New MRI technique aims to spot hidden heart problems

NCT ID NCT06854458

Recruiting now Diagnosis Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will enroll 1,000 adults aged 35-85 with chest pain or shortness of breath to see if a new, detailed MRI blood flow measurement can more accurately diagnose heart disease than standard MRI. Participants will receive a contrast agent called Gadavist during stress and rest imaging. The goal is to improve diagnosis and reduce unnecessary invasive procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gadavist (gadobutrol contrast agent)
What this could lead to: If successful, this could make heart disease diagnosis more accurate and help doctors better understand its severity without invasive procedures.
What could go wrong: This is an observational study, not a treatment trial. The new MRI method may not prove more useful than standard imaging, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC MAGNETIC RESONANCE IMAGING ISCHEMIC HEART DISEASE (IHD) MYOCARDIAL BLOOD FLOW

Contacts and locations

Locations

Atrium Health - Sanger Heart & Vascular Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
St. Francis Hospital and Heart Center
RECRUITING

Roslyn, New York, 11576, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94107, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
UofL Health - Heart Hospital
RECRUITING

Louisville, Kentucky, 40202, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37203, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

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