Brigham And Women's Hospital

This study aims to see which of three newer diabetes medications (dulaglutide, semaglutide, and tirzepatide) works best to prevent serious heart problems like heart attacks and strokes in people with type 2 diabetes and overweight. It will analyze health insurance records from 60…

This study analyzes existing health insurance records to compare two common type 2 diabetes medications, oral semaglutide and sitagliptin. It aims to see which drug is more effective at preventing serious heart failure complications, like hospitalization, in people who have both …

This trial is testing whether a new combination of four drugs taken for 12 weeks can work as well as the standard 26-week treatment for drug-susceptible tuberculosis. It will involve 94 adults with active lung TB, some of whom also have HIV. The main goal is to see if the shorter…

This study tested whether having a personal health coach helps people with early memory concerns or at risk for them stick to recommended lifestyle changes. For 6 months, some participants worked with a coach on goals like diet and exercise, while others received standard doctor …

This study is testing whether the medication dupilumab can help control severe allergic contact dermatitis in people who haven't improved with standard treatments like avoiding allergens and using creams. Seventeen adult participants with confirmed, persistent skin reactions rece…

This study is testing whether the medication dupilumab can help people with aspirin-exacerbated respiratory disease, a condition that causes severe asthma, nasal polyps, and loss of smell. Seventeen participants will receive four doses of the medication over eight weeks. Research…

This study is testing whether patients who need rehab after a hospital stay can recover just as well, or better, at home instead of in a traditional nursing facility. About 300 eligible patients will be randomly assigned to receive care from a tech-enabled medical team in their o…

This study compares two diabetes medications, tirzepatide and semaglutide, to see which works better at preventing heart failure hospitalizations and death in people who have both type 2 diabetes and a specific type of heart failure. Researchers will follow 26,000 patients using …

This study is testing if a quarterly injection called fremanezumab can help prevent migraines that occur around a woman's menstrual period. It involves 72 women aged 18-45 who experience these menstrual migraines. Participants will receive either the real medicine or a placebo in…

This study is testing whether taking a daily magnesium supplement for 12 weeks can help lower blood pressure in adults with elevated readings. Researchers are enrolling 120 participants who will be randomly assigned to take either magnesium or a placebo pill. The main goal is to …

This study aimed to see if a 4-day low-calorie, low-protein 'shake' diet before leg bypass surgery could help prevent vein grafts from failing. Researchers wanted to test if patients could follow this diet at home and if it boosted the body's natural production of hydrogen sulfid…

This study aimed to see if a new drug called ION-682884 could slow or stop the progression of a serious heart condition called TTR amyloid cardiomyopathy. It was designed for a small group of older patients (65-85 years old) who had already completed a 24-month study with a simil…

This study is testing whether a community program called Potlako+ can help people with possible cancer symptoms get diagnosed and treated faster. The program involves educating communities about cancer warning signs and providing patient navigators to guide people through the hea…

This study is testing a new, lower-dose treatment for serious blood clots in the lungs (pulmonary embolism). Doctors use a special catheter with ultrasound to deliver a clot-busting drug directly to the clots. The goal is to clear the clots and help the heart recover while trying…

This large study uses real-world insurance data to compare two weekly injectable diabetes medications, tirzepatide and dulaglutide. It aims to see which drug is better at preventing major heart problems like heart attacks and strokes in people who have both type 2 diabetes and es…

This study is testing a new, fully implanted system designed to give people with below-knee amputations more natural and intuitive control over a robotic prosthetic leg. Up to seven participants will have small magnetic beads and electrodes surgically placed in their residual lim…

This study is testing whether a medication chosen based on a specific gene works better than a standard blood pressure drug for Black patients with high blood pressure. About 300 participants with a particular genetic marker will take either the gene-targeted drug or the standard…

This study is testing whether specific dietary habit interventions can help people lose more weight and keep it off after having sleeve gastrectomy surgery. It involves 44 patients who have already had this type of bariatric surgery. Researchers are measuring changes in hunger, c…

