DIABETES MELLITUS TYPE 2

This study looks at how family support can help people with type 2 diabetes in rural Kentucky eat better and be more active. About 75 participants will share their access to food and exercise options, then follow a 6-month nutrition and activity plan with their families. The goal…

This study tests the safety and effectiveness of tirzepatide in 344 Indian adults with type 2 diabetes or obesity. Participants receive the drug for 46 weeks. Researchers will track side effects, weight loss, and blood sugar control to see if tirzepatide helps manage these condit…

This study tests a Norwegian e-health program called DiaMester that helps adults with type 2 diabetes improve self-management and lose weight. The goal is to see if significant weight loss can lead to diabetes remission. About 99 participants will be randomly assigned to differen…

This study tests a new way to care for adults with type 2 diabetes at community health centers. It uses a team of providers and technology to help patients control their blood sugar. About 120,000 patients from 16 health centers across the U.S. and Puerto Rico will take part over…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals plus c…

This study tests a diabetes education program designed specifically for Arab Americans with type 2 diabetes. Participants will attend peer-led classes in Arabic and receive text messages to help with self-care. The goal is to improve diabetes knowledge, beliefs, and blood sugar l…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will take the drugs or a placebo for 48 weeks. The main goal is to see how much weight they l…

This study looks at time-restricted eating (a form of intermittent fasting) to see if the timing of your daily eating window affects blood sugar control. Researchers will compare three different 9-hour eating windows in 120 adults with obesity who have or are at risk for type 2 d…

This study is testing a new device called the Eversense Gemini System, which helps people with diabetes check their blood sugar levels without finger pricks. The study will include 80 adults with type 1 or type 2 diabetes to see how accurate and safe the new system is compared to…

This study looks at whether a 12-week digital diet program, including extra vegetables and soy foods, can lower blood pressure and improve heart health in 300 adults with obesity, high blood pressure, and often type 2 diabetes. Participants will either follow the diet with highly…

This study tests whether drinking traditional kefir for 12 weeks can improve blood sugar control and heart health in people who are overweight and either at risk for or already have type 2 diabetes. Researchers will measure changes in HbA1c (average blood sugar) and other health …

This study tests whether a total diet replacement program, delivered through an eHealth app, can help overweight adults with early type 2 diabetes achieve remission. 106 participants will be randomly assigned to either eHealth or in-person follow-up, with both groups receiving th…

This study tests whether choline fenofibrate can reduce plaque buildup in the carotid arteries of people with type 2 diabetes and mixed high cholesterol. About 56 participants will receive either choline fenofibrate or a comparison drug (policosanol) for several months. The main …

This study compares standard gastric bypass surgery to bypass plus a nerve-cutting procedure (truncal vagotomy) for helping type 2 diabetes go into remission. About 40 adults with obesity and diabetes will be randomly assigned to one of the two surgeries and followed for a year. …

This study looks at whether people with type 2 diabetes who don't use insulin can wear a continuous glucose monitor (CGM) for only two weeks each month and still control their blood sugar just as well as wearing it all the time. About 150 adults will first wear the CGM continuous…

This study tests whether using a mobile health app helps people with type 2 diabetes and obesity lose weight and improve blood sugar control. Thirty adults will use the app for 6 months, weighing themselves daily and checking blood sugar before and after meals. The goal is to see…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to usual care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device or continue their routine care for 13 weeks to see if it improves blood sugar co…

This study looks at whether combining two common diabetes medications (GLP-1 agonists and SGLT2 inhibitors) can improve heart function and blood vessel health in people with type 2 diabetes who are at high risk for heart problems. About 240 participants will be split into four gr…

This study tests whether adding vicadrostat to the standard medicine empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and existing heart disease. About 11,800 participants will be randomly assigned to receive either vicadros…

This study tests whether wearing a continuous glucose monitor (CGM) every two months helps older adults (60+) with type 2 diabetes improve blood sugar control compared to standard finger-stick monitoring. Participants take oral diabetes drugs but not insulin. The trial lasts 6 mo…

