Brigham And Women's Hospital

This small pilot study is testing whether repeated sessions of low-intensity focused ultrasound can safely reduce seizures in people with drug-resistant temporal lobe epilepsy. Ten adults who still have seizures despite trying at least two medications will receive the ultrasound …

This study tests whether the drug BRS201 (hydroxocobalamin) can improve liver health in people with primary sclerosing cholangitis (PSC), a rare liver disease. About 28 adults with PSC will take the drug or a placebo for 4 weeks each, in random order. The main goal is to see if t…

This study looks at whether teaching Latino adults with type 2 diabetes how to use patient portals and telehealth during a hospital stay helps them manage their care after discharge. Participants get one-on-one digital literacy training from a navigator, while others receive stan…

This study tests a new way to perform arm amputations that may help people better control advanced prosthetic arms and feel where their limb is in space. Researchers will compare 20 participants (10 with the new surgery, 10 with standard amputation) to see if the new technique im…

This study tests whether a supplement called NMN can improve kidney health in people with type 2 diabetes who have early kidney damage. About 156 adults will take either NMN or a placebo pill twice a day for 6 months. The main goal is to see if NMN reduces a key marker of kidney …

This study tests whether taking losartan for 30 days after multi-ligament knee surgery helps people regain motion, strength, and return to work or sport faster. About 90 adults with severe knee injuries will be enrolled. The goal is to reduce complications like stiffness and impr…

This study tests whether computer alerts can help doctors prescribe cholesterol-lowering medications to people with peripheral artery disease (PAD) who aren't currently taking them. About 400 adults with PAD will be randomly assigned to have their doctors receive an alert or not.…

This study tests whether a heart medication (sacubitril/valsartan) can help people who just started hemodialysis. About 100 adults will receive either the drug or a placebo for 16 weeks. The goal is to see if the drug reduces fluid buildup in the heart and helps preserve any rema…

This study aims to help 5 women with absolute uterine factor infertility (no uterus or one that doesn't work) have a baby through a uterus transplant from a donor. Participants will first create embryos through IVF, then receive the transplant, followed by embryo transfer and pre…

This study looks at whether plasma exchange or newer drugs like daratumumab can help the kidneys recover in people with multiple myeloma who have a type of kidney damage called light chain cast nephropathy. About 450 adults with this condition will be followed for 90 days to see …

This study aims to find out which of two common diabetes medications—SGLT2 inhibitors or GLP-1 receptor agonists—is better at preventing serious heart and kidney events in people with type 2 diabetes. About 6,000 adults with diabetes and heart disease or high risk will be randoml…

This study tests if colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. Researchers will measure heart changes using ultrasound in 20 adults. The goal is to see if reducing inflammation can help control heart damage linked to k…

This study is testing whether a new type of radiation machine, guided by MRI, is safe and practical for treating several cancers, including stomach and breast cancer. About 70 adults will receive this targeted radiation alongside chemotherapy. The goal is to see if the MRI guidan…

This study tests whether a higher daily dose of radiation over three weeks can help adults aged 65 and older with newly diagnosed glioblastoma live longer and with fewer side effects. About 56 participants will be randomly assigned to receive either the standard or an increased r…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can reduce cravings and prevent relapse in people with opioid use disorder. About 46 adults who are already taking buprenorphine will receive either semaglutide or a placebo for 12 weeks. Researchers …

This study compares two blood pressure medicines—a mineralocorticoid receptor antagonist and a thiazide-like diuretic—to see which one better improves blood flow and energy efficiency in the heart. Researchers will enroll 75 adults with high blood pressure and a thickened left ve…

This study tests an experimental drug called elranatamab in people with AL amyloidosis whose disease has returned or not responded to prior treatment. The goal is to find the safest and most effective dose and to see how well the drug controls the disease. About 49 participants w…

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes, can help reduce cravings for alcohol in people with alcohol use disorder. Twenty adults will receive either the drug or a placebo for 4 weeks. The goal is to see if it lowers cue-induced craving…

This study tests a program called OPTIONS that helps older adults recover after breaking a hip or leg. The program provides exercise, healthy diet advice, and bone-strengthening medication in nursing homes and after patients go home. Researchers will include about 1,500 people ag…