This large observational study aims to compare the real-world effectiveness and safety of four common second-line type 2 diabetes medications. It will look at how well they prevent heart attacks, strokes, heart failure, and kidney problems in over 780,000 patients. The goal is to…

This early-stage study is testing whether carefully controlled, low doses of inhaled carbon monoxide can be safely given to patients with severe lung failure caused by infections like sepsis or pneumonia. Researchers want to see if a personalized dosing method can reliably reach …

This study is testing whether a community health worker program can improve early childhood development in rural India and Guatemala. The program teaches caregivers how to provide better nurturing care through home visits. Researchers will measure if children's language, motor, a…

This large study compares two fast-acting treatments—electroconvulsive therapy (ECT) and intravenous ketamine—for people experiencing severe suicidal depression. Researchers want to see which treatment works better at quickly reducing suicidal thoughts in 1,500 adults aged 18-90.…

This study aimed to see if an experimental gene therapy called VM202 could safely help people with painful diabetic nerve damage reduce their use of opioid painkillers. It planned to enroll adults who were already taking stable, high doses of opioids for this pain. The main goal …

This study compares two common treatments for people with knee arthritis and a torn meniscus (a piece of cartilage in the knee). Researchers want to know if surgery or a structured physical therapy program works better to improve knee function and reduce pain. About 350 adults wi…

This study tests whether a computer alert system helps doctors prescribe the right cholesterol medications for patients with heart disease. It involves 400 patients at Brigham and Women's Hospital, with half receiving alerts when their cholesterol is too high and half not. The go…

This study is testing two different approaches to help doctors and patients use cholesterol-lowering medications more effectively. It involves about 300 adults with or at high risk of heart artery disease. The goal is to see whether directly notifying doctors or having pharmacist…

This study is testing whether a minimally invasive stomach-shrinking procedure can treat advanced fatty liver disease (NASH) in people with obesity. Researchers will perform the endoscopic sleeve gastroplasty procedure on 20 participants and measure changes in liver scarring, fat…

This early-stage study is testing a new oral treatment called CP101, which contains specific gut bacteria, in people with mild-to-moderate ulcerative colitis. The main goals are to see if the treatment safely establishes itself in the gut and if it helps control the disease. Abou…

This study is testing if a new hormone drug called darolutamide, when given with radiation therapy, works as well as standard hormone therapy for men with intermediate-risk prostate cancer. A key goal is to see if this new combination can control the cancer while causing fewer si…

This study is testing whether adding pistachios to the diet for six months can improve thinking skills, heart health, and overall life satisfaction in older adults. About 100 participants aged 65 to 80 will eat pistachios as part of their regular diet. Researchers will track chan…

This study is testing a smartphone app designed to help people with psoriatic arthritis. The app lets patients regularly report their symptoms, which are sent directly to their doctor's electronic health record. Researchers want to see if using this app helps schedule doctor visi…

This study is testing different ways to help people with inflammatory arthritis who face life challenges like unstable housing or transportation issues that make it hard to get medical care. It compares three levels of support: a simple resource list, help from a community specia…

This study is testing a new finger-clip device that measures lactate levels without needing blood draws. Lactate is a key marker that helps doctors monitor sepsis, a serious infection. Researchers are comparing the device's readings against standard blood tests in healthy volunte…

This study is testing a new type of PET scan to see if it can more accurately determine how far muscle-invasive bladder cancer has spread compared to standard CT or MRI scans. Researchers will enroll 16 participants who are scheduled for bladder removal surgery. The goal is to se…

This study is testing whether replacing sugary drinks like soda with diet drinks or water can help people with overweight or obesity lose weight and improve health. Researchers enrolled 460 adults who regularly drink sugary beverages and assigned them to either keep drinking them…

This study is testing if a gentle, non-invasive light therapy called photobiomodulation can prevent severe mouth sores in patients undergoing a stem cell transplant. It compares three ways to deliver the light: inside the mouth, outside on the cheeks, or a combination of both. Th…

