Could two kidney drugs together be better than one?

NCT ID NCT05254002

Completed Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates whether taking two medications—finerenone and empagliflozin—together can better slow kidney function decline in people with chronic kidney disease and type 2 diabetes compared to taking either drug alone. Participants are randomly assigned to receive the combination, finerenone plus a placebo, or empagliflozin plus a placebo for six months. The main goal is to measure changes in urine protein levels, a key marker of kidney health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: finerenone and empagliflozin
What this could lead to: If successful, this combination could offer a more effective way to slow kidney disease progression in people with type 2 diabetes, potentially reducing the need for dialysis or transplant.
What could go wrong: This is a phase 2 trial, so results are preliminary. The combination may not prove significantly better than each drug alone, and side effects from taking two medications together are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE TYPE 2 DIABETES MELLITUS

Contacts and locations

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Locations

ASL N 4 SSR Liguria_Ospedale di Chiavari - Diabetologia e Malattie Metaboliche

Chiavari, Liguria, 16043, Italy
AZ Delta

Roeselare, 8800, Belgium
AZ Groeninge Campus Kennedylaan

Kortrijk, 8500, Belgium
Academic Medical Research Institute

Los Angeles, California, 90022, United States
Albert Schweitzer Ziekenhuis | Dordwijk - Cardiology Department

Dordrecht, South Holland, 3318 AT, Netherlands
All India Institute of Medical Sciences

Bhubaneswar, National Capital Territory of Delhi, 751019, India
Ansan Hospital | Nephrology

Gyeonggi-do, 425-707, South Korea
Area Sanitaria De Ferrol | Medicina Interna

Ferrol, A Coruña, 15405, Spain
Asan Medical Center | Ophthalmology

Seoul, Seoul Teugbyeolsi, 05505, South Korea
Asian Kidney Hospital and Medical Centre

Nagpur, Maharashtra, 440010, India
Azienda Ospedaliero Universitaria Parma - SC Nefrologia

Parma, Emilia-Romagna, 43126, Italy
Azienda Ospedaliero Universitaria Pisana_Cisanello - Malattie Metaboliche e Diabetologia

Pisa, Tuscany, 56124, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Malattie Metaboliche Diabetologia

Orbassano, Piedmont, 10043, Italy
Azienda Socio Sanitaria Locale N 2 Della Gallura - Diabetologia

Olbia, Sardinia, 07026, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Malattie Endocrine e Diabetologia

Bergamo, Lombardy, 24127, Italy
Azienda Socio Sanitaria Territoriale Rhodense

Rho, Lombardy, 20017, Italy
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo_Ospedale S. Paolo - Gestione integrata della malattia Diabetica

Milan, Lombardy, 20142, Italy
Bangalore Medical College & Research Institute

Bengaluru, India
Barzilai Medical Center | Department of Nephrology and Hypertension

Ashkelon, 7830604, Israel
Biopharma Informatic - McAllen, TX

McAllen, Texas, 78503, United States
Bispebjerg Hospital - Hjerteafdeling

Copenhagen, Capital Region, 2400, Denmark
Blue Sky, MD/ Lamond Family Medicine

Hendersonville, North Carolina, 28792, United States
Bluewater Clinical Research Group

Sarnia, Ontario, N7T 4X3, Canada
CCT Research - Santa Rosa Medical Centers of Nevada

Las Vegas, Nevada, 89119, United States
CHU Dijon - Hopital Francois Miterrand

Dijon, Bourgogne-Franche-Comté, 21000, France
CHU de Charleroi Hôpital civil

Lodelinsart, Hainaut, 6042, Belgium
Cardiologicum Pirna / Dresden-Seidnitz

Pirna, Saxony, 1796, Germany
Casa Sollievo della Sofferenza - Endocrinologia

San Giovanni Rotondo, Apulia, 71013, Italy
Center Hospitalier Michallon - Grenoble

La Tronche (Grenoble Area), Auvergne-Rhône-Alpes, 38043, France
Center for Advanced Medicine - Diabetes Center

St Louis, Missouri, 63110, United States
Centre Hospitalier de l'Universite de Montreal (CHUM) | Cardiology

Montreal, Quebec, H2X 0A9, Canada
Chang Gung Memorial Hospital Kaohsiung

Kaohsiung City, Kaohsiung, 833, Taiwan
Changhua Christian Hospital

Changhua, Changhua, 50006, Taiwan
Charité Campus Benjamin Franklin (CBF)

Berlin, State of Berlin, 12203, Germany
China Medical University Hospital

Taichung, 404327, Taiwan
Circuit Clinical/Crystal Run

Middletown, New York, 10941, United States
Clalit Health | Soroka Medical Center - Internal Medicine Department

Beersheba, 8410101, Israel
ClinPhenomics GmbH&Co. KG

Frankfurt am Main, Hesse, 60596, Germany
Clinical Advancement Center, PLLC

San Antonio, Texas, 78212, United States
Clinical Research Consultants, a JCCT Company

Kansas City, Missouri, 64111, United States
Clinical Research Solutions, Inc.

