Brigham And Women's Hospital

This early-stage trial tests the safety of ropeginterferon in 12 adults with a JAK2 mutation and high-risk features, but no blood cancer yet. Participants receive an injection every 4 weeks and are monitored closely. The goal is to see if the drug can safely reduce mutation level…

This study aims to help pregnant women and new mothers in rural Guatemala avoid obesity while also preventing stunting in their children. About 1,532 women will receive food supplements and behavioral counseling on diet, exercise, and infant feeding. The goal is to improve both m…

This study tests whether a pharmacist can encourage patients and their doctors to switch to a single pill that combines multiple blood pressure medicines. About 720 adults with high blood pressure will take part. The goal is to see if this simpler approach helps lower blood press…

This study compares two antibiotics, fidaxomicin and vancomycin, to see which one is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 60 adults with IBD will take one of the two antibiotics for 10 days, and researchers w…

This study tests whether combining a nerve stimulator (HGNS) with two drugs (AtoOxy) can improve breathing during sleep better than either treatment alone. About 24 adults with sleep apnea who already have or will get the stimulator device will try each combination in random orde…

This study compares two proven asthma management strategies—PARTICS and MART—to see which works better at preventing severe asthma attacks. About 4,100 adults with moderate-to-severe asthma who are at risk for flare-ups will be randomly assigned to one of the two approaches and f…

This study tests a non-invasive procedure called ExAblate MR-guided focused ultrasound for people with moderate to severe obsessive-compulsive disorder (OCD) who haven't improved with standard treatments. The procedure uses sound waves to target a small area in the brain thought …

This study tests whether taking nicotinamide mononucleotide (NMN), a natural compound, before and after heart bypass surgery can reduce damage to the heart and kidneys. About 90 adults at higher risk for complications will receive either NMN or a placebo. The goal is to see if NM…

This study tests whether AI-generated reminders can help doctors prescribe the right heart failure medications. About 500 adults with heart failure will have their doctors receive brief, computer-written suggestions before appointments. The goal is to see if this leads to better …

This early study tests if the drug sparsentan can reduce high levels of protein in the urine (a sign of kidney damage) in 20 cancer patients receiving VEGF inhibitor therapy. The goal is to see if sparsentan can help protect kidney function without interrupting cancer treatment. …

This study tests whether personalized treatment plans, guided by machine learning, can improve care for people with opioid use disorder. Researchers will enroll 75 adults receiving care at behavioral health centers. The goal is to find the best sequence of treatments to lower ove…

This study tests whether dapagliflozin, a drug already used for diabetes and other kidney diseases, can help people with lupus nephritis—a serious kidney condition caused by lupus. About 33 adults with active lupus nephritis will receive either dapagliflozin or a placebo alongsid…

This study tests whether xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low dose, high dose, or placebo capsule for 4 weeks. Researchers…

This study tests whether providing acute hospital care at home, instead of in a hospital, improves outcomes for people with moderate to severe dementia. Two hundred participants will be randomly assigned to either home-based acute care or usual hospital care. The main goal is to …

This early-stage trial tests whether xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 69 adults with mild or inactive IBD will take xylitol by mouth, and researchers will check if the infection…

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF. Scarring is linked to worse outcomes, and the drug is already approved for heart failure. The trial will use MRI scans to measure ch…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help adults with severe alcohol use disorder reduce heavy drinking. Thirty-six participants who recently completed detox will receive either a full dose (30-40mg) or a lo…

This is a small, early-stage study to see if tirzepatide, a medication currently used for diabetes and weight loss, can help people with severe cannabis addiction. Six participants will receive either the drug or a placebo injection in a random order to test its effects. The main…

This study aims to make breast cancer diagnosis faster in Rwanda by training non-radiologist clinicians at rural district hospitals to perform breast ultrasound. Currently, only radiologists at urban hospitals offer this service, causing delays. The project will compare two suppo…

This study tests whether taking rosuvastatin (a statin) daily for one year can safely prevent life-threatening blood clots in people with cancer. Current clot-preventing drugs raise bleeding risks, so a safer option is needed. The trial will enroll 4,000 adults with newly diagnos…

This study tests a smart mattress called Korus that can detect a person's sleeping position and gently move them from stomach to side. The goal is to prevent sudden unexpected death in epilepsy (SUDEP) that can happen during sleep. Ten healthy adults will lie on the mattress in d…

This study tests whether electronic alerts in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goal …

