DIABETES MELLITUS TYPE 2

This study looks at how different exercise programs (moderate continuous training or high-intensity interval training) combined with a diet plan affect appetite, blood sugar, and body fat in people with type 2 diabetes. 146 adults with diabetes or prediabetes and a BMI over 25 to…

This study aimed to see if adding a new drug called ofirnoflast to semaglutide helps control blood sugar and promote weight loss better than semaglutide alone in overweight or obese adults with type 2 diabetes. Participants would have taken the drugs for 12 weeks. However, the st…

This study looks at whether a program that combines in-person doctor-patient conversations with text message reminders can help people with type 2 diabetes take their medications as prescribed. The goal is to improve blood sugar, cholesterol, and blood pressure control, and ultim…

This study looks at how safe and effective Ozempic is for adults with type 2 diabetes when used in everyday medical practice in Korea. About 600 people will take the drug as prescribed by their doctor, and researchers will track side effects and blood sugar events over 26 weeks. …

This study looks at whether semaglutide, a once-weekly injection for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo alongside their usual diabetes medicines. The main goal…

This study tests a wireless glucose monitoring system that sends blood sugar readings from the patient's bedside to the nursing station. The goal is to quickly detect and prevent low blood sugar (hypoglycemia) in hospitalized veterans with type 2 diabetes who are on insulin. Abou…

This study tests whether spermidine, a natural substance found in foods like wheat germ and soy, can improve heart and muscle health in people aged 65 and older with coronary artery disease. About 180 participants will receive either spermidine or a placebo for a period, and rese…

This study compares a combination diabetes drug (iGlarLixi) to insulin alone to see which better reduces liver fat in people with type 2 diabetes and fatty liver disease. About 36 participants will take the assigned treatment for 12 weeks. The goal is to find a better way to mana…

This study looks at the best way to control blood sugar in pregnant women with diabetes who need steroid shots to help their baby's lungs develop before a possible early birth. Steroids can raise blood sugar, which may be harmful. The trial compares three insulin strategies to fi…

This study looks at how well Envlo or Envlomet SR tablets control blood sugar and their safety in 15,000 adults with type 2 diabetes. Participants take the medication as prescribed by their doctor for 24 weeks. The main goal is to see changes in HbA1c, a key blood sugar measure.

This study trains church members to become community health workers who help other Latino(a)s manage diabetes or reduce their risk. The program uses an online platform to track progress and improve access to healthcare. About 400 Spanish-speaking adults will take part, focusing o…

This study tests whether an AI program that shows patients how their health compares to others, plus home blood sugar monitoring, can help people with type 2 diabetes better understand their risks and improve their blood sugar control. About 360 adults aged 36–65 with poorly cont…

This study tests whether eating all meals earlier in the day and getting light therapy at specific times can improve blood sugar control in adults with type 2 diabetes. About 344 participants will follow these routines for several weeks while researchers measure blood sugar, insu…

This study tests a new procedure that uses gentle electric pulses to regenerate the lining of the small intestine in people with type 2 diabetes. Combined with a common diabetes drug, the goal is to help patients stop using insulin while keeping blood sugar under control. The tri…

This study tests whether the drug imeglimin can help people with type 2 diabetes maintain healthy blood sugar levels over three years. About 567 adults on diet and exercise therapy will take the drug and have regular blood tests. The goal is to see how long it takes for blood sug…

This study compares weight-loss surgery to intensive medical treatment for controlling type 2 diabetes in teenagers aged 13 to 19.9 years. The goal is to see if surgery is better at keeping blood sugar levels healthy and reducing related health problems. Participants are randomly…

This study tests whether giving monthly money for healthy food delivery can lower blood sugar in adults with type 2 diabetes. About 1,000 Kaiser Permanente members with Medi-Cal insurance and high blood sugar levels will receive either free food delivery plus money or just free d…

This study tests a new investigational medicine called CagriSema (a combination of two drugs) against an approved drug, tirzepatide, in people with type 2 diabetes. The goal is to see which works better at lowering blood sugar and body weight. About 1,023 adults whose diabetes is…

This early-stage study tests whether a person's own pancreatic cells can be turned into insulin-making cells and transplanted under the belly skin to control diabetes. 24 adults with type 2 diabetes who need insulin shots will take part. The goal is to see if this approach is saf…

This study compares two glucose monitoring methods—fingerstick checks and continuous glucose monitors—in 360 adults with type 2 diabetes who use insulin. Over 12 months, researchers will measure changes in blood sugar control (A1C) and diabetes-related distress. The goal is to se…

This study aimed to see if a virtual weight control program (WW) could lower blood sugar levels in adults with type 2 diabetes and obesity. It planned to enroll about 0 participants aged 18-74 with high blood sugar and overweight. However, the study was withdrawn before any parti…