Waterloo, Ontario, N2T 0C1, Canada
Complexo Hospitalario Universitario A Coruna | Endocrinologia y Nutricion

A Coruña, A Coruña, 15006, Spain
DaVita Clinical Research- El Paso

El Paso, Texas, 79925, United States
DarSalud Care / LifeDOC Research

Memphis, Tennessee, 38119, United States
Diabetes Zentrum Wandsbek

Hamburg, Free and Hanseatic City of Hamburg, 22041, Germany
Diabetologische Schwerpunkt Praxis Dortmund

Dortmund, North Rhine-Westphalia, 44137, Germany
Dignity Health Northridge Hospital Medical Center - Nephrology

Northridge, California, 91325, United States
Dr. Bantwal's Clinic

Bengaluru, 560076, India
Dunes Clinical Research LLC

Dakota Dunes, South Dakota, 57049, United States
Eastern Nephrology Associates - Greenville West

Greenville, North Carolina, 27834, United States
Eastern Nephrology Associates - Kinston

Kinston, North Carolina, 28504, United States
Edith Wolfson Medical Center | Internal Medicine Department

Holon, 5822012, Israel
Eternal Heart Care Centre (EHCC) and Research Institute

Jaipur, Rajasthan, 302020, India
Far Eastern Memorial Hospital | Nephrology Department

New Taipei City, New Taipei, 220, Taiwan
Florida Kidney Physicians - Delray Beach Nephrology

Delray Beach, Florida, 33445, United States
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Endocrinologia

Milan, Lombardy, 20122, Italy
Friedrich-Schiller-Uni. Jena

Jena, Thuringia, 7747, Germany
Fukui-ken Saiseikai Hospital

Fukui-shi, Fukui, 918-8503, Japan
Fukuoka University Chikushi Hospital

Chikushino-shi, Fukuoka, 818-8502, Japan
G.S.V.M. Medical College

Kanpur, Uttar Pradesh, 208002, India
GCP Research | Montreal

Montreal, Quebec, H1M 1B1, Canada
Gelre Ziekenhuizen

Apeldoorn, Gelderland, 7334 DZ, Netherlands
Global Kidney Center

Houston, Texas, 77008, United States
Government Kilpauk Medical College Hospital

Chennai, Tamil Nadu, 600010, India
Government Medical College

Kozhikode, Kerala, 673008, India
Government Medical College and Hospital (GMCH) Nagpur

Nagpur, 440009, India
Grady Memorial Hospital - Endocrinology

Atlanta, Georgia, 30303, United States
Grant Medical Foundation - Ruby Hall Clinic (RHC)

Pune, Maharashtra, 411001, India
HaEmek Medical Center | Internal Medicine C Department - Research Unit

Afula, 1834111, Israel
Hadassah University Medical Center (HUMC)

Jerusalem, 911200, Israel
Hallym University Kangnam Sacred Heart Hospital

Seoul, 7442, South Korea
Hallym University Sacred Heart Hospital

Anyang-si, Gyeonggido, 14068, South Korea
Hamilton Medical Research Group

Hamilton, Ontario, L8M 1K7, Canada
Hanyang University Guri Hospital

Guri-si, Gyeonggi-do, 471-701, South Korea
Healor Primary Care / CCT Research

Las Vegas, Nevada, 89102, United States
Health Corporation of Galilee Medical Center

Nahariya, 2210001, Israel
Health Corporation of the Ziv Medical Center (R.A.)

