Brigham And Women's Hospital

This study tests whether semaglutide (a weekly injection used for diabetes and weight loss) can reduce cravings and prevent relapse in people with opioid use disorder who are also taking buprenorphine. About 46 adults will receive either semaglutide or a placebo for 12 weeks. The…

This study tests a new oral drug called BRS201 in 20 adults with severe ulcerative colitis who have not improved with standard treatments. Participants take the drug twice daily for 4 weeks and attend 8 clinic visits for blood, stool, and urine tests. The goal is to see if BRS201…

This study tests a drug called elranatamab in people with AL amyloidosis that has come back or not responded to prior treatment. The goal is to find a safe dose and see if the drug can reduce abnormal protein levels in the blood. About 49 adults will take part in this early-phase…

This study tests whether the drug BRS201 (hydroxocobalamin) can improve liver health in people with primary sclerosing cholangitis (PSC), a chronic bile duct disease. About 28 adults with PSC will take the drug or a placebo for 4 weeks each, in random order. The main goal is to s…

This study tests whether a supplement called NMN, which boosts a natural cell chemical called NAD, can improve kidney health in people with type 2 diabetes and early kidney disease. About 156 adults will take either NMN or a placebo twice daily for 6 months. The main goal is to s…

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. About 20 adults with mild to severe kidney disease will take colchicine or a placebo. The main goal is to see if the drug helps the heart pump better,…

This study is testing a smartphone app designed to help adults aged 55 and older who have multiple chronic conditions like heart failure, diabetes, and kidney disease. The app provides fall prevention tips, a personalized after-hospital care plan, and tools to track symptoms and …

This study tests whether a higher daily dose of radiation over three weeks can help adults aged 65 and older with newly diagnosed glioblastoma live longer and with fewer side effects compared to the standard three-week radiation course. About 56 participants will be randomly assi…

This study tests whether a uterus transplant can help women who cannot get pregnant because they were born without a uterus or lost it. Up to 10 participants (5 donors and 5 recipients) will go through IVF, transplant, embryo transfer, pregnancy, and delivery. After giving birth,…

This study tests whether a drug called sacubitril/valsartan can help people who just started hemodialysis. The goal is to see if it reduces fluid buildup in the heart and helps the kidneys keep working longer. About 100 adults will receive either the drug or a placebo for 16 week…

This study tests a new way to perform arm amputations that may allow people to better control advanced prosthetic devices and even feel where their limb is in space. Researchers will perform the new surgery on 10 patients and compare them to 10 others who had standard amputations…

This study is testing whether a new type of radiation therapy guided by MRI is safe and works well for people with gastric, breast, or other cancers. About 70 adults will receive this treatment along with chemotherapy. The goal is to see if the MRI guidance helps doctors target t…

This study tests a new surgical technique for people who have had a leg amputation below or above the knee. The goal is to help them gain better control over their residual limb muscles, restore a sense of where the limb is in space (proprioception), and reverse muscle wasting. T…

This study tests a program called OPTIONS that helps older adults recover after breaking a hip or leg. The program provides exercise, healthy diet advice, and bone-strengthening medication in nursing homes and after patients go home. Researchers will include about 1,500 people ag…

This study tests whether treating suddenly ill adults at home is as safe and effective as hospital care. About 3,000 participants with conditions like infections, heart failure, or COPD will receive hospital-level care at home. The goal is to see if home care can lower costs and …

This study explores whether a uterus from a deceased donor can be transplanted into women who cannot get pregnant due to uterine problems. Participants must have healthy ovaries and create at least six embryos through IVF before being placed on a waitlist. After transplant, they …

This study tests whether two medications—pyridostigmine and low-dose naltrexone—can improve daily function and energy in people with ME/CFS or Long COVID who also have trouble standing (orthostatic intolerance). 160 adults aged 18-70 will be randomly assigned to one of four group…

This study looks at whether a type of blood pressure medication (mineralocorticoid receptor antagonist) can improve blood flow and energy use in the heart better than a standard diuretic. It involves 75 adults with high blood pressure and left ventricular hypertrophy (thickened h…

