Periodontal disorder

This study tests whether platelet-rich fibrin (PRF) — a concentrate made from a patient's own blood — can improve gum healing after standard deep cleaning for periodontitis. Twenty adults with moderate to severe gum disease will receive deep cleaning on both sides of the mouth, w…

This study tests whether taking omega-3 fatty acids (fish oil) plus low-dose aspirin can improve gum disease treatment in smokers with advanced periodontitis. Participants receive these supplements or a placebo alongside standard deep-cleaning procedures. The trial measures chang…

This study tests two different medicines placed inside root canals to kill bacteria in teeth with chronic infection. 24 adults with infected molars will receive either a bioceramic or a calcium hydroxide paste. Researchers measure bacterial levels before and after treatment to se…

This study looks at whether bone grafting right after a molar extraction is necessary or if it can be delayed until the dental implant is placed. Forty adults needing a molar implant will be randomly assigned to get either immediate grafting or delayed grafting. The goal is to se…

This study tests two different bone graft materials (GTO® and GenOs®) used with a new, less invasive surgical method called NIPSA to repair bone damage from advanced gum disease. Researchers will compare how well each material helps reattach gums and fill in bone defects over 6 m…

This study tests a new, gentler way to clean deep gum pockets in people with advanced periodontitis. It compares a standard deep-cleaning method using larger tools to a minimally invasive approach using thinner, more delicate instruments. The goal is to see if the gentler method …

This study compares two mouthwashes used alongside standard gum disease treatment. One contains a higher dose of chlorhexidine (0.2%), while the other combines a lower dose of chlorhexidine (0.12%) with cetylpyridinium chloride. The goal is to see if the lower-dose combination wo…

This study compares two methods for disinfecting root canals in teeth with apical periodontitis (an infection at the tooth root). Fifty adults with infected molars will receive either a laser-based disinfection or a standard protocol. The goal is to see which method reduces bacte…

This study is testing whether teaching people with periodontitis (gum disease) to follow an anti-inflammatory diet can improve the results of standard non-surgical gum treatment. One hundred adults with a pro-inflammatory diet will be split into groups; some will get diet educati…

This study tests whether a less invasive surgery called sentinel lymph node biopsy can replace standard neck dissection for early-stage oral cavity cancer. About 686 patients will be randomly assigned to one of the two procedures. The goal is to see if the gentler approach mainta…

This phase 3 trial tests whether the drug bimekizumab can clear or nearly clear the pustules and skin lesions of palmoplantar pustulosis (PPP) on the hands and feet. About 320 adults with moderate to severe PPP will receive either bimekizumab or a placebo for 16 weeks, with an op…

This study looks at whether vitamin D levels and supplements can reduce inflammation in people with gum disease (periodontitis or gingivitis). Researchers will measure markers of inflammation in blood and gum fluid before and after treatment. The study involves 120 adults with di…

This early-stage trial tests whether a bone graft material called beta-TCP (Neocement Inject P®) can better preserve the jawbone after a tooth is pulled, compared to letting the socket heal naturally. Thirty adults needing a tooth extraction will be randomly assigned to receive t…

This study compares three different root canal dressings used between visits in retreatment cases. The goal is to see which one best reduces inflammation, shrinks infection-related lesions, and lowers pain. Sixty adults with previously treated but still infected lower first molar…

This study tests whether microneedling (tiny needle pricks) done before a standard gum surgery can help cover exposed tooth roots in people with thin gums. Thirty-six adults with receding gums will either get microneedling followed by surgery, or surgery with a tissue graft from …

This study compares two medications placed inside the tooth after a failed root canal: standard calcium hydroxide and the painkiller diclofenac sodium. Sixty patients with persistent infection around the tooth root will be randomly assigned to one of the two treatments. Healing w…

This study tests whether adding a resorbable collagen membrane to a bone graft helps preserve the shape and volume of the jawbone after a tooth is removed. Thirty adults with a missing front tooth and significant bone loss will receive either the bone graft alone or with the memb…

This study is testing a gel that turns into a gel when warmed, used alongside standard gum disease treatment. It includes 70 adults, some with type 2 diabetes and some without, to see if the gel helps gums heal better and if healing differs between the two groups. Participants wi…

This study tests whether a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) can improve bone regrowth when used with a gentle, non-surgical deep cleaning for gum disease. About 40 adults with advanced periodontitis and deep bone pockets will b…

This study tests whether adding special proteins or blood-based membranes to deep cleaning helps repair bone and gum damage from advanced gum disease. 88 adults with deep gum pockets and bone loss will receive one of three treatments or cleaning alone. Researchers will measure bo…

This study tests whether a diode laser, apple cider vinegar, or the herb Gymnema Sylvestre can better disinfect root canals in people with type 2 diabetes who have a tooth infection called apical periodontitis. Ninety participants will be split into groups receiving different com…

This study compares two surgical techniques to treat gum recession on the lower front teeth. One method uses a flap moved forward plus a graft, while the other uses a different flap design plus a graft. Researchers will measure how much of the exposed tooth root is covered after …

This study is testing whether a special laser device (FX-405) can improve the treatment of gum disease when used along with standard deep cleaning (scaling and root planing). About 70 adults with moderate to severe gum disease will receive eight 10-minute laser sessions over five…

This study tests whether an electrolysed saline mouth rinse can improve standard gum disease treatment. Sixty adults with advanced periodontitis will use either the saline rinse, a standard antiseptic rinse, or a placebo for one month. The goal is to see if the rinse reduces deep…