Safed, 1311001, Israel
Hirohata Naika Clinic

Kitakyushu, Fukuoka, 807-0857, Japan
Hopital Carémeau - Nîmes

Nîmes, Occitanie, 30029, France
Hospital Clinico Universitario De Valencia | Cardiologia

Valencia, Valencia, 46010, Spain
Hospital Nisa Sevilla Aljarafe | Endocrinologia y Nutricion

Castilleja de la Cuesta, Sevilla, 41950, Spain
Hospital Quironsalud Barcelona | Internal Medicine Department

Barcelona, Barcelona, 8023, Spain
Hospital Universitari Vall D Hebron | Nefrologia

Barcelona, Barcelona, 08035, Spain
Hospital Universitario Dr Peset Aleixandre | Nefrologia

Valencia, Valencia, 46017, Spain
Hospital Universitario Fundacion Jimenez Diaz | Nephrology and Hypertension Department

Madrid, Madrid, 28040, Spain
Hospital Universitario Principe De Asturias | Nefrologia

Alcalá de Henares, Madrid, 28805, Spain
Hospital Universitario Puerta De Hierro De Majadahonda | Nefrologia

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Virgen De La Victoria | Endocrinologia y Nutricion

Málaga, Málaga, 20910, Spain
Hospital Universitario Virgen De Las Nieves | Medicina Interna

Granada, Granada, 18014, Spain
Hospital of South West Jutland | Department of Endocrinology Research

Esbjerg, Region Syddanmark, 6700, Denmark
Hôpital Edouard Herriot - Lyon Cedex

Lyon, Auvergne-Rhône-Alpes, 69003, France
Hôpital Saint Joseph

Paris, Île-de-France Region, 75014, France
Indraprastha Apollo Hospital

New Delhi, National Capital Territory of Delhi, 110076, India
Innovative Research Institute

Port Charlotte, Florida, 33952, United States
Institute of Post-Graduate Medical Education and Research

Kolkata, West Bengal, 700020, India
Jan Yperman Ziekenhuis

Ieper, 8900, Belgium
Jiyugaoka Yamada Internal Medicine Clinic

Obihiro, Hokkaido, 080-0848, Japan
K.L.E.S. Dr. Prabhakar Kore Hospital & Medical Research Centre

Belagavi, Karnataka, 590010, India
Kansas City VA Medical Center - Endocrinology

Kansas City, Missouri, 64128, United States
King George Hospital

Visakhapatnam, Andhra Pradesh, 530002, India
Kokura Memorial Hospital

Kitakyushu, Fukuoka, 802-8555, Japan
Krishna Institute Of Medical Science

Secunderabad, Telangana, 500003, India
Kyung Hee University Hospital at Gangdong

Seoul, 5278, South Korea
LMC Clinical Research Inc. Montreal

Saint-Laurent, Quebec, H4T 1Z9, Canada
Lake Michigan Nephrology

Saint Joseph, Michigan, 49085, United States
Lifepoint Multispecialty Hospital

Pune, 411057, India
Manipal Hospital

Mysore, Karnataka, 570015, India
Many Locations

Many Locations, France
Many Locations

Many Locations, Italy
Many Locations

Many Locations, Japan
Many Locations

Many Locations, Spain
Many Locations

Many Locations, Taiwan
Mavani Dialysis & Kidney Center

Ahmedabad, Gujarat, 380052, India
Max Super Speciality Hospital (MSSH) - Saket

New Delhi, 110017, India
Meander Medisch Centrum

Amersfoort, Utrecht, 3818 TZ, Netherlands
Medical Corporation Taifukukai, Osaka Nishiumeda Clinic

Osaka, Osaka, 530-0001, Japan
Metabolic Research Institute, Inc.

West Palm Beach, Florida, 33401, United States
MultiCare Rockwood Clinic Diabetes & Endocrinology Center

Spokane, Washington, 99202, United States
Naka Kinen Clinic

Naka, Ibaraki, 311-0113, Japan
Nizam's Institute of Medical Sciences (NIMS)

Hyderabad, Telangana, 500082, India
Nola Care Clinical Research

Metairie, Louisiana, 70006, United States
North Texas Kidney Disease Associates Lewisville

Lewisville, Texas, 75057, United States
Oakland Medical Research

Troy, Michigan, 48085, United States
Office of Osvaldo A. Brusco, MD

Corpus Christi, Texas, 78414, United States
Olive View - UCLA Medical Center

Sylmar, California, 91342-1437, United States
Olympus Family Medicine

Salt Lake City, Utah, 84117, United States
Omega Clinical Research - Metairie

Metairie, Louisiana, 70006, United States
Onze Lieve Vrouwe Gasthuis

Amsterdam, North Holland, 1091 AC, Netherlands
Onze-Lieve-Vrouwziekenhuis (OLVZ) - Campus Aalst

