CHRONIC KIDNEY DISEASE

This study tested the safety of a new drug, BAY3283142, in 75 adults with mild to moderate high blood pressure. The drug helps relax blood vessels and is being developed for chronic kidney disease. Participants took different doses or a placebo over several weeks, with researcher…

This study tested a drug called MCI-196 to see if it can lower high phosphorus levels in people with advanced kidney disease who are on dialysis. High phosphorus can cause serious health problems. The trial involved 336 adults and compared MCI-196 to a placebo over several weeks.…

This study tested a pill called AST-120 (a type of charcoal) in over 1,000 people with moderate to severe chronic kidney disease. The goal was to see if adding it to standard care could delay the need for dialysis or a kidney transplant. Researchers also checked safety and qualit…

This study tested a drug called ziltivekimab in 36 adults with advanced chronic kidney disease and high inflammation. The goal was to see if it could safely reduce inflammation and lower heart disease risks. Participants received either a low dose, a high dose, or a placebo injec…

This study tested a new drug called BAY 3283142 in 1222 adults with chronic kidney disease and high protein levels in their urine. The drug works by relaxing blood vessels and was added to standard treatments. Researchers measured changes in urine protein after 16 weeks to see if…

This study tested whether dapagliflozin, a drug used for diabetes, can improve heart structure in people with kidney failure who are on dialysis. Researchers compared the drug to a placebo in 220 adults. The goal was to see if it could reduce heart muscle thickening, a common pro…

This study tested a combined bone marrow and kidney transplant from a partially matched family donor for 10 people with both a serious blood disorder and chronic kidney disease. The goal was to treat both conditions with one donor, potentially reducing the need for lifelong anti-…

This study tested a drug called AST-120 (a type of charcoal that absorbs toxins) in over 1,000 adults with moderate to severe chronic kidney disease. The goal was to see if adding AST-120 to standard care could delay the need for dialysis, a kidney transplant, or a significant ri…

This study looked at the long-term safety of a drug called MCI-196 in 116 adults with advanced kidney disease who are on dialysis and have high phosphate levels. The goal was to see if the drug is safe to take over time and if it helps control phosphate levels. Participants took …

This study tested a drug called MCI-196 in 642 adults on dialysis who had high phosphorus and cholesterol levels. The goal was to see if the drug could safely lower these levels, which are linked to heart problems. Participants took either MCI-196 or a placebo for 12 weeks after …

This study tested a drug called MCI-196 in 245 adults on dialysis with high phosphorus levels. After a 12-week dose adjustment period, some patients switched to a placebo to see if MCI-196 kept phosphorus levels lower. The goal was to manage a common complication of kidney failur…

This study tested two experimental drugs, HRS-1780 and henagliflozin, in 181 adults with chronic kidney disease. The goal was to see if these medications could reduce protein in the urine, a sign of kidney damage, over 13 weeks. Participants were already on standard blood pressur…

This study tested whether a once-weekly injection of exenatide, a drug used for type 2 diabetes, can improve markers of heart and kidney health in people with diabetes and mild kidney problems. 57 adults received either exenatide or a placebo for 38 weeks. Researchers measured ch…

This early-stage study tested a single dose of the experimental drug KBP-5074 in 11 people with severe chronic kidney disease, including some on dialysis. The main goal was to check for side effects and how the drug moves through the body. The study was completed, but results are…

This study tested whether a new investigational medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of its componen…

This early-stage study tested a new drug called AZD4144 in 29 adults with both heart disease and chronic kidney disease. The goal was to check if the drug is safe and if it lowers certain markers of inflammation in the blood. Participants took either the drug or a placebo for 4 w…

This study looked at 186 adults with chronic kidney disease who had high potassium levels while in the hospital. It compared a drug called SZC to usual care to see if continuing SZC after discharge helps keep potassium in a healthy range and reduces hospital visits. The goal is t…

