Can a new pill tame blood sugar in type 2 diabetes?

NCT ID NCT06411275

Completed Disease control Sponsor: Shenzhen HighTide Biopharmaceutical Ltd. Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This clinical trial is testing an investigational drug called HTD1801 (berberine ursodeoxycholate) to see if it can improve blood sugar control in adults with type 2 diabetes that is not well managed by diet and exercise alone. The study will compare the drug against a placebo over 12 weeks, measuring changes in HbA1c (a long-term blood sugar marker) and other glucose measures. Participants will be randomly assigned to receive either the drug or a placebo, and neither they nor the researchers will know which they are getting. The goal is to determine if this oral medication is safe and effective for helping people with type 2 diabetes achieve better blood sugar levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HTD1801 (berberine ursodeoxycholate), taken orally as capsules
What this could lead to: If successful, this could lead to a new oral medication to help people with type 2 diabetes better manage their blood sugar levels.
What could go wrong: This is an early-stage trial with a small number of participants, so results may not be conclusive or apply to everyone. The drug may also have side effects or fail to show significant benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES MELLITUS

Contacts and locations

Locations

Affiliated Hospital of Jiangsu University

Zhenjiang, China
Huizhou Municipal Central Hospital

Huizhou, China
Jinan Central Hospital

Jinan, China
Liaocheng People's Hospital

Liaocheng, China
Nanjing First Hospital

Nanjing, China
Nanjing Jiangning Hospital

Nanjing, China
Peking University People's Hospital

Beijing, China
Sir Run Run Hospital Nanjing Medical University

Nanjing, China
The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, China
The First Affiliated Hospital of Nanyang Medical College

Nanyang, China
The First People's Hospital of Changde City

Changde, China
The Fourth Affiliated Hospital of Harbin Medical University

Harbin, China
The Second Hospital of Jilin University

Changchun, China
Yan'an University Affiliated Hospital

Yanan, China

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