CHRONIC KIDNEY DISEASE

This study tests a weekly injection called survodutide in 120 adults with chronic kidney disease and high protein in their urine. The goal is to see if it can safely lower urine protein levels and protect kidney function over 36 weeks. Participants must already be on standard blo…

This study tests an experimental drug called ABP-671 in 80 adults with chronic kidney disease and high uric acid levels. Participants will receive either the drug or a placebo for 40 weeks to see if it reduces protein in the urine, a sign of kidney damage. The goal is to slow kid…

This study tests a program called Moxie that sends weekly health tips by mail and offers a mobile app to help people manage chronic conditions like heart disease, diabetes, and kidney disease. The goal is to see if it reduces the number of times people are readmitted to the hospi…

This study will test if the drug finerenone can protect the retina (the light-sensitive part of the eye) in 40 adults with chronic kidney disease. Researchers will measure changes in the thickness of the retinal nerve fiber layer using a special camera. The goal is to see if fine…

This study tests whether a daily synbiotic supplement (good bacteria plus prebiotic fiber) can lower inflammation in adults with chronic kidney disease who are not yet on dialysis. One hundred participants will take either the supplement or a placebo for 16 weeks. Researchers wil…

This study tests a new feature on a home dialysis machine for people with kidney failure. The feature, called FlexPoint, allows flexible fluid volume and dwell time during treatment. Researchers will compare standard treatment to the new feature in 24 adults who have been on auto…

This study tests a new care package for adults aged 65 and older who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support. Researchers will compare this approach to usu…

This study looks at whether starting four approved kidney medicines quickly (over about 8 weeks) is safe and works better than the usual step-by-step method in people with type 2 diabetes and chronic kidney disease. About 64 adults will be randomly assigned to either the rapid-st…

This study tests a new medicine called HS-10390 in 182 adults with chronic kidney disease. The goal is to see if it can lower protein levels in urine, a sign of kidney damage. Participants must already be on standard blood pressure medicines. The trial compares HS-10390 to an act…

This study tests whether taking probiotics alongside standard anemia medication (erythropoietin) can improve red blood cell levels in people with chronic kidney disease on dialysis. About 80 adults will receive either erythropoietin alone or erythropoietin plus a daily probiotic …

This study tests a program that combines AI-guided exercise with continuous glucose monitoring for people who have both knee osteoarthritis and obesity. The goal is to see if it improves blood sugar control, reduces pain, and lowers the need for knee replacement surgery. About 31…

This early study tests a device called NEFRONIX that sends ultrasound waves to the kidneys. The goal is to see if it can safely improve kidney function in 20 adults with chronic kidney disease. Participants will receive treatment three times a week for four weeks, and their kidne…

This study looks at whether the triglyceride-glucose (TyG) index, a simple calculation from routine blood tests, can predict insulin resistance in people with pre-diabetes and chronic kidney disease. Researchers will enroll 60 adults to compare the TyG index against standard meth…

This study tests whether a sodium bicarbonate enema can help relieve constipation and reduce harmful waste products (uremic toxins) in people with chronic kidney disease (CKD). The idea is to use the gut as an extra route to remove toxins that damaged kidneys can't clear. The stu…

This study tests whether two types of amino acid supplements can safely improve muscle mass and strength in 20 adults aged 45–75 with advanced chronic kidney disease and muscle loss (sarcopenia). Participants will take the supplements for 6 weeks each, and researchers will measur…

This study will test a mobile app that helps adults with chronic kidney disease in Vietnam track and manage their symptoms from home. The goal is to see if the app is easy to use and helpful for improving quality of life. About 60 people with advanced kidney disease will take par…

This study tests whether laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic problems. 35 adults with at least two related conditions (like high blood pressure, diabetes, or chroni…

This study tests whether a special presentation style called Pecha Kucha helps people on hemodialysis better follow their fluid and diet restrictions. About 70 adults who have been on dialysis for at least 6 months will take part. One group gets the new teaching method, the other…

This study will follow 300 adults with chronic kidney disease to see how well a urine test can detect early signs of kidney damage and track disease progression. Researchers will also observe how common diabetes drugs called SGLT2 inhibitors affect kidney function over time. No n…

This study tests whether community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. CHWs will work one-on-one with participants to create personalized health plans and teach …

This study looks at how three common treatments for coronary artery disease—surgery, stents, or medication—affect kidney function over the long term. Researchers will follow 1,700 patients for at least 5 years, measuring kidney health through annual blood tests. The goal is to he…

This study will follow 500 adults in Spain with chronic kidney disease and type 2 diabetes who are taking finerenone. Researchers want to see if a tool called the Klinrisk score, which estimates kidney disease progression, improves after 2 years of treatment. The study will colle…

This study looks at how common and severe gum disease is in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare them to people with chronic kidney disease and healthy volunteers. Participants ge…

This study will observe 100 adults with chronic kidney disease to see if a diet that causes inflammation is linked to worse gum disease. Participants will have their gum health checked and their food intake recorded. The goal is to understand if changing diet could help improve b…

This study looks at why some people with chronic kidney disease in Spain may not have the same chance to get a kidney transplant. Researchers will review past studies, survey 3,000 patients and doctors, and test a training program to find and fix these unfair differences. The goa…

This study looks at how to safely use a diabetes medication (SGLT2 inhibitor) in people with type 1 diabetes and mild-to-moderate chronic kidney disease. Researchers will track blood sugar and ketone levels using continuous monitors to identify risk factors for diabetic ketoacido…

This study looks at a new way to offer vaccines to adults with chronic illnesses or weakened immune systems while they are in the hospital. The goal is to see if offering vaccines during hospital visits helps more people get vaccinated. Researchers will track how many patients ar…

This study looks at how a diet low in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar control in people with type 2 diabetes and chronic kidney disease. Researchers will compare a high-acid vs. low-acid diet over 8 weeks in 80 adults, al…

This early-stage study tests an experimental drug called CTX001 in 72 healthy adults. The goal is to check for side effects, how the body processes the drug, and how it affects iron levels when taken with or without food and iron. No direct treatment benefit is expected; the stud…

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods affects blood potassium levels in people with advanced chronic kidney disease (stages 3B-5) who are not on dialysis. Participants will try four different 10-day diets, all provi…

This study will test whether a 12-week nutrition and kidney health program works well for adults with chronic kidney disease. About 45 participants will either join group education sessions with cooking classes and food support, or receive standard nutrition advice. The goal is t…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) is linked to multiple chronic conditions such as high blood pressure, diabetes, and heart disease. Participants will have regular health check-ups, blood an…

This study looks at 100 adults with advanced chronic kidney disease who also have fluid buildup around their lungs. The goal is to find out what causes this fluid and which lab test is most accurate for these patients. By comparing chest fluid and blood samples, researchers hope …

This study will use a safe, painless neck ultrasound to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and moderate chronic kidney disease. The goal is to find out how common hidden artery disease is in this high-risk group and how it relates …

This pilot study tests whether a program of education, motivation, and social support can help adults with diabetes and early-stage chronic kidney disease (CKD) keep their kidneys healthier. Researchers will enroll 50 people and compare those who receive the program to those who …