Brigham And Women's Hospital

This study compares two diabetes medications, oral semaglutide and sitagliptin, in over 25,000 adults with type 2 diabetes and heart failure with preserved ejection fraction. The goal is to see which drug better prevents heart failure worsening, hospitalizations, or death. Resear…

This study tests whether electronic alerts in medical records help doctors prescribe stronger cholesterol-lowering medications for heart disease patients with high LDL levels. About 400 adults with heart or blood vessel disease and LDL over 80 mg/dL, already on a statin, are rand…

This early study tests CP101, a capsule containing beneficial gut bacteria, in 30 adults with mild-to-moderate ulcerative colitis. The goal is to see if the bacteria can safely take hold in the gut and help control the disease. Participants receive either a short or extended cour…

This study looks at whether a treatment tailored to a specific gene (LSD1) can better control high blood pressure and protect the kidneys in Black adults who carry a certain risk version of that gene. About 300 participants will follow a controlled diet and have their blood press…

This study tests a new magnetic bead tracking system that works with a bionic leg implant to help people with below-knee amputation control their prosthetic limb more naturally. Up to 7 participants will receive the implant and be followed for about 2 years. The goal is to see if…

This study looks at whether replacing sugary drinks with calorie-free alternatives helps adults with overweight or obesity lose weight. About 460 people who regularly drink sugary beverages will be assigned to one of four drink groups for six months. Researchers will track weight…

This study tests a new way to treat pulmonary embolism (blood clots in the lungs) using a low dose of clot-busting medicine delivered through a thin tube guided by ultrasound. About 60 adults with moderate to severe clots will receive this treatment to see if it safely improves b…

This study compares a new hormone therapy (darolutamide) plus radiation against standard hormone therapy plus radiation for men with intermediate-risk prostate cancer. The goal is to see if the new approach works just as well at controlling the cancer while also helping men keep …

This study looks at different methods to help people with high cholesterol and heart disease get their LDL ("bad") cholesterol to recommended levels. About 300 adults with or at high risk for artery disease will take part. Researchers will compare approaches to improve use of cho…

This study looks at how the drug dupilumab helps people with aspirin-exacerbated respiratory disease (AERD), a condition that includes asthma, nasal polyps, and reactions to aspirin. Seventeen adults with AERD and impaired smell will receive dupilumab for 8 weeks. Researchers wil…

This study tests an experimental drug called ION-682884 in people with a rare heart condition caused by abnormal protein deposits (TTR amyloidosis). The drug is designed to lower the production of this protein in the liver, potentially slowing or stopping heart damage. Only patie…

This study compares two popular diabetes medications, tirzepatide and semaglutide, in 26,000 adults with type 2 diabetes and a specific type of heart failure (preserved ejection fraction). The goal is to see which drug better reduces the risk of hospitalization for heart failure …

This study tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) works better than the standard 6-month treatment for drug-susceptible tuberculosis. About 94 adults with active TB in the lungs will be randomly assigned to either…

This study tests whether using MRI during brachytherapy (a type of internal radiation) can help doctors deliver treatment more accurately for gynecologic cancer. About 49 participants will receive standard brachytherapy, some with an MRI tracker to guide the procedure. The goal i…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at higher risk of coming back after radiation alone. About 134 adults with cancers like melanoma, lung, breast, or colorectal cance…

This study tests whether a non-surgical stomach reduction procedure, called endoscopic sleeve gastroplasty (ESG), can improve liver health in people with obesity and advanced NASH (a severe form of fatty liver disease). Researchers will measure changes in liver function and press…

This study compares two rapid treatments—electroconvulsive therapy (ECT) and ketamine—for adults with severe suicidal depression. Researchers will enroll 1,500 people aged 18 to 90 to see which approach works better and faster. The goal is to quickly reduce suicidal thoughts and …

This study tests a new finger-clasp device, similar to a pulse oximeter, that measures lactate levels from skin fluid instead of blood. Lactate is a key marker for sepsis, a life-threatening infection. The goal is to see if the device works as well as standard blood tests in 6 he…

This study tests a school-based program to help children in South Africa get the HPV vaccine, which prevents cancers caused by HPV. About 600 fifth graders (ages 9-12) and their parents will take part. The program uses communication strategies to encourage vaccine uptake and comp…