This study aims to see if daily cranberry capsules work as well as the antibiotic nitrofurantoin at preventing urinary tract infections (UTIs) after pelvic surgery. It involves 142 women who need a catheter after surgery for pelvic organ prolapse or incontinence. Participants are…

This study aims to test a school-based program designed to increase the number of children who start and finish the HPV vaccine series in South Africa. It will involve about 600 fifth-grade students, their parents, and school staff. The goal is to prevent future HPV-related cance…

This large study is checking if taking daily vitamin D or fish oil supplements can prevent atrial fibrillation, a common irregular heartbeat, in healthy adults. It's part of a major trial involving over 25,000 people without prior heart disease. Researchers are tracking participa…

This study is testing whether a drug called deferoxamine can prevent kidney injury in patients having heart surgery with a heart-lung bypass machine. The trial involves 320 adults at higher risk for this complication, who will receive either the drug or a placebo before and durin…

This study is checking whether taking daily vitamin D or fish oil supplements can prevent anemia in older adults. It's part of a larger trial involving 2,000 participants who don't have anemia when they start. Researchers will track who develops anemia over time and measure blood…

This large study aimed to find out if taking daily vitamin D or fish oil (omega-3) supplements could help prevent cancer, heart attacks, and strokes in healthy people. Over 25,000 older U.S. adults without prior cancer or heart disease were randomly assigned to take either the re…

This large study is checking if taking daily vitamin D or fish oil (omega-3) supplements can help prevent high blood pressure in healthy adults. It involves over 25,000 U.S. men and women without a history of high blood pressure. Researchers will track participants for two years …

This study is checking if taking a daily cocoa extract supplement or a standard multivitamin can help prevent falls and keep older adults more mobile. It involves over 21,000 men aged 60+ and women aged 65+ who are already in a larger heart and cancer study. Researchers want to s…

This study is checking if taking daily vitamin D or fish oil (omega-3) supplements can help prevent common infections in generally healthy adults. It involves over 25,000 people who are already part of a larger health study. Researchers will track how often participants get sick …

This study aimed to test a medication called BXCL501, a small dissolving film placed under the tongue, for quickly calming severe agitation in adults with bipolar disorder or schizophrenia arriving at the emergency department. The goal was to see how well and safely it worked in …

This study aimed to see if a special nerve block could reduce pain and the need for strong opioid painkillers after open-heart surgery. It planned to compare a numbing medicine to a harmless saltwater solution in patients recovering from surgery. The trial was withdrawn before an…

This study is testing whether a testosterone gel can help reduce pain and improve daily life for women over 60 who have chronic back pain and are using opioid painkillers. Researchers will compare the gel to a placebo (inactive substance) over three months to see if it helps with…

This study is testing whether adding activity trackers, phone coaching, and financial rewards to standard recovery care can help people become more physically active after knee replacement surgery. Researchers enrolled 600 adults who had knee replacement for arthritis and randoml…

This study is testing whether a phone-based mental wellness program can help caregivers of bone marrow transplant patients feel better. The program teaches positive thinking skills to reduce stress, anxiety, and depression. Researchers will compare the program's effects to regula…

This study aims to find out if a 12-week program of exercises done at home is as effective as going to a physical therapy clinic for treating new, non-insertional Achilles tendon pain. It will involve 56 adults who have had pain for at least 6 weeks. Participants will be randomly…

This study is testing a smartphone app called Stellar Sleep, which provides a digital version of a proven talk therapy for insomnia. The goal is to see if using this app helps people with insomnia sleep better. The app is designed to be more accessible and affordable than traditi…

This study is testing whether personalized care plans that acknowledge a patient's past trauma can improve their healthcare experience. It involves 200 adults with complex health needs who have frequent medical appointments. Researchers want to see if these plans help patients fe…

This small pilot study is testing whether a smartphone app that delivers therapy, with some coach support, is a helpful and practical way for adults with psoriasis to manage co-occurring depression symptoms. All 30 participants will try the 8-week program. The main goals are to s…

This study aims to understand how a hormone called aldosterone changes over time in people at risk for developing high blood pressure. Researchers will follow 100 adults with borderline blood pressure and other risk factors, measuring their hormone levels and blood pressure repea…

