DIABETES MELLITUS (TYPE 2)

This study tests whether the Ask Me 3® educational program, which encourages patients to ask three key questions during doctor visits, can improve blood sugar control in adults with type 2 diabetes. Participants are randomly assigned to receive the program plus standard care or s…

This study tests whether giving financial incentives — including monthly cash, rewards for buying healthy food, and bonuses for lowering blood sugar — can improve diabetes control in adults who also struggle with food insecurity. Participants receive diabetes education and are ra…

This study looks at the safety and performance of the Endogenex System in 50 adults with type 2 diabetes. Participants previously received a sham (fake) procedure in an earlier study. The main goal is to track any serious side effects related to the device or procedure.

This study tests whether delivering healthy food boxes, remote health monitoring, and one-on-one coaching can help low-income Black adults with type 2 diabetes better control their blood sugar. The trial enrolls 304 participants in the Deep South and tracks changes in HbA1c level…

This study is testing whether a daily semaglutide tablet can safely reduce the risk of heart attacks, strokes, and related deaths in over 21,000 adults with type 2 diabetes who have never had a heart attack or stroke. Participants take either semaglutide or a placebo pill for sev…

This study compares a combination diabetes drug (iGlarLixi) against insulin alone to see which better reduces liver fat in people with type 2 diabetes and a common fatty liver condition called MASLD. About 36 participants will take one of the two treatments for 12 weeks, and doct…

This study looks at how well the diabetes drug empagliflozin (Jardiance) works in everyday medical practice, outside of a controlled research setting. Researchers are comparing it to other diabetes medicines in over 230,000 adults with type 2 diabetes. The goal is to see if the h…

This study was designed to see if taking metformin or salsalate on the morning of surgery could help control blood sugar and reduce complications in people with type 2 diabetes. It planned to enroll patients having elective surgery who regularly take metformin. However, the trial…

This study looks at whether using a continuous glucose monitor (CGM) along with a mobile app can help people with type 2 diabetes control their blood sugar better than standard care. Sixty adults will be randomly assigned to either the digital tool group or usual care, and their …

This study tests whether time-restricted eating (eating all meals within an 8-10 hour window each day) can help people with type 2 diabetes better control their blood sugar and improve heart health. About 60 adults with type 2 diabetes will either follow their usual care or add t…

This study tests a new investigational medicine called CagriSema against an approved drug, tirzepatide, in people with type 2 diabetes whose blood sugar is not well controlled by current pills. About 1,023 adults will receive either CagriSema or tirzepatide once a week for up to …

This study tests a new medicine called SHR-3167 in adults with type 2 diabetes whose blood sugar is not well controlled by pills. About 100 participants will receive different dosing plans to see which works best at lowering blood sugar while avoiding dangerously low sugar levels…

This study compares two methods of tracking blood sugar in people with type 2 diabetes: traditional fingerstick testing and continuous glucose monitors (CGMs). About 360 adults aged 18 to 75 who use insulin will be followed for 12 months to see which method better lowers A1C leve…

This study compares continuous glucose monitoring using the FreeStyle Libre 3 sensor to standard finger-stick testing in 470 adults with type 2 diabetes whose blood sugar is not well controlled. Participants continue their usual medications (basal insulin plus SGLT2 inhibitor and…

This study looks at the best way to control blood sugar in pregnant women with diabetes who receive steroids to help their baby's lungs develop before a possible early birth. About 120 women will be randomly assigned to one of three insulin strategies. The goal is to find which a…

This study tests whether an AI tool that shows patients how their blood sugar control compares to others, combined with home monitoring, can improve risk perception and blood sugar levels in adults with poorly controlled type 2 diabetes. About 360 participants aged 36–65 will be …

This study looks at how safe and effective Ozempic is for adults with type 2 diabetes when used in normal doctor visits. About 600 people in Korea will take Ozempic as their doctor prescribes, and the study lasts around 26 weeks. The main goal is to track any side effects and ser…