This study looked at whether the standard vitamin D supplement (cholecalciferol) helps children with chronic kidney disease, kidney transplants, or nephrotic syndrome reach healthy vitamin D levels. 43 children took a single high-dose vitamin D vial, and researchers measured thei…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also have advanced kidney disease or are on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study looked at whether pentoxifylline, a drug used for other conditions, can lower inflammation in people with chronic kidney disease who do not have diabetes. Researchers measured inflammatory markers in 42 patients with moderate to severe kidney disease. The goal was to s…

This study tested whether an education program based on Roy's Adaptation Model helps kidney patients on immunosuppressive therapy improve their self-efficacy, medication adherence, and overall adaptation to chronic disease. 78 patients participated, receiving either the special e…

This study tested a new drug called MCI-196 against a common statin (simvastatin) and a placebo to see how well it lowers LDL cholesterol in people with advanced chronic kidney disease on dialysis. About 260 adults on stable dialysis took part. The goal was to manage cholesterol …

This study tested a new device called the FLEX System that creates a connection between an artery and a vein (AV fistula) using a small tube inserted through the skin, instead of surgery. The goal was to see if this method is safe and works well for people with chronic kidney dis…

This study tested the long-term safety of a drug called MCI-196 in 632 adults with chronic kidney disease on dialysis who also have high phosphorus levels. Participants took the drug for up to 52 weeks to see how it affected their blood phosphorus and cholesterol. The goal was to…

This study tested the drug dapagliflozin in 100 adults with chronic kidney disease (but not diabetes) to see if it could slow kidney decline, improve anemia, and protect the heart. Participants took either dapagliflozin or a placebo daily for 12 months alongside their usual care.…

This study tested whether the drug finerenone can slow kidney damage in people with type 1 diabetes and chronic kidney disease. About 241 adults took either finerenone or a placebo pill for 6 months, along with their usual treatments. Researchers measured changes in urine protein…

This study tested a once-daily pill called orforglipron against insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had higher heart risk. The goal was to see if the pill is safe and effective at controlling blood sugar and preventing…

This study tested whether pentoxifylline, a drug used for blood flow issues, could prevent kidney damage caused by contrast dye in 70 ICU patients with chronic kidney disease. Participants received the drug before procedures like cardiac catheterization. Researchers tracked how m…

This study tested a simple, guided mindfulness meditation done at bedtime in 58 adults receiving hemodialysis for chronic kidney disease. Participants practiced 15-minute meditation sessions twice a week for four weeks. The goal was to see if this low-cost, drug-free approach cou…

This study looked at whether a 10-minute vibration massage or a 10-minute static stretching exercise could reduce muscle cramps and stress in people undergoing hemodialysis. Thirty adults with chronic kidney disease who experienced leg cramps during dialysis were randomly assigne…

This study tested two drug-free methods to improve sleep and comfort in 60 people on dialysis for kidney failure. One group received reflexology (a special foot massage) and another received sleep hygiene education. Both approaches helped, but reflexology was more effective at im…

This study tested two simple, drug-free ways to reduce pain when inserting needles for dialysis. 75 adults were split into three groups: one listened to calming music, one looked at their healthy arm in a mirror, and one received usual care. Pain levels were measured right after …

This study looked at whether nurse-led mindfulness sessions could help people on hemodialysis feel better emotionally and follow their treatment more closely. Eighty patients took part, with half receiving six weekly mindfulness sessions and the other half getting usual care. The…

This study examined health records of 5,000 older adults with low kidney function who started taking nortriptyline, an antidepressant. Researchers compared those on higher doses (over 10 mg/day) to those on a low dose (10 mg/day) to see if they had more emergency visits, hospital…

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body processes it. The medicine aims to reduce chronic inflammation, which can lead to heart and kidney problems. Participants received either the medicine or a…

This study looked at 40 adults with chronic kidney disease to see if the timing of meals during hemodialysis affects blood pressure stability and how well the treatment removes toxins. Participants were split into groups that ate at different times during their sessions. The goal…