This study aims to find simple, inexpensive markers—like those from blood tests or heart tracings (ECGs)—that can specifically predict which heart disease patients are at highest risk for sudden cardiac death. It is following over 5,700 people with a history of heart attack or mi…

This study aims to understand how often a blood clotting disorder called thrombophilia is the cause of recurrent pregnancy loss (repeated miscarriages). Researchers will look at the medical records of 1,000 women who have experienced multiple miscarriages to see how common the di…

This study is testing whether a structured conversation between emergency room doctors and seriously ill older patients (or their family members) can improve decision-making about starting intensive care. The goal is to see if this 'Time-Limited Trial' conversation is practical f…

This study aims to understand how lithium, a common treatment for bipolar disorder, changes the brain's wiring and activity. Researchers will use MRI brain scans on about 120 people with bipolar depression and healthy volunteers over 26 weeks to see how brain connections shift wi…

This study aims to understand how the brains of very premature babies grow and develop injuries during their time in the neonatal intensive care unit (NICU). Researchers will use a special, safe MRI scanner inside the NICU to take brain pictures of 75 infants approximately every …

This study aims to see if analyzing existing health insurance records can produce results similar to a major clinical trial. Researchers are comparing the heart health outcomes of people with type 2 diabetes who took two different medications, dulaglutide and sitagliptin. The goa…

This study aims to understand why some people develop high blood pressure and heart disease by looking at how their genes and body respond to different amounts of salt. Researchers will enroll 120 adults with mild to moderate high blood pressure, temporarily adjust their medicati…

This study is testing whether artificial intelligence (AI) can help doctors more quickly and accurately outline the prostate gland on ultrasound images. This outlining is a key step in planning a precise, high-dose radiation treatment called brachytherapy. The study will compare …

This study aims to understand how sleep problems contribute to heart and metabolic diseases in rural Southern communities. Researchers will measure the sleep patterns of about 3,680 adults from rural Appalachia and the Mississippi Delta using wearable devices and questionnaires. …

This study is not testing a new treatment. Instead, researchers are using existing health records from thousands of breast cancer patients to see if real-world data can reliably answer the same questions as traditional clinical trials. They're recreating a completed trial that te…

This study aims to better understand preeclampsia, a serious blood pressure condition in pregnancy, by measuring how well the heart pumps blood. Researchers will use a special ultrasound on the heart (echocardiogram) to compare 80 pregnant people—some with untreated preeclampsia …

This study aimed to learn what doctors and patients thought about using a heated probe to seal the needle path after a biopsy of the liver, kidney, or spleen. The goal was to prevent bleeding, especially in patients at higher risk. The study was withdrawn before any participants …

This study aims to understand why some people's blood pressure is more affected by salt in their diet than others, especially looking at differences between African American and Caucasian individuals. Healthy volunteers will follow a low-salt diet for one week and a high-salt die…

This large, long-term study aims to discover why only some cigarette smokers develop Chronic Obstructive Pulmonary Disease (COPD), a serious lung condition. Researchers are following over 10,000 current and former smokers for 15 years to see if specific genes make some people mor…

This study aimed to understand parents' opinions about screening their healthy newborn's entire genetic code. Researchers planned to survey parents shortly after birth and again months later to see if their interest in this type of screening changed over time. The study was withd…

This study tests if educational visits to doctors change how often they prescribe lower-cost 'biosimilar' versions of a common drug (adalimumab/Humira) for autoimmune diseases. Researchers will compare doctors who receive the educational visit to those who do not, measuring chang…

This study aimed to see if a special type of heart MRI scan could identify people with type 2 diabetes who are at the highest risk for heart attacks or heart failure. Researchers planned to scan patients and then follow them for five years to see if the amount of scar tissue seen…

This study aims to understand why some new mothers start using birth control after having a baby while others do not. Researchers are following over 1,300 pregnant people to learn how their knowledge, attitudes, and life circumstances affect their family planning decisions. The g…