This study tests a new approach to starting extended-release buprenorphine, a medication for opioid use disorder. Thirty adults who use opioids will stay in the hospital for 3 days. They will receive fentanyl to prevent withdrawal, then a single injection of buprenorphine. Resear…

This study tests a program to help people with HIV stick to their medication. Participants will either join an adherence club where they pick up 6 months of medicine and get peer support, or receive standard care. The goal is to see if the program improves viral suppression and k…

This study tests a nasal spray called Foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The goal is to see if it safely reduces brain inflammation and improves thinking. Participants use the spray three times a week for 8 weeks, with breaks, and are foll…

This small pilot study is testing whether repeated sessions of low-intensity focused ultrasound can safely reduce seizures in people with drug-resistant temporal lobe epilepsy. Ten adults who still have seizures despite trying at least two medications will receive the ultrasound …

This study tests whether taking losartan for 30 days after multi-ligament knee surgery helps people regain motion, strength, and return to work or sport faster. About 90 adults with severe knee injuries will be enrolled. The goal is to reduce complications like stiffness and impr…

This study looks at whether plasma exchange or newer drugs like daratumumab can help the kidneys recover in people with multiple myeloma who have a type of kidney damage called light chain cast nephropathy. About 450 adults with this condition will be followed for 90 days to see …

This study aims to find out which of two common diabetes medications—SGLT2 inhibitors or GLP-1 receptor agonists—is better at preventing serious heart and kidney events in people with type 2 diabetes. About 6,000 adults with diabetes and heart disease or high risk will be randoml…

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes, can help reduce cravings for alcohol in people with alcohol use disorder. Twenty adults will receive either the drug or a placebo for 4 weeks. The goal is to see if it lowers cue-induced craving…

This study will enroll 1000 adults aged 35-85 with chest pain or shortness of breath to see if measuring blood flow in detail during a stress MRI can more accurately diagnose heart disease than standard imaging. Researchers hope this approach helps doctors better understand the s…

This study tests a new AI-assisted platform called IntelliWell to find rare sperm cells in testicular tissue from men with non-obstructive azoospermia, a condition where no sperm are found in semen. The platform analyzes tissue samples that standard methods say have no usable spe…

This study tests a special MRI method called Treatment Response Assessment Maps (TRAMs) to tell whether an enlarged spot in the brain after radiation is a returning tumor or harmless scar tissue. About 101 adults with brain metastases who had focused radiation will get this MRI b…

This study involves 30 men with advanced prostate cancer who are already scheduled for a standard treatment called 177Lu-PSMA therapy. Researchers want to see if a newer type of PET scan (18F-DCFPyL) can detect cancer spots as well as the current standard scan (68Ga-PSMA-11). The…

This study tests whether a special PET scan using 18F-fluciclovine can better detect advanced prostate cancer that doesn't show up well on standard scans. It involves 30 people with metastatic prostate cancer that either has low PSMA levels or neuroendocrine features. Participant…

This study tests whether a special needle holder can help doctors take more accurate tissue samples from the prostate during an MRI-guided biopsy. The goal is to see if the device helps hit the exact suspicious spot seen on the MRI, reducing missed targets. About 15 adults with s…

This study tests a new portable X-ray machine that takes moving images of the lungs at the bedside in the ICU. It aims to see if this technology can give doctors better information about lung function and blood flow compared to standard X-rays. About 230 adults with various lung …

This study tests whether a special PET scan using a tracer called [64Cu]FBP8 can detect blood clots inside the heart of people with cardiac amyloidosis and atrial fibrillation. Twenty participants will receive the tracer and undergo a combined PET/MRI scan. The goal is to see if …

This study tests whether a computer alert can help doctors remember to prescribe blood clot prevention medicine for high-risk patients when they leave the hospital. About 400 adults aged 40 and older with serious medical conditions will take part. The goal is to see if the alert …

This study tests whether giving high-dose magnesium before and during surgery can prevent kidney damage caused by the chemotherapy drug cisplatin. About 130 adults with mesothelioma will receive either magnesium or a placebo. The goal is to see if magnesium helps keep kidney func…

