Brigham And Women's Hospital

This study is testing whether a supplement called NMN can help protect the heart and kidneys during and after coronary artery bypass graft (CABG) surgery. Researchers will give NMN or a placebo to 90 adults before and after their scheduled heart surgery to see if it reduces tissu…

This early-stage study is testing the safety of a daily supplement called MIB-626 in adults with Down syndrome. The main goal is to see if the supplement is safe and well-tolerated, while also checking if it raises levels of a key body chemical (NAD+) linked to brain health and a…

This small pilot study is testing whether adding a short course of steroid medication to standard hospital care can help patients with severe heart failure shock. The condition causes poor blood flow and triggers harmful inflammation, even when using heart pumps. Researchers will…

This study is testing if a simpler stitching pattern inside the stomach works as well as a more complex one for weight loss. It will involve 10 adults with obesity who will have a minimally invasive procedure using a special device. Researchers will compare weight loss and health…

This study aims to determine if using MRI brain scans to target a rapid depression treatment works better than using scalp measurements. Researchers will compare two methods of guiding accelerated transcranial magnetic stimulation (aTMS), a non-invasive brain stimulation treatmen…

This small, early-stage study is testing whether a common sweetener called xylitol can safely remove C. difficile bacteria from the gut of people with inflammatory bowel disease (IBD). Researchers will give different doses to small groups of participants to find the highest amoun…

This study tests whether personalized medicine trials can help older adults with heart failure find their highest tolerated beta-blocker dose. Fifty participants will either try a personalized approach where they test different doses while tracking how they feel, or receive stand…

This study is testing if a daily pill called colchicine can reduce inflammation and joint pain in people with calcium pyrophosphate deposition (CPPD) disease, a form of arthritis caused by calcium crystals in the joints. Researchers will compare colchicine to a placebo (sugar pil…

This study is testing whether providing hospital-level care at home is better than usual hospital care for people with moderate to severe dementia. It will involve 200 participants who have been hospitalized recently and live with or near a family caregiver. The main goal is to s…

This study aims to see if a medication called sacubitril/valsartan can reduce harmful scarring (fibrosis) inside the heart muscle of people with a specific type of heart failure. Researchers will compare it to another standard medication using heart MRI scans to measure changes i…

This study is testing if a common sweetener called xylitol, taken as a daily capsule, can safely remove C. difficile bacteria from the gut of people with inflammatory bowel disease (IBD). The goal is to prevent these patients from developing a serious C. difficile infection. Abou…

This small pilot study is testing if adding the drug dapagliflozin to standard treatment helps control kidney damage in people with active lupus nephritis. The trial will involve 33 adults who have recently been diagnosed with or had a flare-up of this serious kidney complication…

This study is testing personalized treatment plans for people with opioid addiction. Researchers will use computer algorithms to create customized treatment sequences that may reduce overdose risk and improve recovery. The study will involve 75 adults receiving care at behavioral…

This large study aims to find the best way to manage moderate-to-severe asthma and prevent dangerous flare-ups. It will directly compare two established medication strategies—MART and PARTICS—in 4,100 adults who are at risk for asthma attacks. Researchers will track which approac…

This study is testing a counseling program designed to help men living with HIV in Uganda tell their sexual partners about their status. The program includes education, communication skills training, and personalized planning. Researchers want to see if this approach helps men di…

This study tests whether a computer alert system can help doctors in community clinics prescribe blood thinners to prevent strokes in high-risk patients with atrial fibrillation (an irregular heartbeat). The system reminds doctors about stroke risk and helps assess bleeding conce…

This study tests if pharmacists can help patients and doctors use simpler, combined blood pressure pills. It aims to see if this approach helps patients better control their blood pressure. The trial will involve about 750 people with high blood pressure who are not yet on the co…

This study is testing whether messages generated by an artificial intelligence (AI) tool can help heart doctors better follow established treatment guidelines for their patients. The AI will review a patient's medical records and send a brief, private message to their cardiologis…

This study is testing whether focused ultrasound can safely reduce symptoms of obsessive-compulsive disorder (OCD) in people who haven't improved with standard treatments like therapy and medications. Researchers will use MRI-guided sound waves to target a specific brain area wit…

This study tests if sending patients a brief, informative prompt before their doctor's appointment helps improve conversations about medications. It focuses on older adults (65+) to see if this leads to safer prescribing of statins or safer deprescribing of potentially risky medi…

This study is testing whether therapy combined with the psychedelic compound psilocybin can help people with severe alcohol use disorder reduce their heavy drinking. Thirty-six adults who recently completed detox will receive therapy and be randomly assigned to get either a highe…

