Diabetes duo: could a Two-Pill combo tame blood sugar better than one?

NCT ID NCT07662109

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This phase 3 study tests whether taking two diabetes medications together—elecoglipron and dapagliflozin—works better than either drug alone for controlling blood sugar in adults with type 2 diabetes. The trial enrolls about 2,000 people whose diabetes is not well managed by lifestyle changes or other medications. Participants take one of four daily pill regimens: the combination, elecoglipron alone, dapagliflozin alone, or placebos, and researchers track changes in blood sugar levels and weight over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: elecoglipron and dapagliflozin
What this could lead to: If successful, this combination could offer a more effective daily pill option for managing blood sugar and weight in type 2 diabetes.
What could go wrong: This is a large phase 3 trial, but the combination may not prove significantly better than each drug alone. Side effects from either drug could also occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES MELLITUS

Contacts and locations

Locations

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Huntsville, Alabama, 35801, United States
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Mobile, Alabama, 36608, United States
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Sheffield, Alabama, 35660, United States
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Little Rock, Arkansas, 72205, United States
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Bakersfield, California, 93309, United States
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Los Angeles, California, 90017, United States
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Ontario, California, 91762, United States
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Lake City, Florida, 32055, United States
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Lakeland, Florida, 33813, United States
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Atlanta, Georgia, 30315, United States
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Chicago, Illinois, 60640, United States
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Skokie, Illinois, 60077, United States
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Evansville, Indiana, 47714, United States
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Sioux City, Iowa, 51106, United States
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Zachary, Louisiana, 70791, United States
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Annapolis, Maryland, 21401, United States
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Lutherville-Timonium, Maryland, 21093, United States
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Oxon Hill, Maryland, 20745, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02115, United States
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Troy, Michigan, 48098, United States
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Ridgeland, Mississippi, 39157, United States
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Elkhorn, Nebraska, 68022, United States
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Albuquerque, New Mexico, 87112, United States
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Brooklyn, New York, 11201, United States
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Raleigh, North Carolina, 27607, United States
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Beachwood, Ohio, 44122, United States
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Maumee, Ohio, 43537, United States
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Norman, Oklahoma, 73069, United States
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Kingsport, Tennessee, 37660, United States
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Nashville, Tennessee, 37203, United States
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Dallas, Texas, 75230, United States
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McKinney, Texas, 75069, United States
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Paris, Texas, 75462, United States
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San Antonio, Texas, 78229, United States
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South Jordan, Utah, 84095, United States
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Arlington, Virginia, 22205, United States
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Newport News, Virginia, 23606, United States
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Redmond, Washington, 98052, United States
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Kingwood, West Virginia, 26537, United States
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Buenos Aires, C1012AAR, Argentina
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Buenos Aires, C1425AGC, Argentina
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CABA, C1120AAC, Argentina
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Caba, C1128AAF, Argentina
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Ciudad de Buenos Aires, C1094AAD, Argentina
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Mar del Plata, B7600GNY, Argentina
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Rosario, S2000CVD, Argentina
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San Nicolás, B2900DMH, Argentina
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San Vicente, 5006, Argentina
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Barretos, 14784-400, Brazil
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Brasília, 71625-009, Brazil
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Campinas, 13060-904, Brazil
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Curitiba, 80030-480, Brazil
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Fortaleza, 60430-350, Brazil
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Natal, 59020-035, Brazil
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Porto Alegre, 90630-165, Brazil
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Rio de Janeiro, 22270-060, Brazil
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São José dos Campos, 12243-280, Brazil
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São Paulo, 01228-200, Brazil
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São Paulo, 04012-180, Brazil
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Baotou, China
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Beijing, 100044, China
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Beijing, 100050, China
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Beijing, 102218, China
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Changde, 415000, China
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Changsha, 410015, China
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Changzhou, 272100, China
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Chengdu, 610078, China
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Chengdu, 611130, China
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Chenzhou, 423000, China
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Chifeng, 024000, China
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Hangzhou, 310014, China
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Hefei, 230601, China
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Huai'an, 223005, China
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Jinan, 250031, China
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Jincheng, 048000, China
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Jining, 272006, China
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Jinzhou Shi, 121001, China
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Kaifeng, 475000, China
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Langfang, 065000, China
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Liangyugang, 222002, China
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Luoyang, 471009, China
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Meihekou, 135022, China
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Nanjing, 210011, China
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Nantong, 226001, China
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Nanyang, 473009, China
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Pinggu, 101200, China
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Pingxiang, 337055, China
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Sanya, 572000, China
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Shanghai, 200062, China
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Shanghai, 201199, China
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Shantou, 515065, China
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Shenyang, 110004, China
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Shenyang, 110023, China
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Shijiazhuang, 050000, China
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Shijiazhuang, 050001, China
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Tianjin, 300000, China
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Wuhan, 430010, China
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Wuhu, 241004, China
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Xi'an, 710077, China
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Xiangyang, 441000, China
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Xianyang, 712000, China
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Xuzhou, 221000, China
