TYPE 2 DIABETES MELLITUS

This study tested a new medicine called JW0201 in 200 adults with type 2 diabetes whose blood sugar was not well controlled with their current two-drug regimen. Participants received either JW0201 or a placebo added to their existing treatment. The main goal was to see if JW0201 …

This study looked at whether adding the pill teneligliptin to insulin helps Japanese adults with type 2 diabetes control their blood sugar better. 148 participants took the combination for 16 weeks, with some continuing up to 52 weeks. The main goal was to see changes in HbA1c, a…

This study tested an experimental diabetes drug, TA-7284, in 61 adults with type 2 diabetes. Participants took the pill once daily for 15 days to check safety and how it affects blood sugar and insulin. The goal was to find the right dose for future studies.

This study tested a new drug called MP-513 (Teneligliptin) combined with a standard diabetes medicine (sulfonylurea) in 194 Japanese adults with type 2 diabetes. The goal was to see if the combination safely lowers blood sugar levels over 12 weeks, with an extension up to 52 week…

This study tested different combinations of diabetes medicines (glimepiride, empagliflozin, sitagliptin) with metformin in 172 adults newly diagnosed with type 2 diabetes. Participants took one of four drug pairs or a triple therapy daily for 90 days. Researchers measured blood s…

This study tested a long-acting insulin called Gla-300 in 228 adults with type 2 diabetes whose blood sugar was not well controlled with oral medications. Participants had never used insulin before. The main goal was to check safety, including side effects and low blood sugar eve…

This study looked at the long-term safety and effectiveness of adding canagliflozin to an existing GLP-1 treatment in 71 adults with type 2 diabetes. Participants took the combination for 52 weeks. Researchers tracked side effects, blood sugar control, weight, and blood pressure …

This study tested a drug called ertugliflozin in 166 teenagers (ages 10-17) with type 2 diabetes who were already taking metformin. The goal was to see if adding this drug could safely lower blood sugar levels more than a placebo. After 24 weeks, the drug helped reduce HbA1C, a k…

This study tested whether the drug dapagliflozin works better than standard treatments for people with type 2 diabetes whose blood sugar is not well controlled on metformin alone. Over 600 adults took part, and researchers looked at improvements in blood sugar, weight loss, and s…

This study tested whether empagliflozin, a common diabetes drug, lowers blood pressure more than other oral diabetes medications in people with type 2 diabetes and high blood pressure. 300 adults were randomly assigned to one of two groups and followed for 12 weeks. The main goal…

This study tested a new medicine called XW003 in 211 adults with type 2 diabetes whose blood sugar was not well managed by diet and exercise alone. Participants received either XW003 or a placebo (dummy pill) to see if the drug could safely lower blood sugar levels. The main goal…

This study tested four different doses of an experimental drug called MP-513 in 448 adults with type 2 diabetes who were already taking metformin. The goal was to see if adding MP-513 safely improves blood sugar control over 24 weeks, with an optional extension up to 52 weeks. Pa…

This study tested a new diabetes medicine called MP-513 (Teneligliptin) in 203 Japanese adults with type 2 diabetes. The goal was to see if the drug safely lowers blood sugar levels over 12 weeks compared to a placebo. Participants had to be between 20 and 75 years old, manage th…

This study tested a new medicine called CT-868 in 103 overweight or obese adults with type 2 diabetes. The goal was to see if it could lower blood sugar levels and help with weight loss over 26 weeks. Participants received either the drug or a placebo, and researchers measured ch…

This early-stage study tested a new drug called ZT002 in 32 healthy adults to see if it is safe and how the body processes it. The goal is to develop a treatment for type 2 diabetes. Participants received either the drug or a placebo, and researchers monitored for side effects. T…

This study tested three doses of a new drug called maridebart cafraglutide (AMG 133) against a placebo in 592 adults with overweight or obesity, some of whom also had type 2 diabetes. The main goal was to see how much weight participants lost after 52 weeks. The drug aims to help…

This study tested if weight-loss surgery (vertical sleeve gastrectomy) could improve pancreas, kidney, and heart health in teens aged 12-21 with type 2 diabetes and severe obesity. Researchers measured kidney function, blood flow, and insulin production before and after surgery. …

This study tested the Omnipod M System, a wearable insulin pump, in 40 adults with type 2 diabetes. The goal was to see if the system helps keep blood sugar in a safe range and reduces dangerous highs and lows. Participants used the pump for 6 weeks while researchers tracked thei…

This study tested the safety and effectiveness of the drug MP-513 (Teneligliptin) in 240 Japanese adults with type 2 diabetes. Some took MP-513 alone, others combined it with the older drug glimepiride. Over 52 weeks, researchers tracked side effects and measured blood sugar cont…

