New weekly shot could help obese diabetics shed pounds and control blood sugar

NCT ID NCT07351058

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive either the drug or a placebo for 72 weeks to see how much weight they lose and how their diabetes improves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Enicepatide (a weekly injection that mimics natural hormones to help control appetite and blood sugar)

What this could lead to

If it works, this could offer a new weekly injection option for significant weight loss and better blood sugar control in people with obesity and type 2 diabetes.

What could go wrong

This is a large Phase 3 trial, but the drug is still experimental. It may cause side effects like nausea or vomiting, and not everyone may achieve meaningful weight loss. Results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OR OVERWEIGHT TYPE 2 DIABETES MELLITUS

Contacts and locations

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Study contacts

Contact
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O. Universitaria Policlinico S.Orsola-Malpighi Di Bologna
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Aberdeen Royal Infirmary
RECRUITING

Aberdeen, AB9 2ZB, United Kingdom
Akdeniz University Medical Faculty
RECRUITING

Antalya, 07059, Turkey (Türkiye)
Antrim Area Hospital
RECRUITING

Antrim, BT41 2RL, United Kingdom
Arizona Clinical Trials
RECRUITING

Tucson, Arizona, 85711, United States
Ark Clinical Research
RECRUITING

Long Beach, California, 90815, United States
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, Sicily, 90127, Italy
Baker Heart and Diabetes Insitute
RECRUITING

Melbourne, Victoria, 3004, Australia
Beijing Pinggu Hospital
RECRUITING

Beijing, 101200, China
CEDIC Centro de Investigaciones Clinicas
RECRUITING

Buenos Aires, C1060ABN, Argentina
CHU de Nice
RECRUITING

Nice, 06602, France
CINME
RECRUITING

Buenos Aires, C1056ABI, Argentina
Catalina Research Institute, LLC
RECRUITING

Montclair, California, 91763, United States
Centennial Medical Group
RECRUITING

Columbia, Maryland, 21045-5840, United States
Center for Diabetes, Obesity and Metabolism Inc
RECRUITING

Pembroke Pines, Florida, 33024, United States
Centricity Research Brampton Endocrinology
RECRUITING

Brampton, Ontario, L6S 0C6, Canada
Centricity Research Calgary Endocrinology
RECRUITING

Calgary, Alberta, T2H 2G4, Canada
Centricity Research Columbus Georgia Multispecialty
RECRUITING

Columbus, Georgia, 31904, United States
Centricity Research Morehead City Multispeciality
RECRUITING

Morehead City, North Carolina, 28557, United States
Centricity Research Suffolk Primary Care
RECRUITING

Suffolk, Virginia, 23435, United States
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
RECRUITING

Ciudad Autonoma Buenos Aires, C1425AGC, Argentina
Centro Medico Teknon
RECRUITING

Barcelona, 08022, Spain
Centro Medico Viamonte SRL
RECRUITING

Buenos Aires, C1120AAC, Argentina
Centro de Investigaciones Medicas Mar Del Plata
RECRUITING

Mar del Plata, B7600FYK, Argentina
Centrum Medyczne INTERCOR Sp. z o.o.
RECRUITING

Bydgoszcz, 85-605, Poland
Centrum Medyczne OMEDICA
RECRUITING

Poznan, 60-111, Poland
Changhua Christian Hospital
RECRUITING

Changhua, 50006, Taiwan
Chia-Yi Christian Hospital
RECRUITING

Chiayi City, 600, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
Chu De Tours
RECRUITING

Tours, 37000, France
Chung Shan Medical University Hospital
RECRUITING

Taichung, 40201, Taiwan
Circle Clinical Research
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Clinique des maladies lipidiques de Quebec
RECRUITING

Québec, G1V 4W2, Canada
Coastal Carolina Research Center
RECRUITING

North Charleston, South Carolina, 29405, United States
Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, LA Coruna, 15006, Spain
DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
DelRicht Clinical Research, LLC
RECRUITING

