Brigham And Women's Hospital

This large study compares two diabetes drugs—oral semaglutide and sitagliptin—in over 25,000 people with type 2 diabetes and heart failure. Researchers want to see which drug better prevents heart failure worsening or death. The study uses existing medical records to mimic a clin…

This study tests whether taking 480 mg of magnesium glycinate daily for 12 weeks can lower blood pressure in adults with slightly high systolic blood pressure (130-159 mmHg). 120 participants will be randomly assigned to get the supplement or a placebo. The main goal is to see if…

This study tests a new procedure called BEAM (Bariatric Endoscopic Antral Myotomy) to help people with obesity lose weight. The procedure uses a tube down the throat to make small cuts in the stomach muscle, aiming to change how the stomach empties. Twenty adults with a BMI betwe…

This large study looks at real-world data from 60,000 people with type 2 diabetes and obesity to compare four diabetes drugs—dulaglutide, semaglutide, tirzepatide, and sitagliptin—in preventing heart attacks, strokes, and death. Researchers are analyzing insurance claims to see w…

This study compares two ways of fortifying breast milk for preterm babies in the NICU. One group gets standard fortification, while the other gets a personalized mix based on real-time milk analysis. Researchers will track growth, brain scans, and development up to age 2 to see w…

This study looks at health records of 120,000 people with type 2 diabetes and overweight to compare two injectable drugs: semaglutide and dulaglutide. Researchers want to see which one better reduces the risk of death, heart attack, or stroke. The goal is to understand how these …

This study compares two popular weight-loss medications, tirzepatide and semaglutide, in 100,000 adults who are overweight or obese and at risk for heart problems but do not have diabetes. Researchers are analyzing real-world data to see which drug better prevents death, heart at…

This study looks at whether adding pistachios to the daily diet for 6 months can improve memory, thinking speed, and other brain functions in adults aged 65 to 80. It also checks for changes in blood pressure and overall life satisfaction. About 97 participants who are already in…

This study looks at different methods to help patients with high cholesterol and heart disease get the right medicines to lower their cholesterol. About 300 adults at high risk will take part. The goal is to see which approach helps more people reach their target LDL cholesterol …

This large study compares two popular diabetes drugs, tirzepatide and semaglutide, in 26,000 people who have both type 2 diabetes and a type of heart failure. Researchers will track who ends up in the hospital for heart failure or dies, to see if one drug works better. The goal i…

This pilot study is testing whether adults with serious mental health issues like psychosis, anxiety, or depression can receive hospital-level care in their own homes. Researchers will see how many people are eligible and willing to try this approach. The goal is to offer a safe,…

This study looks at whether replacing sugary drinks (like soda and sports drinks) with calorie-free alternatives (like diet drinks or water) can help adults with overweight or obesity lose weight. About 460 people who drink at least one sugary drink per day will be assigned to on…

This study tests whether the drug eplerenone works better than amlodipine for controlling high blood pressure in Black adults who carry a specific gene variant (LSD1 risk allele). About 300 participants will follow a controlled diet and take escalating doses of one of the two dru…

This study tests new MRI-based tools to make brachytherapy—a type of internal radiation—more accurate for gynecologic cancer. Researchers will compare standard brachytherapy with an MRI-guided version in 49 patients to see if it improves radiation delivery. The goal is better tum…

This study looks at whether taking cocoa extract or a daily multivitamin can reduce falls and improve physical performance in older adults. Over 21,000 men and women aged 60 and older are participating. Researchers are tracking falls that require medical care and repeated falls t…

This study tests whether dupilumab, a drug already used for eczema and asthma, can help people with allergic contact dermatitis — a skin reaction to allergens like nickel or fragrances. Seventeen adults with confirmed allergies will receive the drug, and doctors will track change…

This phase 2 trial tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) works better than the standard 26-week treatment for drug-susceptible tuberculosis. About 94 adults with TB will be randomly assigned to either the short r…

This study aimed to test a monthly injection called ION-682884 in people with TTR amyloid cardiomyopathy, a condition where abnormal protein deposits damage the heart. Only patients who had already completed a 2-year study of a similar drug (inotersen) were eligible. The goal was…

This study tests whether an electronic alert in the medical record can help doctors prescribe better cholesterol-lowering medications for heart disease patients with high LDL. About 400 patients from a single hospital will be randomly assigned to have their doctor receive the ale…

This study tests a procedure that uses ultrasound and a catheter to deliver a low dose of a clot-dissolving drug directly to blood clots in the lungs. The goal is to quickly reduce the strain on the heart and improve blood flow, while keeping the risk of serious bleeding low. The…