This study tested two ways of taking insulin in 218 adults with type 2 diabetes. One group took a combined insulin twice a day, the other took it once a day plus extra insulin shots. After 16 weeks, researchers compared blood sugar control and safety to find which schedule works …

This study tested a medication called TA-7284 in over 1,200 Japanese adults with type 2 diabetes to see if it is safe and helps control blood sugar over a full year. Participants took the drug alone or with other diabetes medicines. The main goals were to track side effects and b…

This study tested an experimental daily pill (TA-7284) in 383 adults with type 2 diabetes to see if it safely lowers blood sugar and helps with weight. Participants took either the drug or a placebo for several weeks. The main goal was to measure changes in HbA1c (average blood s…

This study tested a drug called teneligliptin in 254 Chinese adults with type 2 diabetes. The goal was to see if it safely lowers blood sugar levels over 24 weeks compared to a placebo. Participants took the drug or a dummy pill, and researchers measured changes in HbA1c and fast…

This study tested a treatment called REACT (rilparencel) for people with type 1 or 2 diabetes who also have chronic kidney disease. The treatment uses a person's own kidney cells to try to slow down kidney damage. 53 adults took part, and the study looked at safety and whether it…

This study tested two injectable diabetes drugs, iGlarLixi and IDegAsp, in 582 Chinese adults with type 2 diabetes whose blood sugar was not well controlled by oral medications. The goal was to see which drug worked better at lowering blood sugar over 24 weeks. Both drugs are use…

This study looked at the long-term safety and effectiveness of adding canagliflozin to insulin therapy in people with type 2 diabetes. It included 139 adults who had already completed a 16-week study. Researchers monitored side effects, blood sugar control, and weight changes ove…

This study tested whether a once-weekly injection of exenatide, a drug used for type 2 diabetes, can improve markers of heart and kidney health in people with diabetes and mild kidney problems. 57 adults received either exenatide or a placebo for 38 weeks. Researchers measured ch…

This study tested a new medicine called CagriSema, a once-weekly injection, to help people with overweight or obesity and type 2 diabetes lose weight. About 1,200 adults received either CagriSema or a placebo for around 1.5 years. The main goals were to measure weight loss and ho…

This study looked at whether testosterone therapy can improve bone health in men who have both type 2 diabetes and low testosterone. 92 male veterans aged 35-70 took part. Researchers measured bone strength using special scans and blood tests over 12 months. The goal was to find …

This study tested a long-acting insulin called insulin glargine U300 in 570 Chinese adults with type 2 diabetes whose blood sugar was not well controlled. Some participants had never used insulin before, while others switched from another basal insulin. The main goal was to see h…

This study tested a new weekly medicine called CagriSema, which combines two drugs (semaglutide and cagrilintide), in over 2,700 adults with type 2 diabetes. The goal was to see if the combo lowers blood sugar and body weight better than either drug alone or a placebo. Participan…

This study tested a new drug called HTD1801 in 551 adults with type 2 diabetes whose blood sugar was not well controlled by metformin alone. Participants received either HTD1801 or a placebo for 24 weeks. The main goal was to see if the drug could lower blood sugar levels (HbA1c)…

This study tested whether adding a new medicine called JW0201 helps people with type 2 diabetes who are not well controlled on two other diabetes drugs. About 196 adults took either JW0201 or a placebo for 24 weeks. The main goal was to see if JW0201 lowers blood sugar levels mor…

This study tested a new medicine called MP-513 in 99 Japanese adults with type 2 diabetes. The goal was to see how well it controls blood sugar levels over 4 weeks. Participants took the drug and had their glucose measured after meals and throughout the day.

This study looked at how well and how safely a triple combination of diabetes drugs (zemidapa and metformin) works for people with type 2 diabetes. Over 2,000 patients who were already on other diabetes medicines took part. The main goal was to see if their blood sugar levels imp…

This study screened 316 people with type 2 diabetes who were at high risk for heart disease. Researchers tested whether a medication called liraglutide could help prevent new heart problems like heart attacks or strokes. The goal was to improve blood sugar, cholesterol, and blood…

This study tested a surgical procedure that combines a sleeve gastrectomy with an intestinal diversion to help people with obesity and type 2 diabetes lose weight and improve blood sugar control. 18 adults aged 19-65 with a BMI between 35 and 50 and stable diabetes took part. The…

This study tested a new medication called TA-7284 in 272 adults with type 2 diabetes. The goal was to see if the drug can safely lower blood sugar levels over 24 weeks compared to a placebo. Participants took the pill alone without other diabetes medicines.

