if a larger trial is feasib…

This study tests whether using a mindfulness meditation app at bedtime can help people with chronic insomnia fall asleep faster. Thirty adults with insomnia will be split into three groups: one uses the app with guided meditation, one uses the app without guidance, and one receiv…

This pilot trial tests whether repeated sessions of pulsed low-intensity focused ultrasound can safely reduce seizures in people with drug-resistant temporal lobe epilepsy. Ten adults who still have seizures despite medication will receive the ultrasound treatment. Researchers wi…

This study tests whether Pilates, a gentle mind-body exercise, can help manage pain and other symptoms in people with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder. One hundred adults with persistent pain will be randomly assigned to either Pilates classes…

This study compares three common insomnia treatments—two medications (trazodone and daridorexant) and an online behavioral therapy program—in 1,000 women aged 40-62 who are in or near menopause. Participants will take one treatment for 12 months, wear a Fitbit, and complete sleep…

This study tests whether a mobile app called CAMMA can reduce stress, anxiety, and depression in family caregivers of adults with long-term illnesses in Thailand. About 400 caregivers who use a smartphone and provide at least 4 hours of daily care will participate. The app is des…

This study looks at whether men recovering from robotic prostate surgery can manage pain without automatically receiving opioid painkillers. Half of the 300 participants will get a standard pain plan plus an opioid prescription, while the other half will get only the pain plan an…

This study tests whether a 12-week yoga program can help people with persistent pain after torso surgeries like chest, breast, or abdominal operations. Researchers will enroll 50 adults to see if the program is practical and liked by participants. The goal is to gather informatio…

This study aims to help socioeconomically disadvantaged adults who struggle with insomnia. Researchers will compare two types of behavioral therapy delivered remotely (by phone or video) to see if a shorter treatment works as well as the standard longer one. 350 adults from prima…

This study tests whether giving testosterone to men with chronic back pain who take opioids can improve their pain, sexual function, fatigue, and quality of life. The men have low testosterone caused by opioids. Half will get testosterone injections and half a placebo. The trial …

This study tests an oral pill called treprostinil in 30 adults with severe Raynaud's phenomenon that hasn't improved with usual therapies. Raynaud's causes fingers and toes to change color and become painful when cold or stressed. Participants will take the pill three times daily…

This early-phase study tests whether a combination of two drugs—atomoxetine and DAW2022—can reduce the severity of obstructive sleep apnea (OSA) in 18 adults with moderate-to-severe OSA. The goal is to find a better-tolerated alternative to current treatments by measuring breathi…

This study tests a minimally invasive procedure called transcatheter arterial embolization (TAE) combined with physical therapy for people with chronic shoulder pain from rotator cuff tendinopathy that hasn't improved with standard treatments. About 41 adults with moderate to sev…

This study tests a new form of transcranial magnetic stimulation (TMS) for post-traumatic stress disorder (PTSD). Unlike standard TMS, which takes 6-7 weeks, this accelerated version delivers 10 sessions per day for 5 days. Researchers will enroll 40 adults with PTSD to see if ac…

This study tests whether taking losartan for 30 days after multi-ligament knee surgery helps people regain motion, strength, and return to work or sport. About 90 adults with severe knee injuries will be randomly assigned to receive losartan or a placebo. The goal is to reduce in…

This study tests whether giving oxytocin (the 'love hormone') through an IV during surgery can reduce pain and the need for opioid painkillers after a minimally invasive hysterectomy. Researchers will compare oxytocin to a placebo in 152 adults aged 18-65. The goal is to find a s…

This pilot study tests whether tirzepatide, a drug used for diabetes, can help reduce cravings for alcohol in people with alcohol use disorder. Twenty adults will receive weekly injections of either the drug or a placebo for 4 weeks. The goal is to see if the drug lowers cue-trig…

This study tests whether a noninvasive technique called transcranial magnetic stimulation (TMS) can change brain activity related to hunger and fullness in people with Prader-Willi syndrome. Researchers will stimulate a part of the brain called the cerebellum and measure changes …

This small study looks at whether combining chiropractic care with group medical visits is a practical way to help adults 65 and older who have chronic neck or back pain. Ten participants will receive both chiropractic adjustments and virtual group support sessions. The goal is t…