This study looks at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent high blood pressure or lower it in healthy adults. Over 25,000 people are taking part, with a smaller group having their blood pressure monitored around the clock. The goal is t…

This study compares two treatments—electroconvulsive therapy (ECT) and intravenous ketamine—for quickly reversing acute suicidal depression in 1,500 adults aged 18 to 90. Participants are randomly assigned to receive either ECT or ketamine twice a week for up to four weeks. The m…

This study compares a newer hormone therapy (darolutamide) plus radiation against standard hormone therapy plus radiation for men with intermediate-risk prostate cancer. The goal is to see if the new approach controls the cancer just as well while helping men keep better erectile…

This study looks at whether a non-surgical stomach reduction procedure (endoscopic sleeve gastroplasty) can improve liver health in people with obesity and advanced NASH (a severe form of fatty liver disease). Twenty adults with obesity and biopsy-confirmed NASH with advanced sca…

This study planned to test a gene therapy called VM202 in people with painful diabetic neuropathy who were already taking opioid painkillers. The goal was to see if VM202 could help them safely reduce their opioid dose. However, the trial was withdrawn before any participants wer…

This study compares getting skilled nursing care at home versus in a traditional facility for people who need rehabilitation after a hospital stay. About 300 adults will be randomly assigned to either recover at home with a technology-supported care team or go to a skilled nursin…

This study tests a new system that uses magnetic beads implanted in leg muscles to help people with below-knee amputations control a bionic ankle-foot prosthesis. The beads track muscle movement in real time, sending signals to a robotic leg. Up to 7 participants will receive the…

This Phase 2 trial is testing dupilumab (Dupixent) in 17 people with aspirin-exacerbated respiratory disease (AERD), a condition that includes asthma, nasal polyps, and severe reactions to aspirin. The study aims to see if the drug can reduce markers of inflammation and improve s…

This early-phase study tests CP101, an oral capsule made from healthy donor stool, in 30 adults with mild-to-moderate ulcerative colitis. The goal is to see if the drug can safely restore a healthy gut microbiome and improve symptoms. Participants receive either a short or extend…

This study tests a finger-clasp device called Lab Clasp that measures lactate from fluid just under the skin, similar to a pulse oximeter. Researchers want to see if it matches standard blood tests in 6 healthy adults. If it works, it could make sepsis monitoring easier and less …

This study tests whether a special PET scan using [11C]acetate can detect early signs that the drug rapamycin is working in people with lymphangioleiomyomatosis (LAM), a rare lung disease. Seven adults with LAM and kidney tumors will get one or two scans over 3–6 months. The goal…

This study tests whether a drug called deferoxamine can prevent acute kidney injury in adults undergoing heart surgery. The drug works by removing excess iron, which is thought to damage the kidneys during surgery. About 320 participants will receive either the drug or a placebo …

This study tests if shining a special light inside the mouth, outside the cheek, or both can prevent severe mouth sores in people getting a stem cell transplant. About 78 patients will receive daily light therapy during their transplant stay. The goal is to find the best way to r…

This study looks at whether taking vitamin D and fish oil supplements can reduce the risk of developing anemia in people aged 60 and older. Researchers are following 2000 participants from a larger heart-health trial who did not have anemia at the start. They will compare anemia …

This study compares cranberry tablets to the antibiotic nitrofurantoin for preventing urinary tract infections (UTIs) in women after pelvic organ prolapse or incontinence surgery. About 142 women will be randomly assigned to take either cranberry capsules or nitrofurantoin for a …

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study tests a school-based communication strategy to help more children aged 9-12 in South Africa get the HPV vaccine, which prevents cancers caused by HPV. The program involves health materials and vaccine provision in schools. Researchers will measure how many children sta…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the risk of developing atrial fibrillation (an irregular heartbeat) in healthy adults. Over 25,000 men and women without prior heart disease or stroke took part. Researchers are tracking who deve…

This pilot study tests whether weekly testosterone injections can increase pelvic floor muscle size and improve stress urinary incontinence in women aged 60 and older. The trial involves 30 participants and uses MRI to measure muscle changes. It is a small, early-stage proof-of-c…

This study tests whether a medicine called fremanezumab can reduce migraines that happen around a woman's period. Women aged 18 to 45 with menstrual migraines will get either the medicine or a placebo injection every three months for six months. Researchers will track migraine da…

This study tests a new digital app called Stellar Sleep, which provides cognitive behavioral therapy for insomnia (CBT-I) online. It aims to help people with insomnia improve their sleep by using a smartphone or computer, and it can automatically upload sleep data from wearable d…