This study compares a test interdental brush to other interdental brushes in 88 adults with active periodontal disease. Over 4 weeks, researchers will measure plaque, gum bleeding, and pocket depth to see which brush works best. Participants use the brush twice daily and report a…

This study tests whether adding a special light treatment (antimicrobial photodynamic therapy) to standard deep cleaning helps people with obesity and gum disease. 24 participants will receive either standard cleaning alone or cleaning plus the light therapy. Researchers will che…

This study tests a new cleaning method (air-polishing with erythritol) against standard cleaning (ultrasound) to prevent white spots on teeth and gum inflammation in 60 teens aged 12-16 who are getting braces. Participants will be followed for 2 years to see which method works be…

This study tests whether two nano-sized pastes—nano-calcium hydroxide and nano-chitosan—can reduce inflammation and pain in people who need a second root canal treatment. The trial will enroll 63 adults with a single-rooted tooth that has a persistent infection and no current pai…

This study is testing whether waiting 4 months instead of the usual 6 months after a tooth extraction is safe and effective for placing a dental implant. Forty adults who need a single tooth replaced will be randomly assigned to either the shorter or standard wait time. Researche…

This study is testing a new treatment plan called Bioperio® for people with gum disease (periodontitis). The plan includes professional teeth cleaning, oral hygiene training, and for severe cases, a special gel to help gums reattach. The goal is to close deep gum pockets and impr…

This study looks at whether a toothpaste with a special gum-health ingredient can improve gum health in people with gingivitis. 150 adults will use the test toothpaste for 13 weeks, then switch to a regular fluoride toothpaste for 4 weeks. Researchers will measure gum inflammatio…

This study looks at two treatments for receding gums. One uses a small piece of tissue from the roof of the mouth (the current standard). The other uses a membrane made from the patient's own blood. The goal is to see which method works better and lasts longer. The study needs 50…

This study tests whether adding an oxygen-releasing gel, with or without a special light therapy, to standard deep cleaning can better treat advanced gum disease (stage III periodontitis). About 42 adults with deep gum pockets will be split into three groups to compare the treatm…

This study tests whether using a smart electric toothbrush with an app and flossing can control gum inflammation as well as getting a professional dental cleaning. 92 adults with mild gum disease will be split into two groups: one uses the smart toothbrush alone, the other gets a…

This study tests a synthetic bone graft material (biphasic calcium sulfate) used during sinus lift surgery to rebuild bone in the upper jaw. The goal is to see if it safely creates enough bone to place dental implants in people who lack sufficient bone due to sinus expansion. For…

This study tests two different bone graft materials—one from cow bone and one synthetic—combined with a special enamel protein to repair deep gum and bone defects caused by periodontitis. Forty adults with at least one deep gum pocket (6 mm or more) and a bone defect will receive…

This study tests whether a gel made from polynucleotide and hyaluronic acid, combined with a bone graft, can help repair bone defects caused by advanced gum disease. 66 adults with severe periodontitis will receive either standard surgery, surgery with bone graft alone, or surger…

This study tests two different root canal filling pastes (iRoot SP and nRoot SP) in 160 adults with chronic tooth infection. The goal is to see which paste better heals the infection and relieves symptoms like pain and swelling. Participants will be followed for up to 2 years aft…

This study looks at whether taking a probiotic supplement called Prodentis for a long time after standard gum treatment can improve gum health and immune response. Twenty adults with advanced gum disease who have already had one round of treatment will be followed. Researchers wi…

This study tests whether adding a diode laser to standard deep cleaning (scaling and root planing) improves gum health in kidney transplant patients with gum disease. Eighty participants will be randomly assigned to receive either standard cleaning alone or standard cleaning plus…

This study compares two treatments for deep gum pockets that remain after standard gum disease cleaning. About 36 adults will receive either a growth factor gel (Rh-PDGF) or a tooth protein gel (Emdogain), both combined with bone graft. The goal is to see which better improves gu…

This study tests a new surgical method called 3D tunneling for treating multiple receding gums, comparing it to a standard technique using a gum graft. Researchers will enroll 36 adults with gum recession to see which approach better covers exposed roots and improves gum health. …

This study tests whether a mouthwash made from black mulberry extract can improve gum health when used along with standard dental cleaning (scaling and root planing). Thirty adults with gingivitis will be split into two groups: one gets cleaning alone, the other adds the mulberry…

This 8-week study tests whether using a compact water flosser (Bixdo A30 Pro) along with regular toothbrushing reduces gum inflammation and plaque better than brushing alone. About 165 adults with plaque-induced gingivitis will be randomly assigned to either use the water flosser…

This study compares two treatments to help jawbone heal after a tooth is pulled: the standard platelet-rich fibrin (PRF) made from your own blood, and a newer option using exosomes from stem cells. Exosomes are tiny particles that signal the body to repair tissue and grow bone. R…

This study tests a new way to treat multiple receding gums using a substance made from the patient's own blood (Alb-PRF) compared to the standard connective tissue graft. 26 adults with good oral hygiene will be treated and followed to see how much gum coverage is achieved. The g…

This study tests whether adding different biomaterials (like artificial bone, enamel proteins, or a blood concentrate) to standard gum surgery helps repair bone defects around teeth. Thirty adults with deep gum pockets after initial treatment will receive one of four biomaterial …

This study tests a new, less invasive non-surgical treatment (MINST) against standard non-surgical care for people with gum disease around dental implants (peri-implantitis). About 106 adults will receive one of the two treatments and be followed for 12 months to see which better…

