Massive italian study tracks Real-World use of Cholesterol-Lowering injections

NCT ID NCT05430828

Recruiting now Knowledge-focused Sponsor: Federico II University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is following 5,000 Italian patients who are taking PCSK9 inhibitor injections (Repatha or Praluent) for high cholesterol. Researchers want to see how consistently patients take their medication and how well it lowers their LDL cholesterol in real life, not just in a lab. The study will also track side effects and look at differences by age, sex, and other factors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PCSK9 inhibitors (evolocumab and alirocumab) given as injections
What this could lead to: If successful, this study could show how well these cholesterol-lowering drugs work in everyday use and help doctors improve treatment plans.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply outside Italy.

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Conditions

The condition(s) this trial relates to.

Hypercholesterolemia hyperlipidemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERCHOLESTEROLEMIA

Contacts and locations

Locations

AORN dei Colli - Ospedale monaldi
RECRUITING

Naples, 80131, Italy
ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
Azienda Ospedaliera Ordine Mauriziano Torino
RECRUITING

Torino, 10128, Italy
Azienda Ospedaliera San Camillo-Forlanini
RECRUITING

Roma, 00152, Italy
Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona
RECRUITING

Salerno, 84131, Italy
Azienda Ospedaliero-Univeristaria di Parma
RECRUITING

Parma, 43126, Italy
Azienda Ospedaliero-Universitaria "Maggiore della Carità"
RECRUITING

Novara, 28100, Italy
Federico II University of Naples, Department of Advanced Biomedical Sciences
RECRUITING

Naples, 80131, Italy
Federico II University of Naples, Department of Translational Medical Sciences
RECRUITING

Naples, 80131, Italy
Ospedale SS Annunziata A.O.U.
RECRUITING

Sassari, 07100, Italy
Ospedale di Lecce
RECRUITING

Lecce, 73100, Italy
Ospedale di Rivoli
RECRUITING

Rivoli, 10098, Italy
Ospedali dell'Ovest Vicentino
RECRUITING

Arzignano, 36071, Italy
Policlinico Casilino
RECRUITING

Roma, 00169, Italy
Policlinico Riuniti Foggia
RECRUITING

Foggia, 71122, Italy
Policlinico Tor Vergata
RECRUITING

Roma, 00133, Italy
Policlinico di Milano Ospedale Maggiore - Fondazione IRCCS Ca' Granda
RECRUITING

Milan, 20122, Italy
Presidio Ospedaliero Maria SS Addolorata
RECRUITING

Eboli, 84025, Italy
Presidio Ospedaliero Pescara
RECRUITING

Pescara, 65124, Italy
Sapienza University of Rome
WITHDRAWN

Roma, 00185, Italy
University Magna Graecia of Catanzaro
RECRUITING

Catanzaro, 88100, Italy
University of Bari Aldo Moro
RECRUITING

Bari, 70121, Italy
University of Campania Luigi Vanvitelli
RECRUITING

Caserta, 81100, Italy
University of Naples Federico II, Department of Clinical Medicine and Surgery
RECRUITING

Naples, 80131, Italy
University of Siena
RECRUITING

Siena, 53100, Italy
Università degli Studi di Genova
RECRUITING

Genova, 16126, Italy
Università degli Studi di Messina
RECRUITING

Messina, 98122, Italy

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