This study tests a positive psychology program called PATH for people who have had a stem cell transplant. The goal is to see if it can reduce anxiety and depression and improve quality of life. About 400 adult survivors will be randomly assigned to the program or usual care. The…

This study tests whether Acceptance and Commitment Therapy (ACT), a type of behavioral training, can improve daily functioning in adults with chronic migraine. Forty participants will either receive ACT plus their usual care or just usual care alone. Over a year, they will fill o…

This early-phase trial tests a shorter, more intense radiation schedule for people with retroperitoneal sarcoma, a rare cancer in the abdomen. The main goal is to check safety and side effects like nausea and diarrhea within 30 days. Only 6 participants will be enrolled to see if…

This study tests an accelerated form of Transcranial Magnetic Stimulation (TMS) for depression in pregnant and postpartum individuals. Instead of daily sessions for weeks, participants receive multiple treatments over just 5 days. The goal is to see if this faster approach is saf…

This study uses wearable EKG patches to track heart rhythms in 150 adults having elective open-heart surgery. The goal is to find out how often atrial fibrillation occurs after surgery and what factors increase the risk. Researchers hope this will lead to better prediction and pr…

This study follows 260 adults undergoing heart surgery to see how developing atrial fibrillation afterward impacts their quality of life. Participants fill out surveys about their physical and mental health, as well as any treatments they receive. The goal is to better understand…

This study tests a short, 10-15 minute health assessment called the Practical Geriatric Assessment (PGA) for adults aged 65 and older with early-stage non-small cell lung cancer who are about to receive radiation therapy. The goal is to see if using this quick checkup leads to mo…

This observational study at Brigham and Women's Hospital will use advanced MRI scans to see if brain activity and structure can predict recovery in 50 people who are comatose after a cardiac arrest. Participants will have a special MRI during their standard scan and be followed f…

This study tests a new AI-assisted platform called IntelliWell to find rare sperm cells in testicular tissue from men with non-obstructive azoospermia, a condition where standard analysis finds no sperm. The platform processes tissue that would otherwise be discarded, and if sper…

This study looks at how a person's mental state—like anxiety, sleep problems, and fear of pain—affects how well numbing medication works during surgery. Researchers will follow 1,000 adults to see if these factors change pain levels, opioid use, and the chance of long-term pain. …

This early-stage study tests a small implantable device that is placed directly into tumors to see how different drugs work against ovarian, fallopian tube, and peritoneal cancers. About 20 people with advanced cancer will receive the device during standard surgery. The goal is t…

This study tests whether taking melatonin, a natural sleep hormone, can change the number of uterine contractions in full-term pregnant women. Researchers will give melatonin or a placebo to 120 women during the day and at night to see if it affects contractions. The goal is to u…

This study tests whether a smartphone app that tracks symptoms can help prevent complications after hospital discharge. Researchers will enroll 1,300 adults with multiple chronic conditions leaving the hospital. The app alerts doctors to concerning symptoms in real time, aiming t…

This study tests a smartphone app called MyHealthPal that lets patients take and upload photos of their surgical wounds after surgery. An AI program and a healthcare provider review the images to predict infection risk. About 150 adults having certain surgeries will either use th…

This study looks at whether playing music, with or without a parent's voice, can lower stress and help brain development in very premature babies. About 243 infants born between 24 and 30 weeks will be randomly assigned to hear music, music plus parent voice, or standard care. Re…

This study tests a standardized technique for finding lymph nodes in lung tissue removed during surgery. Researchers want to see if this method finds more nodes and improves cancer staging. About 160 adults with lung cancer who are having a lobectomy will take part. The goal is t…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study uses a special PET scan to look at a brain chemical system in people with multiple sclerosis (MS) and healthy volunteers. The goal is to see if damage to this system is linked to MS symptoms like fatigue and thinking problems. About 19 people will take part. The study …

This study uses special PET scans to look for brain inflammation in people with multiple sclerosis (MS) and Alzheimer's disease. Researchers will compare two radioactive tracers, [F-18]PBR06 and [C-11]PBR28, to see which works better. Up to 250 participants, including healthy vol…

This early-phase study is testing a small implantable device that delivers tiny amounts of different drugs directly into head and neck tumors. The goal is to see which drugs are most effective for each person before they undergo full treatment. The study involves 30 adults with c…

