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New study reveals how diabetes drug semaglutide may protect kidneys

NCT ID NCT04865770

Completed Knowledge-focused Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. 106 participants received either semaglutide or a placebo injection once a week for about a year. Researchers used MRI scans, blood and urine tests, and kidney biopsies to measure changes in kidney oxygen, blood flow, and inflammation.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE DIABETES MELLITUS, TYPE 2

Contacts and locations

Locations

  • Academic Medical Research Institute

    Los Angeles, California, 90022, United States

  • Advent Health-Res Inst

    Orlando, Florida, 32804, United States

  • Atlanta Diabetes Associates

    Atlanta, Georgia, 30318, United States

  • Azienda Ospedaliera Papa Giovanni XXIII

    Bergamo, 24127, Italy

  • Azienda Ospedaliera di Padova Clin.Med.3

    Padova, 35128, Italy

  • Azienda Ospedaliero - Universitaria Sant'Andrea

    Roma, 00189, Italy

  • Centre Hospitalier Universitaire Amiens Picardie-Site Sud

    Amiens, 80054, France

  • Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-2

    Grenoble - Cédex 09, 38043, France

  • Centre Hospitalier Universitaire de Rouen - Hopital de Bois Guillaume

    Bois-Guillaume, 76230, France

  • Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil

    Toulouse, 31059, France

  • Centrum Medyczne "Diabetika"

    Radom, 26-600, Poland

  • Chu de Reims-Hopital Maison Blanche

    Reims, 51092, France

  • Cleveland Clinic_Cleveland

    Cleveland, Ohio, 44195, United States

  • Clinical Research Consultants, LLC

    Kansas City, Missouri, 64111, United States

  • Emory University Hsptl - Atlanta

    Atlanta, Georgia, 30322, United States

  • Endeavor Health Glenbook Hosp

    Evanston, Illinois, 60201, United States

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital de Bellvitge

    L'Hospitalet de Llobregat, 08907, Spain

  • In-Vivo Sp. z o.o.

    Bydgoszcz, 85-048, Poland

  • Istituto Scientifico San Raffaele

    Milan, MI, 20132, Italy

  • LMC ClinRsrh Inc.Brampton

    Brampton, Ontario, L6S 0C6, Canada

  • Lenmed Shifa Private Hospital

    Durban, KwaZulu-Natal, 4901, South Africa

  • Les Hopitaux de Chartres-Hopital Louis Pasteur

    Le Coudray, 28630, France

  • Maxwell Centre

    Durban, KwaZulu-Natal, 4001, South Africa

  • Medical College Of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Miedzyleski Szpital Specjalistyczny, Oddzial Nefrologiczny

    Warsaw, 04-749, Poland

  • N America Res Inst - San Dimas

    San Dimas, California, 91773, United States

  • NE Clin Res of San Antonio

    San Antonio, Texas, 78233, United States

  • Nefrologisk Klinik P 2132

    Copenhagen, 2100, Denmark

  • North Suburban Nephrology LLC

    Gurnee, Illinois, 60031, United States

  • Precise Clinical Solutions (Pty) Ltd

    Durban, KwaZulu-Natal, 4092, South Africa

  • Presidio Ospedaliero Cisanello

    Pisa, 56124, Italy

  • Prof Rayner_Division of Nephrology

    Cape Town, Western Cape, 7925, South Africa

  • Prolato Clinical Research Cntr

    Houston, Texas, 77054, United States

  • Providence Medical Research Center

    Spokane, Washington, 99204, United States

  • Prywatny Gabinet Janusz Gumprecht

    Zabrze, 41-800, Poland

  • Rigshospitalet - Nefrologisk Klinik P 2132

    Copenhagen, 2100, Denmark

  • Roderick A. Comunale II MD Inc.

    National City, California, 91950, United States

  • Steno Diabetes Center Copenhagen

    Herlev, 2730, Denmark

  • Sun Research Institute

    San Antonio, Texas, 78215, United States

  • UC Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • UHN-Toronto General Hospital

    Toronto, Ontario, M5G 2N2, Canada

  • Univ of Washington Med Ctr

    Seattle, Washington, 98195, United States

  • University of Arizona-CaTs

    Tucson, Arizona, 85724, United States

  • University of Minnesota Health Clinical

    Minneapolis, Minnesota, 55455, United States

  • University of Texas San Antonio

    San Antonio, Texas, 78284, United States

  • Uniwersytecki Szpital Kliniczny Nr 2 PUM W Szczecinie

    Szczecin, 70-111, Poland

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