CHRONIC KIDNEY DISEASE

This study is the first time the experimental drug OJR520 is being tested in humans. It aims to check the drug's safety and how the body processes it in both healthy volunteers and people with chronic kidney disease. The trial is currently recruiting 112 participants and is in Ph…

This study tests an injection called UBT251 in 180 adults who are overweight or obese and have chronic kidney disease. The goal is to see if it can reduce protein in the urine, a sign of kidney damage, over 24 weeks. Participants will receive either the drug or a placebo, and the…

This study tests if empagliflozin, a drug used for diabetes, can help children aged 2 to 17 with chronic kidney disease. About 120 kids will take either the drug or a placebo for 6 months, then everyone gets the drug for a year. Researchers will check kidney function and safety t…

This study tests whether combining budesonide and ambrisentan can lower protein in the urine and slow kidney function loss in people with IgA nephropathy, a chronic kidney disease. About 129 adults aged 18–70 with protein in their urine will receive the combo for 36 weeks. The go…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks and strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years…

This study tests a new weekly injection called NNC0519-0130 in 465 adults with chronic kidney disease, some of whom also have type 2 diabetes and are overweight or obese. The goal is to see if the drug improves kidney function and is safe compared to an existing medicine (semaglu…

This study tests whether eating fruits and vegetables with different potassium levels affects blood potassium in people with chronic kidney disease. About 30 adults with moderate-to-severe kidney disease will follow two diets in random order, each with home-delivered produce. Res…

This study looks at the long-term safety of adding finerenone to standard blood pressure medicines for children aged 1 to 18 with chronic kidney disease and protein in their urine. About 100 participants who were in a previous finerenone study will take the drug for up to 18 mont…

This study tests whether adding finerenone to standard blood pressure medicines can reduce protein in the urine of children with chronic kidney disease. About 219 children aged 6 months to under 18 years will take either finerenone or a placebo for 6 months. The goal is to see if…

This study tests a new device that creates dialysis access through a small skin puncture instead of open surgery. It involves 126 adults with kidney failure who need dialysis. The goal is to see if the procedure is safe and works well, with participants followed for up to five ye…

This study is testing whether a new drug called IGT-303 is safe for people with chronic kidney disease. It will involve 94 healthy volunteers and people with kidney disease, who will receive either the drug or a placebo. The main goal is to check for side effects and how the drug…

This study looks at whether taking the blood pressure medication ramipril once or twice a day is better for kidney function in people who have both chronic kidney disease and heart failure. Researchers will measure changes in kidney health and inflammation markers after 30 days. …

This study tests whether specially trained community pharmacists can safely prescribe kidney-protective medications to people with type 2 diabetes and early kidney disease who don't have a family doctor. About 120 adults from Nova Scotia will be randomly assigned to either pharma…

This study tests whether a virtual weight management program, including a weight-loss drug called semaglutide, can help people with obesity and advanced kidney disease lose enough weight to become eligible for a kidney transplant. About 60 adults with a BMI over 35 and high risk …

This study tests whether a 6-week aerobic exercise program can reduce cardiovascular risk in people with chronic kidney disease or rheumatoid arthritis. Participants will do three 45-minute exercise sessions per week. Researchers will measure artery stiffness, blood vessel functi…

This study tests an experimental drug called HRS-1780 in about 2,000 adults with chronic kidney disease. The goal is to see if adding HRS-1780 to standard care can slow the loss of kidney function better than a placebo. Participants take the drug or placebo for 32 months while do…

This study tests a new treatment called AdiaVita, made from umbilical cord blood stem cells and exosomes with glutathione, for people with chronic kidney disease (CKD). About 100 adults aged 18 to 80 with moderate CKD will receive monthly IV infusions and a daily skin spray for t…

This study tests a new oral spray called ACE Reno in 300 adults with chronic kidney disease (CKD) from diabetes, high blood pressure, autoimmune disorders, or other causes. The goal is to see if taking it four times daily for 12 weeks can reduce protein in the urine and help stab…

This study tests whether giving fluids tailored to each patient's needs, guided by a lung water monitor, can prevent acute kidney injury in elderly people with mild-to-moderate kidney disease who undergo a heart procedure called coronary angiography. About 320 participants aged 6…

This study looks at whether a program of aerobic and strength exercises can improve physical performance and quality of life in adults with chronic kidney disease, including those on dialysis. About 50 participants will be randomly assigned to either an exercise group or a contro…

This study tests whether letting patients with chronic kidney disease manage their own blood pressure medications, with guidance from a clinical pharmacist, works better than standard care. About 160 veterans will participate. The goal is to see if this self-management approach l…

This study observes 500 adults in South Korea with chronic kidney disease and type 2 diabetes who are starting finerenone as part of their routine care. Researchers will collect data on patient characteristics, treatment patterns, and side effects over up to 12 months. The goal i…

This study tests an oral medicine called roxadustat for anemia in children and teenagers with chronic kidney disease. Anemia means low red blood cells, which can cause tiredness and weakness. The medicine is already approved for adults and is taken three times a week for up to a …