This study explores whether Pilates-based exercises can reduce pain and improve daily life for adults with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder. Researchers will enroll 100 participants to see if the program is practical and helpful. The goal is t…

This early-stage study tests whether a daily pill called MIB-626 is safe for adults with Down syndrome. The goal is to see if it can help prevent or slow down Alzheimer's disease, which is common in this group. Twenty-four participants will take either the pill or a placebo for 2…

This study tests whether a smartphone app called WELL-MPN can help adults with myeloproliferative neoplasms (MPNs) improve their diet, physical activity, symptoms, mood, and quality of life. About 75 participants will be randomly assigned to use the app or receive standard writte…

This study tests whether using a person's brain scan (MRI) to guide transcranial magnetic stimulation (TMS) works better than the standard scalp-measured approach for treating depression. About 160 adults with major depressive disorder will receive accelerated TMS (10 sessions da…

This study tests whether a 7-day course of intravenous steroids can reduce harmful inflammation and help 30 adults recover from heart failure-related cardiogenic shock. Participants must have high inflammation levels and be in the ICU. The goal is to see if the treatment is safe …

This study tests whether chiropractic care can ease chronic neck pain in adults aged 18 to 65. Sixty participants will either get chiropractic care plus usual treatment or just usual treatment. The goal is to see if the approach is practical and if it reduces pain and improves da…

This study tests a drug called cenobamate to quickly stop frequent seizures or ongoing seizure emergencies (status epilepticus) in intensive care patients. Ten adults aged 18-70 who have many seizures per hour will receive the drug while being closely monitored. The main goals ar…

This study tests whether shining red or near-infrared light on the body (called photobiomodulation) can help healthy adults manage stress. Forty people will undergo a stressful test while researchers measure heart rate and other body signals. The goal is to see if this light ther…

This study compares two ways of placing stitches in the stomach to help people lose weight. The goal is to see if using fewer stitches in a specific area works as well as the standard method. Ten adults with obesity will be followed for a year to measure weight loss and safety.

This study tests whether the drug colchicine can lower inflammation and reduce joint pain in people with calcium pyrophosphate deposition (CPPD) disease. About 150 adults with active joint symptoms will take either colchicine or a placebo daily for 6 months. Researchers will meas…

This study is testing a new smartphone app called Harmonized Healing, which uses personalized music to help people with HIV manage their chronic pain. Researchers want to see if using the app is practical and acceptable for participants over three months. The study will also comp…

This study looks at how a 12-week cardiac rehabilitation exercise program affects the heart and blood proteins in 42 older adults with high blood pressure who don't currently exercise. Participants will have heart tests, fitness tests, and blood draws before and after the program…

This study looks at how irregular sleep and certain types of lighting can throw off your internal body clock and cause stress in the brain. Researchers will measure sleep, thinking skills, and brain chemistry in 40 healthy adults aged 18 to 40. The goal is to understand these con…

This study tests whether sending a brief informational prompt to patients before their primary care visit helps them and their doctor discuss stopping or starting statin medications. Researchers will enroll 1,700 adults aged 65 and older at Brigham and Women's Hospital clinics. T…

This pilot study will bring a mobile lung cancer screening clinic to neighborhoods in Boston with limited access to healthcare. About 125 high-risk adults (ages 50-80, current or former heavy smokers) will get screened and complete surveys about their social needs. Participants w…

This study tests a new program to help men living with HIV in Uganda talk about their HIV status with others. The program includes education, counseling, and practice conversations. Researchers want to see if it helps more men share their status compared to standard care. About 7…

This study looks at whether being female or male changes how the body handles night shift work. Researchers will measure hunger, fullness, and blood sugar control in 36 healthy adults during simulated day and night shifts. The goal is to understand why shift work raises health ri…

This study aims to see if a personalized approach, called N-of-1 trials, can help older adults with heart failure find the highest beta-blocker dose they can tolerate without side effects. Fifty participants aged 60 and older will be split into two groups: one using the personali…

This early-stage study looks at how opioids change breathing during sleep in 26 adults—some healthy, some with obstructive sleep apnea. Participants will receive morphine or a placebo to measure breathing changes. The goal is to understand the risk of opioid-induced breathing pro…

This study looks at whether not getting enough sleep affects blood sugar control differently in healthy men and women. Researchers will have 32 participants stay in a lab for two separate 5-day periods, one with normal sleep and one with limited sleep. They will measure blood sug…