This study looks at whether using a small piece of bone from the back of the jaw (maxillary tuberosity) can help rebuild the bone around a dental implant placed immediately after a tooth is pulled in the front of the mouth. Researchers will measure bone thickness, gum thickness, …

This study tests if using an air-polishing device with erythritol powder to clean tooth roots before gum graft surgery works as well as the standard hand-scraping method. Twenty adults with receding gums will be treated and followed for a year. The goal is to see which approach l…

This study compares standard root canal retreatment with a regenerative method using injectable platelet-rich fibrin (i-PRF) in 140 adults with persistent tooth infections. Participants are randomly assigned to one of the two treatments and followed for two years to assess healin…

This study looks at how well two different bone graft materials preserve the thickness of the front jawbone after a tooth is pulled and an implant is placed right away. About 26 adults who need a front tooth replaced will be randomly assigned to receive one of the two graft types…

This study compares two ways of doing a gum graft to treat gum recession affecting several teeth. All 32 participants will get a modified tunnel procedure, but half will receive a single continuous graft and the other half a segmented graft. The goal is to see which method better…

This study compares two ways to treat gum disease without surgery: using an ultrasonic device or special hand tools. About 36 adults with moderate to severe periodontitis will be randomly assigned to one method. Researchers will check gum pocket depth and bone levels over a year …

This study looks at whether adding a diode laser to standard deep cleaning (scaling and root planing) improves gum disease treatment. Twenty adults with moderate to severe gum disease will have each side of their mouth randomly assigned to cleaning alone or cleaning plus laser. T…

This study tests a new gum cleaning method called guided biofilm therapy (GBT) against standard deep cleaning for people with gum disease (periodontitis). 18 adults will receive either GBT or standard treatment, and researchers will measure gum pocket depth, bleeding, and biomark…

This study tests whether a new collagen matrix can work as well as a traditional gum graft for covering exposed tooth roots. Sixty adults who had braces and now have gum recession will receive either the collagen matrix or a graft taken from the roof of their mouth. The goal is t…

This study tests whether adding a daily probiotic tablet and a coenzyme Q10 toothpaste to standard gum cleaning can improve oral health in pregnant women. Forty pregnant women will be split into two groups: one gets the probiotic plus Q10 toothpaste, the other gets only the Q10 t…

This study tests whether a special toothpaste and mouthwash containing natural 'para-probiotics' can improve gum health and help control blood sugar in people with type 2 diabetes. Forty adults with gum disease and diabetes will use either the para-probiotic products or a standar…

This study tests whether a gel containing lovastatin, a cholesterol drug, can improve standard gum disease treatment. Researchers will compare the medicated gel to a placebo gel in 44 adults with periodontitis, including both smokers and non-smokers. The goal is to see if the gel…

This 6-month study tests whether a special antimicrobial mouthrinse can reduce plaque buildup and improve gum health in adults with gingivitis. Participants will brush and rinse twice daily and visit the clinic every 3 months. The goal is to see if the rinse helps control gum inf…

This study compares two methods of rebuilding jawbone in people who have lost bone and need dental implants. One method uses the patient's own bone, and the other uses donated (allogeneic) bone. The goal is to see if both approaches are equally safe and effective at restoring eno…

This study tests a surgical technique called free mucogingival graft (FMG) to cover exposed tooth roots and improve gum conditions in the lower front teeth. Researchers will enroll 24 healthy adults with gum recession and unfavorable gum tissue. The goal is to see if this approac…

This early-phase study tests whether adding Arestin (minocycline microspheres) to standard deep cleaning (scaling and root planing) improves gum healing and blood sugar control in adults with type 2 diabetes and moderate to severe gum disease. About 42 participants will be random…

This study tests a new surgical method for treating advanced gum disease. Instead of removing all inflamed tissue, the surgeon preserves the granulation tissue (the body's natural healing tissue) to see if it leads to better gum attachment and less bleeding. The trial involves 50…

This study tests a new surgical technique called NIPSA, combined with a gum graft and special proteins, to treat severe gum disease. Forty adults with periodontitis and deep gum pockets will receive the procedure. The goal is to see if this approach can reduce pocket depth and im…

This study compares three different surgical methods to treat gum disease (periodontitis). The goal is to see which technique best reduces deep gum pockets and helps gums reattach to teeth. About 60 adults with gum disease will be randomly assigned to one of the three procedures.…

This study compares a standard gum graft technique with a modified version to treat gum recession on lower front teeth. About 34 healthy, non-smoking adults will receive one of the two procedures. Researchers will use 3D scans to measure tissue thickness and volume changes over 6…

This study compares two surgical techniques (MCAT and VISTA) for treating receding gums in 44 healthy adults. Both methods use a tissue graft to cover exposed roots. Researchers will measure gum thickness changes over 12 months using 3D scans to see which technique works better.

