Massive diabetes drug showdown: 780,000 patients reveal which pill protects heart and kidneys

NCT ID NCT05220917

First seen Jan 10, 2026 · Last updated May 13, 2026 · Updated 19 times

Summary

This study looks at real-world data from over 780,000 people with type 2 diabetes to compare four common second-line medications: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which ones are safest and most effective at preventing heart attacks, strokes, heart failure, and kidney problems. Researchers are not giving anyone new treatments—they are analyzing existing health records to find the best options.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02120, United States

Conditions

Explore the condition pages connected to this study.