CHRONIC KIDNEY DISEASE

This study tested a new automated insulin delivery system for people with diabetes who also have advanced kidney disease or are on dialysis. The goal was to see if this 'artificial pancreas' system could better control blood sugar levels compared to usual care. Fifteen participan…

This early-stage study tested the safety of an experimental oral drug called AZD4144 in people with both heart and kidney disease. Twenty-nine participants took either the drug or a placebo pill daily for 28 days. The main goal was to see if the drug was safe and to measure its e…

This study tested whether a weekly injection of the diabetes medication exenatide could help protect the heart and kidneys in people with type 2 diabetes who were at risk for heart problems and had mildly reduced kidney function. For 38 weeks, some participants received the real …

This study tested whether two different oral medications could help people with chronic kidney disease. Researchers enrolled 181 adults who were already on standard blood pressure medications. They measured how well the drugs reduced protein in urine and protected kidney function…

This study aimed to understand how the diabetes medication semaglutide might help protect the kidneys in people who have both type 2 diabetes and chronic kidney disease. Over one year, 106 participants received either semaglutide or a placebo injection weekly. Researchers used de…

This study tested the long-term safety of MCI-196, a medication that helps control high phosphorus levels in people with advanced kidney disease who are on dialysis. The research followed 632 patients for up to one year to monitor how well they tolerated the medication and whethe…

This study tested whether pentoxifylline, a medication typically used for circulation problems, could reduce inflammation and slow kidney disease progression in non-diabetic patients. Researchers enrolled 42 adults with moderate to severe chronic kidney disease but without diabet…

This study tested whether continuing a potassium-lowering medication called SZC after hospital discharge helps people with chronic kidney disease better maintain safe potassium levels compared to standard care. It involved about 186 adults who were hospitalized for high potassium…

This large, completed Phase 3 trial tested whether the drug MCI-196 could help control two common problems in people with kidney failure on dialysis: high phosphorus and high 'bad' cholesterol. The study involved 642 stable dialysis patients who were randomly assigned to receive …

This large, completed Phase 3 trial tested whether adding a charcoal-based medication called AST-120 to standard care could slow the worsening of moderate to severe chronic kidney disease (CKD). The study involved over 1,000 adults and aimed to see if the treatment could delay th…

This study checked if a standard high-dose vitamin D treatment was effective and safe for children and teens with chronic kidney disease, a transplant, or a kidney syndrome. Researchers gave 43 participants a single large dose of vitamin D and measured their vitamin D levels two …

This study tested a medical device called the FLEX System that creates dialysis access without major surgery. The device makes a connection between an artery and vein through a small needle puncture instead of an open surgical cut. Researchers followed 80 kidney failure patients …

This study tested if common, inexpensive water pills (diuretics) could help people with early-stage chronic kidney disease. Researchers wanted to see if reducing extra body fluid with these pills could lower the risk of heart problems and improve symptoms like tiredness. They mea…

This small pilot study tested whether a special anti-inflammatory diet, customized to fit different cultural food traditions, is practical and acceptable for people living with chronic kidney disease. Researchers worked with 18 adult participants from the Bronx to see if they cou…

This study tested whether adding the medication finerenone to standard care could better protect kidney function in adults with both chronic kidney disease and type 1 diabetes. Researchers compared finerenone against a placebo (inactive pill) in 241 participants over 6 months of …

This large study tested whether adding AST-120 to standard care could slow the worsening of moderate to severe chronic kidney disease. Over 1,000 patients were randomly assigned to receive either AST-120 or a placebo pill, and researchers tracked whether they needed dialysis, a k…

This study tested whether having a clinical pharmacist on the hospital team helps prevent medication errors in patients with kidney problems. Researchers compared three groups: one with no pharmacist, one where doctors got extra training, and one where a pharmacist actively revie…

This study tested whether a new weekly injection called CagriSema could slow kidney damage in adults with type 2 diabetes, chronic kidney disease, and overweight or obesity. It compared CagriSema against its individual components (semaglutide and cagrilintide) and a placebo over …

This study tested whether the drug MCI-196 could safely control high phosphorus levels in people with kidney failure on dialysis. Researchers compared the drug against a placebo in 336 patients over 16 weeks. The goal was to see if the drug could effectively manage this common an…

This study tested whether a drug called MCI-196 could safely and effectively control high phosphorus levels in the blood of adults with kidney failure who are on dialysis. After a 12-week period where all participants received the drug, some were randomly switched to a placebo (d…

This pilot study tested a combined transplant from a partially matched family donor. It aimed to treat patients who had both a serious blood disorder (like leukemia) and advanced kidney disease at the same time. The goal was to cure the blood disorder and restore kidney function …

This study looked at whether changing when patients eat during their kidney dialysis treatment could help keep their blood pressure stable and make the dialysis work better. Researchers tested different meal times on 40 adults with kidney failure who regularly receive dialysis. T…