This study tests a drug called eplerenone in 40 people who have both heart failure with reduced pumping function and severe chronic kidney disease. The goal is to see if the drug is safe and feasible for this group, who have been left out of previous studies. If successful, it co…

This study is testing whether empagliflozin, a drug used for diabetes and kidney disease, is safe for people who have received a kidney transplant. The goal is to see if it can help protect the transplanted kidney and heart from long-term damage. The study will enroll 264 veteran…

This study tests a drug called etelcalcetide in children aged 28 days to under 18 years who have chronic kidney disease and are on dialysis. The goal is to see if it can safely lower high levels of parathyroid hormone, a common complication. About 56 participants will receive eit…

This study is testing an artificial intelligence (AI) system that reads kidney biopsy images to help diagnose chronic kidney disease. Researchers will compare the AI's results to the standard diagnosis made by pathologists. The goal is to see how accurate the AI is at identifying…

This study looks at whether exercising during dialysis or right before it works better for people with kidney failure. About 72 adults on dialysis will be split into two groups and do supervised exercises twice a week for 12 weeks. The goal is to see which timing improves walking…

This study tests whether combining exercise with blood flow restriction (using a cuff to lightly limit blood flow to the limbs) can improve exercise capacity and tolerance in people with chronic kidney disease. Researchers will measure breathing, heart function, and overall fitne…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers want to see if getting a new kidney improves blood flow to the heart and reduces inflammation. Participants will have heart scans and blood tests before and …

This study is building a special collection of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait. Researchers will use these samples, along with medical records, to learn how kidney disease starts and gets worse in people with the sickle cell g…

This study tests an online decision aid for adults with both chronic kidney disease and heart disease. The tool helps patients and doctors understand the risks and benefits of heart procedures like angiograms or surgery, which can be riskier for people with kidney problems. About…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and tests ways to improve their fitness. Researchers will measure changes in exercise capacity and blood pressure in 156 participants, including CKD patients, kidney transplant recipients, an…

This study is creating a large database of 8,000 adults with heart, kidney, or metabolic diseases (like diabetes). Researchers will collect medical records, imaging, and lab results, then follow participants for up to 5 years. The goal is to better understand how these conditions…

This study looks at three different ways to teach people with advanced kidney disease about getting a special blood vessel (called vascular access) for dialysis. About 360 adults will be placed into one of three groups: one gets a video and brochure, another gets the video plus e…

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study looks at whether short-term use of NSAID pain relievers (like ibuprofen) after surgery increases the risk of acute kidney injury in children with mild-to-moderate chronic kidney disease. About 80 children aged 18 months and older will be monitored. The goal is to gathe…

This study aims to find more accurate ways to measure metabolism (how your body uses food for energy) by looking at body size and shape. Researchers will study 2000 healthy people and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital …

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. Researchers will give single or multiple doses of the drug and watch for side effects. The study also checks if people can reliab…

This study looks at 50,000 people in Asia and the US who have chronic kidney disease and type 2 diabetes and are already taking finerenone as part of their regular care. Researchers will collect information from medical records to see how the drug is being used, who is taking it,…

This study tests whether a smartphone app can help doctors and young adults (ages 16-29) with chronic kidney disease follow the latest treatment guidelines. The app provides reminders, education, and care recommendations. Researchers will check if using the app leads to better bl…

This study looks at medical records of over 14,000 people with chronic kidney disease in Spain to see how the drug dapagliflozin is used in routine care and how well it works. Researchers will compare health outcomes and costs before and after the drug became widely available. No…

This study tests a small device that stimulates a nerve in the ear to see if it is safe and tolerable for people with chronic kidney disease (CKD). Twenty adults with moderate to severe CKD will use the device and be monitored for changes in heart rate and blood pressure. The goa…

This study is a large registry that will follow 3000 Chinese adults with chronic kidney disease (CKD) to see what treatments they receive and how their health changes over time. Researchers will track things like kidney function, heart problems, and hospital visits. The goal is t…

This study tests different ways to help people with advanced chronic kidney disease and their caregivers work together when making health decisions. Researchers will compare coaching sessions and training to see which combination works best. The goal is to improve how patients an…

This study aims to learn more about Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed, causing pain and nausea. Researchers will use questionnaires and a breath test to measure symptoms and stomach function in 30 adults with GAV…

This study is a large registry that will follow 90,000 people in China, including those with chronic kidney disease (CKD), those at risk, and healthy volunteers. The goal is to observe how kidney disease starts and gets worse over time. No treatments are given—the study simply co…

This study tests a 12-week education and support program for African American adults with advanced chronic kidney disease. Participants will either receive the program or standard care. The goal is to see if the program helps patients learn more about their condition, manage it b…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 adults with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help design personalized prevention or treatment strategies. Part…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This study follows 1,300 children with chronic kidney disease to learn how their condition changes over time and what factors affect their health. Researchers measure kidney function and track when children need treatments like dialysis or a transplant. The goal is to better unde…