Probiotic tablets vs. mouthwash: a new way to fight gum disease?

NCT ID NCT07489924

Ongoing Disease control Sponsor: Universidad de Colima Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a probiotic tablet (Lactobacillus reuteri) can reduce harmful mouth bacteria as well as a standard chlorhexidine mouthwash in people with gum disease and type 2 diabetes. Twenty participants will use either the mouthwash or the probiotic for 30 days. The main goal is to see how much the bacteria Porphyromonas gingivalis decreases.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Chlorhexidine mouthwash and probiotic (Lactobacillus reuteri) tablets
What this could lead to: If successful, this could show that a simple probiotic tablet is as good as a mouthwash for controlling gum-disease bacteria in people with diabetes.
What could go wrong: This is a very small, early-phase trial with only 20 participants, so results may not apply to everyone. The probiotic might not work as well as the mouthwash.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus periodontal disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2 PERIODONTAL DISEASES

Contacts and locations

Locations

University of Colima

Colima, 28040, Mexico

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