This small pilot study is testing whether tirzepatide, a medication currently used for diabetes and weight loss, can help people with severe cannabis addiction. Six participants will receive either the drug or a placebo injection in a random order to see if it reduces their cravi…

This study is testing a drug called sparsentan to see if it can reduce severe proteinuria, a type of kidney damage, in cancer patients. The damage is caused by a specific class of anti-cancer drugs. The goal is to control this side effect so patients can continue their cancer tre…

This study aims to find out which of two common antibiotics, fidaxomicin or vancomycin, is better at clearing C. difficile bacteria from the gut of people with inflammatory bowel disease (IBD). About 60 adult patients will be randomly assigned to take one of the antibiotics for 1…

This study is testing a new AI-powered tool called IntelliWell. It aims to find rare, usable sperm in testicular tissue samples from men with a severe form of infertility where no sperm is found in semen. If the AI successfully finds sperm that standard lab methods missed, those …

This study is testing a smartphone app designed to help doctors monitor surgical wounds remotely. After certain pain-management surgeries, some participants will use the app to take photos of their wound and answer questions. An AI program will analyze the photos to predict infec…

This study is testing whether bringing lung cancer screening directly to underserved Boston neighborhoods makes it easier for high-risk people to get checked. Researchers will also see if collecting information about participants' social needs and having them record a video messa…

This study tests a program combining food supplements with health coaching for pregnant women in rural Guatemala. It aims to prevent two related problems: mothers gaining too much weight while their babies don't grow properly. Researchers will follow 766 mother-child pairs for a …

This is a small, early-stage study to see if a drug called ropeginterferon is safe and feasible to use in people who have a specific genetic change (JAK2 mutation) that puts them at high risk for developing blood clots or a type of blood cancer. The main goal is to enroll 12 part…

This trial aims to see if a daily cholesterol-lowering pill (rosuvastatin) can safely prevent life-threatening blood clots in people with cancer. It will involve 4,000 patients who are at higher risk for clots but are not taking blood thinners. The study compares the statin to a …

This study is testing whether a brief aromatherapy session can help reduce stress and anxiety in emergency department patients. Researchers want to see if smelling lavender for about 5 minutes is practical and acceptable in a busy hospital setting. The study will involve 60 emerg…

This study is testing whether a smartphone app that provides personalized music can help people with HIV manage their chronic pain. 60 participants will be randomly assigned to either use the music app daily for 3 months or receive educational materials about pain. The main goal …

This study is testing whether a 6-week Pilates program, led by a physical therapist, can help adults with hypermobility conditions like Ehlers-Danlos Syndrome manage their chronic pain and improve daily function. Researchers will measure pain levels, movement fear, and overall ph…

This small pilot study aims to see if a package of chiropractic treatments is practical to study and might help adults with long-term neck pain. It will compare chiropractic care plus standard advice against standard advice alone in 40 people. The researchers will also check if c…

This study is testing whether a smartphone app can help adults with myeloproliferative neoplasms (MPNs), a type of chronic blood cancer, feel better and improve their daily lives. Researchers will compare 75 participants who either use the new wellness app or receive standard wri…

This study aims to understand how poor and irregular sleep harms brain function and thinking skills. Researchers will test whether special 'sleep-informed' lighting can help protect the brain during periods of severe sleep loss. Forty healthy young adults will stay in a sleep lab…

This study aims to develop and test a more precise method for targeting brain stimulation using transcranial magnetic stimulation (TMS). Healthy volunteers will have an MRI brain scan to create a personalized map, then receive TMS to specific brain areas while performing computer…

This study aims to understand if a non-invasive light therapy, called photobiomodulation, can influence the body's automatic stress response. Researchers will measure heart rate and other signals in 40 healthy adults before and after they complete a short, standardized stress tes…

This study aims to understand how a 12-week supervised exercise program benefits the hearts of older adults with high blood pressure. Researchers will enroll 42 sedentary participants and randomly assign them to either follow the exercise program or not. The main goal is to ident…

This study aims to understand if men and women's bodies respond differently to night work and disrupted sleep schedules. Researchers will measure changes in hunger, food cravings, and blood sugar control when participants' sleep is shifted. The findings could help design better w…

This study aims to understand if not getting enough sleep affects blood sugar control differently in healthy men and women. Researchers will have 32 participants spend time in a sleep lab, comparing their body's response to food after nights of normal sleep versus restricted slee…

This study aims to understand how opioid pain medications affect breathing during sleep. Researchers will compare healthy volunteers with people who have obstructive sleep apnea. Participants will receive either morphine or a placebo during monitored sleep to measure breathing ch…