TYPE 2 DIABETES MELLITUS

This study tests an experimental drug called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The drug is given as a shot under the skin, either alone or combined with the existing weight-loss drug tirzepatide. The main goal is to check safety and how…

This study tests whether taking three cholesterol-lowering drugs together works better than taking two in people with type 2 diabetes and high LDL cholesterol. 126 adults aged 35-60 will be split into three groups: one gets rosuvastatin plus ezetimibe, another gets bempedoic acid…

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This early-phase study tests a new oral drug called GS-4571 in healthy people, non-diabetic obese individuals, and non-obese people with type 2 diabetes. The main goals are to see how the drug moves through the body, how safe it is, and how food or acid-reducing drugs affect it. …

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned…

This Phase 3 trial tests a new drug called KAI-9531, given as a weekly injection, in 1700 adults who are overweight or obese and have type 2 diabetes. The study compares KAI-9531 to a placebo to see if it leads to greater weight loss and better blood sugar control over 76 weeks. …

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study compares a continuous glucose monitor (CGM) to standard fingerstick testing in 270 adults with type 1 or type 2 diabetes who use insulin injections. Participants wear the Accu-Chek SmartGuide sensor to track blood sugar levels continuously. The goal is to see if the CG…

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This study is tracking 145 adults with type 2 diabetes in Argentina who are starting semaglutide (either as a pill or injection) as part of their normal care. Researchers will measure changes in blood sugar, weight, waist size, and grip strength over 12 months, along with how sat…

This study tests whether combining two experimental drugs, MET233 and MET097, can help adults with obesity or overweight lose weight, including those with type 2 diabetes. About 381 participants will receive either the drug combination or a placebo to check safety and how well th…

This study tests a new automatic insulin pump (Omnipod M) in 350 adults with type 2 diabetes who already use insulin. The pump adjusts insulin delivery on its own to keep blood sugar in a healthy range. The goal is to see if it improves blood sugar control and is safe to use.

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This study compares a new insulin pump system, Omnipod 6, to the current Omnipod 5 in 200 people with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a healthy range more effec…

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This study tests a new medicine called HM15275 in people with type 2 diabetes. The goal is to see if it can lower blood sugar levels (HbA1c) safely over 36 weeks. About 180 adults who manage their diabetes with diet, exercise, or metformin will take part. Half will get the drug, …

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests whether semaglutide, a diabetes drug, can help heal foot ulcers in people with type 2 diabetes. About 52 adults will receive either semaglutide or a placebo for 20 weeks. The main goal is to see if more ulcers heal completely with the drug. This is an early-phase…

This early study tests a device that uses radiofrequency energy to create vapor and ablate (remove) a small part of the upper intestine. The idea is that this might improve how the body handles sugar. The study will enroll 20 adults with type 2 diabetes to see if the procedure is…

This study is observing 300 adults with type 2 diabetes who are already taking luseogliflozin as part of their routine care. Researchers will track changes in blood sugar levels, body weight, and side effects over time. The goal is to see how well the drug works in real-world set…

This study tests whether a single daily dose of long-acting insulin can control blood sugar as well as the usual regimen of long-acting insulin plus mealtime insulin in pregnant women with diabetes. About 176 participants will be randomly assigned to one of the two approaches and…

This Phase 3 trial tests whether a cell therapy called REACT (rilparencel) can slow kidney decline in 685 adults with type 2 diabetes and chronic kidney disease. Participants receive either two injections of their own kidney cells or sham procedures. The study measures changes in…

This 5-year study tests whether dapagliflozin, a diabetes drug, can prevent serious liver complications in people with chronic hepatitis B and diabetes who already have early liver scarring. 412 participants will receive either dapagliflozin or a placebo daily. The goal is to see…

This study tests whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes. The health workers will lead group meetings, provide health education, and coordinate care with local clinics. About 398 adults with both c…

This Phase 1 study tests retatrutide, a new injectable drug, in 95 adults with type 2 diabetes who already take metformin. The goal is to see if retatrutide improves insulin sensitivity and beta-cell function better than placebo or semaglutide over 28 weeks. Participants will rec…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This early study tests a herbal effervescent tablet taken twice daily before meals in 14 adults with type 2 diabetes. The goal is to see if it safely helps lower blood sugar levels (HbA1c, fasting, and after meals). Participants include those managing diabetes with diet or supple…

This Phase 3 trial is testing a drug called Neovasculgen, given as injections into the leg muscles, to see if it can help heal foot ulcers in people with diabetes. The study will include 144 adults with type 1 or type 2 diabetes who have a non-healing foot ulcer. Participants wil…

This study looks at whether adding regular exercise (treadmill walking) to vitamin D supplements can improve erectile function in men with type 2 diabetes who also have low vitamin D. Forty men will take vitamin D every two weeks for 12 weeks; half will also walk three times a we…

This study tests whether newer diabetes drugs (SGLT2 inhibitors and DPP-4 inhibitors) can delay or prevent diabetic retinopathy, an eye disease that can lead to vision loss. Researchers will compare these newer drugs to older treatments in 70 people with type 2 diabetes. The goal…

This study tests whether sending text message reminders can help homeless people with uncontrolled type 2 diabetes better manage their condition. One hundred participants will receive SMS prompts for medications and appointments. The goal is to see if this simple approach lowers …

This study tests whether denosumab, a drug used for osteoporosis, can also improve muscle mass, strength, and insulin sensitivity in postmenopausal women with type 2 diabetes. About 40 women will receive either denosumab or a placebo for 12 months. The goal is to see if the drug …

This Phase 3 trial tests a new combination pill called Madalena association for people with type 2 diabetes whose blood sugar is not well controlled with two other diabetes drugs. About 270 adults will receive either the new combo pill, standard medications, or placebos to see wh…

