CHRONIC KIDNEY DISEASE

This phase 2 trial tests whether dapagliflozin, a drug already used for diabetes and chronic kidney disease, can slow kidney damage in people with lupus nephritis. Lupus nephritis is a serious complication of lupus that causes kidney inflammation and can lead to chronic kidney di…

This phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can better slow chronic kidney disease (CKD) progression in adults with CKD and high blood pressure. About 2,500 participants will receive either the combination or dapagliflozin alone for 24 mo…

This study tests whether a new drug called vicadrostat, combined with the existing drug empagliflozin, can help people with chronic kidney disease (CKD) that is getting worse. About 492 adults with CKD will be randomly assigned to start both drugs together or one after the other …

This phase II trial tests whether intensive blood pressure management (targeting systolic BP below 120 mmHg) is better than standard care (below 140 mmHg) for patients with advanced kidney or thyroid cancer starting anti-angiogenic TKI therapy. The study enrolls 61 participants a…

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This study tests whether a short course of two drugs, dasatinib and quercetin, can clear senescent (aging) cells in people with chronic kidney disease. The goal is to see if this reduces frailty and improves stem cell function. Thirty participants aged 40-80 with moderate-to-seve…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This study tests whether the drug finerenone can lower protein levels in the urine of people with chronic kidney disease who are not taking certain blood pressure medications. About 180 adults will receive either finerenone or a placebo for 6 months. The goal is to see if fineren…

This Phase 3 trial is testing whether a monthly injection of ziltivekimab can reduce the risk of heart attacks and strokes in 6,200 people who already have heart disease, chronic kidney disease, and signs of inflammation. Participants receive either the drug or a placebo for up t…

This study looks at whether drinking nitrate-rich beetroot juice every day for three months can improve blood vessel health, movement, and thinking in people with chronic kidney disease. About 92 participants with moderate kidney disease will receive either the active beetroot ju…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This study is testing the drug dapagliflozin in 731 Chinese adults with chronic kidney disease. The goal is to see if the drug can slow kidney decline and is safe. Participants take the drug by mouth, and researchers track kidney function and side effects over time.

This study tests whether a 16-week program of group diet coaching and hands-on cooking classes can help Black Americans at risk for chronic kidney disease stick to the low-sodium DASH diet. The program involves 48 participants who either get the coaching and classes right away or…

This study compares two types of peritoneal dialysis—standard and incremental—in 100 adults starting dialysis. The goal is to see if using less dialysis solution (incremental) helps preserve remaining kidney function and reduces cell damage compared to the standard approach. Part…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This early-stage study tests a conditioning regimen to make the recipient's immune system accept a donor kidney without needing lifelong anti-rejection medication. About 20 adults with kidney failure receiving their first transplant from a living donor will participate. The main …

This study was designed to test whether volenrelaxin could help adults with chronic kidney disease by reducing protein in the urine and preserving kidney function. It was a phase 2, placebo-controlled trial planned to last about 24 weeks. However, the study was withdrawn before e…

This phase 4 study tested whether a once-monthly injection of darbepoetin alfa works as well as the standard every-2-week schedule for maintaining healthy hemoglobin levels in people with advanced chronic kidney disease who are not on dialysis. Forty Korean adults completed the 1…

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

This study tests whether a 6-month program of aerobic and resistance exercises, done during dialysis sessions, can improve body composition, muscle oxygen levels, and physical function in 40 adults with chronic kidney disease. Participants are randomly assigned to either the exer…

This study tests if anakinra is better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, severe joint pain. Standard treatments can be risky for these patients. The study measures pain …

This observational study follows 150,000 people with chronic kidney disease and type 2 diabetes to see how finerenone (Kerendia) works in everyday medical care. Researchers will compare those taking finerenone to those not taking it, looking at rates of heart attacks and heart fa…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This observational study follows over 4,600 adults with chronic kidney disease and type 2 diabetes who are starting finerenone, a drug that helps slow kidney damage. Researchers will collect data from routine doctor visits over 12 months to understand why doctors prescribe it, ho…

This study investigates whether a single infusion of L-arginine, an amino acid, can reduce abnormally high sympathetic nerve activity in people with chronic kidney disease (CKD). High nerve activity is linked to increased cardiovascular risk in CKD patients. Researchers will meas…

This study observes 69 adults with chronic kidney disease who are on hemodialysis. Researchers want to find the best way to diagnose malnutrition using the GLIM criteria and other tools. The goal is to see which methods best predict declines in quality of life, muscle strength, a…

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between August 2022 and April 2024. Researchers will analyze how doctors prescribed the drug, dose changes, and lab results like kidney function and pot…

This study tests two ways to help older adults with kidney failure make informed choices about their care. One approach offers education and decision aids; the other adds a supportive care program for those who choose non-dialysis options. Researchers will compare how many patien…

This study is tracking over 1,200 adults in Kazakhstan who have high blood pressure to see how many also have signs of chronic kidney disease (CKD). Researchers will measure things like protein in urine and kidney function. The goal is to understand how often CKD goes undiagnosed…

This study gives a single dose of bepirovirsen to 32 adults with hepatitis B, some with kidney disease and some healthy. Researchers measure how much drug gets into the blood and how long it stays. The goal is to see if kidney problems change drug levels, which could affect futur…

This study was designed to see how a new experimental drug for chronic kidney disease, nurandociguat, affects the way the body processes two common medicines: rosuvastatin (a cholesterol drug) and dabigatran (a blood thinner). Healthy adults would have taken these drugs alone and…

This study looks at whether SGLT2 inhibitors, a type of diabetes drug, can help prevent or manage anemia in people with chronic kidney disease. Researchers will analyze data from 15,000 patients in Japan to see how these drugs affect anemia rates, treatments, and costs. The goal …

This study looks at over 10,000 adults in Ecuador to understand why some people with diabetes develop kidney disease. Researchers will collect health surveys, blood and urine samples, and kidney tissue to study social, environmental, and biological factors. The goal is to find ne…

This study tests whether a Learning Health System (LHS) can improve care for people with high blood pressure, diabetes, and kidney disease in Thai primary care clinics. The LHS uses electronic health records to help healthcare teams identify patients who need more active manageme…

This study tests a special education program for veterans with advanced chronic kidney disease. The goal is to help them understand their condition and choose the best type of dialysis, especially home dialysis. About 656 veterans will take part to see if this program improves th…

This study looks at how well muscle strength tests work for people with chronic kidney disease. It also tests if a supervised online exercise program is helpful and safe. 50 adults with kidney disease (on dialysis or with a transplant) will take part.

This study aims to identify clinical, lifestyle, and genetic factors that affect blood sugar control and kidney complications in adults with type 2 diabetes in Mexico. Researchers will collect medical history, physical test results, and blood samples from 1,000 participants. The …

This observational study follows 350 adults with pulmonary hypertension to see if certain biomarkers in urine and blood are linked to worsening kidney function. Participants undergo standard tests but receive no experimental treatment. The goal is to better understand how kidney …

This study looks at 120 adults on regular hemodialysis to see if a simple blood test called the neutrophil-to-lymphocyte ratio (NLR) can help detect peripheral artery disease (PAD). PAD is a common but often overlooked complication in kidney patients. The goal is to find a cheap,…

This study follows 300 adults with chronic kidney disease who are already taking SGLT2 inhibitors. Researchers want to see if the amount of sugar in their urine is linked to changes in protein levels, a key marker of kidney damage. The goal is to find a simple way to tell if the …