This pilot study tests a new toothpaste designed to protect the natural balance of bacteria in the mouth. 28 adults with periodontitis will brush twice daily for 3 months while continuing their usual gum disease care. Researchers will check if the toothpaste improves oral health …

This study tests whether a new gel containing hyaluronic acid and octenidine can improve gum healing after standard deep cleaning for periodontitis. About 26 adults with advanced gum disease will receive either cleaning alone or cleaning plus the gel. Researchers will measure hea…

This study tests if a probiotic spray containing good bacteria can help prevent and treat gum disease in older adults. Researchers will give 90 elderly participants either the probiotic spray or a placebo for four weeks. They will measure changes in gum health, bleeding, and bad …

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. One hundred survivors who finished cancer treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the pro…

This study tests whether a hyaluronic acid gel can help regrow bone lost to severe gum disease, compared to the standard enamel matrix derivative gel or no gel at all. All treatments use a minimally invasive, non-surgical technique. Sixty adults with advanced periodontitis will b…

This study tests a new way to treat gum disease (periodontitis) using a light-activated dye delivered in tiny biodegradable particles. The goal is to see if this method kills hidden bacteria better than the dye alone. About 27 adults with advanced gum disease will receive standar…

This study tests whether a manuka honey mouthwash can improve gum health in people with kidney failure who are on dialysis and also have gum disease. About 150 adults will rinse with a diluted honey solution three times daily. Researchers will measure gum attachment, bleeding, pl…

This study tests whether using a toothpaste with sodium bicarbonate (baking soda) and fluoride can help maintain gum health in adults who have already had non-surgical gum treatment. One hundred participants will use either the special toothpaste or a placebo for six months, whil…

This study tests whether a gel made from a patient's own blood can improve gum healing after standard deep cleaning for moderate to severe gum disease. About 14 adults with gum pockets of 5mm or deeper will receive the blood gel on one side of the mouth and a saltwater rinse on t…

This study tests a new toothpaste with stannous fluoride to see if it improves gum health and reduces plaque better than regular fluoride toothpaste. About 300 adults with mild to moderate gum inflammation will brush with the test toothpaste for 24 weeks. Researchers will measure…

This study tests whether a special dental gel (Livfresh) can improve gum health when used alongside standard deep cleaning. About 76 adults with moderate gum disease will brush with the gel twice daily for 6 months. Researchers will measure changes in gum pocket depth and bleedin…

This study tests whether a hydrogen peroxide mouth rinse (OROXID®) can improve gum health when used alongside standard dental cleaning. About 90 adults with moderate-to-severe gum disease will use either a 1.5% or 3% rinse or a control rinse for 12 weeks. The goal is to see if it…

This study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as well as a dentist. Participants will have their gums and blood suga…

This study looks at whether deep cleaning for gum disease can improve kidney health in people with uncontrolled type 2 diabetes. 46 adults with both conditions will either get gum treatment right away or after a delay. Researchers will measure kidney markers like creatinine and u…

This study tests whether a daily probiotic lozenge (SALI-10) can prevent gingivitis, a common gum disease that causes bleeding and inflammation. About 60 healthy adults will stop brushing for a short period to allow plaque buildup, then take either the probiotic or a placebo. The…

This study tests whether simvastatin, a common cholesterol drug, can fight infection and reduce inflammation when placed inside a tooth during root canal retreatment. Fifty-four adults with a single-rooted tooth that had a failed root canal and a small area of bone loss around th…

This study compares two popular mouthwashes, Listerine and Chlorhexidine, to see which better controls gum inflammation and plaque in people undergoing orthodontic treatment with braces. Sixty participants aged 13-40 will use one of the rinses and be checked at 2 and 4 weeks. The…

This study tests a procedure called intentional replantation for single-rooted teeth that are considered hopeless due to advanced gum disease. Researchers will remove the tooth, treat it outside the mouth, and put it back in the socket. They will track bone healing, pain, and too…

This study tests whether a gel made from enamel proteins can thicken gum tissue around dental implants. Researchers will measure gum thickness in 32 adults who need implant uncovering surgery. The goal is to see if this treatment improves gum health and implant stability.

This study tests two materials used to fill bone defects caused by gum disease: a collagen matrix and a bovine bone mineral. 80 adults with advanced periodontitis will receive one of the two during surgery. Researchers will measure changes in gum attachment and other healing sign…

This study compares two surgical techniques—coronally advanced flap (CAF) and tunneled coronally advanced flap (TCAF)—for covering receding gums in the lower front teeth. Both methods use a small tissue graft from the roof of the mouth to support the gum. Researchers will track 3…

This study tests whether using an 810 nm diode laser during root canal retreatment helps the bone around the tooth heal better. Forty adults with a failed root canal and a visible infection will receive standard retreatment plus either laser disinfection or a calcium hydroxide pa…

This study tests whether adding low-level laser therapy or hyaluronic acid gel to standard deep-cleaning (scaling and root planing) improves gum healing in people with periodontitis. Forty-five non-smoking adults with untreated gum disease will be randomly assigned to one of thre…

This study compares two surgical techniques—tunneled coronally advanced flap (TCAF) and modified tunnel technique (MTUN)—both using a small piece of tissue from the palate to cover a single receding gum in the lower jaw. Twenty-four adults will be randomly assigned to one procedu…

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to s…

This study tests a non-surgical treatment for deep gum pockets (furcation defects) in people with advanced periodontitis. One side of the mouth gets a chitosan brush plus enamel matrix derivative; the other side gets the brush alone. The goal is to see if the added gel improves g…

This study tests whether adding injectable platelet-rich fibrin (i-PRF) to a standard bone graft helps fill in bone defects caused by advanced gum disease. Sixteen adults with stage III periodontitis will receive either the combo treatment or the graft alone during surgery. Resea…

This study tests three different methods to rebuild the small triangle of gum tissue between teeth, known as the papilla. The methods are: injecting hyaluronic acid filler, injecting a special blood-based protein (ALB-PRF), or a minor surgical procedure. The trial will enroll 24 …

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing whether a simple online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to see if …

