One infusion, two targets: a uric-acid-lowering drug takes aim at heart and kidney disease in youth-onset diabetes
NCT ID NCT03899883
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This pilot trial tests whether a single infusion of pegloticase, a drug that breaks down uric acid, can improve markers of heart and kidney health in young men aged 18–25 with youth-onset type 2 diabetes. High uric acid is common in this group and linked to later complications. The study measures blood pressure, artery stiffness, kidney blood flow, and other indicators one week after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a single infusion of pegloticase (Krystexxa), a drug that breaks down uric acid
- What this could lead to
- If it works, this could point toward a new way to protect the heart and kidneys in young people with type 2 diabetes.
- What could go wrong
- This is a very small pilot study with only 10 participants and a single dose, so results may not apply broadly. The drug can cause allergic reactions and is not yet tested in this age group.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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