This study tests a new type of leg surgery for people who have already had a below- or above-knee amputation. The goal is to help them better control their residual limb, restore a sense of where the limb is in space, and reverse muscle wasting. Researchers will enroll 26 adults …

This study tests a new way to start treatment for opioid use disorder using a long-acting injection of buprenorphine. Thirty adults who use opioids will stay in the hospital for 3 days and receive the injection along with fentanyl to prevent withdrawal. Researchers will monitor h…

This study tests a nasal spray called foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The spray aims to reduce brain inflammation by calming overactive immune cells. Participants will use the spray three times a week for eight weeks and have brain scan…

This study is for women who cannot get pregnant because their uterus is missing or not working. Participants will first create and freeze embryos through IVF. Then they will receive a uterus from a deceased donor. After recovery, an embryo is placed, and if pregnancy occurs, it i…

This study tests a new oral medication, BRS201, in 20 adults with severe ulcerative colitis who have not improved with standard treatments. Participants take the drug twice daily for 4 weeks and attend 8 clinic visits over 12 weeks, including blood draws, stool and urine tests, a…

This pilot study is testing whether adults with acute psychiatric conditions like psychosis, anxiety, or depression can safely receive hospital-level care at home instead of in a traditional hospital. Researchers want to see how many eligible patients agree to join and be randoml…

This study tests a new way to help people with HIV stick to their treatment. Participants join an 'adherence club' where they pick up 6 months of medication at once and can get peer support and counseling. The goal is to see if this approach improves viral suppression and keeps p…

This study explores whether a PET scan that tracks sugar use in the brain can help doctors better understand and monitor multiple sclerosis (MS). Researchers will compare brain scans from 50 people with different types of MS and healthy volunteers. The goal is to see if this imag…

This study tests a new way of using MRI scans to tell the difference between tumor regrowth and radiation damage in people with brain metastases who had focused radiation. About 101 participants will get this special MRI before any surgery. The goal is to see if the scan can accu…

This study tests a new AI-assisted platform called IntelliWell to find rare sperm in testicular tissue from men with non-obstructive azoospermia, a condition where standard analysis finds no sperm. About 20 men will participate, and if sperm are found, they may be used for IVF. T…

This study involves 30 adults with advanced prostate cancer who are already scheduled for a standard treatment. Researchers want to see if a new type of PET scan (18F-DCFPyL) can detect cancer spots as well as or better than the current scan (68Ga-PSMA-11). Participants will get …

This study tests whether a special needle holder can help doctors take more accurate tissue samples from the prostate during an MRI-guided biopsy. The goal is to see if the device helps hit the exact suspicious spot seen on the MRI, reducing missed targets. About 15 adults with s…

This study will test if a special MRI that measures blood flow in detail can more accurately diagnose heart disease in people with chest pain or shortness of breath. Researchers will compare these detailed measurements to standard MRI images in 1000 adults aged 35-85 who are at i…

This study tests a new portable X-ray machine that takes moving images of the lungs at the bedside in the ICU. It aims to see if this technology can give doctors better information about lung function and blood flow compared to standard X-rays. About 230 adults with various lung …

This study tests whether a special PET scan using a tracer called [64Cu]FBP8 can detect blood clots inside the heart of people with cardiac amyloidosis and atrial fibrillation. Twenty participants will receive the tracer and undergo a combined PET/MRI scan. The goal is to see if …

This study tests whether a computer alert can remind doctors to prescribe blood-thinning medicine to high-risk patients after they leave the hospital, to prevent blood clots. About 400 adults aged 40 and older who are hospitalized for serious medical illnesses and have additional…

This study tests whether an AI tool can help doctors find hidden calcium buildup in heart arteries from routine chest CT scans. The goal is to start or strengthen cholesterol-lowering medications early to prevent heart disease. About 1,500 adults aged 40-75 who have had a chest C…

This study tests whether giving high doses of magnesium before and during surgery can prevent kidney damage caused by the chemotherapy drug cisplatin. About 130 adults with mesothelioma will receive either magnesium or a placebo. The goal is to see if magnesium helps keep kidneys…