This study tests if a new weekly injection, retatrutide, works better than the existing drug semaglutide at controlling blood sugar in adults with type 2 diabetes. About 1250 people whose blood sugar is not well managed by metformin (with or without another diabetes pill) will ta…

This study compares a carbohydrate-reduced, high-protein diet to a standard diabetes diet in 100 adults with type 2 diabetes and overweight. Over 12 months, researchers will measure changes in blood sugar, weight, and fat in the liver and pancreas. The goal is to see if the low-c…

This study tests whether monthly support sessions led by trained Black men with diabetes can help other Black men better manage their type 2 diabetes. All participants receive diabetes education, and half also get 6 months of peer support followed by ongoing group activities. The…

This study aimed to see if combining two diabetes medications (an SGLT2 inhibitor and a DPP-4 inhibitor) works better than each drug alone for people with type 2 diabetes whose blood sugar is not well controlled with metformin. The trial was withdrawn before enrolling any partici…

This study tests whether a second treatment using heat energy to ablate the lining of the small intestine can help people with type 2 diabetes who did not respond to the first treatment. The goal is to improve blood sugar control without causing serious side effects like bleeding…

This study looks at whether using a continuous glucose monitor (CGM) helps people with diabetes who are on dialysis keep their blood sugar in a healthy range. About 96 adults with type 1 or type 2 diabetes and on either hemodialysis or peritoneal dialysis will be split into three…

This study looks at whether training community clinic staff through video mentoring can improve diabetes care for low-income Latino adults. About 320 Spanish-speaking adults with type 2 diabetes will take part. The goal is to see if this approach helps lower blood sugar and impro…

This phase 2 study tests an experimental drug called MN-001 (tipelukast) in 40 adults with non-alcoholic fatty liver disease, type 2 diabetes, and high triglycerides. Participants take either the drug or a placebo daily for 24 weeks. The main goals are to see if the drug reduces …

This early study tests a new device that uses heat to treat the lining of the small intestine in people with type 2 diabetes who need insulin. The goal is to see if this procedure, alone or with a diabetes drug called semaglutide, can safely help them stop taking insulin and keep…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight, type 2 diabetes, or other heart-related risks and moderate liver fibrosis will …

This study tests whether choosing diabetes medication based on a person's genetic profile helps control blood sugar better than standard care. About 504 adults with poorly controlled type 2 diabetes will receive either genetically guided or standard treatment. Researchers will co…

This study tests whether having a family member or close friend join in diabetes self-management training helps African American adults with type 2 diabetes improve their blood sugar control and quality of life. About 208 participants and their family partners will take part. The…

This study tests whether transplanting gut bacteria from a healthy donor (fecal microbiota transplantation) can improve insulin sensitivity and blood sugar control in people with type 2 diabetes. Sixteen participants will receive either the transplant or a placebo, and their gluc…

This study tests whether a probiotic (Lactobacillus reuteri) is as good as a standard mouthwash (chlorhexidine) at reducing harmful bacteria in people with both gum disease and type 2 diabetes. Twenty adults will use one of the treatments for 30 days, and researchers will measure…

This study tests a special toolkit designed to help people with type 2 diabetes who need to start using insulin after leaving the hospital. The toolkit provides guidance and support to manage blood sugar safely at home. Researchers will compare blood sugar levels and complication…

This study compares a continuous glucose monitor (FreeStyle Libre 3) to standard finger-stick testing in 470 adults with type 2 diabetes who are on basal insulin and certain other medications. The goal is to see if the monitor improves blood sugar levels (HbA1c) over 16 weeks. Pa…

This study tests whether three different culturally tailored diet patterns (U.S.-style, Mediterranean, and vegetarian) can improve eating habits and reduce type 2 diabetes risk in African American adults. About 198 participants will follow one of the diets for one year. The goal …

This study tests an online program to help 2,000 women who had gestational diabetes get recommended postpartum diabetes screening and join lifestyle programs to prevent type 2 diabetes. Participants receive standard health information plus up to four extra online tools designed t…

This study tests whether a special computer-based brain training program can improve memory and thinking in older adults (60+) who have type 2 diabetes and are at high risk for dementia. 120 participants will be randomly assigned to either the adaptive training or a placebo versi…

This early-stage study tests a new medicine called MK-2828 in 64 people with type 2 diabetes. The main goal is to check if it is safe and well-tolerated. Researchers will also measure how the drug moves through the body and whether it lowers a marker of inflammation (hsCRP). This…

This study looks at whether teaching people with type 2 diabetes about good sleep habits and a simple relaxation technique can help reduce anxiety, improve sleep quality, and lower blood sugar levels. About 52 adults with type 2 diabetes and poor sleep will take part. They will l…