This study aims to see if a special MRI designed for teeth can diagnose jaw joint disorders, tooth infections, and help plan dental implants as well as or better than traditional X-rays. About 470 adults needing dental imaging will get both an MRI and standard X-rays, and the res…

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

This study looks at whether digital tools like intraoral scanners and cone-beam CT can help dentists spot cavities, plaque, and gum disease more accurately than a standard exam. About 350 adults will get both a regular check-up and digital imaging, and researchers will compare th…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study tests whether using a lactoferrin-based toothpaste and mouthwash twice daily, along with regular professional cleanings, can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one using both the toothpas…

This study tests a hydrogel wound dressing (Emanate Perio PODS) to see if it helps gums heal better after scaling and root planing, a deep cleaning for stage 3 periodontitis. 72 adults will use the gel at home twice a day for 30 minutes, or receive no extra treatment. The main go…

This trial compares using tiny titanium tacks versus traditional stitches to hold a gum graft in place after surgery. The goal is to see if the tacks cause less pain and make recovery easier. Adults needing a gum graft around natural teeth will be randomly assigned to one of the …

This study tests whether using different nickel-titanium file systems, alone or with an XP-Endo Finisher irrigation device, can reduce pain after root canal treatment. Eighty adults with infected molars will be randomly assigned to one of four groups. Pain levels will be recorded…

This study tests two standard methods—manual scraping with a hand tool or using a small rotating bur—to clean out unhealthy tissue from a tooth socket after extraction. About 60 adults with long-term tooth infections will be randomly assigned to one method, then all receive a bon…

This study tests whether placing ibuprofen, nitrofurantoin, or calcium hydroxide inside a tooth after root canal treatment can lower pain. About 111 adults with dead nerves in their back teeth will rate their pain on a 0-10 scale. The goal is to find which medication works best t…

This study tests whether applying a topical steroid (triamcinolone acetonide) to the roof of the mouth after gum graft surgery can speed healing, reduce pain, and improve quality of life. About 55 adults needing a gum graft will be randomly assigned to receive either the steroid …

This study compares two different irrigation techniques used during root canal retreatment to see which one leads to less pain afterward. About 100 adults with a previous root canal and ongoing infection will take part. The goal is to find a simple way to improve comfort after th…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether a special toothpaste can improve gum inflammation (gingivitis) in adults. Sixty participants with moderate gum inflammation will use either the test toothpaste or a regular one for 4 weeks. Dentists will check gum health at the start and end to see if the…

This study tests a gel made from natural particles (polynucleotides) injected into the gums to treat black triangles—gaps between teeth caused by gum loss. About 40 adults with at least one black triangle in the smile zone will receive the gel. The goal is to see if it safely fil…

This study compares a new mousse (microRepair ABX) to a standard mouthwash for healing after tooth extraction. About 30 adults who need a tooth pulled will use one of the two treatments. Researchers will check pain, swelling, and healing at 1, 7, and 15 days after surgery to see …

This study compares a new hydrogel wound dressing called Ora-Aid to a standard plastic stent for reducing pain after gum graft surgery. Twenty adults undergoing the procedure will be randomly assigned to receive one of the two treatments. Researchers will track pain levels, paink…

This study tests three different methods to protect the roof of the mouth after a gum graft. Fifty-six adults will rate their pain, swelling, and bleeding using a simple scale. The goal is to find which protection technique makes healing most comfortable.

This study tests whether using 3D imaging (CBCT) to plan clear aligner treatment can lower the chance of gum recession. Forty adults who want to widen their dental arches will be randomly assigned to either 3D-guided or standard 2D planning. Researchers will track gum health, bon…

This study compares two common root canal filling techniques—cold lateral condensation and warm vertical obturation—to see which causes less pain afterward. About 80 adults with infected but pain-free teeth will be randomly assigned to one method. Researchers will measure pain le…

This study tests whether applying a special gel (cross-linked hyaluronic acid) during root-end surgery helps the gums heal faster and reduces pain afterward. About 46 adults with a tooth infection that didn't heal after standard root canal treatment will take part. Half will get …

This study tests whether a mobile app that sends daily push notifications can help teenagers wearing braces improve their oral hygiene. Braces make it harder to clean teeth, leading to plaque buildup and gum problems. Researchers will compare three groups: app with reminders, app…

This study tests if using a device that reads muscle activity (EMG) to guide Botox injections works better than the standard injection method for people with a gummy smile. About 32 adults with excessive gum display will be split into two groups. The goal is to see which method r…

This study tests whether using a special laser along with standard ultrasonic cleaning can reduce pain and kill more bacteria after a root canal. About 120 adults with infected single-root teeth will be treated and asked to rate their pain. The goal is to find a better way to man…

This study tests whether adding antimicrobial photodynamic therapy (aPDT) – a light-based treatment – to standard gum cleaning can reduce bad breath (halitosis) in people with type 2 diabetes and advanced gum disease. Thirty-two participants will receive either standard care or s…

This study tests whether toothbrushes with tapered bristles are better at removing plaque and reducing gum bleeding than regular round bristles, without causing scratches. About 70 adults with gum disease will use one of two toothbrushes at home for 4 weeks. Researchers will chec…

This study tests whether taking ibuprofen before a deep gum cleaning reduces pain and inflammation afterward. Thirty adults with gum disease will either get ibuprofen or a placebo. Researchers will measure inflammatory markers in the blood and pain levels using a simple scale.

