Federico Ii University

This study will follow 3,000 Italian adults taking Inclisiran, a long-acting cholesterol-lowering injection, to see how consistently they take it and how much their LDL (bad) cholesterol drops. Researchers want to understand real-world adherence and effectiveness, not test a new …

This study compares a new once-daily dual-release hydrocortisone to standard glucocorticoid therapy in 150 adults with congenital adrenal hyperplasia. The goal is to see if the once-daily pill improves cholesterol, blood sugar, weight, blood pressure, and quality of life. Partici…

This study tests if the drug Ranolazine can help protect the tiny blood vessels in the heart after a major heart attack. About 100 adults who have had a heart attack and have blockages in more than one artery will receive either standard care or standard care plus Ranolazine. The…

This study looks at whether adding semaglutide to standard diabetes care can lower inflammation and improve blood vessel function in people with type 2 diabetes who do not yet have heart disease. Researchers will measure markers of inflammation and blood vessel health in 80 parti…

This study tests whether eating a Mediterranean diet during pregnancy can prevent allergies in children. Researchers will enroll 276 healthy pregnant women who are at risk of having a baby with allergies. Half will follow a Mediterranean diet, and the other half will eat as usual…

This study tests whether a common probiotic, Lactobacillus rhamnosus GG (LGG), can reduce stomach issues like constipation and diarrhea in children with autism spectrum disorder (ASD). About 50 children aged 4 to 12 with both ASD and ongoing stomach problems will receive the prob…

This study will track 5,000 people in Italy who are prescribed PCSK9 inhibitors for high cholesterol. Researchers want to see how consistently patients take their medication, how long they stay on it, and how much their cholesterol levels drop. The goal is to understand real-worl…

This study is not testing a new drug or treatment. Instead, it will observe 3000 adults with type 2 diabetes in Italy to see how well their heart-related risks are managed according to current guidelines. Researchers will collect data from routine clinic visits to understand what…

This study will follow 1,500 Italian adults taking bempedoic acid for high cholesterol to see how consistently they take the medication and how much their LDL cholesterol drops. Researchers will also track side effects. The goal is to understand how the drug works outside of cont…

This study looks at using a special green dye (ICG) during a surgery called Heller-Dor for people with achalasia, a swallowing disorder. The dye makes it easier for surgeons to see if there are any leaks or leftover muscle fibers during the operation. The goal is to improve safet…

This study is a registry that will follow 1,500 Italian adults taking alirocumab 300 mg for high cholesterol. Researchers want to see how well patients stick with the treatment over time and how much it lowers their LDL (bad) cholesterol in everyday life. The study does not test …

This study looks at how food, gut bacteria, and genetics affect blood sugar spikes in people with type 1 diabetes. About 200 participants will track their meals, provide stool and blood samples, and wear a continuous glucose monitor. The goal is to find patterns that could lead t…