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Could a Blood-Derived gel help rebuild bone lost to gum disease?

NCT ID NCT07146776

Recruiting now Disease control Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether adding injectable platelet-rich fibrin (i-PRF) to a standard bone graft helps fill in bone defects caused by advanced gum disease. Sixteen adults with stage III periodontitis will receive either the combo treatment or the graft alone during surgery. Researchers will measure bone fill and gum attachment levels over six months to see if the i-PRF makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
injectable platelet-rich fibrin (i-PRF) mixed with bovine bone graft
What this could lead to
If it works, this could point toward a better way to repair bone defects caused by gum disease, potentially improving tooth stability.
What could go wrong
This is a very small early trial (16 people) with no blinding, so results may not be reliable or generalizable. The procedure is surgical and carries typical risks like infection or pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRABONY PERIODONTAL DEFECT PERIODONTAL BONE LOSS PERIODONTAL DEFECT PERIODONTAL DISEASES PERIODONTITIS

Contacts and locations

Locations

  • Sağlık Bilimleri Üniversitesi

    RECRUITING

    Istanbul, Üsküdar, Turkey (Türkiye)

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