This study compares two types of stitches (NOVOSYN quick and MONOSYN quick) used in gum surgery to see if they heal equally well. About 84 adults having gum surgery will be randomly assigned one of the two stitches. The main goal is to check early healing signs like skin regrowth…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests two new solutions, Theravex Oral and Theravex Tissue Care Plus, to see if they help gums heal better after a specific gum surgery for receding lower front teeth. Thirty healthy adults will be randomly assigned to receive either the Theravex treatment or a saltwat…

This study looks at whether adding tongue scraping to standard gum disease treatment can improve bad breath. About 39 adults with gum disease and bad breath will either get standard care or standard care plus twice-daily tongue scraping. Researchers will measure breath odor and s…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a gel called Nano Bio Fusion (NBF) to see if it helps heal wounds on the roof of the mouth after gum graft surgery. About 36 adults will apply either the NBF gel or a placebo gel four times a day for four weeks. Researchers will measure wound size, pain, and infl…

This study tests whether a pure green tea mouthwash can reduce dental plaque and gum inflammation better than a placebo or essential oils mouthwashes like Listerine. About 44 healthy adults will rinse with their assigned mouthwash twice daily for 3 weeks, avoiding all other oral …

This study tests a new way to do root canals that skips the manual step of scouting and widening the canal by hand. Instead, dentists use a special rotary file from the start. The goal is to see if this causes less pain after the procedure compared to the traditional method. The …

This study looks at two types of dental sealers used during root canal treatment to see which one leads to less pain afterward. Sixty adults with a painless tooth infection around the root tip will be randomly assigned to receive either a calcium-based bioceramic sealer or a resi…

This study tests whether a hydrogen peroxide mouth rinse called OROXID can help treat gingivitis, a common gum inflammation. About 90 adults with mild gum disease will use the rinse twice daily for 4 weeks, alongside regular brushing. Researchers will measure changes in gum infla…

This study tests whether applying low-level laser light to the gums after tooth extraction and socket preservation can improve healing and reduce pain. About 39 adults will receive either standard care or standard care plus laser treatment on days 1, 3, and 7 after surgery. Resea…

This study tests whether using a microscope during gum surgery leads to better healing than standard dental loupes (magnifying glasses). About 25 adults with gum disease will take part. Researchers will check how well the gums heal and how long the stitching takes.

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study compares two surgical techniques—coronally advanced flap (CAF) and tunneled coronally advanced flap (TCAF)—both combined with a soft tissue graft, to treat receding gums in the upper jaw. Thirty-four adults with multiple gum recessions will be randomly assigned to one …

This study compares two types of ultrasonic devices used to clean deep gum pockets in people with early-stage periodontitis. Researchers want to see which device causes less pain, noise, and vibration during treatment, and how well each helps gums heal. Fifty-two adults will be r…

This study tests whether using a special laser to disinfect the root canal can lower inflammation and pain after a root canal has failed. Fifty-two adults with a failed root canal and a visible infection on X-ray will receive either standard cleaning plus the laser or standard cl…

This study tests whether applying ozone therapy (active oxygen) to the gums after gum surgery can help them heal better and reduce pain. 48 adults with gum overgrowth will be randomly assigned to get either standard gum paste or gum paste plus ozone therapy. The researchers will …

This study looks at how common and severe gum disease is in people with obesity. Researchers will check dental health, analyze saliva for signs of inflammation, and look at genes linked to obesity. They will also study the bacteria in dental plaque to understand the connection be…

This pilot study investigates how a gel made from hyaluronic acid and polynucleotides affects early healing of gum defects after surgery. Researchers will measure molecular markers in gum fluid and use laser imaging to track blood flow changes. The study includes 24 adults with a…

This study looks at how the types of bacteria in the mouth change in people with severe gum disease as they go from having some teeth left to having no teeth, and then after getting dental implants. Researchers will collect microbial samples and analyze DNA to see if different im…

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study follows 100 adults with healthy gums or various stages of gum disease over two years. Researchers will collect saliva and plaque samples at yearly visits to measure specific biomarkers. The goal is to see if these markers can predict who will develop or worsen gum dise…

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This study looks at whether high uric acid levels (hyperuricemia) are linked to more severe gum disease and bone loss. Researchers will measure inflammation and oxidative stress markers in gum fluid and blood from 80 adults. Participants are grouped by gum health and uric acid st…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study looks at whether severe gum disease (periodontitis) is linked to stiffer arteries, which is a sign of heart risk. Researchers will compare 206 adults aged 40-69—half with advanced gum disease and half with healthy gums—using a simple test that measures artery stiffness…

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study looks at whether small composite attachments on molars used with clear aligners increase gum inflammation in teenagers. Researchers will measure inflammatory markers in gum fluid from 30 teens, comparing those with and without attachments. The goal is to understand if …

This study looks at fluid from the gums of 80 people with gingivitis—half children aged 8-12, half young adults aged 15-24. Researchers will measure inflammation markers to see if they differ by age. The goal is to understand how gum disease develops during growth and puberty.