This early-stage study tested the safety of a new oral drug, BAY3283142, in people with high blood pressure and chronic kidney disease. The drug is designed to relax blood vessels. For 10 weeks, 75 participants took either the drug or a placebo pill, and researchers monitored the…

This study tested if a new drug called MCI-196 could lower bad cholesterol (LDL) in people with severe kidney disease who are on dialysis. It compared MCI-196 to a common cholesterol drug (simvastatin) and to a placebo (a dummy pill). The goal was to see if the new drug worked as…

This study aimed to see if a type of diabetes medication (SGLT2 inhibitors) could help protect kidney function in people with chronic kidney disease, whether they had diabetes or not. Researchers compared changes in a key measure of kidney health (eGFR) in 60 adult participants w…

This study tested whether a drug called dapagliflozin, originally for diabetes, could help protect the kidneys, improve anemia, and support heart health in adults with chronic kidney disease who do not have diabetes. About 100 participants were randomly assigned to take either th…

This study tested the long-term safety and effectiveness of a drug called MCI-196 for people on dialysis who have high phosphate levels in their blood. It involved 116 adult patients on stable dialysis treatment. The main goal was to see how safe the drug was over a year, while a…

This study tested whether a diabetes drug called dapagliflozin could improve heart health in people with kidney failure who need regular dialysis. Researchers gave 220 patients either the drug or a placebo pill daily for six months to see if it reduced heart muscle thickening, a …

This study tested whether a special education program, based on a model of how people adapt to challenges, could help kidney patients. The program aimed to improve how well patients stick to their essential immunosuppressive medication and how they cope with their chronic disease…

This study tested if a small, wearable heart monitor could detect dangerous spikes in potassium levels in people on dialysis. Thirty-two patients wore a chest sensor during their dialysis sessions while their blood potassium was checked. Researchers compared the heart signal patt…

This study tested two simple, non-drug methods to reduce the pain of needle insertion for dialysis patients. 75 adults were split into three groups: one listened to calming music, another looked at a mirror showing their healthy arm, and a third received standard care. Researcher…

This study tested whether weekly mindfulness sessions led by nurses could help people on long-term dialysis feel better mentally and stick to their complex treatment plans. Eighty patients were split into two groups: one received six weekly mindfulness sessions, while the other r…

This study tested whether a simple, guided meditation practice could help people on long-term dialysis feel less anxious and more spiritually at peace. 58 adult patients were randomly assigned to either practice a 15-minute mindfulness meditation or just rest quietly during their…

This study aimed to monitor the safety of the drug Forxiga (dapagliflozin) when used by over 1,000 patients with chronic kidney disease in real-world medical settings. It specifically looked to identify any unexpected side effects and understand what factors might influence safet…

This study aimed to understand the link between chronic kidney disease and heart disease risk in older adults. Researchers measured blood vessel health in 101 participants aged 65+ with kidney disease using ultrasound, blood tests, and other non-invasive checks. The goal was to i…

This study aimed to see if taking a phosphate-lowering drug (colestilan) changes how the body absorbs a common blood pressure medication (candesartan). It involved 18 healthy male volunteers to measure drug levels in the blood under different timing schedules. The goal was to gat…

This study aimed to see if telling patients and their doctors about a specific genetic risk for kidney disease would lead to better health management. It involved nearly 6,800 adults of African ancestry with high blood pressure. Researchers tested whether early knowledge of this …

This study looked at whether certain molecules in the blood could help doctors detect chronic kidney disease earlier and predict which patients might not respond well to common anemia treatments. Researchers compared 180 people—60 healthy individuals, 60 with moderate kidney dise…

This small pilot study tested whether treating constipation in people with chronic kidney disease might improve their kidney health. Researchers gave 14 patients with both conditions a constipation treatment and checked if it was practical to deliver. They measured changes in kid…

This study was a survey of 608 heart and kidney specialists. Its purpose was to understand how these doctors think about and use a specific blood test (hsCRP) to detect hidden inflammation in patients with combined heart and kidney diseases. The goal was to gather real-world info…

This study aimed to understand how a specific protein made by the kidneys, called uromodulin, influences the relationship between salt in the diet and blood pressure in people with chronic kidney disease. Researchers enrolled 130 adult patients to measure their salt intake, blood…

This early-stage study aimed to check the safety and how the body processes a new oral drug called KBP-5074 in people with severe chronic kidney disease. It involved 11 patients, some on dialysis and some not, to see how they tolerated single doses. The main goal was to gather in…

This was the first study in humans to test the safety of a new oral medicine called NNC0705-0001. The medicine is being developed to treat chronic inflammation, which increases the risk of heart and kidney disease. The study involved 116 healthy adults to see how safe the drug is…