CHRONIC KIDNEY DISEASE

This study tests a virtual weight management program for 60 adults with obesity and advanced kidney disease who want to lose weight to become eligible for a kidney transplant. Participants either join the program (which includes coaching and a weight-loss medication called semagl…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better protect the kidneys and heart in 5000 adults with chronic kidney disease and high blood pressure. Participants will receive either the combination or dapagliflozin alone. The stu…

This study tests the long-term safety of finerenone, a drug that helps control a key system involved in kidney damage, in children aged 1 to 18 with chronic kidney disease and proteinuria. All 100 participants will take finerenone alongside their usual ACE inhibitor or ARB medica…

This study tests whether empagliflozin, a medicine already used for diabetes, can help children aged 2 to 17 with chronic kidney disease. About 120 kids will take either the drug or a placebo for 6 months, then everyone gets the drug for a year. Researchers will check kidney func…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests whether adding finerenone to standard blood pressure medicines can reduce protein in the urine of children with chronic kidney disease. About 219 children aged 6 months to under 18 years will take either finerenone or a placebo for 6 months. The main goal is to s…

This phase 3 trial tests roxadustat, an oral medication, for treating anemia in children and teenagers with chronic kidney disease. About 100 participants will take the drug three times a week for up to a year. The goal is to see if it can safely raise hemoglobin levels and offer…

This study tests a new treatment called AdiaVita, made from umbilical cord stem cells, for adults with chronic kidney disease. About 100 people aged 18 to 80 with moderate kidney problems will receive monthly infusions and a daily skin spray for three months. The goal is to see i…

This study tests a new device that creates a connection between an artery and a vein using a small needle puncture instead of open surgery. The goal is to provide a reliable access point for dialysis in people with kidney failure. About 126 adults will be enrolled and followed fo…

This study compares two cholesterol-lowering strategies in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate-dose statin plus ezetimibe, the other gets a high-dose statin alone. The goal is to see if the combo is just as g…

This study tests a new drug called TS-172 in 30 adults on peritoneal dialysis who have high phosphorus levels. Participants take the drug daily for several weeks to see if it can safely bring their phosphorus down to a target range. The goal is to find a better way to manage this…

This early-stage study tests an experimental oral drug called ONO-3310 in healthy Japanese men and in people with type 2 diabetes who also have chronic kidney disease. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure its eff…

This study tests whether a 12-week course of a multi-species synbiotic supplement can lower harmful gut toxins and reduce inflammation in adults on hemodialysis. About 30 participants will take the supplement and have their blood and urine levels of toxins and inflammatory marker…

This study is testing whether a 12-week course of a multi-species synbiotic (a mix of probiotics and prebiotics) can improve gut health and reduce harmful toxins in the blood of people on hemodialysis. The trial will enroll 30 adults who have been on dialysis for at least 3 month…

This study tests whether a natural substance called red propolis can lower inflammation and oxidative stress in people with chronic kidney disease (stages 3-5) who are not yet on dialysis. Researchers will measure changes in inflammatory markers like IL-6 and TNF-α. The goal is t…

This study tests whether adding dapagliflozin to baxdrostat reduces protein in the urine (a sign of kidney damage) better than baxdrostat alone. About 218 adults with chronic kidney disease and high blood pressure will take either the combo or baxdrostat plus a placebo. The goal …

This study tests a new drug called tegoprubart along with other medicines to help people with type 1 diabetes and chronic kidney disease receive pancreatic islet cell transplants. The goal is to see if this approach is safe and can improve blood sugar control without needing life…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This early-stage trial tests a new drug called OJR520 in healthy volunteers and people with chronic kidney disease. The main goal is to check if the drug is safe and how the body processes it. About 112 participants will receive either OJR520 or a placebo. This is the first time …

This study tests whether a smartphone app can help people with chronic kidney disease (CKD) follow the latest KDIGO treatment guidelines. Researchers will enroll 80 adults aged 16-30 with CKD who own a smartphone. The app provides reminders, education, and care recommendations to…

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study tests a drug called ferumoxytol, a type of intravenous iron, to treat iron deficiency anemia in children aged 2 to 17 with chronic kidney disease. The trial compares ferumoxytol to another iron drug, iron sucrose, to see which is safer and works better. About 129 child…

This study looks at whether adding a community health worker to a kidney care team helps more patients with advanced kidney disease choose or start home dialysis. About 106 adults with severe chronic kidney disease will be split into two groups: one gets standard team care, the o…