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Xuzhou, 221009, China
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Yan’an, 716000, China
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Yueyang, 414000, China
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Zhumadian, 463000, China
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Zibo, 255499, China
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Hradec Králové, 500 02, Czechia
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Humpolec, 396 01, Czechia
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Jílové u Prahy, 254 01, Czechia
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Ostrava, 702 00, Czechia
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Prague, 147 00, Czechia
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Prague, 149 00, Czechia
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Prague, 160 00, Czechia
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Příbram, 261 01, Czechia
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Aarhus N, 8200, Denmark
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Esbjerg, 6700, Denmark
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Gandrup, 9362, Denmark
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Herlev, 2730, Denmark
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Hillerød, 3400, Denmark
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Hvidovre, 2650, Denmark
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Odense, 5000, Denmark
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Berlin, 13597, Germany
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Cologne, 51069, Germany
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Damme, 49401, Germany
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Deggingen, 73326, Germany
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Duisburg, 47269, Germany
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Essen, 45355, Germany
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Falkensee, 14612, Germany
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Frankfurt, 60596, Germany
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Hamburg, 22607, Germany
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Leipzig, 04249, Germany
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Münster, 48145, Germany
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Nittendorf, 93152, Germany
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Pohlheim, 35415, Germany
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Villingen-Schwenningen, 78048, Germany
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Wallerfing, 94574, Germany
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Weinheim, 69469, Germany
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Alexandroupoli, 68100, Greece
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Athens, 115 25, Greece
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Athens, 11527, Greece
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Athens, 17562, Greece
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Ioannina, 45500, Greece
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Thessaloniki, 54635, Greece
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Thessaloniki, 54642, Greece
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Thessaloniki, 54645, Greece
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Budapest, 1036, Hungary
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Budapest, 1089, Hungary
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Debrecen, 4032, Hungary
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Salgótarján, 3100, Hungary
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Szeged, 6725, Hungary
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Szolnok, 5000, Hungary
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Zalaegerszeg, 8900, Hungary
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Bangalore, 560 092, India
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Belagavi, 590006, India
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Belagavi, 590010, India
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Calicut, 673008, India
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Chennai, 600086, India
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Coimbatore, 641018, India
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Guwahati, 781032, India
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Indore, 452008, India
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Jaipur, 302017, India
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Kochi, 682040, India
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Kochi, 682041, India
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Lucknow, 226030, India
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Madurai, 625020, India
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Mumbai, 400012, India
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Nagpur, 440010, India
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New Delhi, 11029, India
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Thiruvananthapuram, 695031, India
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Chūōku, 103-0027, Japan
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Hachioji-shi, 192-0083, Japan
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Ichikawa-shi, 272-8516, Japan
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Kishiwada-shi, 596-8501, Japan
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Meguro-ku, 153-0053, Japan
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Mito, 310-0826, Japan
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Sapporo, 060-0061, Japan
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Shinjuku-ku, 160-0008, Japan
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Tama-shi, 206-0033, Japan
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Yamato-shi, 242-0004, Japan
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Alor Star, 05400, Malaysia
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Ipoh, 30450, Malaysia
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Kangar, 01000, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Sarawak Miri, 98000, Malaysia
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Seremban, 70300, Malaysia
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Seri Manjung, 32040, Malaysia
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Cuernavaca, 62448, Mexico
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Bialystok, 15-897, Poland
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Częstochowa, 42-217, Poland
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Kielce, 25-355, Poland
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Lodz, 90-338, Poland
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Lublin, 20-718, Poland
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Poznan, 60-354, Poland
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Radom, 26-600, Poland
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Warsaw, 00-124, Poland
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Warsaw, 02-507, Poland
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San Juan, 00918, Puerto Rico
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Bojnice, 97201, Slovakia
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Bratislava, 81108, Slovakia
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Lučenec, 984 01, Slovakia
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Námestovo, 029 01, Slovakia
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Rožňava, 048 01, Slovakia
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Trebišov, 075 01, Slovakia
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Vrútky, 038 61, Slovakia
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Žilina, 010 01, Slovakia
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Brackenfell, 7560, South Africa
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Cape Town, 7500, South Africa
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Cape Town, 7570, South Africa
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Claremont, 7708, South Africa
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Durban, 4091, South Africa
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Durban, 4093, South Africa
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eMkhomazi, 4170, South Africa
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Johannesburg, 1827, South Africa
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KwaDukuza, 4449, South Africa
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Paarl, 7646, South Africa
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Pretoria, 0083, South Africa
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Goyang-si, 411-706, South Korea
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Guri-si, 11923, South Korea
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Gwangju, 61453, South Korea
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Gyeonggi-do, 13620, South Korea
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Seoul, 03722, South Korea
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Seoul, 06273, South Korea
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Seoul, 136-705, South Korea
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Suwon, 16499, South Korea
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Yangsan, 50612, South Korea
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Changhua, 500, Taiwan
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RECRUITING