This study aimed to see if a dissolvable film placed under the tongue could quickly calm agitation in people with bipolar disorder or schizophrenia who come to the emergency room. The drug, BXCL501, is already approved for this use, but the study wanted to test it in the ER setti…

This study aimed to see if a nerve block called a parasternal subpectoral plane block could reduce pain and the need for opioids after heart surgery. It planned to compare a numbing medicine (bupivacaine) to a saltwater placebo in about 100 adults having elective heart surgery. H…

This study compares two ways to treat new Achilles tendon pain: doing exercises at home versus going to a physical therapist. About 56 adults with Achilles tendinopathy will be randomly assigned to one of the two groups for 12 weeks. Researchers will track pain, function, and moo…

This study tests whether phone coaching and financial rewards can help people become more active after total knee replacement. 600 adults aged 40-85 will be split into three groups: usual care, activity tracker only, or activity tracker plus coaching and rewards. The goal is to s…

This study tests whether a trauma-informed care plan (TICP) placed in the electronic medical record helps healthcare teams better care for patients with trauma and complex needs. About 200 patients and their clinicians will use the plan, and researchers will measure how acceptabl…

This study looks at whether intensive computer-based brain exercises can improve memory, attention, and problem-solving in people who have had a brain injury. Thirty adults aged 25-65 with mild cognitive problems will train on a computer for 45-60 minutes a day, five days a week,…

This study uses healthcare claims data from nearly 40,000 people to see if the results of a major clinical trial (EMPEROR-Preserved) can be reproduced in a real-world setting. Researchers are comparing two diabetes drugs, empagliflozin and sitagliptin, in patients with heart fail…

This study tests whether sending a brief prompt to patients before their primary care visit helps them talk to their doctor about stopping unnecessary medications or starting a statin. About 1,700 adults aged 65 and older will be randomly assigned to receive the prompt or usual c…

This study looks at health insurance claims from about 30,000 people with type 2 diabetes to see if real-world data can produce similar results to a large clinical trial called REWIND. The goal is to learn when and how to trust real-world data for answering medical questions. No …

This study looks at healthcare claims from over 78,000 people to see if it can reproduce the results of the EINSTEIN-DVT trial, which compared two blood thinners (rivaroxaban and warfarin) for treating blood clots. The goal is not to test a new drug, but to learn whether real-wor…

This study looks at health records of nearly 150,000 people who had knee replacement surgery to see if real-world data can reproduce the findings of a previous clinical trial (RECORD3). The researchers compare two blood thinners, rivaroxaban and enoxaparin, to see which better pr…

This study uses healthcare claims data from nearly 24,000 people to see if it can reproduce the results of the EMPEROR-Reduced trial, which tested the diabetes drug empagliflozin against sitagliptin in heart failure patients. The goal is not to test a new treatment, but to learn …

This study is not testing a new treatment. Instead, researchers are checking whether information from healthcare claims (like insurance records) can produce the same results as a famous clinical trial called RECORD1. They are looking at data from over 89,000 people who had hip re…

This study tests different ways to invite adults with diabetes who struggle to take their medications as prescribed. Researchers will compare letters and phone call strategies to see which approach gets more people to schedule and attend a pharmacist appointment. The goal is to f…

This study analyzes data from over 377,000 people who had a heart attack and were prescribed blood thinners (clopidogrel, ticagrelor, or prasugrel) in Germany and the United States between 2011 and 2024. Researchers aim to describe how often each drug is used and how much it cost…

This study tests whether artificial intelligence can help doctors outline the prostate on ultrasound images for a type of radiation treatment called brachytherapy. Thirty-six adults with prostate cancer will have their treatment plans made both with and without AI assistance. The…

This study aims to find out whether bright light or meal timing is the main signal that resets the body's internal clock. Researchers will expose 48 healthy adults aged 18-30 to different combinations of light and meal schedules in a controlled setting. They will measure changes …

This study tests a small implantable device that is placed inside prostate tumors to see how they respond to different cancer drugs. About 35 men scheduled for prostate removal surgery will receive the device before their operation. The goal is to learn whether this approach is s…

This early-stage study tests a tiny implantable device that releases very small amounts of several cancer drugs directly into bladder tumors. The goal is to see if the device is safe and can help doctors figure out which drugs kill the tumor best. Only 18 people with muscle-invas…

This study looks at health records from over 780,000 people with type 2 diabetes to compare four common second-line medications: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which drug class is most effective at preventing hea…

This study looks at whether offering doctors educational meetings about biosimilar medications leads them to prescribe more of these lower-cost alternatives instead of the original brand-name drugs. About 1,325 clinicians who prescribe adalimumab for conditions like rheumatoid ar…