This study tested whether a culturally-tailored anti-inflammatory diet is practical and well-liked by racial/ethnic minorities with chronic kidney disease. 18 adults from the Bronx with stage 3 kidney disease took part. Researchers measured diet changes and asked participants if …

This study looked at how colestilan, a drug for high phosphate levels in kidney disease, changes the way the body absorbs candesartan, a blood pressure medicine. Eighteen healthy men took candesartan alone or at different times around colestilan doses. The goal was to see if taki…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. The goal was to see how many have elevated levels of albumin in their urine, which is an early sign of kidney disease. Researchers tracked these levels over about a year to unders…

This study monitored over 1,000 people with chronic kidney disease (but not on dialysis) who were taking the drug Forxiga. Researchers tracked side effects and factors that might affect safety. The goal was to gather real-world safety information, not to test if the drug works.

This study measured four specific molecules in the blood of 180 people, including healthy volunteers and kidney disease patients at different stages. The goal was to see if these molecules could help diagnose chronic kidney disease early or predict resistance to anemia treatment …

This study tested whether a short questionnaire called SCORED can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Researchers enrolled 1,426 participants and checked how well the questionnaire predicted kidney problems compared to standard tes…

This completed study surveyed 608 heart and kidney specialists to understand their awareness and use of a blood test called hsCRP, which measures inflammation. The goal was to learn what doctors think about inflammation's role in managing atherosclerotic cardiovascular disease, c…

This study looked at whether giving people of African ancestry with high blood pressure and their doctors the results of a genetic test for APOL1 gene variants could improve kidney disease management. Over 6,700 adults were randomly assigned to get the test results right away or …

This completed study looked at 130 adults with chronic kidney disease to see if a kidney protein called uromodulin changes how salt affects blood pressure. Researchers measured salt intake and 24-hour blood pressure to find links. The goal was to better understand why some patien…

This study tested whether a small, wearable ECG device can detect high potassium levels (hyperkalemia) in people on dialysis. Thirty-two adults with chronic kidney disease wore the sensor during dialysis sessions over six weeks. Researchers compared ECG readings with blood test r…

This study looked at 49 veterans with early chronic kidney disease to see if common water pills (diuretics) can reduce extra body fluid and improve heart health. Researchers measured changes in blood markers and symptoms like fatigue after 4 weeks of treatment. The goal was to la…

This study tested whether it is possible to treat constipation in people with chronic kidney disease and measure changes in their health. Fourteen adults with both conditions received treatment and were monitored for 6 weeks. The main goal was to see if patients would follow the …

This study observed over 6,500 Chinese adults with chronic kidney disease and type 2 diabetes who started taking the drug finerenone. Researchers looked at patient health records to understand how the drug is used in real life, including its effects on kidney function and potassi…

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. About 106 participants received either semaglutide or a placebo injection once a week for a year. Researchers used MRI scans, blood and urine …

This study looked at whether having a clinical pharmacist work directly with doctors on hospital rounds can reduce medication problems in patients with kidney disease. 160 adults with reduced kidney function took part. The pharmacist identified and helped fix drug-related issues,…

This study looked at how a class of diabetes drugs called SGLT2 inhibitors affects kidney function in people with chronic kidney disease (CKD). Researchers compared 60 patients with and without diabetes to see if the drugs helped preserve kidney function. The goal was to understa…

This study measured blood vessel function in 101 older adults (65+) with chronic kidney disease who were not on dialysis. Researchers used ultrasound and blood tests to look for signs of vessel damage that could raise heart risk. Participants visited the clinic once for these mea…

This study looked at whether starting a higher dose of two common antidepressants (venlafaxine and duloxetine) increases the chance of a serious event—like an emergency room visit, hospital stay, or death—within 30 days in older adults (66+) with chronic kidney disease. Researche…