Diabetes duo: could a Two-Pill combo tame blood sugar better than one?

NCT ID NCT07662109

Not yet recruiting Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tests whether taking two diabetes medications together—elecoglipron and dapagliflozin—works better than either drug alone for controlling blood sugar in adults with type 2 diabetes. The trial enrolls about 2,000 people whose diabetes is not well managed by lifestyle changes or other medications. Participants take one of four daily pill regimens: the combination, elecoglipron alone, dapagliflozin alone, or placebos, and researchers track changes in blood sugar levels and weight over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

elecoglipron and dapagliflozin

What this could lead to

If successful, this combination could offer a more effective daily pill option for managing blood sugar and weight in type 2 diabetes.

What could go wrong

This is a large phase 3 trial, but the combination may not prove significantly better than each drug alone. Side effects from either drug could also occur.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES MELLITUS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Huntsville, Alabama, 35801, United States
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Los Angeles, California, 90017, United States
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Ontario, California, 91762, United States
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Skokie, Illinois, 60077, United States
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Zachary, Louisiana, 70791, United States
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Lutherville-Timonium, Maryland, 21093, United States
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Boston, Massachusetts, 02115, United States
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Raleigh, North Carolina, 27607, United States
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Maumee, Ohio, 43537, United States
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Kingsport, Tennessee, 37660, United States
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McKinney, Texas, 75069, United States
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South Jordan, Utah, 84095, United States
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Newport News, Virginia, 23606, United States
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Redmond, Washington, 98052, United States
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Kingwood, West Virginia, 26537, United States
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Buenos Aires, C1012AAR, Argentina
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Buenos Aires, C1425AGC, Argentina
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CABA, C1120AAC, Argentina
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Caba, C1128AAF, Argentina
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Ciudad de Buenos Aires, C1094AAD, Argentina
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Mar del Plata, B7600GNY, Argentina
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Rosario, S2000CVD, Argentina
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San Nicolás, B2900DMH, Argentina
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San Vicente, 5006, Argentina
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Barretos, 14784-400, Brazil
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Brasília, 71625-009, Brazil
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Campinas, 13060-904, Brazil
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Curitiba, 80030-480, Brazil
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Fortaleza, 60430-350, Brazil
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Natal, 59020-035, Brazil
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Porto Alegre, 90630-165, Brazil
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Rio de Janeiro, 22270-060, Brazil
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São José dos Campos, 12243-280, Brazil
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São Paulo, 01228-200, Brazil
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São Paulo, 04012-180, Brazil
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Baotou, China
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Beijing, 100050, China
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Changde, 415000, China
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Changsha, 410015, China
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Changzhou, 272100, China
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Chengdu, 611130, China
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Chenzhou, 423000, China
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Chifeng, 024000, China
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Hangzhou, 310014, China
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Hefei, 230601, China
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Huai'an, 223005, China
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Kaifeng, 475000, China
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Liangyugang, 222002, China
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Luoyang, 471009, China
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Nanjing, 210011, China
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Nanyang, 473009, China
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Sanya, 572000, China
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Shanghai, 201199, China
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Shantou, 515065, China
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Shenyang, 110023, China
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Shijiazhuang, 050000, China
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Shijiazhuang, 050001, China
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Wuhan, 430010, China
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Wuhu, 241004, China
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Xi'an, 710077, China
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Xiangyang, 441000, China
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Xianyang, 712000, China
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Xuzhou, 221009, China
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Yan’an, 716000, China
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Zhumadian, 463000, China
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Hradec Králové, 500 02, Czechia
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Humpolec, 396 01, Czechia
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Jílové u Prahy, 254 01, Czechia
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Ostrava, 702 00, Czechia
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Prague, 147 00, Czechia
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Prague, 149 00, Czechia
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Prague, 160 00, Czechia
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Příbram, 261 01, Czechia
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Aarhus N, 8200, Denmark
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Esbjerg, 6700, Denmark
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Gandrup, 9362, Denmark
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Herlev, 2730, Denmark
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Hillerød, 3400, Denmark