This study looks at whether taking cocoa extract or a daily multivitamin can help older adults prevent falls and maintain physical strength. Over 21,000 men and women aged 60 and older are taking part. The goal is to see if these simple supplements can reduce injuries and keep pe…

This study looks at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent high blood pressure in healthy adults. Over 25,000 men and women across the U.S. who have never had high blood pressure are taking part. Researchers will measure changes in bloo…

This study tests whether a medicine called deferoxamine can prevent acute kidney injury in adults having heart surgery. The drug works by removing extra iron from the blood, which may protect the kidneys. About 320 participants will receive either the drug or a placebo before sur…

This study tests if a special light treatment (photobiomodulation) can prevent severe mouth sores in people getting a stem cell transplant. About 78 patients will be split into three groups: light inside the mouth, light outside the mouth, or both. They will receive daily light t…

This study compares cranberry tablets to the antibiotic nitrofurantoin for preventing urinary tract infections (UTIs) after pelvic surgery in women. About 142 women having surgery for pelvic organ prolapse or urinary incontinence will take either cranberry capsules or nitrofurant…

This large study tested whether taking daily vitamin D and omega-3 (fish oil) supplements could lower the risk of developing cancer, heart disease, or stroke in healthy older adults. Over 25,000 men and women aged 50+ took the supplements for about 5 years. The goal was to see if…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the chance of developing atrial fibrillation (a type of irregular heartbeat) in healthy people. Over 25,000 men and women without prior heart disease or stroke took part. Researchers are checking…

This study aimed to see if a sublingual film of dexmedetomidine (BXCL501) could quickly reduce agitation in adults with bipolar disorder or schizophrenia visiting the emergency department. It was a single-arm pilot study, but it was withdrawn before enrolling any participants. No…

This study looks at two common treatments for people who have both a torn meniscus and knee arthritis: surgery to remove part of the torn cartilage, or physical therapy without surgery. Researchers want to see which approach works better for improving knee function and reducing p…

This study tests whether taking 480 mg of magnesium glycinate daily for 12 weeks can lower blood pressure in adults with slightly high systolic blood pressure (125-159 mmHg). About 120 participants will take the supplement and have their blood pressure and magnesium levels checke…

This study tests if a medicine called fremanezumab can reduce migraines that happen around a woman's period. Women aged 18 to 45 with menstrual migraines will get either the medicine or a placebo injection every three months for six months. They will track their migraines in a di…

This study tests whether a trauma-informed care plan (TICP) helps patients with complex health needs feel less stress and more understood during medical visits. About 200 patients and their healthcare teams will use the plan, and researchers will measure how acceptable and helpfu…

This study aimed to see if injecting a numbing medicine (bupivacaine) near the chest muscles could lower pain and the need for strong painkillers after open-heart surgery. It planned to compare the numbing medicine against a saltwater placebo in about 100 adults. However, the stu…

This study looks at whether dupilumab can help people with allergic contact dermatitis, a skin reaction caused by contact with allergens. Seventeen adults with confirmed allergies will receive the drug and be monitored for skin clearance and symptom changes. The goal is to see if…

This study tests a program called PATH-C, which uses positive psychology exercises to improve well-being, quality of life, and physical activity in caregivers of people who have had a stem cell transplant for blood cancer. About 80 adult caregivers will take part. The goal is to …

This study looks at whether a home exercise program works as well as formal physical therapy for people with new Achilles tendon pain. About 56 adults with symptoms for at least 6 weeks will be randomly assigned to one of two 12-week programs. Researchers will track pain, functio…

This early-phase study tests whether low doses of inhaled carbon monoxide can be safely given to adults with severe lung injury caused by sepsis or pneumonia. The main goal is to check safety and see if a personalized dosing formula works. Only 5 participants are enrolled, so res…

This study tests a new smartphone app called Stellar Sleep that helps people with insomnia improve their sleep using cognitive behavioral therapy. The app is designed to be easy to use and can automatically track sleep data from wearable devices like FitBits. 60 adults with insom…

This study looks at whether people who need skilled nursing care after a hospital stay can recover just as well at home as in a nursing facility. About 300 adults will either receive care from a technology-enabled team in their own homes or go to a traditional skilled nursing fac…