Aalst, Oost-vlaanderen, 9300, Belgium
Osaka General Medical Center

Osaka, Osaka, 558-8558, Japan
Osmania General Hospital

Telangana, Telangana, 500012, India
Ospedale San Raffaele s.r.l. - Medicina Generale Indirizzo Diabetologico ed Endocrino-Metabolico

Milan, Lombardy, 20132, Italy
Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office

Hakusan, Ishikawa-ken, 924-8588, Japan
Randolph Health Internal Medicine in Asheboro

Asheboro, North Carolina, 27203, United States
Region Midtjylland | Regionshospitalet Godstrup - Nephrology Department

Herning, Central Jutland, 7400, Denmark
Saiseikai Matsuyama Hospital

Matsuyama, Ehime, 791-8026, Japan
Salem VA Medical Center - Endocrinology

Salem, Virginia, 24153, United States
Sameh Fikry Professional Corporation

Waterloo, Ontario, N2J 1C4, Canada
Sawami Man Singh (SMS) Medical College & Attached Hospitals

Jaipur, Rajasthan, 302017, India
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggido, 13620, South Korea
Seoul National University Hospital

Seoul, Seoul Teugbyeolsi, 3080, South Korea
Seth Gordhandas Sunderdas Medical College (GSMC) - King Edward Memorial (KEM) Hospital

Mumbai, Maharashtra, 400012, India
Severance Hospital, Yonsei University Health System

Seoul, Seoul Teugbyeolsi, 03722, South Korea
Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital

Fukuoka, Fukuoka, 811-0213, Japan
Somnos Clinical Research

Lincoln, Nebraska, 68510, United States
Soon Chun Hyang University Cheonan Hospital

Cheonan, Chungcheongnam-do, 31151, South Korea
South Shore Nephrology

Plymouth, Massachusetts, 02360, United States
Southeast Kidney Associates - East Point

East Point, Georgia, 30344, United States
Southwest Kidney Institute, PLC - Suprise

Surprise, Arizona, 85374, United States
Sriram Chandra Bhanj Medical College & Hospital

Cuttack, India
St. Louis Heart and Vascular, PC - Christian Hospital Office

St Louis, Missouri, 63136, United States
Steno Diabetes Center Copenhagen | Herlev - Clinical and Translational Research Department

Herlev, Capital Region, 2730, Denmark
Taichung Veterans General Hospital

Taichung, Taichung, 40705, Taiwan
Taipei Medical University - Shuang Ho Hospital

New Taipei City, New Taipei, 23561, Taiwan
Taipei Veterans General Hospital

Taipei, Taipei, 11217, Taiwan
The Catholic University of Korea, Incheon St.Mary's Hospital

Incheon, Incheon Gwang''Yeogsi, 21431, South Korea
The University of Tennessee Health Science Center - Medical Center Clinic - Nephrology

Memphis, Tennessee, 38163, United States
Thyroid, Endocrinology, and Diabetes - Dallas

Dallas, Texas, 75208, United States
Touro University California - Metabolic Research Center

Vallejo, California, 94592, United States
UNC Hospitals Outpatient Center at Eastowne - Nephrology

Chapel Hill, North Carolina, 27514, United States
UT Health San Antonio - Medical Arts & Research Center - Endocrinology

San Antonio, Texas, 78229, United States
UZ Gent

Ghent, 9000, Belgium
UZ Leuven Gasthuisberg

Leuven, 3000, Belgium
Università degli Studi "G. D'Annunzio" di Chieti - Endocrinologia

Chieti, 66100, Italy
Vedanta Kidney Care

Vadodara, Gujarat, 390007, India
Velocity Clinical Research - Blue Ash

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research - Savannah

Savannah, Georgia, 31406, United States
Victorium Clinical Research

Houston, Texas, 77024-2593, United States
Vinaya Hospital and Research Centre (A Unit of KIMS)

Mangalore, Karnataka, 575003, India
West Orange Endocrinology & Clinical Research

Ocoee, Florida, 34761, United States
William Osler Health centre, Sakuara Medical

Mississauga, Ontario, L5H4K9, Canada
Yonsei University Wonju Christian Hospital

Wŏnju, Gang''Weondo, 26426, South Korea
Zentrum für Diabetologie und Ernährungsmedizin

Ludwigshafen am Rhein, Rhineland-Palatinate, 67059, Germany

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