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This study tests whether mentoring local clinic teams via telehealth can help them start a comprehensive diabetes program for low-income Latino(a)s with type 2 diabetes. The program includes community health workers, help getting medication, and diabetes education. Researchers wi…

This study planned to test whether a virtual weight control program (WW, formerly Weight Watchers) could help adults with type 2 diabetes and obesity lower their blood sugar levels. Participants would have used the WW SmartPoints system and attended weekly online workshops. Howev…

This study tests whether transferring gut bacteria from a healthy donor (fecal transplant) can improve blood sugar control in 16 adults with type 2 diabetes. Participants receive either the transplant or a placebo, and researchers measure insulin sensitivity and blood sugar level…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high…

This study tests a new weekly medicine, retatrutide, against an existing one, semaglutide, in about 1250 adults with type 2 diabetes whose blood sugar is not well controlled by metformin. The goal is to see which works better at lowering blood sugar and weight over 26 months. Par…

This study tests whether the diabetes pill imeglimin can control blood sugar longer than two other common drugs, metformin and vildagliptin. About 567 adults with type 2 diabetes will take one of these pills for up to 3 years. The goal is to see which drug keeps HbA1c (a measure …

This early-phase study tests whether insulin-making cells grown from a patient's own pancreatic tissue can be safely transplanted under the belly skin to reduce or replace insulin shots. Twenty-four adults with insulin-dependent type 2 diabetes will take part. The main goal is sa…

This study tests a special toolkit designed to help people with type 2 diabetes who are starting insulin for the first time when they leave the hospital. About 120 English-speaking adults will be randomly assigned to receive the toolkit or usual care. The goal is to see if the to…

This study compares two approaches for treating type 2 diabetes in teenagers: weight-loss surgery (vertical sleeve gastrectomy) versus intensive medical therapy (including metformin and other drugs). The goal is to see which method provides better blood sugar control and reduces …

This study tests whether a probiotic tablet (Lactobacillus reuteri) can reduce harmful mouth bacteria as well as a standard chlorhexidine mouthwash in people with gum disease and type 2 diabetes. Twenty participants will use either the mouthwash or the probiotic for 30 days. The …

This study tests a program where African American adults with type 2 diabetes and a family member work together to manage the condition. The program focuses on daily self-care, healthy eating, walking, and better communication. Researchers want to see if it improves blood sugar c…

This study tests whether using a continuous glucose monitor (CGM) helps dialysis patients with type 1 or type 2 diabetes control their blood sugar better than standard finger-prick tests. 96 participants will be split into three groups: standard care, intermittent CGM use, or con…

This study tests whether choosing diabetes medications based on a person's genetic profile helps control blood sugar better than standard treatment. About 500 adults with type 2 diabetes that is not well controlled will be randomly assigned to either gene-guided or standard care.…

This study was designed to test whether adding ofirnoflast to semaglutide helps obese people with type 2 diabetes control blood sugar and lose more weight than semaglutide alone. It was a Phase 2 trial planned for about 200 participants, but it was withdrawn before anyone enrolle…

This study looks at whether a low-carb, high-protein diet can help people with type 2 diabetes control their blood sugar and lose weight better than a standard diabetes diet. About 100 overweight or obese adults with type 2 diabetes will follow one of the two diets for 12 months.…

This phase 2 trial tests an oral drug called MN-001 (tipelukast) in 40 adults with non-alcoholic fatty liver disease, type 2 diabetes, and high triglycerides. Participants take either the drug or a placebo daily for 24 weeks. The study measures changes in liver fat and blood fat …

This study tests whether three culturally tailored diet patterns (U.S.-style, Mediterranean, and vegetarian) can improve eating habits and reduce type 2 diabetes risk in 198 African American adults. Participants attend weekly classes for 6 months, then bi-weekly for another 6 mon…

This study tests whether giving people with type 2 diabetes money to buy healthy foods online, plus free delivery, helps lower their blood sugar levels. About 1,000 adults with poorly controlled diabetes will either get money for healthy food plus free delivery, or just free deli…