This Phase 3 trial tests whether HRS-1780 tablets can slow the decline of kidney function in nearly 2,000 adults with chronic kidney disease. Participants take the drug or a placebo alongside standard treatment. The study will track kidney health over 32 months to see if the drug…

This phase 3 trial tests the drug etelcalcetide (Parsabiv) in 24 children aged 2 to 17 with secondary hyperparathyroidism due to chronic kidney disease who are on hemodialysis. The goal is to see if the drug can safely lower parathyroid hormone levels and improve mineral balance.…

This study tests a smartphone app called StenoFood that gives dietary advice and self-monitoring tools to people with type 2 diabetes and early kidney disease. The goal is to see if the app helps them follow low-sodium and moderate-protein diet guidelines. About 104 participants …

This study tests whether specially trained community pharmacists can help people with type 2 diabetes and early kidney disease start and stick with medications that protect the kidneys and heart. The trial will include 120 adults in Nova Scotia who don't have a family doctor. Par…

This early study tests a new treatment called REGEND003, made from human kidney progenitor cells, in 15 people with type 2 diabetes and chronic kidney disease. The main goal is to check if the treatment is safe and tolerable. Participants will receive either the cell therapy or a…

This study tests whether a 6-week aerobic exercise program can reduce cardiovascular risk in people with chronic kidney disease or rheumatoid arthritis. About 90 participants will be assigned to either an exercise program, educational phone calls, or no intervention. Researchers …

This study tests a new medicine called NNC0519-0130, given as a weekly injection, in 465 people with chronic kidney disease, with or without type 2 diabetes, who are also overweight or have obesity. The goal is to see if it can improve kidney function and how safe it is compared …

This study compares drinking water to receiving IV fluids for preventing kidney injury caused by contrast dye used in CT scans. Researchers will enroll 198 emergency department patients with mild-to-moderate kidney disease. Participants will either drink water or get IV fluids be…

This Phase 3 trial compares two treatments for people with high blood pressure and chronic kidney disease: finerenone versus a fixed-dose combination of torsemide and spironolactone. The study will enroll 30 adults to see which approach better lowers blood pressure, reduces prote…

This study looks at whether a program of aerobic and strength exercises can improve physical performance and quality of life in adults with chronic kidney disease, including those on dialysis. About 50 participants will be randomly assigned to either an exercise group or a contro…

This phase 3 trial tests etelcalcetide (Parsabiv) in 56 children aged 28 days to under 18 years who have secondary hyperparathyroidism and chronic kidney disease and are on hemodialysis. The drug aims to lower parathyroid hormone levels and improve mineral balance. Participants r…

This pilot study tests whether the drug eplerenone is safe and feasible for people with both heart failure (reduced pumping ability) and severe chronic kidney disease. Previous studies excluded such patients due to risks like high potassium. The trial will enroll 40 participants …

This phase 3 trial tests whether the drug dapagliflozin (Farxiga) can reduce deaths and heart or kidney problems in people leaving the intensive care unit (ICU). About 600 adults who needed a breathing machine or blood pressure support will take either the drug or a placebo daily…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study tests an experimental drug called IG3018 for people with high uric acid, some of whom also have chronic kidney disease. About 60 adults will receive either the drug or a placebo for 4 weeks. Researchers will check safety, side effects, and how well the drug lowers uric…

This study tests whether people with chronic kidney disease can safely eat potassium-rich fruits and vegetables instead of following the usual low-potassium diet. Thirty participants will receive home-delivered groceries with either high- or low-potassium produce in a random orde…

This study looks at whether lowering high parathyroid hormone levels can help protect bone density in people with advanced chronic kidney disease. About 70 adults aged 50 and older with kidney failure not on dialysis will be assigned to different treatment targets for their hormo…

This phase 3 study tests a new drug called TS-172 in 300 adults on hemodialysis who have high phosphate levels. Participants take the pill daily for up to a year to see if it safely and effectively controls phosphate. The goal is to offer a better treatment option for a common co…

This phase 4 trial tests whether taking ramipril once daily or split into two smaller doses works better for protecting kidney function in 80 adults with chronic kidney disease and heart failure. Over 30 days, researchers will measure changes in blood markers of kidney function, …

This study tests a weekly injection called UBT251 in 180 overweight or obese adults with chronic kidney disease. The goal is to see if it can reduce protein in the urine (a sign of kidney damage) and help with weight control. Participants will receive either the drug or a placebo…