This study tests a new insulin drug, GZR4, against another insulin (Insulin Icodec) in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and causes fewer side effects like low blood sugar. Participants may also…

This study tests whether giving low-income adults with type 2 diabetes vouchers for fruits and vegetables helps them attend diabetes education classes and improve their diet and blood sugar control. 120 participants will be split into three groups: usual care, vouchers alone, or …

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study tests whether an AI software can help doctors spot diabetic retinopathy (an eye disease caused by diabetes) earlier. About 340 adults with type 2 diabetes who have not been diagnosed with eye disease will be randomly assigned to get either standard care or standard car…

This study tests different strategies to prevent foot ulcers in people with type-2 diabetes. It includes 150 adults who are either at mild-to-moderate risk of developing a foot ulcer or have had one that healed at least 6 months ago. Researchers will check blood markers of inflam…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study looks at whether giving a carbohydrate drink before coronary artery bypass surgery can improve insulin sensitivity and recovery in people with type 2 diabetes. About 50 participants will be enrolled. The goal is to see if this simple step can reduce complications and s…

This study tests whether pregabalin, a drug used for nerve pain, can reduce chronic itching in people with type 2 diabetes. 46 adults will receive either pregabalin plus moisturizer or a placebo plus moisturizer for 12 weeks. Researchers will measure itching severity and quality …

This phase 4 trial tests whether itopride, a drug that helps move food through the stomach, can reduce the risk of aspiration during anesthesia in people taking semaglutide. Sixty diabetic patients scheduled for hysterectomy will receive itopride or a placebo for 7 days before su…

This study will follow 500 adults with chronic kidney disease and type 2 diabetes who are taking finerenone, a drug that helps protect the kidneys and heart. Researchers want to see if a tool called the Klinrisk score, which estimates the risk of kidney disease getting worse, imp…

This study is checking if the diabetes medicine exenatide (Byetta, Bydureon) increases the risk of pancreatic cancer. Researchers will look at health records from 24,000 patients across seven European countries, comparing those who started exenatide with those who started other d…

This observational study will follow 50,000 people in Asia and the United States who have chronic kidney disease and type 2 diabetes and are already taking finerenone as part of their regular care. Researchers will collect data from electronic health records and insurance claims …

This study watches 500 adults in South Korea who have chronic kidney disease and type 2 diabetes and are taking finerenone as part of their normal care. Researchers will collect information from medical records and doctor visits over up to 12 months to see why doctors prescribe i…

This study looks at how social factors and health literacy affect the ability of people with diabetes to manage their own care. Researchers will survey 400 adults with type 1 or type 2 diabetes to understand these connections. The goal is to design better support programs that he…

This study is testing whether wearable devices like continuous glucose monitors and smart bracelets, combined with smartphone apps, can help predict and prevent complications in people with type 2 diabetes. Researchers will enroll 6,000 adults and follow them for 3 months, using …

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This study looks at how semaglutide, a drug used for diabetes and weight loss, changes fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers will compare patients taking semaglutide to those not taking it. The goal …

This study looks at whether the standard A1C blood sugar test works correctly in people with a Left Ventricular Assist Device (LVAD), a type of heart pump. Researchers will compare A1C results with continuous glucose monitor (CGM) readings over 3 months in 20 adults with type 2 d…

This study tests whether a machine learning program can detect lipohypertrophy—hidden lumps under the skin caused by insulin injections—using portable ultrasound. About 100 people with diabetes will first have their injection sites scanned. In a second phase, 40 people found to h…

This study looks at how a drug called diazoxide, which activates certain brain centers, can change how much sugar the liver makes. People with type 2 diabetes often have livers that produce too much sugar, leading to high blood sugar. The study will involve 100 participants (both…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study follows over 500 adults with type 2 diabetes who had a heart CT scan years ago. Researchers will repeat the scan to see how plaque builds up in heart arteries over time and identify factors that increase risk. The goal is to better understand heart disease in diabetes,…

This study looks at whether two common diabetes drug combinations (SGLT2 inhibitors plus metformin vs. DPP-4 inhibitors plus metformin) affect memory and depression risk in older adults with type 2 diabetes. Researchers will track 300 participants over time using memory tests and…

This early-phase study tests a new MRI method that uses a special injection called hyperpolarized pyruvate to see how the heart uses energy. Researchers will scan the hearts of up to 112 people with high blood pressure, heart thickening, or heart failure. The goal is to see if th…

This study looks at whether the texture of the carotid artery wall, seen on an ultrasound, can help predict the risk of heart problems in people with type 2 diabetes. Researchers will compare 80 adults with diabetes to healthy controls, measuring artery thickness and texture patt…

This study looks at how heart rate affects metabolism in people with heart failure and diabetes. Researchers will take small samples of fat, muscle, and blood during pacemaker surgery to understand the link. The goal is to find new ways to treat heart failure by targeting metabol…

This study is translating and testing an Arabic version of a survey that measures quality of life in people with type 2 diabetes who have nerve damage or foot ulcers. Researchers will enroll 290 Arabic-speaking adults to ensure the translated survey is accurate, reliable, and cul…

This study looks at how a person's genes influence their response to GLP-1 RA drugs (like exenatide and liraglutide) for type 2 diabetes. Researchers will analyze blood samples from 300 patients to find genetic markers that predict whether the drug lowers blood sugar and weight. …

This study will follow 9,000 people with type 2 diabetes and high blood pressure who are already taking dapagliflozin. Researchers want to see how well the drug controls blood sugar and blood pressure in real-life settings. It is an observational study, meaning no new treatment i…