PERIODONTAL DISEASES

This study tests whether a special dental gel, used at home, can help reduce deep gum pockets more than standard deep cleaning alone. It involves 76 adults with moderate to severe gum disease. Participants will use the gel or a regular toothpaste for 6 months, and researchers wil…

This study tests whether adding a substance made from a patient's own blood (injectable platelet-rich fibrin) to a standard bone graft helps repair bone damage caused by gum disease. Sixteen adults with advanced gum disease and deep bone defects will receive either the combinatio…

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay, and improve their quality of life. One hundred cancer survivors who finished treatment at least 6 months ago will either get the telehealth program or usual …

This study tests a new way to do gum surgery for advanced gum disease. Instead of removing the inflamed tissue, surgeons will try to save it to help the gums heal better. The study will compare the new method to standard surgery in 25 adults and check results after 12 months.

This study compares three surgical techniques to regenerate gum tissue in people with periodontitis, a serious gum infection. Researchers will test a newer method that avoids cutting the small triangles of gum between teeth against two standard approaches. The goal is to see whic…

This study tests if using a sodium bicarbonate (baking soda) fluoride toothpaste every day can help maintain gum health in adults who have already had non-surgical gum treatment. One hundred participants will use either the special toothpaste or a placebo and have their gum healt…

This study tests whether a collagen matrix can help regrow bone and tissue damaged by gum disease as well as a standard bone graft. About 80 adults with advanced gum disease and deep bone defects will receive one of the two treatments during surgery. Researchers will measure chan…

This study tests whether a gel containing lovastatin (a cholesterol drug) placed under the gum can improve standard gum disease treatment. About 44 adults with periodontitis, both smokers and non-smokers, will receive the medicated gel on one tooth and a placebo gel on another af…

This study compares two ways dentists see during gum surgery: standard magnifying glasses (dental loupes) versus a more powerful microscope. The goal is to find out if the microscope leads to better healing of the gums. About 25 adults with gum disease who need surgery will take …

This study tests whether two different stitch materials (Novosyn Quick and Monosyn Quick) work equally well for healing after gum surgery. About 84 adults having gum surgery will receive one type of stitch, and doctors will check healing, pain, and satisfaction about 10 days late…

This study looks at whether training doctors and changing electronic health records can encourage older adults (55+) on Medicaid to visit the dentist. About 929 people from 12 clinics will take part. The goal is to see if these changes lead to more dental visits and better oral h…

This study looks at how the severity of pemphigus vulgaris, a chronic autoimmune skin disease, relates to gum health. Researchers will measure mouth sores and blood markers in 20 adults and compare them with standard gum measurements. The goal is to understand if worse disease le…

This observational study looks at two types of gum tissue from people with severe periodontitis to understand their role in healing after treatment. Researchers will collect tissue samples during surgery and compare them between smokers and non-smokers. The goal is to learn how t…

This study looks at whether certain markers in blood and saliva can help predict how well people with gum disease will heal after non-surgical treatment. Researchers will measure these markers in 180 adults (healthy, with gingivitis, or with advanced periodontitis) before and aft…