This early-stage study tested an oral tablet called ecnoglutide in 87 healthy adults to see if it is safe and how the body processes it. The drug is designed to help manage type 2 diabetes and obesity by mimicking a natural hormone that controls blood sugar and appetite. Since pa…

This study tested whether adding canagliflozin to teneligliptin helps Japanese adults with type 2 diabetes who are not well controlled on teneligliptin alone. 138 participants took the combination daily for 24 weeks. The main goal was to see if it lowered blood sugar levels (HbA1…

This study tested whether adding teneligliptin to metformin helps Chinese adults with type 2 diabetes control their blood sugar better than metformin alone. 247 participants took either the combination or a placebo for 24 weeks. The main goal was to see changes in HbA1c, a key bl…

This study tested the long-term safety and effectiveness of the drug MP-513 (Teneligliptin) in 462 Japanese adults with type 2 diabetes. Participants took the drug alone or with other diabetes pills for 52 weeks. The main goal was to track side effects, and researchers also measu…

This study tested a once-daily combination pill (MT-2412) containing two diabetes drugs, Teneligliptin and Canagliflozin, in 153 Japanese adults with type 2 diabetes whose blood sugar was not well controlled on Teneligliptin alone. Over 52 weeks, researchers monitored safety and …

This study tested a new weekly injection called TG103 in 465 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. Participants received either a low dose, a higher dose, or a placebo shot once a week. The main goal was to see if the dr…

This study tested whether a personalized meal plan (IDP) is practical and helpful for adults with type 2 diabetes. 122 participants were randomly assigned to either receive customized diet advice or standard care for 10 weeks. Researchers measured blood sugar (HbA1c), cholesterol…

This study looked at whether Soliqua 100/33, a combination insulin and GLP-1 drug, can help people with very uncontrolled type 2 diabetes (HbA1c ≥9%) spend more time in a healthy blood sugar range. About 124 participants who were already on at least two diabetes pills wore a cont…

This early-stage study tested an experimental oral drug called XW014 in 127 healthy volunteers and people with type 2 diabetes. The main goal was to check safety and how the body processes the drug, including the effect of food. Researchers gave single or multiple doses to find t…

This study tested a new injectable drug called TG103, taken with the common diabetes pill metformin, in 632 adults with type 2 diabetes. The goal was to see if TG103 helps lower blood sugar better than an existing drug (dulaglutide) over 28 weeks. Participants had poorly controll…

This study tested whether adding teneligliptin to canagliflozin helps Japanese adults with type 2 diabetes who still have high blood sugar despite taking canagliflozin alone. Over 24 weeks, 154 participants took both drugs once daily. The main goal was to see if the combination l…

This study tested a lifestyle program designed for Native Hawaiian and Pacific Islander adults with conditions like prediabetes, type 2 diabetes, high blood pressure, or obesity. Community health workers delivered the program, which included support for social needs like housing …

This study tested different starting doses of insulin using an automated delivery system (Omnipod M with a continuous glucose monitor) in 56 adults with type 2 diabetes. The goal was to see if a simplified setup is safe and helps keep blood sugar in a healthy range. Participants …

This study tested a new oral drug called BMF-219 in healthy adults and people with type 2 diabetes. The goal was to see if it is safe and how it affects blood sugar control over 26 weeks. The trial involved 443 participants and compared the drug to a placebo.

This study tested a new drug, MP-513 (Teneligliptin), added to a standard diabetes pill (pioglitazone) in 204 Japanese adults with type 2 diabetes. The goal was to see if the combination improved blood sugar control over 12 weeks, with a follow-up up to 52 weeks. Participants had…

This study tested whether adding canagliflozin (a diabetes pill) to insulin helps people with type 2 diabetes control their blood sugar better than insulin alone. About 146 adults with type 2 diabetes who were already on a stable insulin dose took either canagliflozin or a placeb…

This study looked at how a single dose of the experimental drug LY3209590 enters and leaves the blood in children with type 2 diabetes. Fifteen children took part, and the study lasted about 100 days. The goal was to understand the drug's processing in the body, not to treat the …

This study tested whether a personalized diet program based on behavior change theory could help people with type 2 diabetes better manage their condition. Researchers worked with 30 adults who had type 2 diabetes to see if the program improved blood sugar control and other healt…

This study looked at whether interacting with a live turtle or watching turtle videos could help adults with type 2 diabetes lower their blood sugar levels (HbA1c) and feel more confident about taking their diabetes medication. Fifty-one participants were split into groups that e…

This study looked at whether taking a daily powder of bitter melon, blueberry, or cranberry could help people with type 2 diabetes control their blood sugar and feel better. 120 adults took the powder twice a day for 12 weeks. Researchers measured their average blood sugar (HbA1c…

This study tested a 12-week intensive aerobic and resistance exercise program in 58 adults aged 40-85 with type 2 diabetes and mild cognitive issues. Researchers measured changes in thinking skills, blood sugar, inflammation, and physical function. The goal was to see if exercise…

This study looked at whether giving a carbohydrate-rich drink before abdominal surgery is safe and helpful for people with type 2 diabetes. Traditionally, patients fast before surgery, which can stress the body and slow recovery. The study involved 120 adults and measured stomach…

