New weekly shot could help obese diabetics shed pounds and control blood sugar

NCT ID NCT07351058

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive either the drug or a placebo for 72 weeks to see how much weight they lose and how their diabetes improves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Enicepatide (a weekly injection that mimics natural hormones to help control appetite and blood sugar)
What this could lead to: If it works, this could offer a new weekly injection option for significant weight loss and better blood sugar control in people with obesity and type 2 diabetes.
What could go wrong: This is a large Phase 3 trial, but the drug is still experimental. It may cause side effects like nausea or vomiting, and not everyone may achieve meaningful weight loss. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OR OVERWEIGHT TYPE 2 DIABETES MELLITUS

Contacts and locations

Locations

A.O. Universitaria Policlinico S.Orsola-Malpighi Di Bologna
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
AO di Perugia - Ospedale S. Maria della Misericordia
RECRUITING

Perugia, Umbria, 06156, Italy
Aberdeen Royal Infirmary
RECRUITING

Aberdeen, AB9 2ZB, United Kingdom
Adana Sehir Egitim ve Arastirma Hastanesi
RECRUITING

Adana, 1370, Turkey (Türkiye)
Affiliated Drum Tower Hospital of Nanjing University Medical School
RECRUITING

Nanjing, 210008, China
Affiliated Hospital of Jiangsu University
RECRUITING

Zhenjiang, Jiangsu, 212002, China
Akdeniz University Medical Faculty
RECRUITING

Antalya, 07059, Turkey (Türkiye)
Ankara University Medical Faculty
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Antrim Area Hospital
RECRUITING

Antrim, BT41 2RL, United Kingdom
Applied Medical Informatics Research Inc. (A.M.I.R.)
RECRUITING

Montreal, Quebec, H4A 3T2, Canada
Arechavaleta Granell Maria del Rosario
RECRUITING

Guadalajara, Jalisco, 44650, Mexico
Arizona Clinical Trials
RECRUITING

Tucson, Arizona, 85711, United States
Ark Clinical Research
RECRUITING

Long Beach, California, 90815, United States
Asst Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, Lombardy, 20162, Italy
Avant Santé Research Center
RECRUITING

San Pedro Garza García, Nuevo León, 66260, Mexico
Azienda Ospedaliera Papa Giovanni XXIII
RECRUITING

Bergamo, Abruzzo, 24127, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, Sicily, 90127, Italy
Azienda Ospedaliero-Universitaria "Renato Dulbecco" Catanzaro
RECRUITING

Catanzaro, Calabria, 88100, Italy
Baker Heart and Diabetes Insitute
RECRUITING

Melbourne, Victoria, 3004, Australia
Baskent Universitesi - Adana Uygulama Ve Arastirma Merkezi
RECRUITING

Sariçam, 01250, Turkey (Türkiye)
Beijing Pinggu Hospital
RECRUITING

Beijing, 101200, China
CEDIC Centro de Investigaciones Clinicas
RECRUITING

Buenos Aires, C1060ABN, Argentina
CEMDEC S.A. de C.V.
RECRUITING

Delegacion Cuauhtemoc, Mexico CITY (federal District), 06100, Mexico
CHU de Nice
RECRUITING

Nice, 06602, France
CINME
RECRUITING

Buenos Aires, C1056ABI, Argentina
CPQuali Pesquisa Clinica Ltda
RECRUITING

São Paulo, São Paulo, 01228-000, Brazil
Cangzhou People's Hospital
RECRUITING

Cangzhou, Hebei, 061011, China
Catalina Research Institute, LLC
RECRUITING

Montclair, California, 91763, United States
Centennial Medical Group
RECRUITING

Columbia, Maryland, 21045-5840, United States
Center for Diabetes, Obesity and Metabolism Inc
RECRUITING

Pembroke Pines, Florida, 33024, United States
Centricity Research Brampton Endocrinology
RECRUITING

Brampton, Ontario, L6S 0C6, Canada
Centricity Research Calgary Endocrinology
RECRUITING

Calgary, Alberta, T2H 2G4, Canada
Centricity Research Columbus Georgia Multispecialty
RECRUITING

Columbus, Georgia, 31904, United States
Centricity Research Morehead City Multispeciality
RECRUITING

Morehead City, North Carolina, 28557, United States
Centricity Research Suffolk Primary Care
RECRUITING

Suffolk, Virginia, 23435, United States
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
RECRUITING

Ciudad Autonoma Buenos Aires, C1425AGC, Argentina
Centro Medico Teknon
RECRUITING

Barcelona, 08022, Spain
Centro Medico Viamonte SRL
RECRUITING

Buenos Aires, C1120AAC, Argentina
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares SC
RECRUITING

Ciudad Madero, Tamaulipas, 89440, Mexico
Centro de Investigaciones Medicas Mar Del Plata
RECRUITING