This study tests a new prevention approach for C. difficile, a serious hospital infection that causes over 29,000 deaths yearly. Researchers will identify patients carrying the bacteria without symptoms and give them a personalized prevention package. The goal is to stop these ca…

This study tests whether two medications, Pyridostigmine and Low-Dose Naltrexone, can improve daily function and reduce symptoms in people with ME/CFS or Long COVID who also have trouble standing (orthostatic intolerance). 160 adults aged 18-70 will be randomly assigned to take o…

This study compares two types of talk therapy for insomnia given over video or phone. It involves 350 adults who have trouble sleeping and face economic or social disadvantages. The goal is to see if a shorter, simpler therapy works as well as the standard longer one, making slee…

This study tests a quick, 5-day version of transcranial magnetic stimulation (TMS) for depression in pregnant and postpartum individuals. TMS uses magnetic pulses to stimulate the brain without surgery. The goal is to see if this accelerated treatment is safe, tolerable, and feas…

This study tests a new, quick form of brain stimulation (accelerated TMS) for people with PTSD. Instead of the usual 6-7 weeks of daily treatment, this approach delivers 10 sessions per day for just 5 days. The goal is to see if it can rapidly reduce PTSD symptoms in 40 adults, i…

This study tests a procedure called transcatheter arterial embolization (TAE) combined with physical therapy for people with long-lasting shoulder pain from rotator cuff tendinopathy. About 41 participants will either get TAE plus physical therapy or physical therapy alone. The g…

This study tests whether giving oxytocin (a natural hormone) through an IV during surgery can lower pain and the need for strong painkillers after a minimally invasive hysterectomy. About 152 adults having this surgery will receive either oxytocin or a placebo. The goal is to see…

This study tests whether men recovering from robotic prostate surgery can manage pain without automatically receiving opioid painkillers. Half of the 300 participants will get a standard pain plan plus an opioid prescription, while the other half get only the pain plan and can re…

This study tests a positive psychology program (PATH) for 400 adults who had a stem cell transplant. The goal is to see if it reduces anxiety and depression and improves quality of life compared to usual care. Participants will be followed for 10 weeks.

This study is testing whether using a mindfulness meditation app at bedtime can help people with chronic insomnia fall asleep more easily. Thirty adults with long-term sleep problems will be split into three groups: one using a guided meditation app, one using an unguided version…

This study looks at whether combining chiropractic care with group medical visits can help adults 65 and older who have chronic spine pain. Ten participants will receive chiropractic adjustments and attend virtual group sessions. The goal is to see if this approach is practical a…

This study tests an oral pill called treprostinil in 30 adults with severe Raynaud's phenomenon that hasn't improved with usual therapies. Raynaud's causes fingers and toes to change color and become painful in cold or stress due to narrowed blood vessels. Participants will take …

This early-phase study tests whether a combination of two drugs, atomoxetine and DAW2022, can reduce the severity of obstructive sleep apnea (OSA). Researchers will monitor 18 adults with moderate-to-severe OSA overnight to see if the drugs lower breathing interruptions and impro…

This early-phase trial tests a shorter course of radiation therapy for people with retroperitoneal sarcoma, a rare cancer in the abdomen. The main goal is to see if this approach is safe by tracking side effects like nausea, vomiting, and diarrhea within 30 days. Only 6 participa…

This study looks at whether yoga can help people who have pain that lasts for months after surgery. Researchers will enroll 50 adults who had torso surgeries and still have moderate pain. Participants will take yoga classes or join a health education program to see which helps mo…

This study is testing whether a type of behavioral therapy called Acceptance and Commitment Therapy (ACT) can help reduce disability and improve daily life for adults with chronic migraine. Researchers will compare adding 8 ACT classes to usual headache treatments against usual t…

This study aims to find out which of three common insomnia treatments works best for women going through perimenopause and postmenopause. It will compare two prescription medications (trazodone and daridorexant) with an online behavioral therapy program over 12 months. Researcher…

This study is testing whether testosterone replacement therapy can improve pain, energy, sexual function, and overall quality of life in men. It focuses on men with chronic back pain who have been taking opioid painkillers for at least six months and have developed low testostero…