This study tests a wireless glucose monitoring system (Glucose Telemetry System) in 218 hospitalized veterans with type 2 diabetes who are at high risk for low blood sugar (hypoglycemia). The device sends blood sugar readings from the patient's bedside to a monitor at the nursing…

This study planned to test whether adding two newer diabetes drugs (Forxiga and Januvia) to standard metformin treatment could better control blood sugar in people with type 2 diabetes. It aimed to enroll adults aged 18–80 whose diabetes was not well controlled on metformin alone…

This study tests whether a computerized brain-training program can improve thinking skills in older adults (60+) who have type 2 diabetes and are at high risk for dementia. 120 participants will be randomly assigned to either adaptive cognitive training or a placebo version, both…

This study looks at how different exercise programs (moderate or high-intensity) and a diet plan affect appetite, blood sugar, and body fat in people with type 2 diabetes. About 146 adults will take part in a 12-week program. The goal is to find the best combination to improve he…

This study tests a web-based tool called the BMI-CDS (Weight Loss Wizard) in 40 primary care clinics. The tool gives doctors and patients with type 2 diabetes and obesity personalized estimates of the benefits and risks of treatments like weight-loss surgery or medication. Over 1…

This pilot study tests a device that uses radiofrequency vapor to ablate (remove) a thin layer of the duodenum (the first part of the small intestine) in 16 adults with type 2 diabetes who need insulin. The goal is to see if this procedure, with or without the drug semaglutide, i…

This study tests whether a second treatment using heat energy to reshape the lining of the small intestine can help people with type 2 diabetes who did not improve after the first treatment. The goal is to safely lower blood sugar levels. The study involves 12 adults who previous…

This study tests whether combining a shared decision-making checklist during doctor visits with mobile text reminders helps people with type 2 diabetes take their medications as prescribed. About 378 patients from community health centers in Michigan are taking part. The goal is …

This pilot study tests whether having older Black men with diabetes lead support groups can help other older Black men better manage their type 2 diabetes. All 48 participants receive standard diabetes education, and half also get 6 months of monthly peer-led support sessions. Th…

This study is observing 15,000 adults with type 2 diabetes who are starting Envlo or Envlomet SR tablets. Researchers will check how well these drugs control blood sugar (HbA1c) over 24 weeks and monitor for side effects. The goal is to see if they work safely in everyday medical…

This trial tests an online program to help women who had gestational diabetes get the recommended diabetes screening and lifestyle programs after giving birth. The program includes standard health information plus optional interactive components like values reflection and persona…

This study tests whether sending personalized screening invitations based on a person's race, ethnicity, and diabetes risk, plus offering phone navigation for those who don't respond, leads to more people getting tested for diabetes compared to generic invitations or usual care. …

This study tests whether a self-affirmation writing exercise—where people write about their core values—before routine diabetes checkups can reduce feelings of stigma and improve diabetes management. About 150 adults with type 2 diabetes who already use continuous glucose monitor…

This study tests a non-invasive light therapy called photobiomodulation (low-level laser) for people with diabetic peripheral neuropathy—nerve damage causing pain, tingling, and numbness in the feet. 36 adults with type 2 diabetes and foot pain for at least 6 months will receive …

This study tests a self-guided digital program called covivio to help adults with type 2 diabetes manage emotional distress tied to their condition. About 250 participants will either use the app alongside their usual care or continue with usual care alone. The goal is to see if …

This study tests whether teaching people with type 2 diabetes about good sleep habits and a simple relaxation exercise can help them sleep better, feel less anxious, and improve their blood sugar control. Fifty-two adults with poor sleep quality will be followed for six months. T…

This study tests whether a new medicine called CagriSema can reduce nerve pain in people with type 2 diabetes. About 142 adults with painful diabetic neuropathy will receive either CagriSema or a placebo for around 10 months. The main goal is to see if the drug lowers weekly pain…

This registry will follow 500 people with type 2 diabetes who have already been treated with the Endogenex System. The goal is to collect long-term safety data and see how the device performs in everyday use. Participants must agree to share their medical records and attend follo…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to…