Mar del Plata, B7600FYK, Argentina
Centro de Pesquisas Clinicas
RECRUITING

São Paulo, São Paulo, 01228-200, Brazil
Centrum Medyczne INTERCOR Sp. z o.o.
RECRUITING

Bydgoszcz, 85-605, Poland
Centrum Medyczne OMEDICA
RECRUITING

Poznan, 60-111, Poland
Changhua Christian Hospital
RECRUITING

Changhua, 50006, Taiwan
Chia-Yi Christian Hospital
RECRUITING

Chiayi City, 600, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
Chosun University Hospital
RECRUITING

Gwangju, 61453, South Korea
Chu De Tours
RECRUITING

Tours, 37000, France
Chung Shan Medical University Hospital
RECRUITING

Taichung, 40201, Taiwan
Circle Clinical Research
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Clinica do Coracao
RECRUITING

Aracaju, Sergipe, 49055-530, Brazil
Clinicos Asociados Bocm, S.C.
RECRUITING

México, Mexico CITY (federal District), 03300, Mexico
Clinique des maladies lipidiques de Quebec
RECRUITING

Québec, G1V 4W2, Canada
Coastal Carolina Research Center
RECRUITING

North Charleston, South Carolina, 29405, United States
Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, LA Coruna, 15006, Spain
Complejo Hospitalario Universitario de Ferrol
RECRUITING

Ferrol, LA Coruna, 15405, Spain
DIACENTRUM Brandýs nad Labem s.r.o.
RECRUITING

Brandýs nad Labem, 25001, Czechia
DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
DelRicht Clinical Research, LLC
RECRUITING

New Orleans, Louisiana, 70115, United States
Diabeteszentrum Hamburg West
RECRUITING

Hamburg, 22607, Germany
Diabetologische Schwerpunktpraxis Pirna Hausärztliche Versorgung
RECRUITING

Pirna, 01796, Germany
Diavital Jesenice s.r.o.
RECRUITING

Jesenice, 25242, Czechia
Diex Recherche Sherbrooke
RECRUITING

Sherbrooke, Quebec, J1L 0H8, Canada
Division of Endocrinology and Metabolism;Internal Medicine
RECRUITING

Chiang Mai, 50200, Thailand
Dokuz Eylul University Medicine Faculty
RECRUITING

Izmir, 35340, Turkey (Türkiye)
ETG Debica
RECRUITING

Dębica, 39-200, Poland
ETG Siedlce
RECRUITING

Siedlce, 08-110, Poland
Eirvera, LLC
RECRUITING

St. Petersburg, Florida, 33711, United States
Ekamed sp. z o.o.
RECRUITING

Lublin, 20-718, Poland
Elevate Clinical Research
RECRUITING

Lake Charles, Louisiana, 70605, United States
Elite Clinical Trials
RECRUITING

Blackfoot, Idaho, 83221, United States
Emerson Clinical Research Institute
RECRUITING

Washington D.C., District of Columbia, 20009, United States
Encompass Clinical Research
RECRUITING

Spring Valley, California, 91978, United States
Era Health Research
RECRUITING

Redmond, Washington, 98052, United States
Essential Medical Research
RECRUITING

Tulsa, Oklahoma, 74137, United States
Eulji General Hospital
RECRUITING

Seoul, 01830, South Korea
European Hospital Georges Pompidou (HEGP)
RECRUITING

Paris, 75908, France
FDI Clinical Research
RECRUITING

San Juan, 00927, Puerto Rico
FLEDIP s.r.o.
RECRUITING

Prague, 160 00, Czechia
Fukuhama Chuo Clinic
RECRUITING

Fukuoka, 810-0066, Japan
Fylde Coast Clinical Research at Layton Medical Centre
RECRUITING

Blackpool, Lancashire, FY3 7EN, United Kingdom
Gangdong Kyung Hee University Hospital
RECRUITING

Seoul, 05278, South Korea
George Eliot Hospital
RECRUITING

Nuneaton, CV10 7DJ, United Kingdom
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
RECRUITING

Goiânia, Goiás, 74605-020, Brazil
HMC Health Group
RECRUITING

London, TW47NR, United Kingdom
HRI ? Medical Center, LLC
RECRUITING

Houston, Texas, 77004, United States
HRI ? Pasadena, LLC
RECRUITING

Pasadena, Texas, 77505, United States
Hallym University Kangnam Sacred Heart Hospital
RECRUITING

Seoul, 07441, South Korea
Hasegawa Medicine Clinic
RECRUITING

Hokkaido, 066-0032, Japan
Headlands Research Brownsville
RECRUITING

Brownsville, Texas, 78526, United States
Hebei Petro China Central Hospital
RECRUITING