This study tests a new medicine called LY3938577 against a standard insulin (degludec) in 100 adults with type 2 diabetes who already use basal insulin. The goal is to see if the new drug helps keep blood sugar in a healthy range more safely and effectively over about 26 weeks. P…

This study compares having one laser treatment session versus several sessions for people with proliferative diabetic retinopathy, a serious eye condition that can lead to blindness. Researchers want to see which approach is safer and works better. About 40 adults with diabetes a…

This study tests an oral drug called dapansutrile in 300 adults with type 2 diabetes. The drug targets inflammation, which may help lower blood sugar and reduce diabetes complications. Participants will take either the drug or a placebo for several months to see if it safely impr…

This study looks at whether treating insomnia with cognitive behavioral therapy (CBT-I) can lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will either receive CBT-I or a general health education program. The goal is to see…

This study tests if a once-weekly insulin shot (icodec) works as well as daily insulin shots for controlling blood sugar in people with type 2 diabetes. About 586 adults who have never used insulin before will take either the weekly or a daily insulin for 13 months. The goal is t…

This study tests whether mobile health apps like Weight Watchers and Healthi can help low-income Hispanic adults with type 2 diabetes lose weight and improve blood sugar control. Participants will weigh themselves daily and check blood glucose before and after meals for 6 months.…

This study is testing whether semaglutide (a drug used for diabetes and weight loss) can improve psoriasis when added to a standard topical cream. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will take either semaglutide or a placebo pill for 1…

This study looks at whether combining guided exercise with cognitive behavioral therapy (CBT) can help Black men with type 2 diabetes and depressive symptoms improve their blood sugar control and quality of life. About 80 men will take part in a 7-month program that includes week…

This study is testing whether taking daily vitamin D3 or yeast beta-glucan (a type of fiber) supplements can improve blood sugar control and lower the risk of heart disease in people with type 2 diabetes. The trial will involve 2,500 adults aged 40 to 79 and will last 5 years, in…

This study tests whether a keto diet using canola oil (healthy fats) is better for heart health than a traditional keto diet high in saturated fat or a low-fat diet. Researchers will measure cholesterol, blood sugar, and inflammation in 175 adults with prediabetes or type 2 diabe…

This study looks at whether using a continuous glucose monitor (CGM) can help kidney transplant recipients with type 2 diabetes keep their blood sugar in a healthy range. About 80 adults who received a kidney transplant in the past year and use insulin will wear a CGM device. The…

This study looks at whether adding omega-3 (fish oil) to a common cholesterol-lowering statin can reduce plaque buildup in the carotid arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to receive either atorvastatin plus omeg…

This study tests whether a specially trained nurse case manager can help formerly incarcerated Black men with poorly controlled type 2 diabetes improve their blood sugar levels, blood pressure, and quality of life. One hundred participants will be randomly assigned to receive eit…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This early-stage study tests a new medicine called MK-1403 in people with type 2 diabetes. The main goals are to check if it is safe and well-tolerated, and to see how the body processes it. Researchers will also measure if it lowers a marker of inflammation (hsCRP) in the blood.…

This early study is testing if a patient's own fat cells, specially treated with a laser, can help control type 2 diabetes. Ten adults with diabetes will have fat removed from their belly, processed, and then injected into the lining of the small intestine. The goal is to see if …

This early-stage study tests a new drug called ARO-ALK7 in 138 adults with obesity, some of whom also have type 2 diabetes. The goal is to check if the drug is safe and how it affects weight and blood sugar. Participants receive either the drug or a placebo, and some may also tak…

This study looks at whether giving hospitalized diabetes patients who struggle to afford food access to free meals and nutrition education can reduce food insecurity and improve health. About 160 adults with type 1 or type 2 diabetes will be randomly assigned to receive either st…

