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Can a gel help gums reattach to teeth after surgery?

NCT ID NCT05073575

Disease control Sponsor: Federico II University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether applying hyaluronic acid gel to exposed tooth roots during gum surgery improves healing compared with surgery alone. Researchers plan to enroll 80 adults with periodontitis who have suprabony defects, meaning bone loss that leaves pockets at least 5 mm deep. Participants are randomly assigned to receive open flap debridement with or without the gel. The main measure is the gain in clinical attachment level, which reflects how firmly the gum reattaches to the tooth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hyaluronic acid gel applied to exposed tooth roots during gum surgery
What this could lead to
If it works, adding hyaluronic acid to gum surgery could improve attachment of gums to teeth and reduce pocket depths, potentially slowing bone loss and tooth loss.
What could go wrong
This is a small, early-stage trial, and results may not show a clear benefit over standard surgery alone. Hyaluronic acid is generally safe, but any surgery carries risks like infection or swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Jan 2023

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with periodontitis * Age ≥ 18 years old * Single-rooted and multi-rooted teeth * Presence of suprabony periodontal defects at a minimum of two adjacent teeth and a maximum of 7 adjacent teeth in either the maxilla or the mandible with a PD ≥ 5 mm after completion of non-surgical periodontal treatment and re-evaluation * Intrabony defect with an intraosseous component \< 2 mm Exclusion Criteria: * Patients with systemic diseases * Prolonged antibiotic or anti-inflammatory treatment within 4 weeks prior to surgery * Pregnant or lactating * Tobacco smokers (≥ 10 cigarettes per day) * Multi-rooted teeth with furcation involvement * Increased tooth mobility (grade II and III)

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal bone loss

Contacts and locations

Locations

  • University of Naples Federico II

    Naples, Naples, 80131, Italy

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