This study looks at how the brain uses sugar (glucose) in people with multiple sclerosis (MS) compared to healthy volunteers. Researchers will use a special PET scan to measure brain activity and compare it with MRI scans and blood tests. The goal is to find better ways to diagno…

This study aims to understand how brain connections (synapses) are lost in progressive multiple sclerosis (MS). Researchers will use a new type of PET scan to measure synaptic density in 30 people with progressive MS, relapsing-remitting MS, and healthy volunteers. The goal is to…

People with rheumatoid arthritis have double the risk of heart attack. This study is testing whether a blood test for troponin, along with a heart scan, can catch heart disease early. Researchers will enroll 120 adults aged 40-79 with RA and at least one heart risk factor. The go…

This study follows 60 infants at high risk for Cerebral Visual Impairment (CVI), a brain-based vision problem often missed until later childhood. Researchers will collect data from clinical exams, brain scans, and vision tests up to 24 months of age. The goal is to create a model…

This study looks at whether a person's genes (specifically the CAV-1 gene) affect how well GLP-1 weight-loss drugs lower blood pressure and body weight. Researchers will enroll 30 overweight or obese adults to take a GLP-1 drug and measure changes. The goal is to learn why some p…

This study tests whether a carefully designed diet can prevent or reduce the negative health effects of night shift work. Twenty-four healthy adults will complete two inpatient stays, eating identical meals and providing blood, urine, saliva, stool, and rectal swab samples. Resea…

This study uses a noninvasive brain stimulation technique called TMS to investigate how the cerebellum influences feelings of fullness and eating behavior. Researchers will compare brain activity and food choices in 150 healthy adults after they eat or fast. The goal is to better…

This study looks at whether using a lower amount of bicarbonate in the dialysis fluid is better for the heart than the usual higher amount. About 141 hospitalized adults on long-term dialysis will be randomly assigned to receive either lower or higher bicarbonate during their dia…

This study tests whether a special ultrasound treatment, combined with a contrast agent, can improve blood flow and heart function in people with cardiac amyloidosis. Researchers will measure changes using PET scans and echocardiograms. The trial includes 70 participants with and…

This study is for people with light chain amyloidosis, a rare disease where abnormal proteins build up in the heart and other organs. Researchers will use special PET and MRI scans to take detailed pictures of these protein deposits in the heart. The goal is to better understand …

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study compares two surgical methods for removing small lung nodules (spots) in 200 adults with lung cancer. One method uses a special image-guided marker to help the surgeon find the spot; the other is standard surgery. The goal is to see how long each surgery takes and how …

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce pain. Participants will either receive cognitive behavioral therapy or fibromyalgia education over 8 weeks. The goal is to see if self-regu…

This study looks at whether a cholesterol-lowering drug called Evolocumab can improve blood flow in the small blood vessels of the heart. About 50 people with stable coronary artery disease will get the drug for 12 months and have heart scans before and after. A small control gro…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers will use PET scans and echocardiograms to measure blood flow and heart function before and after transplant. The goal is to see if improving kidney function …

This study aims to find the genes that make some people develop severe COPD at a young age, even if they smoke. Researchers will collect DNA and health information from 2,000 participants with early-onset COPD. The goal is to understand why some people are more prone to this lung…

This study looks at how different diets affect your body's daily rhythms, like when you feel hungry and how you burn energy. Healthy adults aged 18-45 will eat provided meals and track their food intake. They will also have two short hospital stays for blood, urine, saliva, and s…

This study tests a new computer tool that creates a 3D model of a broken shinbone to help surgeons plan where to place screws and plates before surgery. The tool uses the patient's own CT scan to simulate different repair options. About 40 adults with a lower leg fracture will ta…

This study tests whether teaching Latino patients with type 2 diabetes how to use patient portals and telehealth during a hospital stay helps them manage their care after discharge. 84 adults will receive either one-on-one digital training or standard care. The main goal is to se…

This study tests whether a computer alert in the electronic health record can help doctors identify patients with familial hypercholesterolemia, a genetic condition that causes very high cholesterol. About 450 adults at Brigham and Women's Hospital will be included. The alert cal…