CHRONIC KIDNEY DISEASE

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure c…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This Phase 2 trial tests whether the drug SAL0140 can reduce protein in the urine, a sign of kidney damage, in 249 adults with chronic kidney disease. Participants will receive either SAL0140 or a placebo for 16 weeks. The goal is to see if the drug can help control the disease a…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This study tests a new medicine called ABP-671 in 80 adults with chronic kidney disease and high uric acid levels. Participants will receive either the drug or a placebo for 40 weeks. The main goal is to see if the drug reduces protein in the urine, a sign of kidney damage.

This large Phase 3 study tests whether the drug HRS-7535 can help people with chronic kidney disease (CKD) avoid serious outcomes like kidney failure, dialysis, or heart-related death. About 3690 adults with CKD will receive either the drug or a placebo, added to their usual care…

This early-stage study tests a new drug called PMG1016 in 30 healthy adults to see if it is safe and how the body processes it. The drug is given as a single IV infusion. This is the first time PMG1016 is being tested in humans, and it aims to gather safety data before moving to …

This study compares a two-drug combination (dapagliflozin plus finerenone) against dapagliflozin alone in 88 adults with type 2 diabetes and chronic kidney disease. The goal is to see if the combo better reduces protein in urine, a key sign of kidney damage. Participants take pil…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study tests a new medicine called HS-10390 in 182 adults with chronic kidney disease. The goal is to see if it can lower protein levels in urine, a sign of kidney damage, better than standard care. Participants must already be on stable blood pressure medication and have mod…

This study tests whether adding pea fiber to the daily diet of people on dialysis can lower harmful waste products in their blood. 72 adults on dialysis will eat baked goods with or without pea fiber for 8 weeks. Researchers will measure changes in toxin levels and heart health m…

This trial tests a new feature called FlexPoint on a peritoneal dialysis machine used at home. The feature adjusts fluid volume and dwell time during treatment. Researchers will compare three different settings in 24 adults with chronic kidney disease to see which works best for …

This study tests whether a daily synbiotic supplement (probiotics plus prebiotics) can lower inflammation and improve digestive symptoms in adults with chronic kidney disease stages 3 to 5 who are not yet on dialysis. One hundred participants will receive either the supplement or…

This early-phase study tests whether adding the drug venetoclax to standard transplant preparation is safe for people with chronic kidney disease and a blood cancer. Only 3 adults aged 18-70 will take part. The goal is to see if the combination helps the new stem cells and kidney…

This study will test whether SGLT2 inhibitors, a type of diabetes drug, can help correct anemia in people with chronic kidney disease (CKD). Anemia is common in CKD and often requires iron or hormone injections, which have side effects. The trial will enroll 60 adults with CKD st…

This early study will test whether gentle ultrasound pulses applied to the kidneys can improve kidney function in 20 adults with chronic kidney disease (CKD). Participants will receive the ultrasound treatment three times a week for four weeks. Researchers will measure changes in…

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This study tests whether the drug finerenone can protect the retina (the light-sensitive layer at the back of the eye) in people with chronic kidney disease. Researchers will measure changes in retinal nerve thickness over time in 40 adults with stage 2-4 kidney disease. The goal…

This study tests a weekly injection called survodutide in 120 people with chronic kidney disease and high protein in their urine. The goal is to see if the drug can lower protein levels and protect kidney function over 36 weeks. Participants must be on stable standard treatments …

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study will check if a new urine test can find early signs of chronic kidney disease and track its progress. Researchers will also look at how well common diabetes drugs (SGLT2 inhibitors) help protect the kidneys. About 300 adults with mild-to-moderate kidney disease will ta…

This study looks at whether the triglyceride-glucose (TyG) index, a simple measure from a blood test, can predict insulin resistance in people with pre-diabetes and chronic kidney disease. Researchers will enroll 60 adults with and without kidney problems to see how well the TyG …

This study tests whether an experimental drug called SP16 can prevent acute kidney injury in people with chronic kidney disease who are having heart surgery with a heart-lung machine. About 120 participants will be randomly assigned to receive either SP16 or a placebo, and neithe…

