Brigham And Women's Hospital

This early-stage trial tests a supplement called MIB-626 (a form of NMN) in 24 adults with Down syndrome. The goal is to see if it is safe and can raise NAD+ levels, which may help protect against Alzheimer's disease. Participants take the pill or a placebo for 28 days and are mo…

This study looks at whether using ureteral stents (small tubes) after bladder cancer surgery leads to more or fewer problems than not using them. About 190 adults having their bladder removed will be randomly assigned to get stents or not. The main goal is to see who ends up back…

This study tests whether pharmacists can encourage doctors and patients to switch to a single pill that combines multiple blood pressure medicines. About 720 adults with high blood pressure will take part. The goal is to see if this approach helps lower blood pressure more effect…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder reduce heavy drinking. Thirty-six adults who recently completed detox will receive either a high or low dose of psilocybin du…

This pilot study tests whether the drug ropeginterferon is safe and feasible for 12 people with a JAK2 mutation and high-risk features who do not yet have a blood cancer. Participants receive an injection every 4 weeks and are monitored closely. The goal is to see if this approac…

This study tests a drug called sparsentan to reduce high levels of protein in the urine (proteinuria) caused by certain cancer treatments. About 20 adults with cancer who are taking VEGF inhibitors and have developed proteinuria will receive sparsentan for 8 weeks. The goal is to…

This study tests whether combining a nerve-stimulating implant with two medications (atomoxetine and oxybutynin) can improve breathing during sleep more than either treatment alone. Twenty-four adults with obstructive sleep apnea who already have the implant will try each combina…

This study tests whether AI-generated messages can help doctors improve medication plans for adults with heart failure. About 500 patients will have their doctors receive brief suggestions before appointments. The goal is to see if more patients get the right medications within 3…

This early-phase study tests the drug cenobamate in 10 adults (ages 18–70) in the intensive care unit who are having frequent seizures or a prolonged seizure (status epilepticus). The goal is to see if cenobamate can quickly reach and maintain a target level in the blood, stop se…

This study will test whether providing acute hospital care at home, instead of in a traditional hospital, can help people with moderate to severe dementia spend more days at home after an acute illness. Researchers will randomly assign 200 participants to either receive home-base…

This study tests two ways to use asthma inhalers to prevent serious attacks. One strategy (MART) uses a combination inhaler for daily control and quick relief. The other (PARTICS) adds a separate steroid inhaler whenever a rescue inhaler is used. About 4,100 adults with moderate-…

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …

This study tests a non-invasive procedure that uses sound waves to target a small area in the brain thought to be involved in obsessive-compulsive disorder (OCD). It is for adults aged 25-64 with moderate to severe OCD that has not improved with standard treatments like therapy a…

This study tests if xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low or high dose of xylitol or a placebo for four weeks. Researchers …

This pilot study tests whether tirzepatide, a drug used for diabetes, can reduce cravings in people with severe cannabis use disorder. Six adults will receive either tirzepatide or a placebo injection and then be exposed to cannabis-related cues to measure craving intensity. The …

This pilot study tests whether xylitol, a common sugar alcohol, can safely clear C. difficile bacteria from the guts of people with inflammatory bowel disease (IBD). About 69 adults with mild or inactive IBD will take different doses of xylitol for up to 8 weeks. Researchers will…

This study aims to create personalized treatment plans for people with opioid use disorder by using machine learning to find the best sequence of medications and behavioral therapy. Researchers will test these plans in a small pilot study with 75 adults to see if they are feasibl…

This study compares two antibiotics, fidaxomicin and vancomycin, to see which one is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 60 adults with IBD will take one of the two antibiotics for 10 days and be followed fo…

This study looks at two ways to train non-radiologist doctors and nurses in rural Rwandan hospitals to perform breast ultrasound. The goal is to help women get diagnosed with breast cancer earlier, without having to travel to a big city hospital. About 1,792 women will take part,…

This study tests the Korus smart mattress in 10 healthy adults to see if it can accurately detect body positions (like lying on the stomach) and automatically reposition the person to a safer side-lying position. The goal is to prevent sudden unexpected death in epilepsy (SUDEP) …