Langfang, 065000, China
Hector-Center für Ernährung, Bewegung und Sport, Universitätsklinikum Erlangen;Medizinische Klinik 1 ? Gastroenterologie, Pneumologie und Endokrinologie
RECRUITING

Erlangen, 91054, Germany
Heidelberg Repatriation Hospital
RECRUITING

Heidelberg, Victoria, 3081, Australia
Herz- und Diabeteszentrum NRW Universitätsklinik der Ruhr-Universität Bochum Medizinische Fakultät OWL (Universität Bielefeld);Klinik für Diabetologie und Endokrinologie
RECRUITING

Bad Oeynhausen, 32545, Germany
Higashijujo Sakai Diabetes Internal Medicine Clinic
RECRUITING

Tokyo, 114-0001, Japan
Hopital Saint Joseph Saint Luc
RECRUITING

Lyon, 69007, France
Hopital de la Conception
RECRUITING

Marseille, 13000, France
Hospital Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Universitari Germans Trias i Pujol
RECRUITING

Badalona, Barcelona, 08916, Spain
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Fundacion Jimenez Diaz.
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Huai He Hospital of Henan University
RECRUITING

Kaifeng, Henan, 475001, China
Huizhou Central People's Hospital
RECRUITING

Huizhou, 516001, China
Hull Royal Infirmary
RECRUITING

Hull, HU3 2JZ, United Kingdom
IBPCLIN Instituto Brasil de Pesquisa Clinica
RECRUITING

Rio de Janeiro, 20241-180, Brazil
IME - Instituto Médico Especializado
RECRUITING

Buenos Aires, C1405BCH, Argentina
Infinity Clinical Research
RECRUITING

Norco, California, 92860, United States
InnoDiab Forschung GmbH
RECRUITING

Essen, 45136, Germany
Instittuto Nacional de Ciencias Medicas y Nutricion "Salvador Subiran"
RECRUITING

México, Mexico CITY (federal District), 14000, Mexico
Instituto Jalisciense de investigacion en diabetes y obesidad S.C.
RECRUITING

Guadalajara, Jalisco, 44650, Mexico
Instituto centenario
RECRUITING

Ciudad Autonoma Buenos Aires, C1204AAD, Argentina
Instituto de Diabetes Obesidad y Nutricion, SC
RECRUITING

Cuernavaca, Morelos, 62250, Mexico
Jinan Central Hospital
RECRUITING

Jinan, Shandong, 250013, China
Juno Research, LLC
RECRUITING

Houston, Texas, 77040, United States
Kangbuk Samsung Hospital
RECRUITING

Seoul, 03181, South Korea
Kanuni Sultan Suleyman Training and Research Hospital
RECRUITING

Istanbul, 34303, Turkey (Türkiye)
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Kasugai Municipal Hospital
RECRUITING

Aichi, 486-8510, Japan
Knowle House Surgery
RECRUITING

Plymouth, PL5 3JB, United Kingdom
Koc University Medical Faculty Hospital
RECRUITING

Istanbul, Zeytinburnu, 34010, Turkey (Türkiye)
LMC Clinical Research Inc
RECRUITING

Toronto, Ontario, M4G 3E8, Canada
Lakeview Clinical Research
RECRUITING

Guntersville, Alabama, 35976, United States
Logan Hospital
RECRUITING

Meadowbrook, Queensland, 4131, Australia
Lynn Health Science Institute
RECRUITING

Oklahoma City, Oklahoma, 73112, United States
Lynn Institute of Norman
RECRUITING

Norman, Oklahoma, 73072, United States
MVZ Diabeteszentrum Dr. Tews GmbH;Praxis für Diabetologie
RECRUITING

Gelnhausen, 63571, Germany
Manassas Clinical Research Center
RECRUITING

Manassas, Virginia, 20110, United States
Medeniyet University Goztepe Training and Research Hospital
RECRUITING

Istanbul, 34668, Turkey (Türkiye)
Medical Center Metas SC
RECRUITING

Col Saucito, Chihuahua, 31110, Mexico
Medicor Research Inc
RECRUITING

Greater Sudbury, Ontario, P3C 1X3, Canada
Medizentrum Essen Borbeck
RECRUITING

Essen, 45355, Germany
Mesut Durmaz - Facharzt für Innere Medizin, Endokrinologie & Diabetologie
RECRUITING

Hof, 95030, Germany
Musgrove Park Hospital
RECRUITING

Taunton, TA1 5DA, United Kingdom
NTT Medical Center Sapporo
RECRUITING

Hokkaido, 060-0061, Japan
NZOZ Eskulap Pabianice
RECRUITING

Pabianice, 95-200, Poland
NZOZ Osteo-Medic s.c. A. Racewicz, J.Supronik
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-351, Poland
NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki s.c.
RECRUITING

