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Could a melatonin gel help gums heal after deep cleaning?

NCT ID NCT07813936

Disease control Sponsor: Alexandria University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers are testing whether a 2% melatonin gel placed directly into gum pockets can improve outcomes when added to standard non-surgical periodontal therapy. The trial enrolls 23 systemically healthy adults with Stage II Grade B periodontitis. Each participant receives standard cleaning on both sides of the mouth, but one side also gets the melatonin gel and the other gets a placebo gel. The team measures changes in clinical attachment loss, pocket depth, bleeding on probing, and melatonin levels in gum fluid.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A 2% melatonin gel applied directly into gum pockets
What this could lead to
If it works, a melatonin gel could become a simple add-on to standard gum cleaning that helps repair the tissue holding teeth in place.
What could go wrong
This is a small, single-center study of 23 people, so any benefit may be modest or may not hold up in larger groups. Melatonin gel applied to the gums could cause local irritation, and the split-mouth design means each person receives both the gel and a placebo in different parts of the mouth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 23 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy patients diagnosed with Stage II Grade B Periodontitis * Patients with good oral hygiene compliance Exclusion Criteria: * Smokers (due to the effect of smoking on melatonin levels and healing) * Pregnant or lactating females. * Patients who have received antibiotics, anti-inflammatory drugs, or antioxidant supplements within the last 6 months. * Patients taking systemic melatonin for sleep disorders. * Patients who have undergone periodontal therapy in the last 6 months.

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Conditions

The condition(s) this trial relates to.

periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal diseases

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Outpatient Clinic of Periodontology and Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt

    Alexandria, Egypt

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