This study uses a special PET scan to look at a brain chemical system in people with multiple sclerosis (MS) and healthy volunteers. The goal is to see if damage to this system is linked to MS symptoms like fatigue and thinking problems. About 19 participants will have brain scan…

This study is testing a small implantable device that delivers tiny amounts of different drugs directly into head and neck tumors. The goal is to see which drugs kill cancer cells best in each person, without giving the full treatment yet. About 30 adults with certain head and ne…

This study tests a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease after they leave the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms and questions for doc…

This study looks at why some people respond better to GLP-1 weight-loss drugs than others. Researchers will give the medication to 30 overweight or obese adults and measure changes in blood pressure and weight. They want to see if a specific gene (CAV-1) affects how well the drug…

This study uses a brain stimulation technique called TMS to map how different parts of the prefrontal cortex affect behavior in people with depression, OCD, anxiety, or schizophrenia. Participants will receive TMS at random brain locations and complete various tests and questionn…

This study looks at whether a short, 10-15 minute health assessment called the Practical Geriatric Assessment (PGA) helps older adults (65+) with early-stage lung cancer who are getting radiation therapy. The assessment checks things like physical function, nutrition, and mood to…

This study looks at whether a new, step-by-step method for examining lung tissue after surgery can find more lymph nodes than the usual approach. Finding more lymph nodes helps doctors stage lung cancer more accurately and decide if extra treatment like chemotherapy is needed. Ab…

This study follows 260 adults undergoing heart surgery to see how developing atrial fibrillation afterward affects their quality of life. Participants will fill out surveys about their physical and mental well-being. The goal is to better understand the real-world impact of this …

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce pain. Participants will either receive cognitive behavioral therapy or fibromyalgia education over 8 weeks. The goal is to see if this brai…

This study tests whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. Researchers will compare costs, safety, and patient satisfaction between home and hospital care. The goal is to see if home hosp…

This study looks at whether brain MRI scans can find breast cancer that has spread to the brain in people with certain types of advanced breast cancer. About 214 participants will get regular brain scans to see if this helps catch problems early. The goal is to learn if screening…

This study looks at how HIV and TB medicines work in children under 6 years old who have both infections. The goal is to find the best doses to make treatments safer and more effective. Twenty children will take part, and researchers will measure drug levels in their blood.

This study looks at whether playing music, with or without a parent's voice, can lower stress and improve brain development in very preterm infants. About 243 babies born between 24 and 30 weeks will be randomly assigned to hear music, music with parent voice, or standard care. R…

This study is for people with light chain amyloidosis, a rare disease where abnormal proteins build up in organs, especially the heart. Researchers will use advanced PET and MRI scans to see these protein deposits and measure heart function over 12 months. The goal is to better u…

This study aims to find better ways to detect heart disease early in people with rheumatoid arthritis (RA), who face double the risk of heart attack. Researchers will use heart scans and blood tests in 120 adults aged 40-79 with RA and at least one other risk factor. The goal is …

This study is testing a new type of brain scan (PET) to see how brain connections change in people with progressive multiple sclerosis (MS). Researchers will compare scans from 30 people with different types of MS and healthy volunteers. The goal is to better understand the disea…

This study looks at whether a drug called Evolocumab (a PCSK-9 inhibitor) can improve blood flow in the heart's small vessels over 12 months. About 50 adults with stable coronary artery disease and high cholesterol will get the drug and have heart scans before and after. A small …

This study tests whether a carefully designed diet can prevent or reduce the negative health effects of night shift work. Healthy adults aged 18-45 will complete two inpatient stays, eating identical meals and providing blood, urine, saliva, stool, and rectal swab samples. Resear…

This study uses a special PET scan to look at brain inflammation in people with multiple sclerosis (MS) and Alzheimer's disease. Researchers want to see if the pattern of inflammation differs between these diseases and how it relates to symptoms. About 250 adults aged 18 to 85 wi…

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Current non-invasive tests are often less accurate in this group. Participa…

This study follows 60 infants at high risk for Cerebral Visual Impairment (CVI)—a brain-based vision problem—from birth to age 2. Researchers use brain scans, eye tests, and developmental checkups to find early signs of CVI. The goal is to create a model that helps doctors diagno…