This study tests whether an electronic alert in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goa…

This pilot study will bring a mobile lung cancer screening clinic to underserved neighborhoods in Boston. 125 high-risk adults (ages 50-80, current or former heavy smokers) will receive a low-dose CT scan and a video message to encourage future screening. The goal is to see if th…

This pilot study will test whether adding chiropractic care (including spinal adjustments, massage, and exercises) to usual medical care helps adults with chronic neck pain. Sixty participants will be split into two groups: one gets chiropractic plus usual care, the other gets us…

This study tests whether adding a new non-opioid painkiller called suzetrigine to standard pain management can reduce opioid use and complications after ureteroscopic surgery for kidney stones. About 100 adults aged 21-80 will receive either suzetrigine or placebo alongside usual…

This study tests whether colchicine, a drug used for gout, can lower inflammation and pain in people with CPPD disease. About 150 adults will take either colchicine or a placebo daily for 6 months. Researchers will measure blood markers and joint symptoms to see if the drug helps…

This pilot study will test whether a device that gently stimulates a nerve in the ear (taVNS) can reduce facial redness and flushing in people with rosacea. Ten adults with moderate-to-severe rosacea will use the device daily for 4 weeks, then be followed for another 4 weeks to s…

This study tests whether using a virtual reality headset to practice a type of mindfulness therapy called Acceptance and Commitment Therapy (ACT) can reduce migraine-related disability. About 160 adults with episodic migraine will either continue their usual care or add VR sessio…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

This study tests a digital app called WELL-MPN designed to help adults with myeloproliferative neoplasms (MPNs) improve their diet, physical activity, symptoms, and emotional well-being. About 75 participants will be randomly assigned to use the app or receive standard written li…

This study tests if placing stitches only in the lower part of the stomach works as well as placing stitches in both the lower and upper parts for weight loss. Ten adults with obesity will get one of the two stitch patterns using a device called Endomina. Researchers will track h…

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty participants will either use the music app daily for 3 months or receive educational materials about pain. The main goal is to see if the app is practical a…

This study compares a new type of brain scan—watching movie clips during functional MRI (fMRI)—to standard task-based fMRI for mapping language areas in people with brain tumors (gliomas). The goal is to see if the simpler movie-watching method works as well or better for helping…

This study tests whether shining red/near-infrared light on the neck and inside the nose (called photobiomodulation) can improve how the body handles stress. Forty healthy adults will undergo a stressful test while wearing either a real or sham light device. Researchers will meas…

This study tests whether a structured phone-based peer support program called STEPP-Care is practical and helpful for caregivers of people undergoing stem cell transplants. About 90 adult caregivers will be enrolled. The main goal is to see if at least 60% of participants complet…

This study tests a personalized approach to find the best beta-blocker dose for older adults with heart failure. Fifty participants will either receive the N-of-1 intervention (testing different doses in 2-week cycles) or enhanced usual care. The goal is to see if this patient-dr…

This study looks at how a 12-week cardiac rehabilitation exercise program affects the heart and blood proteins in 42 older adults with high blood pressure who don't exercise regularly. Participants will be randomly assigned to either the exercise program or a control group that r…

This study looks at whether being male or female changes how the body handles hunger and blood sugar when sleep and eating are out of sync, like during night shifts. Researchers will compare 36 healthy adults in a controlled lab setting. Results could lead to personalized shift s…

This study will give a single dose of morphine or a placebo to 26 adults (some healthy, some with obstructive sleep apnea) during a sleep study night. Researchers will measure how much their breathing changes. The goal is to understand why opioids can dangerously slow breathing d…

This study is testing a new program to help men living with HIV in Uganda feel more comfortable telling their sexual partners about their HIV status. The program includes education, counseling, and practice conversations. Researchers want to see if it helps more men share their s…

This study looks at whether not getting enough sleep affects blood sugar control differently in healthy men and women. Researchers will ask 32 adults to sleep only 4 hours a night for three nights and then measure their blood sugar and hormone responses after a meal. The goal is …