This study tests a new medicine called CagriSema (a combination of two drugs) to see if it can reduce painful nerve damage in people with type 2 diabetes. About 142 adults with diabetes and nerve pain will receive either CagriSema or a placebo for around 10 months. The main goal …

This study tests two different ways to monitor people with type 2 diabetes from home using technology. About 60 adults with poorly controlled diabetes will try one of two telemonitoring designs. The goal is to see which design works best and is most acceptable to patients and hea…

This study looks at whether routine screening for heart disease is a good use of resources for people with type 2 diabetes who are at very high risk but have no known heart problems. Researchers will analyze data from 90,000 patients in French health databases to compare costs an…

This study looks at how a person's genes might change the way their body responds to canagliflozin, a drug used for type 2 diabetes. Healthy volunteers of Amish descent will take the drug for five days, and researchers will measure how much sugar comes out in their urine and chec…

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This pilot study looks at how the diabetes drug metformin reaches the lens of the eye and whether it can slow the growth of lens cells in the lab. Researchers will measure metformin levels in lens capsules and blood from 40 diabetic patients having cataract surgery. The goal is t…

This study aims to see if personalized screening invitations—tailored by race, ethnicity, and diabetes risk—are more effective than generic invitations at getting people tested for type 2 diabetes or prediabetes. About 500,000 adults from Parkland clinics will receive either a ta…

This study looks at over 547,000 people in France who started taking SGLT2i drugs for type 2 diabetes. Researchers want to learn about the patients' backgrounds, how doctors prescribe these drugs, and what other medicines they take. They will also track serious health events like…

This study aims to find genetic variations that increase the risk of type 2 diabetes, its complications like kidney disease, and related conditions such as obesity. Over 2,300 adults, especially American Indians and Mexican Americans, will provide health history, blood samples, a…

This study tests a web-based tool that gives doctors and patients personalized information about the benefits and risks of different obesity treatments, such as surgery or medication. The goal is to see if this tool helps more patients with type 2 diabetes and severe obesity get …

This study looks at how well a daily low-dose (80 mg) enteric-coated aspirin works in 50 adults with type 2 diabetes who have not taken aspirin recently. Researchers measure blood platelet function before and after 7 days of aspirin to see if the drug fully prevents clotting. The…

This study looked at whether the diabetes drug empagliflozin (Jardiance) is as safe and effective in everyday patients as it was in earlier clinical trials. Researchers tracked over 230,000 adults with type 2 diabetes who started taking empagliflozin or a similar drug. The goal w…

This study looks at ways to help people in rural Pennsylvania become more physically active. It includes 880 adults who are overweight, have type 2 diabetes, or are not active. Researchers will track activity levels using questionnaires and wearable devices to see what works best…

This study aims to find out which factors—like lifestyle, genes, and health history—are linked to poor blood sugar control and kidney disease in adults with type 2 diabetes in Mexico. Researchers will collect data from 1,000 participants through exams, questionnaires, and blood t…

This study looks at how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will examine immune cells (monocytes) from 40 participants to see if they trigger a hormone that raises blood pressure. The goal is to better understand the co…

This study follows 500 children with growth hormone deficiency who are taking somapacitan as part of their normal care. Researchers will monitor side effects, medication errors, and whether any children develop new health problems like cancer or type 2 diabetes over 10 years. The…

This study looks at whether giving extra support to care teams at community health centers helps them better screen patients for non-medical needs—like food, housing, or transportation—and connect them to community services. About 20 health centers will take part. The goal is to …

This study looks at American Indians with type 2 diabetes who have kidney problems. Researchers want to see if a past treatment (losartan) still helps protect their kidneys years later. About 141 people who were in an earlier study or their relatives can join. No new treatment is…

This study follows 837 people who either have type 2 diabetes or are at risk because it runs in their family. Researchers track who develops diabetes over time to improve a risk prediction model. No treatments or interventions are given—only observation and questionnaires.

This study looks at whether a medication used for heart failure can also help treat diabetes by increasing a hormone that boosts insulin after meals. Researchers will measure GLP-1, insulin, and blood sugar levels in 25 adults with type 2 diabetes or pre-diabetes and high blood p…

This study looked at how different types of aerobic exercise (moderate steady walking vs. short bursts of intense activity) and diet advice affect the energy centers (mitochondria) and stress levels inside cells of people with type 2 diabetes. 146 adults with diabetes or prediabe…

This long-term study aims to understand how early, hidden signs of heart disease develop and predict future heart attacks, strokes, and heart failure. It follows over 6,400 adults from four different ethnic groups who started the study with no known heart disease. Researchers use…