This study watches 100 adults who are having jaw surgery to fix their bite. Researchers will check gum thickness, gum health, and bone around the teeth before surgery and at 1, 3, and 6 months after. The goal is to see how these tissues change over time. No treatment is given—thi…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study collects dental plaque and checks oral health in 100 adults with high plaque levels. Half have mild gum inflammation, half have moderate-to-severe gingivitis. Researchers will compare the types of bacteria in plaque to understand why some people develop gum disease and…

This study surveys 100 general practitioners in Italy to assess their knowledge of how oral health, especially gum disease, relates to systemic conditions like diabetes. Participants complete a 35-question digital questionnaire. The goal is to identify gaps in knowledge and impro…

This study aims to fine-tune a Hindi questionnaire that measures how gum disease (periodontitis) affects a person's quality of life. Researchers will enroll 106 adults with gum disease to see how well the questionnaire detects meaningful changes over time. The goal is to make sur…

This study looks at whether children with thin gums are more likely to have severely crowded teeth. Researchers will examine 180 kids aged 5 to 16 at different stages of tooth development. The goal is to find early warning signs so dentists can prevent future gum problems.

This study looks at whether deep dental cleaning (subgingival instrumentation) can reduce 'allostatic load' — the wear and tear stress puts on the body. Researchers will treat 112 adults aged 30-50 with gum disease and measure inflammation, blood sugar, and cholesterol levels bef…

This study is building a large database of health information from 5,000 people with ALS and other motor neuron diseases. Participants share details like symptoms, test results, and disease progression during regular clinic visits. The de-identified data is then shared with resea…

This study looks at a protein called Surfactant Protein D (SP-D) in the gum fluid of people with gum disease (periodontitis). Researchers will measure SP-D levels before and 6 months after a gentle, non-surgical cleaning treatment. The goal is to see if SP-D levels change with tr…

This study is looking at the gum health and mouth bacteria of 30 women who have had three or more miscarriages. Researchers want to see if there is a connection between certain bacteria in the mouth and pregnancy loss. Participants will have a standard dental checkup and provide …

This study looks at whether gum disease is more common in people who have had a heart attack. Researchers will compare the gum health of 320 adults—some who recently had a heart attack and some who haven't—to see if there's a link. The goal is to gather information that could lea…

This study is checking how often the fungus Candida albicans shows up in the gums of 100 Syrian adults with periodontitis (serious gum disease). Researchers will collect plaque samples and measure gum health to see if the fungus is linked to more severe disease. The goal is to be…

This study checks how often two tiny parasites (Entamoeba gingivalis and Trichomonas tenax) are found in the mouths of people with and without gum disease. Researchers will collect spit and plaque samples from 120 adults and look at them under a microscope. The goal is to learn i…

This study looks at how the community of bacteria in the mouth changes after three types of gum or implant surgery. Researchers will collect plaque samples before and after surgery from 84 adults with gum disease or implant infection. The goal is to learn which surgeries help res…

This study looks at how smoking cigarettes, e-cigarettes, or a water pipe (narghile) affects the gums and teeth of university students aged up to 25. Researchers will measure plaque, gum inflammation, pocket depth, and other signs of gum disease in 90 smokers. The goal is to see …

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This study looks at how antibiotics like amoxicillin and metronidazole work in the body when used with deep cleaning for severe gum disease. Researchers want to find the best dose and treatment length (3 vs 7 days) to kill harmful bacteria without overusing antibiotics. About 45 …

This study looks at how receding gums affect people's quality of life, like eating, smiling, and feeling confident. Researchers will screen 346 adults aged 18-45 to find out how common gum recession is and what causes it. No treatments are tested—just observation and questionnair…

This study looks at whether bacteria in your mouth can influence the buildup of fatty plaques in the neck arteries that supply blood to the brain. Researchers will collect samples from 200 adults having surgery to remove these plaques and compare the bacteria found in the mouth, …

This study is testing whether a standard deep-cleaning procedure for gum disease (scaling and root planing) changes the levels of three specific proteins in saliva. The researchers will compare these changes between smokers and non-smokers with moderate to advanced gum disease. A…

This study watches how gum grafts heal in 15 people after routine surgery for receding gums. Researchers use painless scans and blood flow tests to track swelling and new blood vessel growth. Saliva samples are also checked for healing markers. The goal is to learn what normal he…

This study aims to find biological markers in saliva, gum fluid, and tissue that can predict which people with mild gum inflammation will develop serious periodontitis. Researchers will use advanced techniques to analyze samples from 228 adults aged 18-40 with gingivitis or early…

This observational study at the University of Chile is examining whether a specific immune pathway (JAK1/2) is overactive in people with periodontitis, a common gum disease. Researchers will compare gum tissue from 30 healthy adults and those with inflamed gums to measure pathway…

This study looks at two proteins, Gas6 and sMerTK, in the fluid around teeth to see if they differ between healthy gums, gingivitis, and periodontitis. Researchers will collect samples from 90 adults and measure these proteins. The goal is to better understand the biology of gum …

This study looks back at 130 patients who had upper back teeth removed. Some had their tooth socket filled with bone graft material to preserve the jawbone, while others healed naturally. Researchers will compare CT scans taken months later to see if the preserved group has more …

This study uses a special high-frequency ultrasound to take detailed images of gum tissue. Researchers will compare healthy gums to gums with gingivitis (early gum disease) to see if the ultrasound can detect inflammation. About 40 adults will participate, and the goal is to find…

This study looks at how different oral hygiene routines (including mouthwash) affect gum health, mouth bacteria, and inflammation in people with gingivitis. About 250 adults will use assigned products twice daily for 4 weeks, then stop for 2 weeks to see how their gums and microb…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study looks at how standard gum disease treatments—deep cleaning with or without a special mouthwash—change proteins in your saliva and affect blood vessel health. Researchers will study 30 adults with gum disease to see if these treatments help or harm the good bacteria tha…

