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A deep-dive into gum disease: can a standard cleaning calm the body's tissue-damage signals?

NCT ID NCT07797127

Disease control Sponsor: Adiyaman University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

This trial looks at people who have both periodontitis (gum disease around natural teeth) and peri-implantitis (inflammation around dental implants). Researchers will measure three proteins in the fluid around teeth and implants before and after routine non-surgical therapy, which includes deep cleaning and oral hygiene instructions. The goal is to see whether this standard treatment changes those protein levels and improves clinical measures like pocket depth. The study includes 30 systemically healthy adults aged 18 to 65 with at least one implant in use for a year or more.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Routine non-surgical periodontal therapy, including scaling and root planing and oral hygiene instructions
What this could lead to
If successful, this could show that routine non-surgical therapy reduces tissue-destruction markers in both teeth and implants, potentially improving treatment monitoring for gum and implant disease.
What could go wrong
This is a small, early study with 30 participants, so results may not apply broadly. The biomarkers measured may not reliably reflect disease activity or treatment response.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of systemically healthy male and female adults, aged 18 to 65 years, who apply to the Adıyaman University Faculty of Dentistry, Department of Periodontology. The test group includes patients concurrently diagnosed with both Generalized Stage III-IV Periodontitis and Peri-implantitis. The control group consists of individuals with completely healthy periodontal and peri-implant tissues.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged between 18 and 65 years and providing written informed consent. * Systemically healthy (absence of diabetes, osteoporosis, immunological diseases, etc.). * Having a dental implant with prosthetic loading that has been in function for at least 1 year. * No history of periodontal treatment within the last 6 months. * No use of medications that could affect study outcomes (mouthwashes, antibiotics, non-steroidal anti-inflammatory drugs \[NSAIDs\], corticosteroids) in the 3 months prior to sampling. * For the Test Group: Concurrent presence of both Peri-implantitis (bleeding on probing/suppuration, PD \>= 5mm, radiographic bone loss \>= 2mm) and Periodontitis (Generalized Stage III-IV, presence of bleeding on probing and clinical attachment loss) in the same oral cavity. * For the Control Group: Completely healthy periodontal and peri-implant tissues (negative bleeding on probing, PD \<= 3mm, no bone loss), with a low plaque index score (\<20%) and good oral hygiene. Exclusion Criteria: * Current use of smoking and tobacco products (or having quit within the last 5 years). * History of any periodontal or peri-implant surgical/non-surgical treatment within the last 6 months. * Use of antibiotics, anti-inflammatory drugs (NSAIDs), or immunosuppressive drugs within the last 3 months. * Pregnancy, lactation (breastfeeding), or use of oral contraceptives. * Presence of faulty restorations, overhanging fillings, or removable prosthesis clasps that increase plaque accumulation on the tooth or implant to be examined (to eliminate local factors). * Detection of mobility in the implant to be examined (this is considered implant failure/loss, not just peri-implantitis). * Presence of active orthodontic treatment (brackets/wires) in the regions where samples will be collected.

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Conditions

The condition(s) this trial relates to.

hereditary mixed polyposis syndrome Peri-Implantitis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periimplantitis Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Adıyaman University Faculty of Dentistry, Department of Periodontology

    Adıyaman, Adıyaman Province, 02040, Turkey (Türkiye)

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