New Orleans, Louisiana, 70115, United States
Diabeteszentrum Hamburg West
RECRUITING

Hamburg, 22607, Germany
Diabetologische Schwerpunktpraxis Pirna Hausärztliche Versorgung
RECRUITING

Pirna, 01796, Germany
Diex Recherche Sherbrooke
RECRUITING

Sherbrooke, Quebec, J1L 0H8, Canada
Division of Endocrinology and Metabolism;Internal Medicine
RECRUITING

Chiang Mai, 50200, Thailand
ETG Debica
RECRUITING

Dębica, 39-200, Poland
ETG Siedlce
RECRUITING

Siedlce, 08-110, Poland
Eirvera, LLC
RECRUITING

St. Petersburg, Florida, 33711, United States
Ekamed sp. z o.o.
RECRUITING

Lublin, 20-718, Poland
Elevate Clinical Research
RECRUITING

Lake Charles, Louisiana, 70605, United States
Emerson Clinical Research Institute
RECRUITING

Washington D.C., District of Columbia, 20009, United States
Encompass Clinical Research
RECRUITING

Spring Valley, California, 91978, United States
Era Health Research
RECRUITING

Redmond, Washington, 98052, United States
Essential Medical Research
RECRUITING

Tulsa, Oklahoma, 74137, United States
European Hospital Georges Pompidou (HEGP)
RECRUITING

Paris, 75908, France
FDI Clinical Research
RECRUITING

San Juan, 00927, Puerto Rico
Fukuhama Chuo Clinic
RECRUITING

Fukuoka, 810-0066, Japan
Fylde Coast Clinical Research at Layton Medical Centre
RECRUITING

Blackpool, Lancashire, FY3 7EN, United Kingdom
George Eliot Hospital
RECRUITING

Nuneaton, CV10 7DJ, United Kingdom
HMC Health Group
RECRUITING

London, TW47NR, United Kingdom
HRI ? Medical Center, LLC
RECRUITING

Houston, Texas, 77004, United States
HRI ? Pasadena, LLC
RECRUITING

Pasadena, Texas, 77505, United States
Hasegawa Medicine Clinic
RECRUITING

Hokkaido, 066-0032, Japan
Higashijujo Sakai Diabetes Internal Medicine Clinic
RECRUITING

Tokyo, 114-0001, Japan
Hopital de la Conception
RECRUITING

Marseille, 13000, France
Hospital Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Universitario Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Huizhou Central People's Hospital
RECRUITING

Huizhou, 516001, China
Hull Royal Infirmary
RECRUITING

Hull, HU3 2JZ, United Kingdom
IME - Instituto Médico Especializado
RECRUITING

Buenos Aires, C1405BCH, Argentina
Infinity Clinical Research
RECRUITING

Norco, California, 92860, United States
InnoDiab Forschung GmbH
RECRUITING

Essen, 45136, Germany
Instituto centenario
RECRUITING

Ciudad Autonoma Buenos Aires, C1204AAD, Argentina
Juno Research, LLC
RECRUITING

Houston, Texas, 77040, United States
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Kasugai Municipal Hospital
RECRUITING

Aichi, 486-8510, Japan
Knowle House Surgery
RECRUITING

Plymouth, PL5 3JB, United Kingdom
LMC Clinical Research Inc
RECRUITING

Toronto, Ontario, M4G 3E8, Canada
Lakeview Clinical Research
RECRUITING

Guntersville, Alabama, 35976, United States
Logan Hospital
RECRUITING

Meadowbrook, Queensland, 4131, Australia
Lynn Health Science Institute
RECRUITING

Oklahoma City, Oklahoma, 73112, United States
Lynn Institute of Norman
RECRUITING

Norman, Oklahoma, 73072, United States
Manassas Clinical Research Center
RECRUITING