This study tests whether taking taurine, a common amino acid supplement, can improve blood sugar control, cholesterol levels, and inflammation in people with type 2 diabetes. Researchers will give taurine or a placebo to 94 adults with diabetes for 12 weeks. The main goal is to s…

This study tests whether teaching diabetes self-management in churches can help people with type 2 diabetes in the Marshall Islands control their blood sugar. About 288 adults with diabetes and their family members will take part. Trained community health workers will lead the cl…

This study tests whether a communication technique called 'linguistic nudging' helps doctors and patients with type 2 diabetes make better treatment decisions together. 250 adults will be split into two groups: one where doctors use nudging and patients use a mobile app, and anot…

This study aims to improve long-term diabetes management by combining traditional Chinese medicine with Western medicine through a digital platform. Researchers will enroll 10,000 adults with type 2 diabetes to test whether an integrated online and offline approach can lower bloo…

This study tests a new way to help people with uncontrolled type 2 diabetes who also have unmet social needs, like food or housing. The program uses a tool in the medical record to identify these needs and connects patients with community health workers and local organizations. A…

This study tests whether a special training program for primary care doctors and nurses leads to better health for their patients with type 2 diabetes. Over 7,700 patients will be part of the study, which compares clinics where staff receive the training to those that do not. The…

This study is testing a procedure called Duodenal Mucosal Resurfacing (DMR) for people with type 2 diabetes. Doctors use a scope to treat the lining of the first part of the small intestine. The goal is to see if this one-time procedure, and possibly a repeat treatment, can help …

This study tests whether using a detailed heart scan (Cleerly CAD Staging) to guide treatment can prevent heart attacks, strokes, and other heart-related events better than the usual approach of managing risk factors like cholesterol and blood pressure. The trial will include 7,5…

This study looks at whether drinking one cup of regular milk each day can lower the risk of type 2 diabetes in people with lactose intolerance who also have prediabetes. Researchers will compare regular milk to lactose-free milk over 12 weeks in 40 adults. They will measure chang…

This study looks at how common thinking problems are in people aged 65+ with type 2 diabetes. It then tests a program that combines healthy habits, exercise, and mental activities to see if it can prevent or slow down memory and thinking decline. About 420 participants will be fo…

This early-phase study tests a new drug called LY4057996 in healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the drug moves through the body and its effe…

This study tests whether 12 weeks of home-based heat therapy can improve blood sugar control, insulin sensitivity, and blood vessel function in adults with type 2 diabetes. Participants will use heat sessions at home, and researchers will measure changes in key health markers. Th…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce severe leg pain and improve blood flow in people with both painful diabetic neuropathy and peripheral artery disease. Fifteen adults who already have a permanent s…

This study tests whether a brief self-affirmation writing exercise before regular doctor visits can reduce feelings of stigma and improve diabetes management in adults with type 2 diabetes. About 150 participants will be randomly assigned to do the full exercise or a shorter vers…

This study tests an 8-week remote program that combines positive psychology and motivational interviewing to help people with type 2 diabetes increase their physical activity. 280 adults with type 2 diabetes who are not very active will participate. The program includes weekly se…

This study tests whether a 12-week low-calorie diet can improve heart function, reduce symptoms like breathlessness, and help people walk farther. It includes 63 adults with heart failure with preserved ejection fraction, obesity, and type 2 diabetes. Participants are randomly as…

This study from Stanford University aims to understand why people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors (CGMs) to track how 100 adults (with prediabetes, type 2 diabetes, or healthy) react to specific meals. The g…

This study tests a smartphone app designed to help young people (ages 16-24) with type 2 diabetes manage their health. Participants will wear a continuous glucose monitor and a Fitbit for 30 days while using the app and receiving health tips. The goal is to see if the app is easy…

This study looks at how a natural gut hormone called GIP affects bone breakdown and formation. Researchers will give 12 healthy adults GIP either continuously or for 8 hours a day for 3 days, then measure bone markers in blood and bone cells. The goal is to understand if the way …