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Hvidovre, 2650, Denmark
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Odense, 5000, Denmark
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Berlin, 13597, Germany
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Cologne, 51069, Germany
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Damme, 49401, Germany
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Deggingen, 73326, Germany
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Duisburg, 47269, Germany
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Essen, 45355, Germany
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Falkensee, 14612, Germany
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Frankfurt, 60596, Germany
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Hamburg, 22607, Germany
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Leipzig, 04249, Germany
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Münster, 48145, Germany
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Nittendorf, 93152, Germany
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Pohlheim, 35415, Germany
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Villingen-Schwenningen, 78048, Germany
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Wallerfing, 94574, Germany
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Weinheim, 69469, Germany
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Alexandroupoli, 68100, Greece
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Athens, 115 25, Greece
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Athens, 11527, Greece
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Athens, 17562, Greece
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Ioannina, 45500, Greece
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Thessaloniki, 54635, Greece
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Thessaloniki, 54642, Greece
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Thessaloniki, 54645, Greece
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Budapest, 1036, Hungary
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Budapest, 1089, Hungary
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Budapest, 1132, Hungary
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Debrecen, 4032, Hungary
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Salgótarján, 3100, Hungary
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Szeged, 6725, Hungary
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Szolnok, 5000, Hungary
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Zalaegerszeg, 8900, Hungary
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Hachioji-shi, 192-0083, Japan
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Ichikawa-shi, 272-8516, Japan
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Alor Star, 05400, Malaysia
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Ipoh, 30450, Malaysia
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Kangar, 01000, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Sarawak Miri, 98000, Malaysia
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Seremban, 70300, Malaysia
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Seri Manjung, 32040, Malaysia
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Bialystok, 15-897, Poland
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Częstochowa, 42-217, Poland
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Kielce, 25-355, Poland
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Lodz, 90-338, Poland
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Lublin, 20-718, Poland
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Poznan, 60-354, Poland
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Radom, 26-600, Poland
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Warsaw, 00-124, Poland
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Warsaw, 02-507, Poland
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San Juan, 00918, Puerto Rico
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Goyang-si, 411-706, South Korea
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Guri-si, 11923, South Korea
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Gwangju, 61453, South Korea
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Gyeonggi-do, 13620, South Korea
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Seoul, 03722, South Korea
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Seoul, 06273, South Korea
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Seoul, 136-705, South Korea
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Yangsan, 50612, South Korea
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Changhua, 500, Taiwan
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 813, Taiwan
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New Taipei City, 220, Taiwan
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Taichung, 40201, Taiwan
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Taichung, 40705, Taiwan
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Taichung, 433004, Taiwan
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Tainan, 70403, Taiwan
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Tainan County, 71044, Taiwan
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Taipei, 10002, Taiwan
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Taoyuan, 333, Taiwan
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Kyiv, 02002, Ukraine
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Kyiv, 03037, Ukraine
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Kyiv, 03049, Ukraine
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Kyiv, 03057, Ukraine
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Kyiv, 04114, Ukraine
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Kyiv, 04210, Ukraine
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Lviv, 79010, Ukraine
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Lviv, 79016, Ukraine
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Uzhhorod, 88002, Ukraine
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Uzhhorod, 88014, Ukraine
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Vinnytsia, 21001, Ukraine
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Blackburn, BB2 1AX, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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Guisborough, TS14 7DJ, United Kingdom
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Nantwich, CW5 5NX, United Kingdom
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Rotherham, S65 1DA, United Kingdom
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Stowmarket, IP142SY, United Kingdom
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Thetford, IP24 1JD, United Kingdom
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Weston-super-Mare, BS24 7PR, United Kingdom
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Witney, OX28 6JS, United Kingdom
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Yate, BS37 4AX, United Kingdom
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Hanoi, 10000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Hochiminh City, 700000, Vietnam
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Hochiminh, 700000, Vietnam
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Hồ Chí Minh, 700000, Vietnam
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Huế, 530000, Vietnam
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Rach Gia, 920000, Vietnam