This study aimed to see if a gene therapy called VM202 could help people with painful diabetic neuropathy reduce or stop taking opioid painkillers. It planned to enroll adults with diabetes who were already taking daily opioids. The trial was withdrawn before any participants wer…

This study looks at whether taking vitamin D and omega-3 supplements can reduce the risk of infections like colds, flu, and urinary tract infections in healthy adults. It involves over 25,000 participants from a larger heart and cancer prevention trial. Researchers will also meas…

This early-phase study tests a special PET scan agent (18F-fluciclovine) to see if it can more accurately show how far muscle-invasive bladder cancer has spread compared to standard CT or MRI scans. Sixteen adults with bladder cancer scheduled for bladder removal surgery will rec…

This study looks at how lithium, a common treatment for bipolar disorder, changes the brain's wiring. Researchers will use MRI scans to track brain connections in 120 people with bipolar depression over 26 weeks. The goal is to understand why lithium works, not to test a new trea…

This study looks at whether an educational discussion tool helps postpartum patients who had high blood pressure during pregnancy become more involved in their own care. About 150 new mothers will either receive the tool shortly after delivery or not, and researchers will compare…

This study looks at how changing eating habits can help people lose more weight after bariatric surgery. Researchers will track hunger, calorie intake, and energy use in 44 patients who had sleeve gastrectomy. The goal is to find better ways to support long-term weight loss after…

This study was designed to see if a 4-day low-protein, low-calorie diet before elective vein bypass surgery is practical for patients to follow at home. It also aimed to measure changes in the body's stress and healing signals. The study was withdrawn before enrolling any partici…

This early-stage study tests whether a daily pill called MIB-626 can enter the brain and affect aging-related pathways in people with mild Alzheimer's disease. Researchers will measure the drug and its byproducts in spinal fluid and use advanced brain scans to see if it boosts NA…

This study looks at medical records from over 800 people with advanced lung cancer to see if they can recreate the results of two earlier clinical trials. The goal is not to test a new treatment, but to learn whether real-world data can be trusted for future research. Participant…

This study tracks how well treatment is working in men with metastatic hormone-sensitive prostate cancer using special PET scans (PSMA-PET). Twenty participants will get a scan before starting standard therapy and another after 6 months. The goal is to see if these scans can help…

This study aims to measure oxygen levels inside cervical cancer tumors during a standard treatment called brachytherapy. About 10 adults with cervical cancer will have a tiny sensor placed in their tumor to record oxygen. The goal is to learn how oxygen levels relate to treatment…

This study looks at how eating habits after bariatric surgery affect weight loss. Researchers will compare people who lost a lot of weight with those who lost less, measuring hunger, appetite, and related hormones. The goal is to understand why some people have better results tha…

This study looks at medical records from 60,000 people with type 2 diabetes and obesity to compare three drugs (dulaglutide, semaglutide, tirzepatide) against an older drug (sitagliptin) for preventing heart attacks, strokes, and death. The goal is to see which drug works best in…

This study planned to use a computer program (machine learning) and a simple heart test (single-lead ECG) to predict potassium levels in the blood of hospitalized patients. Researchers would have analyzed data from a previous study at Brigham and Women's Hospital. However, the st…

This study aimed to see if a computer program could predict how long patients would stay in a home hospital. Researchers planned to use information from past patients to train the computer model. However, the study was withdrawn before any participants were enrolled.

This study aims to understand what causes POTS and dysautonomia, especially after COVID-19. Researchers will collect blood samples from 100 women (including those with POTS, Long COVID, and healthy volunteers) to analyze immune system markers. The goal is to find biological clues…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the chance of developing anemia in older adults. Researchers will track 2000 participants from a larger heart health study over 2 years, checking for new anemia cases and changes in blood protein…

This study tests whether a smartphone app can help people with psoriatic arthritis manage their condition with fewer in-person visits. About 278 adults who already use certain arthritis medications will use the app to report symptoms. Researchers will check if the app reduces how…

This study looks at how a specific gene (Caveolin-1) and salt intake affect blood vessel function in people with high blood pressure. About 120 adults with mild to moderate hypertension will follow low- and high-salt diets while researchers measure heart and blood vessel response…

This study looks at health insurance claims from about 30,000 people with type 2 diabetes to see if they can get the same results as a famous clinical trial called REWIND. The goal is not to test a new drug, but to learn whether real-world data can be trusted to answer important …