This study looks at whether regularly flushing a nephrostomy tube with salt water (saline) helps prevent it from getting blocked. About 20 adults who have or will get a nephrostomy tube will be randomly assigned to either flush the tube routinely or not flush it. Researchers will…

This study tests a prevention bundle for hospital patients at high risk of getting a C. difficile infection. The goal is to find patients who carry the germ without symptoms and give them a personalized plan to prevent them from getting sick or spreading it to others. About 300 a…

This study tests whether an AI tool can help doctors find hidden calcium buildup in heart arteries from routine chest CT scans. The goal is to start or strengthen cholesterol-lowering medications early to prevent heart disease. About 1,500 adults aged 40-75 who have had a chest C…

This study tests whether men recovering from robotic prostate surgery can manage pain without automatically receiving opioid painkillers. Participants are counseled on pain management and then randomly assigned to either receive a standard opioid prescription plus other pain medi…

This study tests an oral pill called treprostinil in 30 adults with severe Raynaud's phenomenon that hasn't improved with standard therapies. Raynaud's causes fingers and toes to change color and become painful in cold or stress due to narrowed blood vessels. Participants will ta…

This study tests a new, fast-acting brain stimulation treatment for PTSD. Instead of the usual 6-7 weeks of daily sessions, this approach delivers 10 targeted treatments per day for just 5 days. Researchers will enroll 40 adults with PTSD to see if this accelerated method can red…

This study tests whether yoga can help people manage persistent pain that lasts months after torso surgery. Researchers will enroll 50 adults who have had surgeries like chest or abdominal operations and still feel moderate pain. The goal is to see if a 12-week yoga program is pr…

This early-phase trial tests a shorter, more intense radiation schedule for people with retroperitoneal sarcoma, a rare cancer in the abdomen. The main goal is to see if this approach is safe by tracking side effects like nausea and diarrhea within 30 days. Only 6 participants wi…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help adults with chronic migraine do more of their daily activities. Forty people will either get ACT plus their usual care, or just usual care. Over a year, they will fill out ques…

This study tests a faster version of transcranial magnetic stimulation (TMS) for depression in pregnant and postpartum individuals. Instead of daily sessions for 6-8 weeks, participants receive multiple sessions each day for just 5 days. The goal is to see if this accelerated app…

This study tests whether giving oxytocin (a natural hormone) through an IV during surgery can lower pain and reduce the need for opioid painkillers after a minimally invasive hysterectomy. About 152 adults aged 18-65 will take part. Half will get oxytocin, half a placebo, and nei…

This study tests whether using a mindfulness meditation app at bedtime can help people with chronic insomnia fall asleep more easily. Thirty adults with long-term sleep problems will be split into three groups: one using the app with guided meditation, one using the app without g…

This study tests a positive psychology program (PATH) for 400 adults who received a stem cell transplant. The program aims to reduce anxiety and depression and improve quality of life. Participants will be randomly assigned to the program or usual care, and their symptoms will be…

This study compares three common insomnia treatments—trazodone, daridorexant, and online cognitive behavioral therapy—in 1,000 women aged 40-62 who are in perimenopause or early menopause. Participants take nightly medication or complete a behavioral program for 12 months, tracki…

This study compares two types of talk therapy for insomnia given over video or phone. It involves 350 adults who have trouble sleeping and face economic or social disadvantages. The goal is to see if a shorter, simpler therapy works as well as the standard longer one, making slee…

This study tests a procedure called transcatheter arterial embolization (TAE) combined with physical therapy for people with long-lasting shoulder pain from rotator cuff tendinopathy. About 41 participants will either get TAE plus physical therapy or physical therapy alone. The g…

This study looks at whether combining chiropractic care with group medical visits can help adults 65 and older who have chronic spine pain. Ten participants will receive chiropractic adjustments and attend virtual group sessions. The goal is to see if this approach is practical a…

This early-phase study tests whether a combination of two drugs, atomoxetine and DAW2022, can reduce the severity of obstructive sleep apnea (OSA). Researchers will monitor 18 adults with moderate-to-severe OSA overnight to see if the drugs lower breathing interruptions and impro…

