CHRONIC KIDNEY DISEASE

This study tests whether a monthly injection of ziltivekimab can reduce the risk of heart attacks, strokes, and heart-related death in 6,200 people with heart disease, chronic kidney disease, and signs of inflammation. Participants are randomly assigned to receive either the acti…

This study aimed to test a new drug called volenrelaxin in adults with chronic kidney disease. The trial was withdrawn before any participants were enrolled. The goal was to see if the drug could improve kidney function over 24 weeks.

This study looks at whether keeping blood pressure very low (below 120 mmHg) is better than the usual target (below 140 mmHg) for people with advanced kidney or thyroid cancer starting certain targeted therapies. The goal is to reduce the risk of heart and kidney problems caused …

This study tests the drug dapagliflozin in 731 Chinese adults with chronic kidney disease to see if it can slow kidney function decline and reduce complications. Participants take the drug alongside their current treatments. The goal is to gather safety and effectiveness data for…

This study tested whether a once-monthly shot of darbepoetin alfa can keep hemoglobin levels stable in people with advanced chronic kidney disease who are not on dialysis. Forty Korean adults who had stable hemoglobin on every-2-week shots switched to monthly shots for 12 weeks. …

This study tests whether the drug finerenone can lower protein in the urine (a sign of kidney damage) better than a placebo in 180 adults with chronic kidney disease who are not taking certain blood pressure medicines. Participants will take finerenone or a dummy pill for 6 month…

This study compares two ways of doing peritoneal dialysis—standard (full dose) versus incremental (lower dose tailored to the patient's remaining kidney function)—in 100 adults starting dialysis. The goal is to see which approach better preserves residual kidney function and redu…

This study tests whether starting two kidney medications (vicadrostat and empagliflozin) at the same time is better than starting them one after the other in adults with chronic kidney disease at risk of worsening. About 416 participants will take the drugs daily for 3 months, wi…

This study looks at whether drinking beetroot juice every day for three months can improve blood vessel health, movement, and thinking in people with chronic kidney disease (CKD). About 92 adults with moderate CKD will take part. The goal is to see if a natural supplement can hel…

This study tests whether a 16-week diet coaching program with cooking classes can help Black Americans at risk for chronic kidney disease stick to the DASH diet. About 48 adults with early kidney disease or risk factors like diabetes or high blood pressure will take part. The goa…

This study tests if a single dose of ravulizumab can prevent serious kidney problems after heart surgery in adults with chronic kidney disease (CKD). About 736 participants will receive either the drug or a placebo before surgery. The goal is to see if the drug reduces the risk o…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can improve kidney function in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Participants will have MRI scans to measure kidney oxygen levels and fat content ov…

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor that tracks sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps redu…

This study tests whether anakinra works better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, painful joint inflammation, and common treatments like colchicine and NSAIDs are not saf…

This study looks at whether a 6-month program of combined aerobic and resistance exercises, done during dialysis sessions, can improve muscle strength, body composition, and quality of life in people with chronic kidney disease. Forty adults on hemodialysis will be randomly assig…

This study reviews medical records of 1,200 Indian adults with chronic kidney disease and type 2 diabetes who started taking finerenone between August 2022 and April 2024. Researchers will look at how doctors prescribed the drug, dose changes, and lab results like kidney function…

This study looks at real-world data from 150,000 people with chronic kidney disease and type 2 diabetes to see how safe and effective the drug finerenone is in routine medical care. Researchers will compare heart problems like heart attacks and hospitalizations for heart failure …

This study looks at how a new medicine for chronic kidney disease, nurandociguat, affects the way the body processes two other drugs (rosuvastatin and dabigatran). Healthy adults aged 18 to 58 will take these drugs alone and then with nurandociguat to measure drug levels and chec…

This study aims to understand why some people with diabetes develop kidney disease, focusing on social, environmental, and biological factors in Ecuador. Researchers will collect data from over 10,000 adults, including those with and without diabetes, to identify early signs and …

This study looks at 300 adults with chronic kidney disease who are already taking a standard SGLT2 inhibitor. Researchers want to see if the amount of sugar in their urine is linked to changes in protein levels, a key marker of kidney damage. The goal is to find a simple way to t…

This study looks at whether a simple blood test called the neutrophil-to-lymphocyte ratio (NLR) can help detect peripheral artery disease (PAD) in people on regular kidney dialysis. About 120 adult dialysis patients will be checked for PAD and have their NLR measured. The goal is…

This study examines whether SGLT2 inhibitors, a type of diabetes medication, are linked to anemia in people with chronic kidney disease (CKD). Researchers will analyze health records from 15,000 patients in Japan to track anemia development, treatments, and costs. The goal is to …

This study aims to find out which factors—like lifestyle, genes, and health history—are linked to poor blood sugar control and kidney disease in adults with type 2 diabetes in Mexico. Researchers will collect data from 1,000 participants through exams, questionnaires, and blood t…

This study examines the connection between certain biomarkers (substances in urine and blood) and kidney function decline in 350 adults with pulmonary hypertension, a type of high blood pressure affecting the lungs. Participants undergo a heart procedure and are followed to see i…

This study looks at how well certain tools measure muscle strength and activity in people with chronic kidney disease. It also tests whether a supervised online exercise program is helpful and practical. About 50 adults with kidney disease (on dialysis, with a transplant, or not …

This study watches how doctors prescribe finerenone to people with chronic kidney disease and type 2 diabetes in everyday care. It does not test a new treatment—just collects information from medical records and doctor visits over 12 months. About 4,600 adults will take part to h…

This study looks at whether a special education program helps veterans with advanced chronic kidney disease understand their condition and choose the best type of dialysis. About 656 veterans will take part, and researchers will track how many choose home dialysis. The goal is to…