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Can a Patient's own blood help heal deep gum pockets?

NCT ID NCT07794046

Disease control Sponsor: Halil Ata BIÇAKÇIOĞLU Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This trial tests whether adding a gel made from a patient's own blood, called albumin platelet-rich fibrin (Alb-PRF), to standard nonsurgical gum treatment improves healing of deep gum pockets in adults with periodontitis. Each participant has matched gum sites randomly assigned to receive either standard cleaning alone or standard cleaning plus the Alb-PRF gel. Researchers measure pocket depth and gum attachment at several time points over six months, and also check for changes in bacteria linked to gum disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Albumin platelet-rich fibrin (Alb-PRF), a material made from the participant's own blood, applied into gum pockets alongside standard nonsurgical periodontal therapy.
What this could lead to
If it works, adding Alb-PRF to standard gum cleaning could improve healing of deep gum pockets and help control the bacteria that drive periodontitis.
What could go wrong
This is a small early-stage trial with 24 participants, so results may not apply broadly. The added benefit of Alb-PRF over standard therapy alone remains uncertain, and the procedure carries typical risks like infection or discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 65 years. * Diagnosis of periodontitis according to the 2017 classification of periodontal and peri-implant diseases and conditions. * Presence of at least two clinically comparable periodontal sites within the same mouth that are suitable for a split-mouth design. * Periodontal probing depth of 5 mm or greater at the sites selected for randomization. * No systemic condition that would contraindicate nonsurgical periodontal therapy or adversely affect periodontal healing. * No current use of medications known to affect periodontal tissue healing. * No periodontal surgical treatment within the previous 6 months. * Ability to understand the study procedures, provide written informed consent, and attend the scheduled follow-up visits. Exclusion Criteria: * Current smoking or smoking cessation within the previous 6 months. * Diabetes mellitus, uncontrolled hypertension, serious cardiovascular disease, autoimmune disease, liver failure, kidney failure, or another systemic condition that may adversely affect periodontal healing or treatment. * Use of antibiotics, corticosteroids, bisphosphonates, antiresorptive agents, immunosuppressive agents, or other medications known to affect periodontal healing within the previous 6 months. * Pregnancy or lactation. * Acute periodontal abscess or acute endodontic infection at a selected study site. * Hematologic disease, bleeding disorder, anticoagulant therapy, or another condition that may interfere with venous blood collection. * Known hypersensitivity to any material used in the study. * Inadequate oral hygiene or inability to meet the oral hygiene requirements of the study protocol. * Current orthodontic treatment. * Inability or unwillingness to attend the scheduled follow-up visits.

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Conditions

The condition(s) this trial relates to.

Periodontal Pocket periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Gazi University Faculty of Dentistry, Department of Periodontology

    Ankara, Ankara, 06490, Turkey (Türkiye)

  • Çankırı Karatekin University Faculty of Dentistry, Department of Periodontology

    Çankırı, Çankırı, 18100, Turkey (Türkiye)

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