This study looked at whether shivering from cold temperatures can improve blood sugar levels over 24 hours in people with prediabetes or type 2 diabetes. Researchers had 24 participants experience different intensities of cold-induced shivering. The goal was to see if this simple…

This study looked at 186 pregnant women with type 1 or type 2 diabetes to understand how fats (lipids) in the mother's and baby's blood relate to birth weight. Even when blood sugar is well-controlled, babies of diabetic mothers are often larger than average, which can cause deli…

This study looked at how the diabetes drug metformin changes gut bacteria and thinking skills in 50 older adults with type 2 diabetes. Participants were followed for one year, with some taking metformin for six months. Researchers measured memory, attention, and other mental func…

This study tested a disaster preparedness education program in 68 people with type 2 diabetes and diabetic foot. The program aimed to improve how ready they are for disasters, how well they care for their feet, and their confidence in foot care. Participants were split into two g…

This study looked at whether using a blood test called glycated albumin (GA) to guide diabetes medication works better than the usual HbA1c test. 200 adults newly diagnosed with type 2 diabetes were split into two groups: one where doctors used GA levels to adjust treatment, and …

This study tested a personalized approach to see if some people with type 2 diabetes who take multiple daily insulin injections could safely stop their mealtime insulin. Researchers used blood tests (C-peptide and GAD antibodies) to guide treatment decisions. 239 participants wor…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. The goal was to see how many have elevated levels of albumin in their urine, which is an early sign of kidney disease. Researchers tracked these levels over about a year to unders…

This study looked at nearly 242,000 adults with type 2 diabetes to find out which glucose-lowering medications are best for heart health and other important outcomes. Researchers also examined whether benefits differ by age, sex, race, or kidney function. The goal is to help pati…

This study tested whether gentle reminders in electronic health records could help doctors avoid unnecessary tests and treatments in older adults. Researchers focused on three common issues: testing for bladder infections without symptoms, PSA tests in older men, and overtreating…

This study tested whether a generative AI simulation program can improve how medical students communicate a type 2 diabetes diagnosis. 120 students were split into two groups: one used the AI platform DIALOGUE-DM2, the other followed traditional teaching. The goal was to see if A…

This study looked at whether a short therapy program for depression could help prevent type 2 diabetes in teenage girls at high risk. Researchers tested a cognitive-behavioral therapy group against a health education group in 147 girls aged 12-17 with depressive symptoms and a fa…

This study combined data from four earlier trials to track 262 adults with type 2 diabetes and obesity for up to 13 years. Researchers compared the long-term effects of bariatric surgery versus standard medical and lifestyle treatments on blood sugar control. The goal was to see …

This study looked at how four different diabetes medications (HRS-1780, henagliflozin, metformin, and HRS-7535) affect each other in the body. It involved 24 healthy adult men who took the drugs in a fixed order. The goal was to measure drug levels and safety, not to treat any di…

This study looked at whether wearing a continuous glucose monitor (CGM) can help predict low blood sugar (hypoglycemia) in adults with type 2 diabetes. 41 participants wore either a regular CGM or a hidden one for a short time. The goal was to compare how often low blood sugar ha…

This study looked at whether the incremental shuttle walk test (a walking test that gets faster over time) is a reliable and valid way to measure exercise capacity in people with type 2 diabetes. 120 adults with diabetes completed the test twice, one week apart, along with a stan…

This study observed over 6,500 Chinese adults with chronic kidney disease and type 2 diabetes who started taking the drug finerenone. Researchers looked at patient health records to understand how the drug is used in real life, including its effects on kidney function and potassi…

This early-stage study looked at how different versions of an experimental diabetes pill (HRS-7535) are absorbed by the body, and whether a high-fat meal changes that. It involved 24 healthy adults aged 18-45. The goal was to gather information, not to treat or cure diabetes.

This study looked at whether people with type 2 diabetes who show signs of premature aging are more likely to develop heart muscle disease. Researchers measured aging markers in blood and used heart imaging in 150 adults aged 40-55 with diabetes but no heart symptoms. The goal wa…

This study looked at how the experimental drug TA-7284 behaves in people with type 2 diabetes who also have moderate kidney impairment. Researchers measured drug levels in the blood and urine, and checked for side effects. The goal was to understand how kidney function affects th…

This study followed 24 adults with type 2 diabetes who use insulin pumps. Over 14 days, researchers used continuous glucose monitors to track blood sugar levels and linked them to insulin doses and meals. The goal was to understand real-life patterns, not to test a new treatment.

This early-phase study investigated whether raising ketone levels in the blood could improve heart function in people with both type 2 diabetes and heart failure. Researchers gave 41 participants infusions of a ketone substance at different doses and used heart scans (MRI and PET…