Kaohsiung City, 80756, Taiwan
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NOT_YET_RECRUITING

Kaohsiung City, 813, Taiwan
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NOT_YET_RECRUITING

New Taipei City, 220, Taiwan
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NOT_YET_RECRUITING

New Taipei City, 24352, Taiwan
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RECRUITING

Taichung, 40201, Taiwan
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RECRUITING

Taichung, 40705, Taiwan
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RECRUITING

Taichung, 433004, Taiwan
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NOT_YET_RECRUITING

Tainan, 70403, Taiwan
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NOT_YET_RECRUITING

Tainan County, 71044, Taiwan
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RECRUITING

Taipei, 10002, Taiwan
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NOT_YET_RECRUITING

Taoyuan, 333, Taiwan
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NOT_YET_RECRUITING

Bangkok, 10400, Thailand
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NOT_YET_RECRUITING

Banphaeo, 74120, Thailand
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Changwat Sara Buri, 18000, Thailand
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Khlong Luang, 12120, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 70000, Thailand
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Mueang, 20000, Thailand
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Ratchathewi, 10400, Thailand
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NOT_YET_RECRUITING

Ankara, 06540, Turkey (Türkiye)
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NOT_YET_RECRUITING

Ankara, 6200, Turkey (Türkiye)
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NOT_YET_RECRUITING

Gaziantep, 27470, Turkey (Türkiye)
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NOT_YET_RECRUITING

Istanbul, 34010, Turkey (Türkiye)
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NOT_YET_RECRUITING

Istanbul, 34265, Turkey (Türkiye)
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NOT_YET_RECRUITING

Istanbul, 34384, Turkey (Türkiye)
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NOT_YET_RECRUITING

Konya, 42130, Turkey (Türkiye)
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NOT_YET_RECRUITING

Kyiv, 02002, Ukraine
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NOT_YET_RECRUITING

Kyiv, 03037, Ukraine
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NOT_YET_RECRUITING

Kyiv, 03049, Ukraine
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NOT_YET_RECRUITING

Kyiv, 03057, Ukraine
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NOT_YET_RECRUITING

Kyiv, 04114, Ukraine
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NOT_YET_RECRUITING

Kyiv, 04210, Ukraine
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NOT_YET_RECRUITING

Lviv, 79010, Ukraine
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NOT_YET_RECRUITING

Lviv, 79016, Ukraine
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NOT_YET_RECRUITING

Uzhhorod, 88002, Ukraine
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NOT_YET_RECRUITING

Uzhhorod, 88014, Ukraine
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NOT_YET_RECRUITING

Vinnytsia, 21001, Ukraine
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NOT_YET_RECRUITING

Blackburn, BB2 1AX, United Kingdom
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NOT_YET_RECRUITING

Dundee, DD1 9SY, United Kingdom
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NOT_YET_RECRUITING

Guisborough, TS14 7DJ, United Kingdom
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NOT_YET_RECRUITING

Nantwich, CW5 5NX, United Kingdom
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NOT_YET_RECRUITING

Rotherham, S65 1DA, United Kingdom
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NOT_YET_RECRUITING

Thetford, IP24 1JD, United Kingdom
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RECRUITING

Weston-super-Mare, BS24 7PR, United Kingdom
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RECRUITING

Witney, OX28 6JS, United Kingdom
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NOT_YET_RECRUITING

Woodbridge, IP136TH, United Kingdom
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NOT_YET_RECRUITING

Yate, BS37 4AX, United Kingdom
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NOT_YET_RECRUITING

Hanoi, 10000, Vietnam
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NOT_YET_RECRUITING

Ho Chi Minh City, 700000, Vietnam
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NOT_YET_RECRUITING

Hochiminh City, 700000, Vietnam
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NOT_YET_RECRUITING

Hochiminh, 700000, Vietnam
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NOT_YET_RECRUITING

Hồ Chí Minh, 700000, Vietnam
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NOT_YET_RECRUITING

Huế, 530000, Vietnam
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NOT_YET_RECRUITING

Rach Gia, 920000, Vietnam

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