This study looks at medical records from 770 people with advanced lung cancer to see if real-world data can produce the same results as a previous clinical trial (KEYNOTE-042). The goal is to learn when and how to trust real-world data for future research. No new treatments are g…

This study looks at whether information from electronic health records can be used to recreate the results of two earlier clinical trials (CheckMate 017 and 057) for advanced lung cancer. Researchers will compare survival outcomes in patients who started either nivolumab or docet…

This study is testing a new method to deliver transcranial magnetic stimulation (TMS) more precisely to specific brain networks. Researchers will use MRI scans from 50 healthy adults to map brain connections, then apply TMS to targeted areas while measuring reaction times and bra…

This study was designed to test a new system that uses tiny silica particles on HIV medication (Biktarvy) and a smartphone app to help people track whether they have taken their pills. The goal was to see if the system is easy to use and accurate over 90 days. However, the study …

This study looks at how vitamin D and vitamin K interact to affect bone density and fracture risk in older adults. Researchers are analyzing data from over 25,000 participants who took vitamin D and omega-3 supplements or placebos. The goal is to see if people with low vitamin K …

This study reviewed records of 166 knee replacement patients who received a nerve block for pain. Researchers compared pain scores 6-24 hours after the block wore off between two groups: one that received extra education about pain management before surgery and one that did not. …

This study examines whether patients who have a thyroid nodule found on a PET scan can safely skip a follow-up ultrasound without affecting their survival. Researchers will compare death rates over 7 years between those who had an ultrasound within 3 months and those who did not.…

This study measures oxygen levels inside cervical cancer tumors during a type of radiation called brachytherapy. Ten adult patients with cervical cancer will have tiny oxygen sensors placed in their tumors during the procedure. The goal is to see if oxygen levels relate to how we…

This study uses repeated MRI scans to track brain injury and growth in very preterm babies (born before 33 weeks) during their NICU stay. Researchers will also test a program called SENSE-plus, which involves daily gentle sensory activities like touch and sound, to see if it help…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study tests a structured conversation guide that emergency doctors can use with seriously ill older adults or their families to make shared decisions about intensive care. The trial involves 40 participants and aims to see if the tool is acceptable and feasible. It does not …

This study tests a personalized approach to monitor and support child development in rural India and Guatemala. Over 600 children under 2 years old receive monthly visits from community health workers who assess development and help caregivers create nurturing care plans. The goa…

This study looks at whether a sticker-like sensor on the skin can accurately measure carbon dioxide levels in newborns with brain injury who are receiving cooling treatment. About 53 babies will take part. If it works, it could replace frequent blood draws and make monitoring eas…

This study looks at how lithium, a common treatment for bipolar disorder, affects the brain's wiring. Researchers will use MRI scans to track changes in brain connections over 26 weeks in 120 adults with bipolar depression. The goal is to understand why lithium works, not to test…

This study looks at what happens in the body to cause POTS and dysautonomia after viral infections, including COVID-19. About 100 women will give a blood sample and share medical records. Researchers will study immune system markers to find clues that could lead to better diagnos…

This study looks at whether a special syringe called EpiFaith® helps anesthesia residents learn how to place labor epidurals more quickly. 34 residents with little experience will each perform 20 epidural placements using either the standard syringe or the EpiFaith® syringe. Rese…

This study tests a program called PATH-C that uses positive psychology exercises to improve well-being, quality of life, and physical activity in caregivers of stem cell transplant patients. About 80 adult caregivers will be randomly assigned to the program or usual support. The …

This study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…

This observational study aims to measure how well the heart pumps blood in people with untreated preeclampsia compared to healthy pregnant women. Researchers will use a non-invasive ultrasound (echocardiography) to check heart function at rest, after blood pressure medication, an…

This study follows over 1,300 pregnant people to learn what influences their use of birth control after giving birth. Researchers will look at knowledge, attitudes, and barriers to contraception. The goal is to improve birth spacing and help families plan better.