This large international study aims to understand and predict the future for young people at clinical high risk for psychosis. Researchers are collecting detailed information from nearly 2,000 at-risk participants and 640 healthy volunteers over two years to develop prediction to…

This study aims to understand why some people lose more weight than others after bariatric surgery. Researchers are comparing the daily eating habits of 44 patients who had good weight loss results with those who had poor results. The goal is to see if differences in hunger, appe…

This pilot study is testing whether watching virtual reality (VR) videos of patient encounters can help reduce weight-based bias in resident physicians. Researchers will compare VR videos showing clinical encounters to neutral educational videos to see if they change doctors' imp…

This study is testing a new digital platform designed to improve how patient information is shared when someone is transferred between different hospitals. The goal is to make sure doctors at the receiving hospital have all the necessary details to provide safe, continuous care. …

This study is testing whether a new type of syringe helps new anesthesia residents learn how to place labor epidurals more quickly and successfully. It will compare the new EpiFaith syringe, which has a spring-loaded indicator, to the standard syringe. The goal is to see if using…

This small, early-stage study is testing whether an oral supplement called MIB-626 can reach the brain and affect biological pathways related to aging in people with mild Alzheimer's disease. Researchers will measure the supplement's levels in spinal fluid and brain scans in 22 p…

This study aims to understand the relationship between vitamin K levels and bone health in older adults. It investigates whether having low vitamin K increases the risk of fractures and whether it changes how well vitamin D supplements work to improve bone density and strength. T…

This study aimed to develop a computer program that could predict how long patients would need to stay in home hospital care. Researchers used existing patient records to train the program, then tested it on different patient groups. The goal was to help hospitals better plan car…

This study is testing whether a non-invasive skin sensor can reliably monitor carbon dioxide (CO2) levels in newborns with brain injury who are receiving therapeutic cooling. The goal is to see if this continuous monitoring is practical and accurate compared to blood tests. Resea…

This study is testing whether a type of advanced scan called PSMA-PET can be used to monitor how well treatment is working for men with metastatic prostate cancer that responds to hormone therapy. Twenty participants will receive standard treatment and undergo two of these scans—…

This study is not testing a new treatment. Instead, researchers are analyzing existing electronic health records from about 770 patients with advanced lung cancer. They want to see if data from real-world medical practice can reliably reproduce the results of a previous major dru…

This study is not testing a new treatment. Instead, researchers are using existing electronic health records from over 800 lung cancer patients to see if they can accurately recreate the results of two past clinical trials. The goal is to understand when and how real-world patien…

This study is observing 1600 people with rheumatoid arthritis over many years to learn more about the disease. Researchers are collecting health information and blood samples to try to find markers that can predict how severe the arthritis will get and how well treatments will wo…

This study aimed to understand how the drug alemtuzumab affects brain inflammation in people with relapsing-remitting multiple sclerosis (MS). Researchers planned to use a special type of brain scan (PET) to measure inflammation before and after treatment. The goal was to learn i…

This study aims to discover the biological reasons behind conditions like POTS and dysautonomia, which can occur after viral infections including COVID-19. Researchers will compare blood samples from 100 women with these conditions to samples from healthy people. The goal is to f…

This study is testing whether a new educational discussion guide helps new mothers who had high blood pressure during pregnancy. Researchers are comparing two groups of 150 postpartum patients: one receives the guide right away, and the other receives it later. The main goal is t…

This study aims to understand how different types of environmental stimulation affect brain health and thinking skills in older adults. Researchers are enrolling 72 healthy participants aged 65 and older to measure changes in memory, attention, and brain function. The goal is to …

This study is testing whether a special type of PET scan can show early signs that a drug called rapamycin is working in patients with a rare lung disease called LAM. Researchers want to see if the scan can detect changes in tumor metabolism before other tests show improvement. A…

This study looks at whether patients who have a small thyroid lump found by chance during a PET scan need a follow-up ultrasound. Researchers are comparing the long-term survival rates of 5,000 people who got an ultrasound within 3 months to those who did not. The goal is to see …