This study looks at whether the adrenaline (epinephrine) commonly added to local anesthesia for tooth extraction raises blood sugar levels. Researchers will measure blood glucose before, during, and after the procedure in 90 adults—half with type 2 diabetes and half without. The …

This study looks at ways to help more adults with type 2 diabetes get screened for colorectal cancer. Researchers are testing a program that works with patients, their care teams, and clinics to make screening easier. The goal is to see if this approach increases the number of pe…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at whether drinking a beverage with artificial sweeteners (erythritol or xylitol) changes how blood platelets clump together, which could affect heart attack or stroke risk. Researchers will measure platelet activity and blood levels of these sweeteners in 50 hea…

This study looks at how long you need to fast and how stopping the diabetes/weight-loss drug tirzepatide changes the amount of food left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 people with type 2 diabetes or obesity. The goal …

This study follows over 800 people who either have type 2 diabetes or have a strong family history of it. Researchers track who develops diabetes over time using blood tests and questionnaires. The goal is to improve a risk prediction model for type 2 diabetes. The study is curre…

This study looks at whether giving extra support to community health centers helps them screen patients for non-medical needs like food or housing and refer them to community resources. Twenty health centers will be randomly assigned to get this support or not. The goal is to see…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study looks at ways to help adults in rural Pennsylvania become more physically active. It includes 880 people who are overweight, have type 2 diabetes, or are not very active. Researchers will track activity levels using questionnaires and wearable devices to see what works…

This study trains Latino church members to become community health workers who help others manage diabetes and reduce health barriers. About 400 Spanish-speaking adults at risk for or with type 2 diabetes are taking part. The program uses an online platform to track progress and …

This 10-year observational study will follow 500 children with growth hormone deficiency who are receiving the once-weekly injection somapacitan as part of their routine care. Researchers will track side effects, medication errors, and new cases of cancer or type 2 diabetes. The …

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study looks at whether routine screening for heart disease is a good use of healthcare money for people with type 2 diabetes who are at very high risk but have no known heart problems. Researchers will analyze data from 90,000 patients in French health databases to compare c…

This study analyzes health records from over 547,000 people in France who started taking SGLT2 inhibitors for type 2 diabetes between 2020 and 2024. Researchers will describe patient characteristics, prescription patterns, and track the occurrence of heart attacks, strokes, heart…

This study looks at how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to study immune cells called monocytes and see if they trigger a hormone that raises blood pressure. The goal i…

This study looks at whether a person's genes can predict how their body responds to canagliflozin, a drug used for type 2 diabetes. About 700 healthy Amish adults will take the drug for five days, and researchers will measure changes in urine sugar and other markers. The goal is …

This study looks at how well a daily 80 mg dose of enteric-coated aspirin works in 50 adults with type 2 diabetes who have not taken aspirin recently. Researchers measure blood platelet function before and after 7 days of treatment to see if the aspirin fully prevents clotting. T…

This study aims to identify clinical, lifestyle, and genetic factors that affect blood sugar control and kidney complications in adults with type 2 diabetes in Mexico. Researchers will collect medical history, physical test results, and blood samples from 1,000 participants. The …

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study looked at how different types of aerobic exercise (moderate continuous training vs. high-intensity interval training) and diet counseling affect cell health in people with type 2 diabetes. Researchers measured changes in mitochondria (the cell's power plants) and oxida…

This study looks at two different ways to monitor people with type 2 diabetes from home, using smartphones and other devices. The goal is to see which design is more acceptable and practical for patients and healthcare providers. The results will help plan a larger future study. …

This pilot study looks at whether metformin, a standard diabetes medicine, gets into the lens capsule of the eye and can slow the growth of lens cells that cause cataracts. Researchers will collect blood and lens tissue from 40 people with type 2 diabetes and age-related cataract…

This study tests whether a heart failure medication called Entresto (sacubitril/valsartan) can boost a natural hormone that helps control blood sugar after meals. Researchers will give the drug or a comparison drug (valsartan) to 25 adults with type 2 diabetes or prediabetes and …