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Could a Patient's own blood regrow gum and bone better than animal grafts?

NCT ID NCT04254861

Recruiting now Disease control Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests two types of gum surgery for people with advanced gum disease (periodontitis). One surgery uses a product made from the patient's own blood (PRGF) to help regenerate damaged gum and bone. The other uses a standard animal-derived bone graft and membrane. Researchers will compare how well each method reduces deep gum pockets and promotes bone regrowth over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PRGF (platelet-rich growth factor from patient's own blood)
What this could lead to
If PRGF works as well as or better than the standard bone graft, it could offer a simpler, natural alternative for regenerating gum and bone tissue damaged by periodontitis.
What could go wrong
This is a small, early-stage study (74 people) comparing two surgical techniques. PRGF is still experimental for this use, and results may not apply to all patients or guarantee long-term success.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIODONTAL DISEASES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Barts and The London Dental Hospital

    RECRUITING

    London, E1 2AD, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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