This study looks at the link between gum (periodontal) disease and hepatitis B+D infection, and whether the drug bulevirtide changes that relationship. Researchers will measure inflammation markers in saliva and gum fluid from 25 adults: those with hepatitis B+D on bulevirtide, t…

This observational study looks at gum tissue from people with aggressive or chronic periodontitis and healthy gums. Researchers use advanced genetic tools to map cell types and signals that make aggressive disease different. Only small tissue and blood samples are taken during pl…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study looks at whether using different concentrations of sodium hypochlorite (a type of bleach) during root canal retreatment can change pain levels and certain nerve chemicals in the tooth. Sixty adults needing a repeat root canal will be randomly assigned to receive 1%, 2.…

This study looks at whether taking probiotics (with or without vitamin B12) can improve the health of the mouth's bacteria and reduce gum disease in adults with severe periodontitis. Participants will receive standard gum treatment plus either a probiotic lozenge, a probiotic wit…

This study aims to find out if a specific bacteria called Treponema parvum is more common in people with gum disease (periodontitis) compared to healthy people. Researchers will collect plaque samples from the gums of 112 participants and use a DNA test to measure the amount of t…

This study surveys 100 French dentists who treat children to understand why they often choose extraction for non-vital baby teeth, even though effective alternatives like pulpectomy exist. The goal is to collect and analyze their treatment choices, reservations, and decision-maki…

This study is recruiting 50 adults to understand what factors make gum recession more likely after orthodontic treatment. Researchers will measure gum health, bite patterns, and other dental features in people with and without a history of braces. The goal is to create a simple g…

This study looks at whether sleep quality is linked to gum disease (periodontitis). Researchers will measure sleep quality, fatigue, and certain substances in saliva from 48 healthy adults with or without gum disease. The goal is to better understand how oral health and sleep are…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study looks at how the severity of pemphigus vulgaris, a chronic autoimmune skin disease, relates to gum health. Researchers will examine 20 adults with confirmed PV, measuring mouth sores and gum pocket depth, and comparing these with blood antibody levels. The goal is to u…

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how gum disease and smoking change certain proteins in saliva. Researchers will collect saliva and check gum health in 116 people with and without periodontitis. The goal is to see if these proteins can help diagnose gum disease and understand smoking's role.

This study tests whether artificial intelligence can predict if a less invasive procedure called full pulpotomy (removing only the infected pulp) will succeed in treating painful molars, compared to standard root canal treatment. Researchers will enroll 58 adults with irreversibl…

This study aims to better understand periodontitis and peri-implantitis by analyzing biological samples like plaque, saliva, and gum fluid from 219 participants. Researchers will compare samples from people with severe gum disease to those with healthy gums. The goal is to identi…

This study looks at whether root canal treatment can reduce inflammation markers linked to heart disease in people with stable coronary artery disease and infected tooth roots. Eighty adults will either get immediate root canal treatment or wait three months. Researchers will mea…

This study observes 50 adults with advanced gum disease (periodontitis) to see how much their deep gum pockets shrink after standard non-surgical treatment. Researchers measure pocket depth before treatment and again at 1, 3, and 6 months afterward. The goal is to understand how …

This study is looking at whether certain markers in blood and saliva can predict how well people with gum disease heal after non-surgical treatment. Researchers will measure these markers in 180 adults with healthy gums, gingivitis, or advanced periodontitis before and after trea…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study aims to develop a better way to measure oral health using photographs and imaging software, rather than traditional dental exams. About 275 adults will use different toothpastes or mouthwashes for up to 6 months, and researchers will track plaque levels, gum health, an…

This study looks at how inflammation in the gums affects the body's immune response during wound healing after a tooth is pulled. Researchers will measure gum health before extraction, take small tissue samples right after and again two weeks later, and check healing at three mon…

This study looks at a protein called Mitofusin-1 in saliva to see if it can help measure how severe gum disease is and how well treatment works. Researchers will compare healthy people, those with mild to severe gum disease, and smokers with severe gum disease. Participants give …

This observational study in 46 people with severe gum disease aims to understand how two types of gum tissue (infra-osseous and supra-osseous granulation tissue) differ in their healing potential and infection-fighting properties. Researchers will collect tissue samples during pe…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study looks at why people's gums respond differently to the buildup of dental plaque. Researchers will monitor 80 healthy adults aged 18-35 as they stop brushing for a period to allow plaque to grow naturally. The goal is to identify the biological reasons behind varying lev…

This study at the University of Michigan is testing whether ultrasound can monitor bone graft healing after tooth extraction, potentially replacing more invasive scans. About 140 adults needing a tooth extraction and bone graft for a future dental implant will have their healing …

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely. No treatment or medication is involved—just ob…

This study looks at whether training medical staff and using electronic health records can encourage older adults (55+) on Medicaid to visit the dentist more often. About 929 participants from 12 primary care clinics will be split into two groups: one where doctors get extra trai…

This study looks at whether starting to close the gap left by a tooth extraction early (1 week after) or later (8 weeks after) changes the chance of developing a gum cleft. Nineteen orthodontic patients will have one side of their mouth assigned to early closure and the other to …

This study examines how B cells, a type of immune cell, behave in the blood and gums of people with periodontitis (gum disease). Researchers want to see if certain B cell patterns are linked to more aggressive disease and how they change after surgery. The goal is to improve diag…

This study compares five different non-surgical treatments for advanced gum disease (periodontitis) to see how they affect inflammation throughout the body and the risk of bacteria entering the bloodstream. Researchers will measure blood markers like C-reactive protein and interl…