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Herbal gel could boost gum disease treatment

NCT ID NCT07697209

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study tests whether a gel made from Centella asiatica (a herb) can improve standard treatment for gum disease. Adults with periodontitis receive either standard deep cleaning alone or cleaning plus the gel applied to the gums once a week for three months. Researchers measure gum health and antioxidant markers to see if the gel reduces inflammation and helps gums heal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Centella asiatica nanoemulsion gel
What this could lead to
If effective, this gel could become a simple, natural add-on treatment to improve outcomes for people with gum disease.
What could go wrong
This is a small, early-stage trial with 45 participants, so results may not apply widely. The gel is tested as an add-on, not a standalone cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Mar 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 25-55 years, either sex * Diagnosis of periodontal health OR Stage III periodontitis (per 2017 World Workshop Classification) Exclusion Criteria: * Known allergy or sensitivity to any component of the study medication * Systemic antibiotics or anti-inflammatory medications within the preceding 6 months * Uncontrolled diabetes mellitus * Cardiovascular disease * Rheumatoid arthritis * Renal disease * Pulmonary disease * Thyroid disease * Malignancy * Current smokers * Pregnant or lactating women * Unable or unwilling to comply with prescribed oral hygiene instructions

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal bone loss Periodontal diseases

Contacts and locations

Locations

  • faculty of dentistry Mansoura university, Mansoura, 35516

    Al Mansurah, Egypt

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