Ruda Śląska, 41-709, Poland
NZOZ Regionalna Poradnia Diabetologiczna
RECRUITING

Wroclaw, 50-127, Poland
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10048, Taiwan
Ninewells Hospital and Medical School - Tayside Health Board
RECRUITING

Dundee, DD1 9SY, United Kingdom
Nucleo de Pesquisa Clinica do Rio Grande do Sul NPCR
RECRUITING

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Nuevas Tecnologias en Diabetes y Endocrinologia
RECRUITING

Seville, 41003, Spain
Orange County Research Center
RECRUITING

Lake Forest, California, 92630, United States
Panstwowy Instytut Medyczny - MSWiA
RECRUITING

Warsaw, 02-507, Poland
Paratus Clinical Western Sydney
RECRUITING

Blacktown, New South Wales, 2148, Australia
Peking University People's Hospital
RECRUITING

Beijing, 100044, China
Pingxiang People's Hospital
RECRUITING

Pingxiang, 337000, China
Pinnacle Clinical Research - San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Policlinico Universitario Agostino Gemelli
RECRUITING

Rome, Lazio, 00168, Italy
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States
Prospective Research Innovations Inc.
RECRUITING

Rancho Cucamonga, California, 91730, United States
Rajavithi Hospital
RECRUITING

Bangkok, 10400, Thailand
Ramathibodi Hospital
RECRUITING

Bangkok, 10400, Thailand
Remington Davis Inc
RECRUITING

Columbus, Ohio, 43215, United States
Rophe Adult and Pediatric Medicine/SKYCRNG
RECRUITING

Union City, Georgia, 30291, United States
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Schwerpunktpraxis für Diabetes und Ernährungsmedizin, Dr. med. Winfried Keuthage
RECRUITING

Münster, 48153, Germany
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggido, 13620, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shanghai Fifth People's Hospital Affiliated to Fudan University
RECRUITING

Shanghai, 201304, China
Shanghai Pudong New Area People's Hospital
RECRUITING

Shanghai, 201299, China
Siping Central People's Hospital
RECRUITING

Siping, 136001, China
Siriraj Hospital
RECRUITING

Bangkok, 10700, Thailand
Songklanagarind Hospital
RECRUITING

Hat Yai, 90110, Thailand
South Texas Research Institute - Edinburg
RECRUITING

Edinburg, Texas, 78539, United States
Southern Adelaide Diabetes and Endocrine Services (SADES)
RECRUITING

Oaklands Park, South Australia, 5046, Australia
Southmead General Hospital
RECRUITING

Bristol, BS10 5NB, United Kingdom
TGElliott Inc. dba BC Diabetes
RECRUITING

Vancouver, British Columbia, V5Y 3W2, Canada
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Tampa Bay Medical Research, Inc.
RECRUITING

Clearwater, Florida, 33761, United States
Thammasat University Hospital
RECRUITING

Khlong Luang, 12120, Thailand
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, Jiangsu, 221002, China
The First Affiliated Hospital of Henan University of Science and Technology
RECRUITING

Luoyang, China
The First Affiliated Hospital of Ningbo University
RECRUITING

Ningbo, Zhejiang, 315010, China
The First Affiliated Hospital of Soochow University
RECRUITING

Suzhou, 215333, China
The First Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The Second Affiliated Hospital of Nanjing Medical University
RECRUITING

Nanjing, 210003, China
The Second People's Hospital of Hefei
RECRUITING

Hefei, 230011, China
The University of Osaka Hospital
RECRUITING

Osaka, 565-0871, Japan
TreDia s.r.o.;Diabetologická ambulance Praha 9
RECRUITING

Praha 9 - Klánovice, 19014, Czechia
Uijeongbu St. Mary's Hospital
RECRUITING

Gyeonggi-do, 11765, South Korea
Umberto I Policlinico di Roma-Università di Roma La Sapienza
RECRUITING

Rome, Lazio, 00161, Italy
Universitaets Klinikum Frankfurt - Zentrum der Inneren Medizin
RECRUITING

Frankfurt, 60596, Germany
Unterfrintroper Hausarztzentrum
RECRUITING

Essen, 45359, Germany
VA Pittsburgh Healthcare System
RECRUITING

Pittsburgh, Pennsylvania, 15240, United States
Velocity Clinical Research
RECRUITING

Dallas, Texas, 75230, United States
Wuxi People's Hospital
RECRUITING

Wuxi, 214023, China
Yan'an University Xianyang Hospital
RECRUITING

Xianyang, Shaanxi, 712000, China
Yonsei University Wonju Severance Christian Hospital
RECRUITING

Gangwon-do, 26426, South Korea
Zentrum für klinische Forschung Köln - Dünnwald;Dünnwald Praxis
RECRUITING

Köln - Dünnwald, 51069, Germany

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