PERIODONTAL DISEASES

This trial tests whether applying a gel containing hyaluronic acid and chlorhexidine after a minimally invasive deep cleaning can improve gum healing in people with advanced periodontitis (stage III or IV). Participants receive either the deep cleaning alone or the cleaning plus …

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…

This study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…

This study tests whether a probiotic tablet (Lactobacillus reuteri) can reduce harmful mouth bacteria as well as a standard chlorhexidine mouthwash in people with gum disease and type 2 diabetes. Twenty participants will use either the mouthwash or the probiotic for 30 days. The …

This study tests whether a protein from camel milk, made into tiny nanoparticles, can help repair bone damage caused by severe gum disease. About 44 adults with deep gum pockets and bone loss will receive the treatment during surgery. The goal is to see if the camel protein helps…

This study follows 100 people who already have short, 3D-printed dental implants in the back of the upper or lower jaw. Researchers measure bone loss and other dental health markers over three years to see how well these implants hold up. The goal is to learn whether these specia…

This study looks at how smoking changes the body's immune response in gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link between smoking and infl…

This study looks at whether the Parkinson's drug Levodopa-Benserazide affects gum health and inflammation. Researchers will measure gum health and saliva markers in 136 people, including Parkinson's patients with and without gum disease, and healthy controls. The goal is to under…

This study looks at whether offering dental exams and cleanings to people with cirrhosis can improve their oral health and overall well-being. Researchers will also ask participants about barriers to getting dental care. About 100 adults with confirmed cirrhosis will take part, a…

This study looks at 50 people with gum disease—25 smokers and 25 non-smokers—to see if a protein in saliva called histatin-1 is linked to healing after standard non-surgical gum treatment. Researchers measure the protein and gum health at the start, one month, and three months af…

This study follows 30 adults who had surgery for advanced gum disease (periodontitis). Researchers want to see if the surgery keeps teeth healthy and how long the benefits last. Participants are checked at regular visits with exams and X-rays. This is an observational study, mean…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that can quickly tell if someone has a bloodstream infection, which could help diagnose sepsis faster. About 100 adults with gum disease ar…