This study is testing whether a special ultrasound treatment can improve blood flow and heart function in people with cardiac amyloidosis, a condition where abnormal proteins build up in the heart. Researchers will compare results from 70 participants, including those with the di…

This study looks at how different diets affect your body's daily rhythms, like when you feel hungry and how you burn energy. Healthy adults aged 18-45 will eat provided meals and track their food intake. They will also have two short hospital stays for blood, urine, and saliva te…

This study looks at how healthy women respond to sleep loss at different points in their menstrual cycle. Researchers will measure things like reaction time, sleepiness, and body temperature in 100 women aged 18-35. The goal is to understand if the menstrual cycle affects how the…

This study looks at how a natural brain chemical called allopregnanolone affects mood and thinking in women going through menopause who have depressive symptoms. Researchers will give a supplement called pregnenolone to 80 healthy women aged 40-60 to see how it changes their tend…

This study looks at whether using a lower amount of bicarbonate in the dialysis fluid (30 mEq/L) is better for the heart than the usual higher amount (35 mEq/L) in adults with kidney failure who are in the hospital. About 141 participants will be randomly assigned to one of the t…

This study uses a safe, noninvasive technique called transcranial magnetic stimulation (TMS) to temporarily change brain activity in healthy adults. Researchers want to learn how a part of the brain called the cerebellum helps control feelings of fullness and food choices. 150 pa…

This study looks at how kidney transplants affect heart health in people with advanced chronic kidney disease. Researchers will measure blood flow to the heart and heart function before and after transplant in 80 adults. The goal is to understand if improving kidney function and …

This study aims to find out how often atrial fibrillation (an irregular heartbeat) happens after heart surgery and who is most at risk. About 150 adults having planned open-heart surgery will wear a small heart monitor patch to track their heart rhythm. The results will help doct…

This study tests a computer tool that creates a 3D model of a broken shinbone from a CT scan. It helps surgeons plan where to place screws and plates before surgery. The goal is to see if the tool works well in real hospital settings without changing standard care. About 40 adult…

This study looks at why some people with brain injuries improve their thinking skills after using a computer-based brain training program. Researchers will test memory, attention, and other mental abilities, and measure a protein called BDNF in blood and saliva. The goal is to fi…

This study tests a special PET scan (18F-fluciclovine) to see if it can find advanced prostate cancer that standard PSMA scans might miss. About 30 people with metastatic prostate cancer that has low PSMA levels or neuroendocrine features will get one scan and two blood draws. Th…

This study tests whether a computer alert can help doctors identify patients with familial hypercholesterolemia, a genetic condition that causes very high cholesterol. About 450 adults at certain clinics will be included. The goal is to see if the alert increases diagnosis and he…

This study looks at two ways to remove small lung spots (nodules) in people with lung cancer. One method uses special imaging during surgery (iVATS), the other is standard surgery (VATS). The goal is to see how long each surgery takes, how long patients stay in the hospital, and …

This study aims to find the genes that make some people more likely to develop severe COPD at a young age. Researchers will study 2,000 people with early-onset COPD and compare their DNA to healthy individuals. The goal is to better understand why some smokers get COPD while othe…

This study tests whether a smartphone app that tracks symptoms in real time can help doctors catch and prevent health problems after patients leave the hospital. Researchers will enroll 1,300 adults with multiple chronic conditions who are being discharged from general medicine s…

This study explores whether a smartphone app can help doctors monitor surgical wounds from home. About 150 adults having certain surgeries can choose to use the app or not. App users take photos of their incision and answer questions daily or weekly. An AI program and a healthcar…

This study is testing whether a noninvasive brain stimulation method called TMS can help people with Prader-Willi syndrome feel full and eat less. Twenty participants will receive TMS and have their brain activity measured before and after. The goal is to learn how TMS affects br…

This study aims to find out if routinely flushing a kidney drainage tube with salt water is necessary to prevent it from getting clogged. Researchers will randomly assign 20 adult patients with these tubes to either continue their normal flushing routine or to stop flushing it fo…