This study is testing whether testosterone replacement therapy can improve pain, energy, sexual function, and overall quality of life in men. It focuses on men with chronic back pain who have been taking opioid painkillers for at least six months and have developed low testostero…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers want to see if getting a new kidney improves blood flow to the heart and reduces inflammation. Participants will have heart scans and blood tests before and …

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Standard non-invasive tests are often less accurate in this group. Research…

This study looks at whether a short, 10-15 minute health check (called the Practical Geriatric Assessment) helps older adults with lung cancer get more support like nutrition advice or physical therapy before starting radiation. About 64 people aged 65 and older with early-stage …

This study looks at how different diets affect your body's daily rhythms, like when you feel hungry and how you burn energy. Healthy adults aged 18-45 will eat provided meals, track their food, and complete two short hospital stays for blood, urine, and saliva tests. The goal is …

This study looks at how healthy women aged 18-35 react to sleep loss during different phases of their menstrual cycle. Researchers will measure alertness, body temperature, and hormone levels in 100 participants. The goal is to understand if the menstrual cycle affects how the bo…

This study follows 60 babies who are at high risk for cerebral visual impairment (CVI), a brain-based vision problem that often goes undiagnosed until later childhood. Researchers will use brain scans, vision tests, and developmental checkups to find early signs of CVI by age 2. …

This study tests whether a computer alert system can help doctors remember to prescribe cholesterol-lowering medications to people with peripheral artery disease (PAD) who aren't currently taking them. About 400 adults with PAD will take part. The goal is to see if the alerts lea…

This study aims to understand how different parts of the brain's prefrontal cortex control behaviors in people with major depression, obsessive-compulsive disorder, generalized anxiety disorder, or schizophrenia. Participants will receive transcranial magnetic stimulation (TMS) a…

This study involves 171 adults with light chain amyloidosis, a condition where abnormal proteins build up in the heart. Researchers will use special PET and MRI scans to track these deposits and measure heart function over 6 to 12 months. The goal is to better understand what cau…

This study is testing a safe, noninvasive technique called TMS (transcranial magnetic stimulation) to see if it can affect brain areas linked to hunger and fullness in people with Prader-Willi syndrome. Twenty participants will receive TMS and have brain scans before and after. T…

This study looks at whether using a lower amount of bicarbonate (a chemical that balances acid in the blood) during dialysis is better for the heart than the usual higher amount. About 141 adults on long-term dialysis who are in the hospital will be randomly assigned to receive e…

This study tests whether a computer alert can help doctors identify patients with familial hypercholesterolemia, a genetic condition that causes very high cholesterol. About 450 adults at risk will be included. The goal is to see if the alert increases diagnosis rates and helps l…

This study uses a new type of PET scan to look at brain connections (synapses) in people with progressive multiple sclerosis (MS). Researchers will compare these scans with standard MRI and blood tests to better understand how MS damages the brain. The goal is to learn more about…

This study looks at how the brain uses sugar (glucose) in people with multiple sclerosis (MS) compared to healthy volunteers. Researchers will use a special PET scan to measure brain activity and compare it with standard MRI scans and blood tests. The goal is to find better ways …

This study looks at whether a person's genes affect how well they respond to a common weight-loss medication called GLP-1 receptor agonists. Researchers will give the drug to 30 overweight or obese adults and measure changes in blood pressure and body weight. The goal is to under…

This study is testing whether routine brain MRI scans can detect breast cancer that has spread to the brain in patients with certain types of advanced breast cancer. Researchers will follow 214 participants over time to see if early detection improves quality of life and reduces …

This study uses a special PET scan to look at a brain chemical system (norepinephrine) in people with multiple sclerosis (MS) and healthy volunteers. The goal is to see if damage to this system is linked to MS symptoms like fatigue and trouble thinking. About 19 people will take …

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce chronic pain. Participants will attend 8 weekly sessions with a pain psychologist and be randomly assigned to either cognitive behavioral t…