This study compares two special dialysis membranes (HYDROLINK and HeprAN) to see if they can safely reduce or eliminate the need for heparin, a blood thinner that raises bleeding risk. About 302 adults on long-term hemodialysis will take part. The goal is to complete dialysis ses…

This study tests whether people with chronic kidney disease can safely adjust their own blood pressure medications at home, guided by a pharmacist. 160 veterans with uncontrolled high blood pressure and stage 2-4 kidney disease will either self-manage their meds or just monitor t…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This Phase 3 trial tests a new drug called MT1013 against an existing drug, cinacalcet, in 424 adults on dialysis who have secondary hyperparathyroidism (overactive parathyroid glands). The study aims to see if MT1013 better controls parathyroid hormone levels and improves bone h…

This study tests a liquid medication called ACE Reno, taken under the tongue four times daily for 12 weeks, in 300 adults with chronic kidney disease from diabetes, high blood pressure, autoimmune disorders, or other causes. The goal is to see if it safely reduces protein in the …

This study tests whether combining budesonide (Nefecon) and ambrisentan can reduce protein in the urine and preserve kidney function in people with IgA nephropathy who are at risk of kidney failure. About 129 adults will take both pills daily for 36 weeks. Researchers will measur…

This study is testing an artificial intelligence model that reads kidney biopsy images to diagnose chronic kidney disease. Researchers will compare the AI's results to the standard diagnosis made by pathologists. About 2,900 patients with chronic glomerulonephritis will participa…

This study looks at whether a blood test for cystatin C can detect acute kidney injury earlier than the standard test in people with chronic kidney disease who receive contrast dye for CT scans or heart procedures. Researchers will compare how often kidney injury is found using e…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study tests whether using a lung water monitor to tailor fluid intake can prevent acute kidney injury in elderly patients with kidney disease who are undergoing coronary angiography. 320 participants will receive hydration rates adjusted based on their lung water levels. The…

This study tests the safety of a new drug called IGT-303 in healthy volunteers and people with chronic kidney disease (CKD). About 94 participants will receive either the drug or a placebo, given as a shot under the skin or into a vein. Researchers will monitor for side effects t…

This study tests whether doing physical therapy during dialysis or just before it works better for people with end-stage kidney disease. 72 adults on hemodialysis will be split into two groups and exercise twice a week for 12 weeks. Researchers will measure walking ability, stren…

This phase 2 trial tests whether taking sodium bicarbonate pills and doing regular stationary bike exercise can improve exercise capacity in people with chronic kidney disease (CKD). Researchers will enroll 156 adults with CKD, kidney transplant recipients, or healthy controls. P…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. …

This study will follow 500 adults with chronic kidney disease and type 2 diabetes who are taking finerenone, a drug that helps protect the kidneys and heart. Researchers want to see if a tool called the Klinrisk score, which estimates the risk of kidney disease getting worse, imp…

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This observational study will follow 50,000 people in Asia and the United States who have chronic kidney disease and type 2 diabetes and are already taking finerenone as part of their regular care. Researchers will collect data from electronic health records and insurance claims …

This study watches 500 adults in South Korea who have chronic kidney disease and type 2 diabetes and are taking finerenone as part of their normal care. Researchers will collect information from medical records and doctor visits over up to 12 months to see why doctors prescribe i…

This early-stage trial tests a new drug called CTX001 in 72 healthy adults. The goal is to check for side effects and see how the drug affects iron levels in the blood, with or without iron supplements and food. It is a first step toward possibly treating anemia and iron deficien…

This study looks at whether short-term use of NSAID pain relievers (like ibuprofen) after surgery increases the risk of acute kidney injury in children with mild-to-moderate chronic kidney disease. About 164 children over 18 months old with CKD stages 2-3a who are having urologic…

This study tests whether a 12-week nutrition and kidney health program, called THINK-Well, works well for adults with chronic kidney disease. The program includes group nutrition classes, cooking practice, and food bucks to buy healthy foods. Researchers want to see how many peop…

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study is looking at 1,000 liver transplant recipients to see if testing their blood, urine, and tissue samples can detect early signs of chronic kidney disease, acute rejection, or hepatitis C. The goal is to find simple biomarkers that could lead to earlier treatment and fe…

This study will compare kidney function in 3,000 adults with Crohn's disease or ulcerative colitis to 3,000 adults without these conditions. Participants will provide blood and urine samples and have a kidney ultrasound. The goal is to learn how common kidney problems are in IBD …