This study tests a program called Potlako+ that combines community education, support for healthcare providers, and patient navigation to help people with cancer symptoms get diagnosed and treated faster. About 874 participants in Botswana will be split into two groups: one recei…

This pilot study tests whether watching virtual reality (VR) videos of patient visits can reduce weight-based bias in 52 resident doctors at Brigham and Women's Hospital. Participants will take bias tests before and after the VR experience, and again at one week and one month. Th…

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with mild to moderate high blood pressure. Researchers will measure kidney blood flow, artery flexibility, and blood pressure after low- and high-salt diets, as well as after an infusion of a…

This study looks at whether changing what you eat can help people lose more weight after bariatric surgery. Researchers will track hunger, calorie intake, and energy use in 44 patients who had sleeve gastrectomy. The goal is to find better ways to support long-term weight loss af…

This study compares the eating habits of 44 people who had sleeve gastrectomy surgery for obesity. Researchers want to understand why some patients lose more weight than others by looking at hunger, appetite, and related hormones. The goal is to find dietary patterns that lead to…

This study tests whether a smartphone app can help people with psoriatic arthritis manage their condition with fewer in-person doctor visits. About 278 adults who already use certain arthritis medications will use the app to report symptoms. Researchers will compare visit frequen…

This study looks at how different types of mental and social activities might help keep the brain flexible and thinking skills strong in people over 65. Researchers will measure memory, attention, and problem-solving using computer tests. The goal is to learn more about healthy a…

This study looks at how eating salt changes the way our genes control blood pressure. Researchers will test 88 healthy adults aged 25-45 to see how their bodies respond to salt and a hormone called angiotensin II. The goal is to understand why some people are more sensitive to sa…

This study looks at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. Participants have mild memory concerns or are at risk for cognitive decline.…

This study aimed to survey parents of healthy newborns about their interest in genome screening. Parents would complete a short survey in the hospital and a longer one months later to see if their opinions changed. The study was withdrawn before any participants were enrolled.

This study explores whether special PET scans (PSMA-PET) can better track how well treatment is working in men with metastatic hormone-sensitive prostate cancer. Twenty participants will receive standard care and undergo scans before and after 6 months of treatment. The goal is t…

This study aimed to see if a special heart MRI could detect 'diffuse scar tissue' in people with type 2 diabetes and predict their risk of heart attacks or death. Researchers planned to follow participants for 5 years after a low-risk stress test. However, the study was withdrawn…

This study planned to test a technique called radiofrequency track cautery during liver, kidney, or spleen biopsies in patients at high risk for bleeding. The idea was to use a small heated probe to seal the biopsy track and reduce bleeding. However, the study was withdrawn befor…

This observational study is collecting data from 2,617 young people (ages 12-30) at clinical high risk for psychosis, plus healthy controls, across 13 countries. Researchers will use clinical assessments, cognitive tests, and biomarkers to build algorithms that predict who will r…

This study looks at how sleep problems like apnea, insomnia, and poor sleep quality are linked to heart disease and diabetes in rural southern areas. About 3,680 adults already in a larger health study will wear sleep trackers and answer questionnaires. The goal is to understand …

This study follows 100 adults aged 35-70 with mildly elevated blood pressure to see how their aldosterone hormone system changes over time. Participants will eat special high-salt or low-salt diets for a few days each year to test how their body responds. The goal is to better un…

This study was designed to see if the drug alemtuzumab reduces brain inflammation in people with relapsing-remitting multiple sclerosis (RRMS). Researchers planned to use a special PET scan to measure inflammation. The study was withdrawn before any participants were enrolled, so…

This study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…

This study follows over 5,700 people with coronary artery disease and mild heart damage to see if blood tests and ECGs can better predict who is at risk for sudden cardiac death. The goal is to find inexpensive markers that could help doctors decide who needs a defibrillator. Par…

This study looks at whether taking vitamin D and omega-3 (fish oil) supplements can lower the risk of infections like colds, flu, and urinary tract infections in healthy adults. It also measures a protein called hCAP18, which is part of the body's natural defense against germs. O…

This study follows 1,598 adults with rheumatoid arthritis (RA) over time to identify biological markers that can predict how well a patient will respond to a drug or whether they might have side effects. Researchers also aim to understand how the disease progresses and affects da…

This study tests whether a simple educational guide can help postpartum patients who had high blood pressure during pregnancy become more active in their own care. Researchers will give the tool to some mothers shortly after delivery and compare their engagement scores with those…

This study is looking at over 10,000 smokers to find out if certain genes make some people more likely to develop COPD, a serious long-term lung disease. Participants are having their lung function tested and getting chest CT scans. The goal is to understand why some smokers get …

This study was designed to see if a short-term protein-calorie restriction diet before elective vein graft surgery is practical and how it affects the body. It planned to enroll adults scheduled for non-emergency lower extremity vein bypass surgery. However, the trial was withdra…

This study aims to find out how often a blood clotting disorder called thrombophilia is the cause of recurrent pregnancy loss. Researchers will review the medical records of 1,000 women aged 18-40 who have had two or more miscarriages. The goal is to improve awareness and help do…