Manassas, Virginia, 20110, United States
Medicor Research Inc
RECRUITING

Greater Sudbury, Ontario, P3C 1X3, Canada
Medizentrum Essen Borbeck
RECRUITING

Essen, 45355, Germany
Mesut Durmaz - Facharzt für Innere Medizin, Endokrinologie & Diabetologie
RECRUITING

Hof, 95030, Germany
NTT Medical Center Sapporo
RECRUITING

Hokkaido, 060-0061, Japan
NZOZ Eskulap Pabianice
RECRUITING

Pabianice, 95-200, Poland
NZOZ Osteo-Medic s.c. A. Racewicz, J.Supronik
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-351, Poland
NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki s.c.
RECRUITING

Ruda Śląska, 41-709, Poland
NZOZ Regionalna Poradnia Diabetologiczna
RECRUITING

Wroclaw, 50-127, Poland
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10048, Taiwan
Ninewells Hospital and Medical School - Tayside Health Board
RECRUITING

Dundee, DD1 9SY, United Kingdom
Nuevas Tecnologias en Diabetes y Endocrinologia
RECRUITING

Seville, 41003, Spain
Orange County Research Center
RECRUITING

Lake Forest, California, 92630, United States
Panstwowy Instytut Medyczny - MSWiA
RECRUITING

Warsaw, 02-507, Poland
Paratus Clinical Western Sydney
RECRUITING

Blacktown, New South Wales, 2148, Australia
Peking University People's Hospital
RECRUITING

Beijing, 100044, China
Policlinico Universitario Agostino Gemelli
RECRUITING

Rome, Lazio, 00168, Italy
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States
Prospective Research Innovations Inc.
RECRUITING

Rancho Cucamonga, California, 91730, United States
Rajavithi Hospital
RECRUITING

Bangkok, 10400, Thailand
Ramathibodi Hospital
RECRUITING

Bangkok, 10400, Thailand
Remington Davis Inc
RECRUITING

Columbus, Ohio, 43215, United States
Rophe Adult and Pediatric Medicine/SKYCRNG
RECRUITING

Union City, Georgia, 30291, United States
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Shanghai Fifth People's Hospital Affiliated to Fudan University
RECRUITING

Shanghai, 201304, China
Shanghai Pudong New Area People's Hospital
RECRUITING

Shanghai, 201299, China
Siriraj Hospital
RECRUITING

Bangkok, 10700, Thailand
Songklanagarind Hospital
RECRUITING

Hat Yai, 90110, Thailand
South Texas Research Institute - Edinburg
RECRUITING

Edinburg, Texas, 78539, United States
Southern Adelaide Diabetes and Endocrine Services (SADES)
RECRUITING

Oaklands Park, South Australia, 5046, Australia
Southmead General Hospital
RECRUITING

Bristol, BS10 5NB, United Kingdom
TGElliott Inc. dba BC Diabetes
RECRUITING

Vancouver, British Columbia, V5Y 3W2, Canada
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Tampa Bay Medical Research, Inc.
RECRUITING

Clearwater, Florida, 33761, United States
Thammasat University Hospital
RECRUITING

Khlong Luang, 12120, Thailand
The Second Affiliated Hospital of Nanjing Medical University
RECRUITING

Nanjing, 210003, China
The Second People's Hospital of Hefei
RECRUITING

Hefei, 230011, China
TreDia s.r.o.;Diabetologická ambulance Praha 9
RECRUITING

Praha 9 - Klánovice, 19014, Czechia
Umberto I Policlinico di Roma-Università di Roma La Sapienza
RECRUITING

Rome, Lazio, 00161, Italy
Universita Degli Studi Di Perugia
RECRUITING

Perugia, Umbria, 06129, Italy
Unterfrintroper Hausarztzentrum
RECRUITING

Essen, 45359, Germany
Velocity Clinical Research
RECRUITING

Dallas, Texas, 75230, United States
Yan'an University Xianyang Hospital
RECRUITING

Xianyang, Shaanxi, 712000, China