New combo shot shows promise for weight loss in chinese adults

NCT ID NCT05996848

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new weekly injection called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help Chinese adults with obesity or overweight lose weight. About 300 participants received either CagriSema, semaglutide alone, or a placebo for around one year. The main goals were to see how much weight they lost and how many achieved at least a 5% reduction in body weight.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CagriSema (cagrilintide and semaglutide combination)
What this could lead to: If successful, this could provide a new weekly injection option for significant weight loss in Chinese adults with obesity or overweight.
What could go wrong: This is a Phase 3 trial, but results may not apply to all populations. Side effects from the drugs (like nausea or gastrointestinal issues) are possible, and the long-term safety is still being studied.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OR OVERWEIGHT

Contacts and locations

Locations

Central Hospital of Minhang District, Shanghai-Endocrinology

Shanghai, Shanghai Municipality, 201199, China
Central Hospital of Minhang District-Endocrinology

Shanghai, Shanghai Municipality, 201199, China
Changzhou No.2 People's Hospital

Changzhou, Jiangsu, 213003, China
Chinese People's Liberation Army General Hospital-Endocrinology

Beijing, Beijing Municipality, 100853, China
Chongqing University Three Gorges Hospital

Chongqing, Chongqing Municipality, 404000, China
Fujian Medical University Union Hospital-Endocrinology

Fuzhou, Fujian, 350001, China
General Hospital of Tianjin Medical University

Tianjin, Tianjin Municipality, 300052, China
General Hospital of Tianjin Medical University-Endocrinology

Tianjin, Tianjin Municipality, 300052, China
Hengshui People's Hospital (Harrison International Peace Hospital)-Endocrinology

Hengshui, Hebei, 053000, China
Huaihe Hospital of Henan University

Kaifeng, Henan, 475000, China
Huaihe Hospital of Henan University-Endocrinology

Kaifeng, Henan, 475000, China
Huashan Hospital Fudan University

Shanghai, Shanghai Municipality, 200040, China
Huashan Hospital Fudan University

Jingan/Shanghai, 200040, China
Huizhou Central People's Hospital-Endocrinology

Huizhou, Guangdong, 516001, China
Jinan Central Hospital

Ji'nan, Shandong, 250013, China
Jinan Central Hospital

Jin'an, Shandong, 250013, China
Jinan Central Hospital

Jinan, Shandong, 250013, China
Shanghai Pudong New Area People's Hospital-Endocrinology

Shanghai, Shanghai Municipality, 201200, China
Suzhou Municipal Hospital-Endocrinology

Suzhou, Jiangsu, 215002, China
The Affiliated Hospital of Jiangsu University

Zhenjiang, Jiangsu, 212001, China
The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221002, China
The First Affiliated Hospital of Henan University of Science and Technology-Endocrinology

Luoyang, Henan, 471003, China
The First Affiliated Hospital of Henan university of Science

Luoyang, Henan, 471003, China
The First Affiliated Hospital of Soochow University-Endocrinology

Suzhou, Jiangsu, 215006, China
The First Bethune hospital of Jilin University-Endocrinology

Changchun, Jilin, 130061, China
The First People's Hospital of Changde City-Endocrinology

Changde, Hunan, 415003, China
The First People's Hospital of Changzhou

Changzhou, Jiangsu, 213003, China
The First People's Hospital of Changzhou

Changzhou, Jiangsu, 213004, China
The Second Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, 210011, China
The Second Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450003, China
The Second Affiliated Hospital of Zhengzhou University-Endocrinology

Zhengzhou, Henan, 450003, China
The Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, 050000, China
The Second Hospital of Hebei Medical University-Endocrinology

Shijiazhuang, Hebei, 050000, China
The Second Hospital of Tianjin Medical University

Tianjin, Tianjin Municipality, 300211, China
The first hospital of Jilin University

Changchun, Jilin, 130021, China
Tongren Hospital Shanghai Jiao Tong Univ. School of Medicine

Shanghai, Shanghai Municipality, 200336, China
Tongren Hospital Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200336, China

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