This study uses a safe, noninvasive technique called transcranial magnetic stimulation (TMS) to temporarily change brain activity in healthy adults. Researchers want to learn how a part of the brain called the cerebellum helps control feelings of fullness after eating. 150 partic…

This study tests whether a smartphone app that tracks symptoms can help prevent complications after patients leave the hospital. Researchers will enroll 1,300 adults with multiple chronic conditions who are being discharged from the hospital. The app alerts doctors to problems ea…

This study explores whether a smartphone app can help doctors monitor surgical wounds remotely. About 150 adults having surgery will choose to use the app or not. App users take photos of their wound and answer questions daily or weekly. An AI program and a healthcare provider re…

This study looks at why some people improve their thinking skills after a brain injury through computer-based brain training. Researchers will test memory, attention, and other mental abilities in 30 adults aged 25-65 who had a brain injury at least a year ago. They will also mea…

This study aims to find the genes that make some people develop severe COPD at a young age (before 53). Researchers will compare the DNA of 2,000 people with early-onset COPD to healthy people. The goal is to understand why some smokers get COPD while others don't, which could le…

This study aims to find better ways to predict heart disease in people with rheumatoid arthritis (RA), who face twice the risk of heart attack. Researchers will measure calcium in heart arteries and a protein called troponin in 120 adults aged 40-79 with RA and at least one other…

This study tests whether a powerful cholesterol-lowering drug (evolocumab) can improve blood flow in the small vessels of the heart in people with stable coronary artery disease. About 50 participants will receive the drug for 12 months and have heart scans before and after to me…

This study uses a special PET scan to look at brain inflammation in people with multiple sclerosis or Alzheimer's disease, compared to healthy volunteers. Researchers want to see if the pattern of inflammation differs between these diseases and relates to symptoms. Up to 250 adul…

This study looks at whether teaching digital skills to Latino adults with type 2 diabetes while they are in the hospital helps them use online patient portals and telehealth after they go home. Participants will get one-on-one training from a digital navigator, while others recei…

This study looks at whether playing music or music with a parent's voice can lower stress and improve brain development in very preterm babies (born between 24 and 30 weeks). About 243 infants from two hospitals will be randomly assigned to hear music, music with parent voice, or…

This study is testing a small implantable device that delivers tiny amounts of different drugs directly into head and neck tumors. The goal is to see which drugs kill cancer cells best in each person, without giving the full treatment yet. About 30 adults with certain head and ne…

This study looks at whether a new, step-by-step method for examining lung tissue after surgery can find more lymph nodes than the usual approach. Finding more lymph nodes helps doctors stage lung cancer more accurately and decide if extra treatment like chemotherapy is needed. Ab…

This study follows 260 adults undergoing heart surgery to see how developing atrial fibrillation afterward affects their quality of life. Participants will fill out surveys about their physical and mental well-being. The goal is to better understand the real-world impact of this …

This study looks at how HIV and TB medicines work in children under 6 years old who have both infections. The goal is to find the best doses to make treatments safer and more effective. Twenty children will take part, and researchers will measure drug levels in their blood.

This study tests whether a carefully designed diet can prevent or reduce the negative health effects of night shift work. Healthy adults aged 18-45 will complete two inpatient stays, eating identical meals and providing blood, urine, saliva, stool, and rectal swab samples. Resear…

This study is testing whether a special ultrasound treatment can improve blood flow and heart function in people with cardiac amyloidosis, a condition where abnormal proteins build up in the heart. Researchers will compare results from 70 participants, including those with the di…

This study aims to find out how often atrial fibrillation (an irregular heartbeat) happens after heart surgery and who is most at risk. About 150 adults having planned open-heart surgery will wear a small heart monitor patch to track their heart rhythm. The results will help doct…

This study tests a computer tool that creates a 3D model of a broken shinbone from a CT scan. It helps surgeons plan where to place screws and plates before surgery. The goal is to see if the tool works well in real hospital settings without changing standard care. About 40 adult…

This study looks at two ways to remove small lung spots (nodules) in people with lung cancer. One method uses special imaging during surgery (iVATS), the other is standard surgery (VATS). The goal is to see how long each surgery takes, how long patients stay in the hospital, and …