This study compares people with high and low genetic risk for type 2 diabetes to see if their bodies handle sugar differently. Researchers will measure blood sugar and insulin responses after a sugary drink. Participants are non-diabetic volunteers aged 10 to 70. No treatment or …

This study looks at how Semaglutide, a diabetes drug that also helps with weight loss, changes the amount of fat stored inside the heart and leg muscles. Researchers will use special MRI scans to measure fat levels in 60 adults with type 2 diabetes. The goal is to understand if r…

This study reviews medical records of 400 adults aged 40-70 who were recently diagnosed with type 2 diabetes in five Southeast Asian countries. Researchers will look at health data from before and after diagnosis to understand how heart disease risk is distributed among these pat…

This study follows 1250 people at higher risk for pancreas cancer—such as those with new diabetes, pancreas cysts, or a family history—to find early warning signs in the blood. Participants visit Omaha twice a year to give blood samples. The goal is to develop a screening test th…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track inflammation, heart energy use, and thinking skills over time. The goal is to find early warning signs of heart failure and memory decline, so doctors can pers…

This study looks at why some adults with diabetes find it hard to take their medicines regularly. Researchers will survey 220 people to understand factors like knowledge, beliefs, family support, and access to care. The goal is to find the biggest barriers and use that informatio…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome can change the way the body processes certain drugs. Researchers will measure inflammation markers and immune cells in blood samples from 150 adults and children with …

This study looks at how well different forms and doses of daily aspirin work in people with type 2 diabetes to prevent blood clots. About 30 participants will first take a standard coated aspirin for a week. Those whose blood does not respond well will then try three other aspiri…

This study looks at kidney tissue from adults with diabetic kidney disease who are already having a kidney biopsy or surgery. Researchers want to understand how SGLT2 inhibitors, a common diabetes medicine, change the kidney's molecular makeup. Participants donate a tissue slide,…

This study looks at why type 2 diabetes often goes away quickly after bariatric surgery. Researchers will track how the body stores and uses fat from food in 40 people having surgery—some with diabetes, some without. The goal is to find out if changes in fat tissue are the key to…

This study follows 100 people with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to blindness. Researchers will use advanced eye scans and tests over two years to track small changes in the retina. The goal is to find early warning si…

This study looks at how social needs—like food, housing, or safety—affect the health and self-care of African American adults with diabetic kidney disease. Researchers will talk with 330 participants to understand what helps or hinders their care, then design a program tailored t…

This study looks at ways to help women aged 18-44 with type 2 diabetes learn more about their condition and how to take care of themselves before getting pregnant. Researchers will compare two groups of women to see if special education and support can improve blood sugar control…

This study looks at whether community health workers can help more women get tested for type 2 diabetes after having a baby. Women who had diabetes during pregnancy are at high risk, but many miss the recommended test. The trial will involve 330 women in urban slums of Pune, Indi…

This study aims to find new biological clues that explain why some people with severe obesity develop type 2 diabetes while others do not. Researchers will collect tissue samples (fat, muscle, liver, blood) from 270 adults during planned weight-loss surgery. By comparing samples …

This study follows 2,000 adults with type 2 diabetes to see how their diet, body composition, and grip strength change over time. Participants will have basic health checks like height, weight, and strength tests. The goal is to learn more about the disease, not to test a new tre…

This study looks at how long you need to fast and how stopping the diabetes drug tirzepatide changes the amount of food or drink left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 adults with type 2 diabetes or obesity. The goal is …

This study is checking if a new version of a glucose sensor (the ROME GS) works just as well and is as safe as the current model (Eversense 365). About 60 adults with type 1 or type 2 diabetes will wear the sensor to see how accurately it measures blood sugar levels. The goal is …

This study looks at how a type of diabetes medicine (GLP-1 receptor agonists) affects fat tissue function in people with chronic kidney disease. Researchers want to see if improving fat health can slow kidney damage. About 250 adults with early-to-moderate kidney disease, obesity…