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure rises during activity. Researchers will measure muscle oxygen and acid levels in 110 veterans with and without CKD. The goal is to understand the body's response,…

This study uses a quick, painless eye scan (OCT) to see if blood vessels in the eye look different in people with high blood pressure or chronic kidney disease compared to healthy people. Researchers want to learn if these differences improve with treatment. About 150 adults aged…

Many people with chronic kidney disease also have heart disease, but heart procedures like angiograms and surgery can raise the risk of kidney complications. This study tests an online decision aid called 'My Heart and CKD' that helps patients and doctors weigh the benefits and r…

This study looks at how semaglutide, a drug used for diabetes and weight loss, changes fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers will compare patients taking semaglutide to those not taking it. The goal …

This observational study will follow 3,000 Chinese adults with chronic kidney disease (CKD) to see how they are treated in real-world clinics and what happens to their health over time. Researchers will track medications, kidney function, heart risks, and hospital visits. The goa…

This study tests whether community health workers and special training for doctors can help more kidney patients get on the transplant waitlist. Five patients will be assigned to either usual care or extra support from a community health worker who addresses social needs like hou…

This study is creating a large database of 8,000 adults with heart, kidney, or metabolic diseases to track their health over up to 5 years. Researchers will collect medical records, imaging, and lab data to understand how these conditions interact and affect long-term outcomes. T…

This study follows children with chronic kidney disease to track how their condition changes over time and what factors affect their health. Researchers will monitor kidney function, heart health, and other outcomes in about 1,300 participants. The goal is to better understand th…

This study is building a special collection of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait, along with some healthy volunteers. Researchers will use these samples and medical records to learn how kidney disease starts and gets worse in pe…

This study compares three ways to help people with advanced chronic kidney disease prepare for hemodialysis vascular access. 360 participants will either get a video and brochure, the same materials plus coaching sessions, or usual care. The goal is to see which approach helps mo…

This study tracks 15 people getting a simultaneous liver-kidney transplant to see how much their own kidneys recover. Researchers use a special nuclear scan and blood tests to measure kidney function before and after transplant. The goal is to create a way to predict who might no…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study looks at how common stomach symptoms like pain and nausea are in people with Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed. Researchers will use a simple breath test done at home to check how well the stomach empt…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study tests whether a simple neck ultrasound can accurately measure fluid status in people receiving chronic haemodialysis. Researchers will compare ultrasound results with standard methods in 100 participants. The goal is to find a safer, non-invasive way to guide fluid rem…

This study compares two muscle relaxant drugs (rocuronium and cisatracurium) used during general anesthesia in people with chronic kidney disease. Researchers want to see which drug leads to fewer lung problems after surgery. About 490 adults with kidney disease will take part.

This study tests different coaching sessions to help people with stage 4 chronic kidney disease and their caregivers work together on health decisions. 128 patient-caregiver pairs will try one or more training components, like extra coaching or communication practice. The goal is…

This observational study will follow 90,000 people in China, including those with chronic kidney disease (CKD) and those at risk, to track how the disease develops and worsens over time. Researchers will collect real-world data to better understand CKD and improve prevention stra…

This pilot study is testing whether a device that gently stimulates a nerve in the ear is safe and tolerable for people with chronic kidney disease (CKD). Twenty adults with moderate to advanced CKD will use the device for 15 minutes. Researchers will measure heart rate changes a…

This study looks at whether a special exercise program, which combines regular training with a technique that limits blood flow to the muscles, can help people with chronic kidney disease improve their ability to exercise. The researchers will measure changes in breathing muscle …

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

This study looks at how different forms of vitamin D work in the body. Researchers will measure free vitamin D (the active form) in healthy adults, pregnant women, and people with hormone or kidney problems. The goal is to see if free vitamin D gives a more accurate picture of vi…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help create personalized prevention and treatment plans. Particip…

This study tests a 12-week program that provides education, navigation, and self-management support to African American adults hospitalized with advanced chronic kidney disease. The goal is to see if the program improves patients' understanding of kidney disease, blood pressure, …

This study looks at how the body handles a new drug called S-892216 in people with mild, moderate, or severe kidney problems, including those on dialysis, compared to people with healthy kidneys. About 40 adults will take a single dose of the drug, and researchers will measure it…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers will use PET scans and echocardiograms to measure blood flow and heart function before and after transplant. The goal is to see if improving kidney function …

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…