This study looks at 5000 people who had a thyroid nodule found on a PET-CT scan. It compares survival rates between those who had a follow-up thyroid ultrasound within 3 months and those who did not. The goal is to see if skipping the ultrasound leads to worse survival over 7 yea…

This study aimed to test a new system that adds tiny, edible silica particles to HIV pills. People living with HIV could use a smartphone app to scan the pills and automatically record when they take their medication. The goal was to see if the system is easy to use and accuratel…

This study follows over 5,700 people with coronary artery disease to find blood or ECG markers that could predict sudden cardiac death. The goal is to better identify who needs a defibrillator and who doesn't. Participants have had a heart attack or mild heart muscle weakness, bu…

This study looks at how vitamin K levels affect bone health in older adults who are already taking vitamin D. Researchers want to see if low vitamin K leads to more fractures or lower bone density. About 26,000 men and women aged 50+ are involved, and the goal is to understand th…

This study tests different ways to invite adults with diabetes to meet with a pharmacist for medication support. About 590 participants will receive different letters and phone call schedules to see which approach works best. The goal is to find a simple, repeatable method that c…

This study looks at whether a sticker-like sensor on the skin can accurately measure carbon dioxide levels in newborns with brain injury who are receiving cooling treatment. About 53 babies will take part. The goal is to see if this non-invasive method works as well as standard b…

This study looks at how different types of stimulating activities might improve thinking skills in healthy adults over 65. Researchers will measure memory, attention, and problem-solving using computer tests. The goal is to understand if the brain can stay flexible and adapt even…

This study looks at whether adding pistachios to the daily diet for 6 months can improve memory, thinking speed, and heart health in adults aged 65 to 80. About 97 participants will eat pistachios and take tests on thinking, blood pressure, and life satisfaction. The goal is to s…

This study aims to measure how well the heart pumps blood in people with untreated preeclampsia compared to healthy pregnant women. Researchers will use an ultrasound of the heart (echocardiography) to check heart function at rest and after treatment. The study involves 80 partic…

This study aimed to survey parents of healthy newborns about their interest in genome screening. Researchers planned to ask parents questions shortly after birth and again months later to see if opinions changed. The study was withdrawn before enrolling any participants, so no re…

This pilot study tests whether watching virtual reality (VR) videos can reduce weight-based bias in doctors-in-training. About 52 resident physicians at Brigham and Women's Hospital will take bias tests before and after watching either a VR experience of patient encounters or a n…

This study looks at real-world data from over 780,000 people with type 2 diabetes to compare four common second-line medications: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which ones are safest and most effective at prevent…

This study was designed to see if the drug alemtuzumab reduces activity of certain brain immune cells (microglia) in people with relapsing-remitting multiple sclerosis. Researchers planned to use special PET scans to measure changes over 18 months. However, the study was withdraw…

This study tests whether artificial intelligence (AI) can help doctors outline the prostate on ultrasound images during a type of radiation treatment called brachytherapy for prostate cancer. Researchers will compare AI-assisted outlines to those done manually, measuring accuracy…

This study looked at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. About 95 participants with mild memory concerns or at risk for cognitive de…

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with cancer symptoms or at risk will take part. Half the communities get the prog…

This observational study is gathering data from over 2,600 young people (ages 12-30) who are at clinical high risk for psychosis. Researchers will use clinical assessments, cognitive tests, and biomarkers to develop algorithms that predict whether someone will recover, develop ps…

This study aimed to see if a special heart MRI can find hidden scar tissue in the hearts of people with type 2 diabetes. Researchers planned to follow participants for 5 years to see if the amount of scar tissue was linked to heart attacks or death. The study was withdrawn before…

This pilot study is testing whether adults with acute psychiatric conditions like psychosis, anxiety, or depression can safely receive hospital-level care at home instead of in a hospital. Researchers are enrolling 41 participants to see how many people are eligible and willing t…

This study tests a structured conversation between emergency doctors and seriously ill older adults (or their family members) to improve shared decision-making about intensive care. About 40 participants will be involved, and researchers will measure how long the conversation tak…

This study looks at whether information from real cancer patients' electronic health records can produce results similar to a past clinical trial (KEYNOTE-042) for advanced lung cancer. Researchers will analyze data from about 770 patients to see if real-world data can be trusted…