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study tests whether a special teaching method called Pecha Kucha can help people on hemodialysis better follow their fluid and diet restrictions. The method uses a fast, visual slideshow to make information easier to remember. 70 patients will be split into two groups: one g…

This study tests whether a nurse-led program of laptop-based education, phone reminders, and a booklet can help people on hemodialysis better follow their diet and fluid restrictions, be more active, and improve their quality of life. About 112 adults who have been on dialysis fo…

This study tests whether two types of amino acids (protein building blocks) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease and sarcopenia (muscle loss). Participants will take the supplements for 6 weeks while researchers …

This study will test whether a sodium bicarbonate enema can help relieve constipation and reduce harmful waste products in people with chronic kidney disease (CKD). The researchers believe the gut can act as an extra filter to remove toxins that build up when kidneys fail. They p…

This study tests whether a relaxation method called autogenic training can help people on hemodialysis who suffer from restless leg syndrome, poor sleep, and fatigue. About 54 adults aged 45-55 will practice guided relaxation exercises for 8 weeks. Researchers will measure change…

This study tests whether taking probiotics daily can help chronic kidney disease patients on dialysis better respond to anemia medication (erythropoietin). About 80 adults will receive either erythropoietin alone or erythropoietin plus probiotics for 3 months. Researchers will tr…

This study will test a mobile app called Smart Kidney that helps adults with chronic kidney disease track and manage their symptoms remotely. Sixty participants in Vietnam will use the app for 6 weeks. The goal is to see if the app is easy to use and helpful for symptom managemen…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study will look at how people with chronic kidney disease use a digital app called MyRenalCare. Researchers want to see if the app helps improve health, lowers hospital visits, and reduces costs and environmental impact. About 1,000 adults under kidney care will be included.

This study tests whether a simple electronic alert in the medical record system can help doctors prescribe guideline-recommended medications for adults with type 2 diabetes and kidney disease. About 600 patients will be randomly assigned to have their doctor receive an alert or n…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This study looks at why fluid builds up around the lungs in people with advanced chronic kidney disease (CKD). Researchers will test 100 adults to see if standard diagnostic methods work well for these patients. The goal is to improve accuracy so doctors can treat the right cause…

This study looks at whether eating a high-protein meal changes kidney function in a way that can be measured by a skin sensor. Researchers will give 25 adults an injection of a fluorescent dye and track how quickly it clears from the body before and after the meal. The goal is to…

This observational study looks at whether a diet that promotes inflammation can make gum disease worse in people with chronic kidney disease. Researchers will assess the diets and gum health of 100 adults with kidney disease. The goal is to understand if eating more inflammatory …

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods affects blood potassium levels in people with chronic kidney disease (stages 3B-5). Participants will try four different 10-day diets, all provided for free, to see which foods …

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This observational study will check how common left ventricular hypertrophy (thickening of the heart muscle) is in people with chronic kidney disease. It will also look at whether treating anemia with erythropoietin can reduce that thickening. About 100 adults with moderate to se…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This observational study will follow 200 hospitalized adults with chronic kidney disease to see how diabetes and related metabolic problems affect their outcomes. Researchers will track deaths, need for dialysis, and major heart events during the hospital stay. The goal is to bet…

This study will see if community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. About 300 adults who are medically underserved will work with a CHW to create a personal hea…

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study will examine why some people with chronic kidney disease in Spain may have a harder time getting a kidney transplant than others. Researchers will survey 3,000 patients and interview doctors and patients to understand barriers like age, income, or where someone lives. …

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This study looks at 1,700 people with heart disease to see how different treatments—surgery, stents, or medication—affect kidney function over 5 years. Researchers will track changes in kidney health and check for new or worsening kidney disease. The goal is to help doctors choos…

This study will check 100 adults on long-term hemodialysis for thyroid problems, abnormal cholesterol, and high uric acid. Researchers want to see how common these issues are and how they relate to each other. The goal is to better understand the health challenges faced by people…