Can a puff of insulin replace a needle for diabetes?

NCT ID NCT00418522

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial tests whether inhaled insulin (Exubera) can control blood sugar as well as insulin glargine (Lantus) injections in adults with type 2 diabetes who are not well controlled on two or more oral medications. Participants will receive either inhaled insulin before meals or daily insulin injections for six months, alongside their usual oral agents. The main goal is to see how much each approach lowers HbA1c, a key marker of long-term blood sugar control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Inhaled insulin (Exubera) compared to insulin glargine (Lantus) injections
What this could lead to: If effective, inhaled insulin could offer a needle-free alternative for managing type 2 diabetes, potentially improving convenience and adherence.
What could go wrong: This is a Phase 4 trial, but results may not show a clear advantage over standard injections. Inhaled insulin may have side effects like cough or lung function changes, and it may not suit everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2

Contacts and locations

Locations

Pfizer Investigational Site

Phoenix, Arizona, 85051, United States
Pfizer Investigational Site

Tucson, Arizona, 85712, United States
Pfizer Investigational Site

Concord, California, 94520, United States
Pfizer Investigational Site

Encino, California, 91436, United States
Pfizer Investigational Site

Fresno, California, 93720, United States
Pfizer Investigational Site

Fullerton, California, 92835, United States
Pfizer Investigational Site

Long Beach, California, 90806, United States
Pfizer Investigational Site

Mission Viejo, California, 92691, United States
Pfizer Investigational Site

Pasadena, California, 91105, United States
Pfizer Investigational Site

San Diego, California, 92120, United States
Pfizer Investigational Site

San Diego, California, 92128, United States
Pfizer Investigational Site

San Luis Obispo, California, 93401, United States
Pfizer Investigational Site

Spring Valley, California, 91978, United States
Pfizer Investigational Site

Stockton, California, 95204, United States
Pfizer Investigational Site

Walnut Creek, California, 94598, United States
Pfizer Investigational Site

West Hills, California, 91307, United States
Pfizer Investigational Site

Golden, Colorado, 80401, United States
Pfizer Investigational Site

Waterbury, Connecticut, 06708, United States
Pfizer Investigational Site

Newark, Delaware, 19713, United States
Pfizer Investigational Site

Chiefland, Florida, 32626, United States
Pfizer Investigational Site

Clearwater, Florida, 33765, United States
Pfizer Investigational Site

Hollywood, Florida, 33023, United States
Pfizer Investigational Site

Kissimmee, Florida, 34741, United States
Pfizer Investigational Site

Miami, Florida, 33156, United States
Pfizer Investigational Site

Ocala, Florida, 34471, United States
Pfizer Investigational Site

Saint Cloud, Florida, 34769, United States
Pfizer Investigational Site

Winter Park, Florida, 32789, United States
Pfizer Investigational Site

Atlanta, Georgia, 30322, United States
Pfizer Investigational Site

Lawrenceville, Georgia, 30045-3388, United States
Pfizer Investigational Site

Lawrenceville, Georgia, 30045, United States
Pfizer Investigational Site

Woodstock, Georgia, 30189, United States
Pfizer Investigational Site

Boise, Idaho, 83702, United States
Pfizer Investigational Site

Hayden Lake, Idaho, 83835, United States
Pfizer Investigational Site

Indianapolis, Indiana, 46254, United States
Pfizer Investigational Site

Overland Park, Kansas, 66211, United States
Pfizer Investigational Site

Topeka, Kansas, 66606, United States
Pfizer Investigational Site

Lexington, Kentucky, 40503, United States
Pfizer Investigational Site

Louisville, Kentucky, 40213, United States
Pfizer Investigational Site

Baton Rouge, Louisiana, 70808, United States
Pfizer Investigational Site

New Orleans, Louisiana, 70121, United States
Pfizer Investigational Site

Haverhill, Massachusetts, 01830-6141, United States
Pfizer Investigational Site

Springfield, Missouri, 65807, United States
Pfizer Investigational Site

Omaha, Nebraska, 68131, United States
Pfizer Investigational Site

Las Vegas, Nevada, 89104, United States
Pfizer Investigational Site

Staten Island, New York, 10301, United States
Pfizer Investigational Site

Charlotte, North Carolina, 28209-3734, United States
Pfizer Investigational Site

Statesville, North Carolina, 28625, United States
Pfizer Investigational Site

Winston-Salem, North Carolina, 27103, United States
Pfizer Investigational Site

Kettering, Ohio, 45429, United States
Pfizer Investigational Site

Maumee, Ohio, 43537-9402, United States
Pfizer Investigational Site

Toledo, Ohio, 43606, United States
Pfizer Investigational Site

Oklahoma City, Oklahoma, 73103, United States
Pfizer Investigational Site

Medford, Oregon, 97504, United States
Pfizer Investigational Site

Melrose Park, Pennsylvania, 19027, United States
Pfizer Investigational Site

Greenville, South Carolina, 29615, United States
Pfizer Investigational Site

Greer, South Carolina, 29651, United States
Pfizer Investigational Site

Spartanburg, South Carolina, 29303, United States
Pfizer Investigational Site

Milan, Tennessee, 38358, United States
Pfizer Investigational Site

Arlington, Texas, 76014-2010, United States
Pfizer Investigational Site

Beaumont, Texas, 77701, United States
Pfizer Investigational Site

Dallas, Texas, 75230, United States
Pfizer Investigational Site

Dallas, Texas, 75231, United States
Pfizer Investigational Site

Dallas, Texas, 75246, United States
Pfizer Investigational Site

El Paso, Texas, 79935, United States
Pfizer Investigational Site

Houston, Texas, 77008, United States
Pfizer Investigational Site

Houston, Texas, 77083, United States
Pfizer Investigational Site

San Antonio, Texas, 78229-3900, United States
Pfizer Investigational Site

San Antonio, Texas, 78229, United States
Pfizer Investigational Site

Bennington, Vermont, 05201-5018, United States
Pfizer Investigational Site

Richmond, Virginia, 23249, United States
Pfizer Investigational Site

Federal Way, Washington, 98003, United States
Pfizer Investigational Site

Menomonee Falls, Wisconsin, 53051, United States
Pfizer Investigational Site

Carolina, 00983, Puerto Rico

More trials for these conditions

Other studies related to the condition(s) this trial covers.