This study tests a new digital tool that helps hospitals share patient information more reliably when a person is transferred from one hospital to another. The goal is to reduce medical mistakes and improve safety. About 1,000 adults being transferred to a major hospital will tak…

This study looks back at 166 knee replacement patients who received a nerve block for surgery. Researchers want to see how much pain patients feel after the block wears off, and whether an educational intervention helps reduce that pain. The goal is to better understand and manag…

This study follows 100 adults aged 35-70 with mildly elevated blood pressure to see how a hormone called aldosterone changes over time. Researchers will measure blood pressure and hormone levels to learn more about how the body controls salt and blood pressure. The goal is to bet…

This study tests whether a special guide, called the International Guide for Monitoring Child Development (GMCD), helps improve language, motor, and thinking skills in young children. Researchers are working with community health workers in India and Guatemala to see how well the…

This study looks at how sleep problems like apnea, insomnia, and poor sleep quality are linked to heart disease and diabetes in rural areas of the southern U.S. About 3,680 adults already part of a larger health study will wear sleep trackers and answer questionnaires. The goal i…

This study looks at medical records from over 6,000 people with advanced breast cancer to see if researchers can get the same results as a past clinical trial (PALOMA-2) using only real-world data. The goal is to learn when and how to trust real-world data for future research. Pa…

This study looks at how eating salt changes the way our genes control blood pressure. Researchers will test 88 healthy adults aged 25-45 to see how their bodies respond to salt and a hormone called angiotensin II. The goal is to understand why some people are more salt-sensitive,…

This study involves 50 healthy adults to develop a more accurate way to stimulate brain networks using transcranial magnetic stimulation (TMS). Participants undergo an MRI scan to map brain connections, then receive different TMS sessions while performing a computer task. The goa…

This study looks at whether giving people with inflammatory arthritis extra support—like a list of local resources, help from a community specialist, or a nurse navigator—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have…

This study follows over 1,300 pregnant women to understand what influences their use of birth control after childbirth. Researchers want to learn how knowledge, attitudes, and practical barriers affect whether women can space their next pregnancy as they wish. The goal is to find…

This study aims to find out how often blood clotting disorders (thrombophilia) cause repeated pregnancy loss. Researchers will review the medical records of 1,000 women aged 18-40 who have had two or more miscarriages. The goal is to improve awareness and diagnosis so women can g…

This study tests whether offering doctors one-on-one educational meetings about biosimilar medications leads them to prescribe more biosimilars instead of the original brand-name drugs. About 1,325 clinicians who prescribe adalimumab will be randomly offered either an in-person o…

This study planned to test a technique that uses heat to seal the needle track after a liver, kidney, or spleen biopsy, aiming to reduce bleeding in patients at high risk. It was withdrawn before enrolling any participants. The goal was to see how well patients and doctors tolera…

This study looks at whether a special syringe called EpiFaith® helps anesthesia residents learn to place labor epidurals more quickly. Thirty-four residents with little experience will each perform 20 epidural placements using either the standard syringe or the EpiFaith® syringe.…

This study explores whether a special PET scan using [11C]acetate can detect early signs that the drug rapamycin is working in people with lymphangioleiomyomatosis (LAM), a rare lung disease. Seven adults with LAM and at least one kidney tumor will receive one or two PET scans ov…

This study uses repeated MRI scans to track brain injury and growth in very premature babies (born before 33 weeks) while they are in the NICU. Researchers aim to understand when and why brain injuries happen and how the brain grows, so they can better identify babies at risk and…

This study looks at whether using a wrist activity tracker, plus coaching and financial rewards, can help people become more physically active after total knee replacement surgery. About 600 adults aged 40-85 who are scheduled for knee replacement will be randomly assigned to usu…

This study aims to find out why some smokers develop chronic obstructive pulmonary disease (COPD) while others do not. Researchers are studying over 10,000 smokers and non-smokers to see if certain genes make some people more likely to get COPD. The study does not test any new tr…

This study follows about 1,600 adults with rheumatoid arthritis (RA) over time to learn which biological markers can predict how well a drug will work or cause side effects. Researchers also aim to identify markers that show how the disease will progress. Participants receive the…